Cited by 312Phytochemicals and Antioxidant ActivitiesNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

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Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress

Youdim, Kuresh A, Martin, Antonio, Joseph, James A·2000·Free Radical Biology and Medicine

DOI 10.1016/s0891-5849(00)00329-4

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Abstract

The objective of this study was to investigate the ability of endothelial cells (EC) to incorporate anthocyanins and to examine their potential benefits against various oxidative stressors. Endothelial dysfunction has been proposed to play an important role in the initiation and development of vascular disease, with studies having shown that administration of antioxidants improves endothelial function. Elderberry extract contains 4 anthocyanins, which where incorporated into the plasma membrane and cytosol of EC following 4 h incubation at 1 mg.ml(-1). However, incorporation within the cytosol was considerably less than that in the membrane. Uptake within both regions appeared to be structure dependent, with monoglycoside concentrations higher than that of the diglucosides in both compartments. The enrichment of EC with elderberry anthocyanins conferred significant protective effects in EC against the following oxidative stressors: hydrogen peroxide (H(2)O(2)); 2, 2'-azobis(2-amidinopropane) dihydrochloride (AAPH); and FeSO(4)/ascorbic acid (AA). These results show for the first time that vascular EC can incorporate anthocyanins into the membrane and cytosol, conferring significant protective effects against oxidative insult. These findings may have important implications on preserving EC function and preventing the initiation of EC changes associated with vascular diseases.

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Authors: Youdim, K. A., Martin, A., & Joseph, J. A.
Affiliations: Tufts University (US)
Corresponding author: Youdim, Kuresh A
ORCID: Youdim, Kuresh A
Joseph, James A
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2000-07
Volume: 29
Issue: 1
Pages: 51-60
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/s0891-5849(00)00329-4
OpenAlex: W2154801407
Cited by: 312
References: 65
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 20 · 2016: 10 · 2015: 18 · 2014: 12 · 2013: 22 · 2012: 17
FWCI: 5.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Agriculture
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: endothelial cells, oxidative stress, endothelial dysfunction, diglucosides, hydrogen peroxide, AAPH, iron ascorbate, antioxidant defense, vascular disease
MeSH terms: Amidines, Animals, Anthocyanins, Aorta, Ascorbic Acid, Cattle, Cell Division, Cells, Cultured, Endothelium, Vascular, Ferric Compounds, Fruit, Humans, Kinetics, Mitochondria, Plant Extracts, Oxidants, Oxidative Stress

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Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress

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