Determination of Optimal Conditions for Synthesis of Peroxynitrite by Mixing Acidified Hydrogen Peroxide with Nitrite
Abstract
The measured parameters for the formation of peroxynitrous acid via the reaction of acidified hydrogen peroxide with nitrous acid and its self-decomposition corroborate with an earlier suggested mechanism in which H2NO2+ nitrosates H2O2. The activation energies for the formation and decay of peroxynitrous acid have been determined to be 15 and 19 kcal/mol, respectively. We found that perchlorate, nitrate, sulfate and phosphate ions have no effect on the formation and decay rates, whereas chloride ions enhance the rate of the formation of peroxynitrous acid at low peroxide concentrations, and have no effect at high peroxide concentrations. This suggests that at relatively low concentration of H2O2, Cl- competes with H2O2 for H2NO+ to yield NOCl, which may also nitrosate H2O2. Simulation of the experimentally observed parameters for the decay and formation rates suggests that it is not possible to obtain 100% yield of peroxynitrite under any condition. High yields of peroxynitrite were obtained at room temperature using an efficient double mixer where acidified peroxide was mixed with nitrite; after an appropriate delay, the reaction was quenched with strong alkali. An excess of more than 10% of H2O2 over nitrite, or vice versa, is sufficient to get ca. 85-90% of peroxynitrite, almost free from nitrite or H2O2, respectively. The results also suggest that conventional use of ice-cold solutions of the reactants and the alkali solutions is not required if an efficient mixer and appropriate quenching times are available.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HO mediates the degradation of heme in mammals.
“HO mediates the degradation of heme in mammals. This enzyme catalyzes the degradation of the protoporphyrin IX (heme b) to biliverdin (805, 806).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [806]
HO catalyzes the degradation of protoporphyrin IX (heme b) to biliverdin.
“This enzyme catalyzes the degradation of the protoporphyrin IX (heme b) to biliverdin (805, 806).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [806]
Cites
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029 · see citing works
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511 · see citing works
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H., & Beckman, J. S. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00030a017 · Cited by 1,338 · see citing works
[23] Oxidative chemistry of peroxynitrite
Beckman, J. S., Chen, J., Ischiropoulos, H., & Crow, J. P. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33026-3 · Cited by 973 · see citing works
H2O2 Determination by the I3- Method and by KMnO4 Titration
Klassen, N. V., Marchington, D., & Mcgowan, H. (1994) · Analytical Chemistry · doi:10.1021/ac00090a020 · Cited by 957 · see citing works
Pathological implications of nitric oxide, superoxide and peroxynitrite formation
Beckman, J. S., & Crow, J. P. (1993) · Biochemical Society Transactions · doi:10.1042/bst0210330 · Cited by 676 · see citing works
The reaction of NO· with O2·− and HO2·−: A pulse radiolysis study
Goldstein, S., & Czapski, G. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00034-u · Cited by 398 · see citing works
Self-citationThe chemistry of pernitrites. Part I. Kinetics of decomposition of pernitrous acid
Hughes, M., & Nicklin, H. G. (1968) · Journal of the Chemical Society A Inorganic Physical Theoretical · doi:10.1039/j19680000450 · Cited by 352 · see citing works
Metabolic Fate of Peroxynitrite in Aqueous Solution
Pfeiffer, S., Gorren, A. C. F., Schmidt, K., Werner, E. R., Hansert, B., Bohle, D. S., & Mayer, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3465 · Cited by 329 · see citing works
Formation and decay of peroxynitric acid: a pulse radiolysis study
Loegager, T., & Sehested, K. (1993) · The Journal of Physical Chemistry · doi:10.1021/j100141a025 · Cited by 211 · see citing works
[27] Syntheses of peroxynitrite: To go with the flow or on solid grounds?
