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Cited by 545Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesMesenchymal stem cell research

The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.

Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS

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Gensert, JoAnn M, Goldman, James E·1997·Neuron
DOI 10.1016/s0896-6273(00)80359-1
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Abstract

Remyelination occurs in demyelinated CNS regions in diseases such as multiple sclerosis. Identification of the cell type(s) responsible for this remyelination, however, has been elusive. Here, we examine one potential source of remyelinating oligodendrocytes-immature, cycling cells endogenous to adult white matter-and demonstrate that this population responds to demyelination by differentiating into myelinating oligodendrocytes. Dividing cells in subcortical white matter of adult rats were labeled by stereotactic injection of a replication-deficient lacZ-encoding retrovirus (BAG). Following a focal demyelination induced with lysolecithin, many of the BAG-labeled cells differentiated into myelinating oligodendrocytes engaging in repair of the lesion. Identification of endogenous cells capable of remyelination provides a target for the study of CNS repair processes in demyelinating diseases.

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Crossref · 10.1016/s0896-6273(00)80359-1

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Citations

Cites

Research works printed but not linked: 7

  1. Allen, I.V., and Kirk, J. (1992). Demyelinating diseases. In Greenfield's Neuropathology, J.H. Adams and L.W. Duchen, eds. (New York: Oxford University Press), pp. 447–520.
  2. Prineas, 1989, Multiple sclerosis, Lab. Invest, 61, 489
  3. Raine, C.S. (1991). Demyelinating diseases. In Textbook of Neuropathology, R.L. Davis and D.M. Robertson, eds. (Baltimore: Williams and Wilkins), pp. 535–620.
  4. Raine, 1981, Multiple sclerosis, Lab. Invest, 45, 534
  5. Ramon y Cajal, S. (1995). Pathways from the temporal olfactory cortex. In Histology of the Nervous System of Man and Vertebrates, Volume II (New York: Oxford University Press), pp. 589–602.
  6. Szuchet, S. (1995). The morphology and ultrastructure of oligodendrocytes and their functional implications. In Neuroglia, H. Kettenmann and B.R. Ransom, eds. (New York: Oxford University Press), pp. 23–43.
  7. Wu, 1992, Multiple sclerosis, Lab. Invest, 67, 88

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Metadata

Authors
Gensert, J. M., & Goldman, J. E.
Affiliations
  • Columbia University Irving Medical Center (US)
  • Columbia University (US)
Corresponding author
Gensert, JoAnn M
ORCID
Goldman, James E
Venue
Neuron
Publisher
Elsevier BV
Published
1997-07
Volume
19
Issue
1
Pages
197-203
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/s0896-6273(00)80359-1
OpenAlex
W2005578607
Cited by
544
References
40
Citations by year
2026: 3 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 12 · 2018: 23 · 2017: 15 · 2016: 17 · 2015: 25 · 2014: 23 · 2013: 29 · 2012: 21
FWCI
5.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS17125, R01NS017125)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords
remyelination, demyelination, oligodendrocyte precursor cells, myelinating oligodendrocytes, white matter, retroviral labeling, subcortical white matter, multiple sclerosis, CNS repair, adult neurogenesis
MeSH terms
Animals, Axons, Central Nervous System, Demyelinating Diseases, Female, Lysophosphatidylcholines, Stem Cells, Rats, Sprague-Dawley, Rats

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