The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.
Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS
Open accessAbstract
Remyelination occurs in demyelinated CNS regions in diseases such as multiple sclerosis. Identification of the cell type(s) responsible for this remyelination, however, has been elusive. Here, we examine one potential source of remyelinating oligodendrocytes-immature, cycling cells endogenous to adult white matter-and demonstrate that this population responds to demyelination by differentiating into myelinating oligodendrocytes. Dividing cells in subcortical white matter of adult rats were labeled by stereotactic injection of a replication-deficient lacZ-encoding retrovirus (BAG). Following a focal demyelination induced with lysolecithin, many of the BAG-labeled cells differentiated into myelinating oligodendrocytes engaging in repair of the lesion. Identification of endogenous cells capable of remyelination provides a target for the study of CNS repair processes in demyelinating diseases.
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“Importantly, however, a multitude of experimental evidence has shown that remyelination is associated with proliferation and differentiation of oligodendrocyte precursor cells into mature oligodendrocytes”
From BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis (2025) · cites this paper as [23]
Citations
Cites
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Cited by
Sorted by citations
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
The glial scar and central nervous system repair
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M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
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Remyelination in the CNS: from biology to therapy
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Neural Tissue Engineering: Strategies for Repair and Regeneration
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Metadata
- Authors
- Gensert, J. M., & Goldman, J. E.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Corresponding author
- Gensert, JoAnn M
- ORCID
- Goldman, James E
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 19
- Issue
- 1
- Pages
- 197-203
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2005578607
- Cited by
- 544
- References
- 40
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 12 · 2018: 23 · 2017: 15 · 2016: 17 · 2015: 25 · 2014: 23 · 2013: 29 · 2012: 21
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS17125, R01NS017125)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- remyelination, demyelination, oligodendrocyte precursor cells, myelinating oligodendrocytes, white matter, retroviral labeling, subcortical white matter, multiple sclerosis, CNS repair, adult neurogenesis
- MeSH terms
- Animals, Axons, Central Nervous System, Demyelinating Diseases, Female, Lysophosphatidylcholines, Stem Cells, Rats, Sprague-Dawley, Rats
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