Koppenol, W. H., Kissner, R., & Beckman, J. S. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)69030-2 · Cited by 210 · see citing works
Formation and decay of peroxynitrous acid: a pulse radiolysis study
Loegager, T., & Sehested, K. (1993) · The Journal of Physical Chemistry · doi:10.1021/j100127a016 · Cited by 202 · see citing works
Pryor, W. A., Cueto, R., Jin, X., Koppenol, W. H., Ngu-Schwemlein, M., Squadrito, G. L., Uppu, P. L., & Uppu, R. M. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00105-s · Cited by 197 · see citing works
Grätzel, M., Henglein, A., & Taniguchi, S. (1970) · Berichte der Bunsengesellschaft für physikalische Chemie · doi:10.1002/bbpc.19700740322 · Cited by 190 · see citing works
Interaction of Nitrous Acid with Hydrogen Peroxide and with Water
Anbar, M., & Taube, H. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01653a007 · Cited by 179 · see citing works
Chemical synthesis with a quenched flow reactor. Hydroxytrihydroborate and peroxynitrite
Reed, J. W., Ho, H. H., & Jolly, W. L. (1974) · Journal of the American Chemical Society · doi:10.1021/ja00811a062 · Cited by 150 · see citing works
Direct and indirect oxidations by peroxynitrite, neither involving the hydroxyl radical
Goldstein, S., Squadrito, G. L., Pryor, W. A., & Czapski, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00280-8 · Cited by 143 · see citing works
Self-citationCzapski, G., & Goldstein, S. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00081-8 · Cited by 134 · see citing works
Self-citationBohle, D. S., Hansert, B., Paulson, S. C., & Smith, B. D. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00095a062 · Cited by 125 · see citing works
Halfpenny, E., & Robinson, P. L. (1952) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9520000928 · Cited by 106 · see citing works
Autoxidation of hydroxylamine in alkaline solutions
Hughes, M., & Nicklin, H. G. (1971) · Journal of the Chemical Society A Inorganic Physical Theoretical · doi:10.1039/j19710000164 · Cited by 103 · see citing works
Flash Photolysis of Nitrate Ions in Aqueous Solution
Wagner, I., Strehlow, H., & Busse, G. (1980) · Zeitschrift für Physikalische Chemie · doi:10.1524/zpch.1980.123.1.001 · Cited by 91 · see citing works
The Chemistry of Peroxonitrites
Edwards, J. O., & Plumb, R. C. (1994) · Progress in inorganic chemistry · doi:10.1002/9780470166420.ch8 · Cited by 80 · see citing works
[29] Synthesis of peroxynitrite by azide-ozone reaction
Uppu, R. M., Squadrito, G. L., Cueto, R., & Pryor, W. A. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)69032-6 · Cited by 73 · see citing works
Álvarez, B., Denicola, A., & Radí, R. (1995) · Chemical Research in Toxicology · doi:10.1021/tx00048a006 · Cited by 71 · see citing works
Binding sites of nitric oxide synthases
Liu, Q., & Gross, S. S. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68033-1 · Cited by 67 · see citing works
Kinetics and mechanism of the formation and decay of peroxynitrous acid in perchloric acid solutions
Benton, D. J., & Moore, P. T. (1970) · Journal of the Chemical Society A Inorganic Physical Theoretical · doi:10.1039/j19700003179 · Cited by 65 · see citing works
Color centers in UV-irradiated nitrates
Plumb, R. C., & Edwards, J. O. (1992) · The Journal of Physical Chemistry · doi:10.1021/j100187a014 · Cited by 64 · see citing works
A novel route to peroxynitrite anion
Leis, J. R., Peña, M. E., & Ríos, A. (1993) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39930001298 · Cited by 51 · see citing works
Uppu, R. M., & Pryor, W. A. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)69033-8 · Cited by 24 · see citing works
Flash photolysis of aqueous solutions of azide and nitrate ions
Barat, F., Hickel, B., & Sutton, J. (1969) · Journal of the Chemical Society D Chemical Communications · doi:10.1039/c2969000125b · Cited by 16 · see citing works
Goldstein, S., & Czapski, G. (1996) · Inorganic Chemistry · doi:10.1021/ic960233k · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Lukeš, P., Doležalová, E., Sisrová, I. (., & Člupek, M. (2014) · Plasma Sources Science and Technology · doi:10.1088/0963-0252/23/1/015019 · Cited by 1,187 · see citing works
