The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress
Abstract
The objective of this study was to investigate the ability of endothelial cells (EC) to incorporate anthocyanins and to examine their potential benefits against various oxidative stressors. Endothelial dysfunction has been proposed to play an important role in the initiation and development of vascular disease, with studies having shown that administration of antioxidants improves endothelial function. Elderberry extract contains 4 anthocyanins, which where incorporated into the plasma membrane and cytosol of EC following 4 h incubation at 1 mg.ml(-1). However, incorporation within the cytosol was considerably less than that in the membrane. Uptake within both regions appeared to be structure dependent, with monoglycoside concentrations higher than that of the diglucosides in both compartments. The enrichment of EC with elderberry anthocyanins conferred significant protective effects in EC against the following oxidative stressors: hydrogen peroxide (H(2)O(2)); 2, 2'-azobis(2-amidinopropane) dihydrochloride (AAPH); and FeSO(4)/ascorbic acid (AA). These results show for the first time that vascular EC can incorporate anthocyanins into the membrane and cytosol, conferring significant protective effects against oxidative insult. These findings may have important implications on preserving EC function and preventing the initiation of EC changes associated with vascular diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Youdim et al. have reported the incorporation of elderberry anthocyanins by endothelial cells, following a 4-h incubation at a concentration of 1 mg/mL.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [60]
In the citing paper
“Several lines of evidence indicate a role for berry anthocyanins in significantly decreasing oxidative damage and inflammation in cellular and animal models of CVD.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [60]
In the citing paper
“In addition to the cellular bioavailability, elderberry anthocyanins significantly decreased cytotoxicity caused by chemical inducers of oxidative stress.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [60]
Citations
Cites
Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104
Free Radicals as Mediators of Tissue Injury and Disease
Kehrer, J. P. (1993) · Critical Reviews in Toxicology · doi:10.3109/10408449309104073 · Cited by 1,460
Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J., & Bickford, P. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08114.1999 · Cited by 980
Self-citationRedox Regulation of NF-kappa B Activation
Flohé, L., Brigelius‐Flohé, R., Saliou, C., Traber, M. G., & Packer, L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00501-1 · Cited by 859
Taddei, S., Virdis, A., Ghiadoni, L., Magagna, A., & Salvetti, A. (1998) · Circulation · doi:10.1161/01.cir.97.22.2222 · Cited by 757
Effect of Plant Flavonoids on Immune and Inflammatory Cell Function
Middleton, E. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5335-9_13 · Cited by 735
Day, A. J., DuPont, M. S., Ridley, S., Rhodes, M. J. C., Rhodes, M. J. C., Morgan, M. R. A., & Williamson, G. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01101-6 · Cited by 730
Effects of flavonoids on immune and inflammatory cell functions
Middleton, E., & Kandaswami, C. C. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90489-6 · Cited by 675
Tsai, S., Lin‐Shiau, S., & Lin, J. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702357 · Cited by 511
Synthesis of von Willebrand Factor by Cultured Human Endothelial Cells
JAFFE, E. A., Hoyer, L. W., & Nachman, R. L. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.5.1906 · Cited by 485
Research works printed but not linked: 2
- Detre, 1986, Studies on vascular permeability in hypertension, Clin. Physiol. Biochem., 4, 143
- Mosmann, 1983, Rapid colorimetric assay for cellular growth and survival, J. Immunol., 65, 55
Cited by
Sorted by citations
Items 301–312 of 312
Aktywność biologiczna bzu czarnego (Sambucus nigra L.)
Nurzyńska-Wierdak, R., & Krajewska, A. M. (2022) · Annales Horticulturae · doi:10.24326/ah.2022.1.2
Weng, X., Li, W., Xu, H. M., Li, S., Wang, X., Li, K., Xu, L., Liu, J., Yue, X., & Li, F. (2023) · Small Ruminant Research · doi:10.1016/j.smallrumres.2023.107035
Souza, A. A. D., Viana, D. S. B., Marinho, R. D. M. D. P., Jesus, T. A. B. D., & Rodrigues, N. D. R. (2023) · OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA · doi:10.55905/oelv21n11-002
Stinging Nettle (Urtica Simensis): A Review of Its Role in Plant Pathology and Disease Management
Mamo, T. (2024) · Science Development · doi:10.11648/j.scidev.20240503.11
Honesová, S. J., Dadáková, E., Brožíková, S., Janů, T., Baldíková, E., Hasoňová, L., Vo, T. T. H., Moudrá, P., & Samková, E. (2025) · Konference o jakosti potravin a potravinových surovin / Conference on Food Quality and Safety · doi:10.11118/978-80-7701-048-1-0068
ÖZGÜR, E. B., Dinçoğlu, A. H., & Özgür, M. (2026) · Scientific Reports · doi:10.1038/s41598-026-58405-1
Assessment of Phytochemicals in Preventing Oxidatively Damaged DNA in Bladder Cancer
Zainol, M. (2011) · Figshare
Kinetika inhibicije DPPH radikala i antiradikalna aktivnost polifenola iz plodova aronije i bazge
Jakobek, L., Šeruga, M., Novak, I., Medvidović‐Kosanović, M., & Šeruga, B. (2009) · Pomologia Croatica
Guerra, Y. A., Galarce‐Bustos, O., Tapia, C. A., Obregón, C., Hernández, D. G., & Avello, M. (2026) · Research Square · doi:10.21203/rs.3.rs-9235979/v1
Biomarkers of tea and coffee-derived polyphenol exposure in human subjects
Chan, S. Y. (2004) · UWA Profiles and Research Repository (UWA)
The effect of oligomeric procyanidins on endothelial function and cholesterol homeostasis
Rull, G. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique)
Metadata
- Authors
- Youdim, K. A., Martin, A., & Joseph, J. A.
- Affiliations
- Tufts University (US)
- Corresponding author
- Youdim, Kuresh A
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 29
- Issue
- 1
- Pages
- 51-60
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2154801407
- Cited by
- 312
- References
- 65
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 20 · 2016: 10 · 2015: 18 · 2014: 12 · 2013: 22 · 2012: 17
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- endothelial cells, oxidative stress, endothelial dysfunction, diglucosides, hydrogen peroxide, AAPH, iron ascorbate, antioxidant defense, vascular disease
- MeSH terms
- Amidines, Animals, Anthocyanins, Aorta, Ascorbic Acid, Cattle, Cell Division, Cells, Cultured, Endothelium, Vascular, Ferric Compounds, Fruit, Humans, Kinetics, Mitochondria, Plant Extracts, Oxidants, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