Hydroxyl Radical-Mediated Modification of Proteins as Probes for Structural Proteomics
Xu, G., & Chance, M. R. (2007) · Chemical Reviews · doi:10.1021/cr0682047 · Cited by 680 · see citing works
Biochemistry of Peroxynitrite and Protein Tyrosine Nitration
Ferrer‐Sueta, G., Campolo, N., Trujillo, M., Bartesaghi, S., Carballal, S., Romero, N., Álvarez, B., & Radí, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00568 · Cited by 650 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
Neurodegenerative disorders: the role of peroxynitrite
Torreilles, F., Salman-Tabcheh, S., Guérin, M.-C., & Torreilles, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00014-4 · Cited by 430 · see citing works
Chemistry of Peroxynitrites as Compared to Peroxynitrates
Goldstein, S., Lind, J., & Merényi, G. (2005) · Chemical Reviews · doi:10.1021/cr0307087 · Cited by 412 · see citing works
Self-citationCuevasanta, E., Lange, M., Bonanata, J. N., Coitiño, E. L., Ferrer‐Sueta, G., Filipović, M. R., & Álvarez, B. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.672816 · Cited by 343 · see citing works
Abello, N., Kerstjens, H. A. M., Postma, D. S., & Bischoff, R. (2009) · Journal of Proteome Research · doi:10.1021/pr900039c · Cited by 359 · see citing works
Sulfenic Acid Formation in Human Serum Albumin by Hydrogen Peroxide and Peroxynitrite
Carballal, S., Radí, R., KIRK, M. C., Barnes, S., Freeman, B. Α., & Álvarez, B. (2003) · Biochemistry · doi:10.1021/bi027434m · Cited by 312 · see citing works
Direct EPR Detection of the Carbonate Radical Anion Produced from Peroxynitrite and Carbon Dioxide
Bonini, M. G., Radi, R., Ferrer-Sueta, G., Ferreira, A. M. D. C., & Augusto, O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10802 · Cited by 293 · see citing works
Santos, C. X. C., Anjos, E. I., & Augusto, O. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1491 · Cited by 275 · see citing works
Hydroxyl Radical Formation during Peroxynitrous Acid Decomposition
Coddington, J. W., Hurst, J. K., & Lymar, S. V. (1999) · Journal of the American Chemical Society · doi:10.1021/ja982887t · Cited by 257 · see citing works
Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest
Carballal, S., Trujillo, M., Cuevasanta, E., Bartesaghi, S., Möller, M. N., Folkes, L. K., García-Bereguiain, M. Á., Gutiérrez‐Merino, C., Wardman, P., Denicola, A., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.10.705 · Cited by 219 · see citing works
Peroxynitrite: reactive, invasive and enigmatic
Groves, J. T. (1999) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(99)80036-2 · Cited by 206 · see citing works
Ogusucu, R., Rettori, D., Munhoz, D. C., Netto, L. E. S., & Augusto, O. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.10.042 · Cited by 196 · see citing works
Tyrosine Nitration by Simultaneous Generation of ⋅NO and O⨪2 under Physiological Conditions
Goldstein, S., Czapski, G., Lind, J., & Merényi, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3031 · Cited by 177 · see citing works
Self-citationDaiber, A., Oelze, M., Coldewey, M., Bachschmid, M., Wenzel, P., Sydow, K., Wendt, M., Kleschyov, A. L., Stalleicken, D., Ullrich, V., et al. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.002600 · Cited by 177 · see citing works
Oliveira, M. W. S., Minotto, J. B., de Oliveira, M. R., Zanotto‐Filho, A., Behr, G. A., da Rocha, R. F., Moreira, J. C. F., & Klamt, F. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70256-5 · Cited by 156 · see citing works
Miyamoto, S., Martinez, G. R., Martins, A. P. B., de Medeiros, M. H. G., & Mascio, P. D. (2003) · Journal of the American Chemical Society · doi:10.1021/ja029262m · Cited by 155 · see citing works
Álvarez, B., Demicheli, V., Durán, R., Trujillo, M., Červeñanský, C., Freeman, B. Α., & Radí, R. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.06.006 · Cited by 136 · see citing works
Acidity and nucleophilic reactivity of glutathione persulfide
Benchoam, D., Semelak, J. A., Cuevasanta, E., Mastrogiovanni, M., Grassano, J. S., Ferrer‐Sueta, G., Zeida, A., Trujillo, M., Möller, M. N., Estrin, D. A., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014728 · Cited by 121 · see citing works
Synthesis of Peroxynitrite from Nitrite and Hydrogen Peroxide
Robinson, K. M., & Beckman, J. S. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)96019-9 · Cited by 119 · see citing works
Plasma quercetin metabolites: structure–antioxidant activity relationships
Justino, G. C., Santos, M., Canário, S., Borges, C., Florêncio, M. H., & Mira, L. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.007 · Cited by 108 · see citing works
Zheng, S., Wang, Y., Chen, C., Zhou, X., Liu, Y., Yang, J., Geng, Q., Chen, G., Ding, Y., & Yang, F. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191710919 · Cited by 107 · see citing works
Mechanism and Thermochemistry of Peroxynitrite Decomposition in Water
Merényi, G., Lind, J., Goldstein, S., & Czapski, G. (1999) · The Journal of Physical Chemistry A · doi:10.1021/jp984686h · Cited by 104 · see citing works
Self-citationRole of the Carbonate Radical Anion in Tyrosine Nitration and Hydroxylation by Peroxynitrite
Santos, C. X. C., Bonini, M. G., & Augusto, O. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1751 · Cited by 105 · see citing works
Demicheli, V., Quijano, C., Álvarez, B., & Radí, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.034 · Cited by 103 · see citing works
The Yield of Hydroxyl Radical from the Decomposition of Peroxynitrous Acid
Gerasimov, O. V., & Lymar, S. V. (1999) · Inorganic Chemistry · doi:10.1021/ic990384y · Cited by 101 · see citing works
Surmeli, N. B., Litterman, N. K., Miller, A.-F., & Groves, J. T. (2010) · Journal of the American Chemical Society · doi:10.1021/ja105684w · Cited by 94 · see citing works
Mechanisms of Peroxynitrite Decomposition Catalyzed by FeTMPS, a Bioactive Sulfonated Iron Porphyrin
Shimanovich, R., & Groves, J. T. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2247 · Cited by 91 · see citing works
Silva, T. F. C. V., Soares, P. A., Manenti, D. R., Fonseca, A., Saraiva, I., Boaventura, R. A. R., & Vilar, V. J. P. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.10.058 · Cited by 86 · see citing works
Peroxynitrite does not decompose to singlet oxygen ( 1 Δ g O 2 ) and nitroxyl (NO − )
Martinez, G. R., Mascio, P. D., Bonini, M. G., Augusto, O., Briviba, K., Sies, H., Maurer, P., Röthlisberger, U., Herold, S., & Koppenol, W. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190256897 · Cited by 83 · see citing works
Hydroxyl Radical Formation by O−O Bond Homolysis in Peroxynitrous Acid
Lymar, S. V., Khairutdinov, R. F., & Hurst, J. K. (2003) · Inorganic Chemistry · doi:10.1021/ic030104l · Cited by 80 · see citing works
Liang, Y., Song, J., & Yang, X. (2004) · Analytica Chimica Acta · doi:10.1016/j.aca.2003.12.054 · Cited by 79 · see citing works
The chemistry of peroxynitrite. Reaction mechanisms and kinetics
Lobachev, V. L., & Rudakov, E. S. (2006) · Russian Chemical Reviews · doi:10.1070/rc2006v075n05abeh001212 · Cited by 72 · see citing works
Su, J., & Groves, J. T. (2009) · Journal of the American Chemical Society · doi:10.1021/ja902473r · Cited by 71 · see citing works
An original nitrate sensor based on silver nanoparticles electrodeposited on a gold electrode
Fajerwerg, K., Ynam, V., Chaudret, B. N., Garcon, V. C., Thouron, D., & Comtat, M. (2010) · Electrochemistry Communications · doi:10.1016/j.elecom.2010.08.003 · Cited by 69 · see citing works
McLean, S., Bowman, L. A. H., Sanguinetti, G., Read, R. C., & Poole, R. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085506 · Cited by 67 · see citing works
Lehnig, M. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1268 · Cited by 65 · see citing works
Lu, C., Lin, J.-M., & Huie, C. W. (2004) · Talanta · doi:10.1016/j.talanta.2003.10.049 · Cited by 63 · see citing works
Lu, C., Qu, F., Lin, J., & Yamada, M. (2002) · Analytica Chimica Acta · doi:10.1016/s0003-2670(02)01010-3 · Cited by 62 · see citing works
Justino, G. C., Borges, C., & Florêncio, M. H. (2008) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3869 · Cited by 60 · see citing works
Torres, M. J., Turell, L., Botti, H., Antmann, L., Carballal, S., Ferrer‐Sueta, G., Radí, R., & Álvarez, B. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.03.011 · Cited by 55 · see citing works
Formation and Reactions of Sulfenic Acid in Human Serum Albumin
Álvarez, B., Carballal, S., Turell, L., & Radí, R. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)73005-6 · Cited by 54 · see citing works
Peteu, S. F., Boukherroub, R., & Szunerits, S. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.02.025 · Cited by 54 · see citing works
Yaqoob, M., Biot, B. F., Nabi, A., & Worsfold, P. J. (2011) · Luminescence · doi:10.1002/bio.1366 · Cited by 54 · see citing works
Oxidation of Peroxynitrite by Inorganic Radicals: A Pulse Radiolysis Study
Goldstein, S., Saha, A., Lymar, S. V., & Czapski, G. (1998) · Journal of the American Chemical Society · doi:10.1021/ja9735362 · Cited by 55 · see citing works
Self-citationLu, C., Lin, J.-M., Huie, C. W., & Yamada, M. (2004) · Analytica Chimica Acta · doi:10.1016/j.aca.2003.12.057 · Cited by 53 · see citing works
Goldstein, S., & Czapski, G. (1999) · Journal of the American Chemical Society · doi:10.1021/ja9822254 · Cited by 53 · see citing works
Self-citationProtection by Flavonoids Against the Peroxynitrite-mediated Oxidation of Dihydrorhodamine
Santos, M., & Mira, L. (2004) · Free Radical Research · doi:10.1080/10715760400003384 · Cited by 51 · see citing works
Insights into the mechanism of the reaction between hydrogen sulfide and peroxynitrite
Cuevasanta, E., Zeida, A., Carballal, S., Wedmann, R., Morzan, U. N., Trujillo, M., Radí, R., Estrin, D. A., Filipović, M. R., & Álvarez, B. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.12.017 · Cited by 45 · see citing works
Adegoke, O., & Nyokong, T. (2012) · Journal of Luminescence · doi:10.1016/j.jlumin.2012.08.002 · Cited by 45 · see citing works
Demicheli, V., Moreno, D. M., Jara, G. E., Lima, A. E., Carballal, S., Ríos, N., Batthyány, C., Ferrer‐Sueta, G., Quijano, C., Estrin, D. A., et al. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00045 · Cited by 44 · see citing works
Liang, Y., & Song, J. (2005) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2004.12.010 · Cited by 42 · see citing works
Distance-Dependent Diffusion-Controlled Reaction of •NO and O2•− at Chemical Equilibrium with ONOO−
Botti, H., Möller, M. N., Steinmann, D., Nauser, T., Koppenol, W. H., Denicola, A., & Radí, R. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp105606b · Cited by 40 · see citing works
Lim, J., Park, S., Ryu, S., Park, S., & Kim, M. S. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.4c10363 · Cited by 39 · see citing works
Hrabárová, E., Juránek, I., & Šoltés, L. (2011) · General Physiology and Biophysics · doi:10.4149/gpb_2011_03_223 · Cited by 37 · see citing works
Friesen, D. A., Kajita, T., Danielson, E., & Meyer, T. J. (1999) · Inorganic Chemistry · doi:10.1021/ic990543d · Cited by 36 · see citing works
Inactivation of cystathionine β-synthase with peroxynitrite
Celano, L., Gil, M., Carballal, S., Durán, R., Denicola, A., Banerjee, R. V., & Álvarez, B. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.08.022 · Cited by 33 · see citing works
Phenolic acids protect low density lipoproteins from peroxynitrite-mediated modificationin vitro
MORTON, L. W., Croft, K. D., Puddey, I. B., & Byrne, L. (2000) · Redox Report · doi:10.1179/135100000101535429 · Cited by 32 · see citing works
Effect of Ionizing Radiation on the Redox Chemistry of Penta- and Hexavalent Americium
Horne, G. P., Grimes, T. S., Bauer, W. F., Dares, C. J., Pimblott, S. M., Mezyk, S. P., & Mincher, B. J. (2019) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.9b00854 · Cited by 31 · see citing works
Comparative study of HOCl-inflicted damage to bacterial DNA ex vivo and within cells
Suquet, C., Warren, J. J., Seth, N., & Hurst, J. K. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.10.006 · Cited by 33 · see citing works
Silva, T. F. C. V., Vieira, E., Lopes, A. R., Nunes, O. C., Fonseca, A., Saraiva, I., Boaventura, R. A. R., & Vilar, V. J. P. (2016) · Separation and Purification Technology · doi:10.1016/j.seppur.2016.11.011 · Cited by 31 · see citing works
Wang, Y., & Chen, Z. (2010) · Talanta · doi:10.1016/j.talanta.2010.05.020 · Cited by 31 · see citing works
Carbonate-catalyzed chemiluminescence decomposition of peroxynitrite via (CO2)2∗ intermediate
Lu, C., & Lin, J. (2004) · Catalysis Today · doi:10.1016/j.cattod.2004.04.045 · Cited by 30 · see citing works
Atala, E., Velásquez, G., Vergara, C., Mardones, C., García, J. L. R., Tapia, R. A., Quina, F. H., Mendes, M. A., Speisky, H., Lissi, E. A., et al. (2013) · The Journal of Physical Chemistry B · doi:10.1021/jp400423w · Cited by 29 · see citing works
Flow-injection chemiluminescence determination of chloroquine using peroxynitrous acid as oxidant
Liang, Y. (2003) · Talanta · doi:10.1016/j.talanta.2003.09.017 · Cited by 29 · see citing works
Liu, K., Duan, Q., Zheng, Z., Zhou, R., Zhou, R., Tang, W., Cullen, P. J., & Ostrikov, K. (2021) · Plasma Processes and Polymers · doi:10.1002/ppap.202100016 · Cited by 28 · see citing works
Yan, Z., Xiao, A., Lü, H., Liu, Z., & Chen, J. (2014) · New Carbon Materials · doi:10.1016/s1872-5805(14)60136-0 · Cited by 28 · see citing works
The decomposition of peroxynitrite does not yield nitroxyl anion and singlet oxygen
Merényi, G., Lind, J., Czapski, G., & Goldstein, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150238197 · Cited by 28 · see citing works
Self-citationKatG from Salmonella Typhimurium is a peroxynitritase
McLean, S., Bowman, L. A. H., & Poole, R. K. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.03.029 · Cited by 26 · see citing works
Sun, S., Zhang, J., Sheng, C., & Zhong, H. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129788 · Cited by 23 · see citing works
Lis, S., & Kaczmarek, M. (2012) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2012.10.012 · Cited by 23 · see citing works
Loumaye, E., Ferrer‐Sueta, G., Álvarez, B., Rees, J., Clippe, A., Knoops, B., Radí, R., & Trujillo, M. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.07.002 · Cited by 23 · see citing works
Chemiluminescence determination of nitrogen oxide in air with a sequential injection method
Wang, Y., Fan, S., & Wang, S. (2005) · Analytica Chimica Acta · doi:10.1016/j.aca.2004.11.072 · Cited by 22 · see citing works
Berardinelli, A., Hamrouni, A., Dirè, S., Ceccato, R., Camera‐Roda, G., Ragni, L., Palmisano, L., & Parrino, F. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128336 · Cited by 22 · see citing works
Sonochemical formation of peroxynitrite in water: Impact of ultrasonic frequency and power
Ferkous, H., Hamdaoui, O., & Pétrier, C. (2023) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2023.106488 · Cited by 22 · see citing works
McLean, S., Bowman, L. A. H., & Poole, R. K. (2010) · Microbiology · doi:10.1099/mic.0.044214-0 · Cited by 22 · see citing works
In vitro nitro-fatty acid release from Cys-NO2-fatty acid adducts under nitro-oxidative conditions
Padilla, M. N., Mata-Pérez, C., Melguizo, M., & Barroso, J. B. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.12.009 · Cited by 21 · see citing works
Celedón, G., González, G., Pino, J. A., & Lissi, E. A. (2006) · Free Radical Research · doi:10.1080/10715760601090305 · Cited by 21 · see citing works
Li, L., Zhang, B., Liu, F., Xue, Z., Lu, X., & Liu, X. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.127560 · Cited by 20 · see citing works
Pressure Dependence of Peroxynitrite Reactions. Support for a Radical Mechanism
Coddington, J. W., Wherland, S. E., & Hurst, J. K. (2001) · Inorganic Chemistry · doi:10.1021/ic981359f · Cited by 19 · see citing works
O-Atom Scrambling in the Aqueous Isomerization of Pernitrous Acid
Bohle, D. S., & Hansert, B. (1997) · Nitric Oxide · doi:10.1006/niox.1997.0155 · Cited by 19 · see citing works
Chakraborty, S., Cai, Y., & Tarr, M. A. (2014) · PROTEOMICS · doi:10.1002/pmic.201300174 · Cited by 43 · see citing works
Lehnig, M., Kirsch, M., & Korth, H. (2003) · Inorganic Chemistry · doi:10.1021/ic020650z · Cited by 18 · see citing works
Pathophysiological chemistry of nitric oxide and its oxygeneration by-products
Bohle, D. S. (1998) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(98)80060-4 · Cited by 18 · see citing works
Osmium tetroxide, used in the treatment of arthritic joints, is a fast mimic of superoxide dismutase
Goldstein, S., Czapski, G., & Heller, A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.027 · Cited by 17 · see citing works
Self-citationFina, B. L., Santamaría, B., Ferreyra, M. G., Schierloh, L. P., Chamorro, J. C., Cejas, E., & Prevosto, L. (2024) · Food Control · doi:10.1016/j.foodcont.2024.110530 · Cited by 16 · see citing works
Hrabárová, E., Gemeiner, P., & Šoltés, L. (2007) · Chemical Papers · doi:10.2478/s11696-007-0058-8 · Cited by 16 · see citing works
Li, L., Qian, L., Fan, W., Ding, L., Xue, Z., Liu, X., & Lu, X. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.129071 · Cited by 16 · see citing works
Carballal, S., Valez, V., Álvarez-Paggi, D., Tovmasyan, A. G., Batinic̈‐Haberle, I., Ferrer‐Sueta, G., Murgida, D. H., & Radí, R. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.023 · Cited by 15 · see citing works
Striped, bioactive Ce–TiO 2 materials with peroxynitrite-scavenging activity
Gravina, A. N., Ruso, J. M., Laiuppa, J. A., Santillán, G. E., Marco-Brown, J. L., D’Elía, N. L., & Messina, P. V. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21556c · Cited by 14 · see citing works
Daiber, A., & Münzel, T. F. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-411-1_3 · Cited by 14 · see citing works
Chemistry of nitrogen dioxide and its biological implications
Goldstein, S., & Samuni, A. (2024) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2024.100020 · Cited by 13 · see citing works
Self-citationPriyam, A., Bhattacharya, S. C., & Saha, A. (2008) · Physical Chemistry Chemical Physics · doi:10.1039/b813620c · Cited by 13 · see citing works
Self-citationCMOS arrays as chemiluminescence detectors on microfluidic devices
Rodrigues, E. R. G. O., & Lapa, R. A. S. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3518-x · Cited by 13 · see citing works
Goldstein, S., & Czapski, G. (1997) · Nitric Oxide · doi:10.1006/niox.1997.0142 · Cited by 13 · see citing works
Self-citationPeroxynitrite: A tale of two radicals
Bounds, P. L., & Koppenol, W. H. (2024) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2024.100038 · Cited by 12 · see citing works
A biomimetic skin microtissue biosensor for the detection of fish parvalbumin
Jiang, D., Xu, Y., Jiang, H., Xiang, X., & Wang, L. (2024) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2024.108805 · Cited by 12 · see citing works
Cardiolipin interactions with cytochrome c increase tyrosine nitration yields and site-specificity
Demicheli, V., Tomasina, F., Sastre, S., Zeida, A., Tórtora, V., Lima, A. E., Batthyány, C., & Radí, R. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108824 · Cited by 12 · see citing works
- Authors
- Saha, A., Goldstein, S., Cabelli, D., & Czapski, G.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Brookhaven National Laboratory (US)
- Corresponding author
- Czapski, Gidon
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 24
- Issue
- 4
- Pages
- 653-659
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2079636467
- Cited by
- 143
- References
- 33
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 6 · 2016: 5 · 2015: 1 · 2014: 8 · 2013: 2 · 2012: 4
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- peroxynitrite, peroxynitrous acid, hydrogen peroxide, nitrite, reaction mechanism, activation energy, chloride, nitrosyl chloride, reaction yield optimization, quenching
- MeSH terms
- Cold Temperature, Hydrogen Peroxide, Hydrogen-Ion Concentration, Kinetics, Nitrates, Nitrites, Osmolar Concentration, Perchlorates, Solutions, Thermodynamics, Oxidants
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
