Cited by 545Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesMesenchymal stem cell research

The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.

Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS

Open access

Gensert, JoAnn M, Goldman, James E·1997·Neuron

DOI 10.1016/s0896-6273(00)80359-1

Open this paper in CoChat — free account Open PDF

Abstract

Remyelination occurs in demyelinated CNS regions in diseases such as multiple sclerosis. Identification of the cell type(s) responsible for this remyelination, however, has been elusive. Here, we examine one potential source of remyelinating oligodendrocytes-immature, cycling cells endogenous to adult white matter-and demonstrate that this population responds to demyelination by differentiating into myelinating oligodendrocytes. Dividing cells in subcortical white matter of adult rats were labeled by stereotactic injection of a replication-deficient lacZ-encoding retrovirus (BAG). Following a focal demyelination induced with lysolecithin, many of the BAG-labeled cells differentiated into myelinating oligodendrocytes engaging in repair of the lesion. Identification of endogenous cells capable of remyelination provides a target for the study of CNS repair processes in demyelinating diseases.

Integrity signals

Registry

Crossref · 10.1016/s0896-6273(00)80359-1

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence
Bignami, A., Eng, L. F., Dahl, D. R., & Uyeda, C. T. (1972) · Brain Research · doi:10.1016/0006-8993(72)90398-8 · Cited by 1,456
Use of a recombinant retrovirus to study post‐implantation cell lineage in mouse embryos.
Sanes, J. R., Rubenstein, J. L. R., & Nicolas, J. F. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04620.x · Cited by 1,116
Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species
Deibler, G. E., Martenson, R. E., & Kies, M. W. (1972) · Preparative Biochemistry · doi:10.1080/00327487208061467 · Cited by 939
Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer.
Price, J., Turner, D., & Cepko, C. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.156 · Cited by 870
Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions
Prineas, J. W., Barnard, R. O., Kwon, E. E., Sharer, L. R., & Cho, E. ‐. (1993) · Annals of Neurology · doi:10.1002/ana.410330203 · Cited by 574
Proliferation and differentiation of rat neuroepithelial precursor cells in vivo
Frederiksen, K., & McKay, R. D. G. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01144.1988 · Cited by 551
Identification of an adult-specific glial progenitor cell
Wolswijk, G., & Noble, M. (1989) · Development · doi:10.1242/dev.105.2.387 · Cited by 487
Proliferating bipotential glial progenitor cells in adult rat optic nerve
ffrench‐Constant, C., & RAFF, M. C. (1986) · Nature · doi:10.1038/319499a0 · Cited by 385
Multiple Sclerosis: Remyelination in Acute Lesions
Raine, C. S., & WU, E. (1993) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199305000-00003 · Cited by 285
The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord
Hall, S. M. (1972) · Journal of Cell Science · doi:10.1242/jcs.10.2.535 · Cited by 271

Show all 40 references

Research works printed but not linked: 7

Allen, I.V., and Kirk, J. (1992). Demyelinating diseases. In Greenfield's Neuropathology, J.H. Adams and L.W. Duchen, eds. (New York: Oxford University Press), pp. 447–520.
Prineas, 1989, Multiple sclerosis, Lab. Invest, 61, 489
Raine, C.S. (1991). Demyelinating diseases. In Textbook of Neuropathology, R.L. Davis and D.M. Robertson, eds. (Baltimore: Williams and Wilkins), pp. 535–620.
Raine, 1981, Multiple sclerosis, Lab. Invest, 45, 534
Ramon y Cajal, S. (1995). Pathways from the temporal olfactory cortex. In Histology of the Nervous System of Man and Vertebrates, Volume II (New York: Oxford University Press), pp. 589–602.
Szuchet, S. (1995). The morphology and ultrastructure of oligodendrocytes and their functional implications. In Neuroglia, H. Kettenmann and B.R. Ransom, eds. (New York: Oxford University Press), pp. 23–43.
Wu, 1992, Multiple sclerosis, Lab. Invest, 67, 88

Sorted by citations

Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
The glial scar and central nervous system repair
Fawcett, J. W., & Asher, R. A. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00072-6 · Cited by 1,808
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Neural Tissue Engineering: Strategies for Repair and Regeneration
Schmidt, C. E., & Leach, J. B. (2003) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.5.011303.120731 · Cited by 1,244
The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
Bareyre, F. M., Kerschensteiner, M., Raineteau, O., Mettenleiter, T. C., Weinmann, O., & Schwab, M. E. (2004) · Nature Neuroscience · doi:10.1038/nn1195 · Cited by 1,088
Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis
Pluchino, S., Quattrini, A., Brambilla, E., Gritti, A., Salani, G., Dina, G., Galli, R., Carro, U. D., Amadio, S., Bergami, A., et al. (2003) · Nature · doi:10.1038/nature01552 · Cited by 1,071
TNFα promotes proliferation of oligodendrocyte progenitors and remyelination
Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012
Origin of oligodendrocytes in the subventricular zone of the adult brain
Menn, B., Garcia-Verdugo, J. M., Yaschine, C., Gonzalez-Perez, O., Rowitch, D., & Alvarez-Buylla, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1299-06.2006 · Cited by 972
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Oligodendrocytes: biology and pathology
Bradl, M., & Lassmann, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0601-5 · Cited by 933
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865
Why does remyelination fail in multiple sclerosis?
Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 862
Regenerating the damaged central nervous system
Horner, P. J., & Gage, F. H. (2000) · Nature · doi:10.1038/35039559 · Cited by 831
Plasticity of motor systems after incomplete spinal cord injury
Raineteau, O., & Schwab, M. E. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067570 · Cited by 825
The oligodendrocyte precursor cell in health and disease
Levine, J. M., Reynolds, R., & Fawcett, J. W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01691-x · Cited by 673
CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination
Zawadzka, M., Rivers, L. E., Fancy, S. P. J., Zhao, C., Tripathi, R., Jamen, F., Young, K., Goncharevich, A., Pohl, H., Rizzi, M., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.04.002 · Cited by 650
Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome
Hofstetter, C. P., Holmström, N., Lilja, J., Schweinhardt, P., Hao, J., Spenger, C., Wiesenfeld‐Hallin, Z., Kurpad, S. N., Frisén, J., & Olson, L. (2005) · Nature Neuroscience · doi:10.1038/nn1405 · Cited by 650
The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation
Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625
Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic
Zhang, Z. G., & Chopp, M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70061-4 · Cited by 596
Neurotrophin-3 and Brain-Derived Neurotrophic Factor Induce Oligodendrocyte Proliferation and Myelination of Regenerating Axons in the Contused Adult Rat Spinal Cord
McTigue, D. M., Horner, P. J., Stokes, B. T., & Gage, F. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05354.1998 · Cited by 592
Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells
Wolswijk, G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00601.1998 · Cited by 562
Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination
Nait‐Oumesmar, B., Decker, L., Lachapelle, F., Avellana‐Adalid, V., Bachelin, C., & Van Evercooren, A. B. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00873.x · Cited by 560
Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex
Dimou, L., Simon, C., Kirchhoff, F., Takebayashi, H., & Götz, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2831-08.2008 · Cited by 551
A regenerative approach to the treatment of multiple sclerosis
Deshmukh, V. A., Tardif, V., Lyssiotis, C. A., Green, C. C., Kerman, B., Kim, H. J., Padmanabhan, K., Swoboda, J. G., Ahmad, I., Kondo, T., et al. (2013) · Nature · doi:10.1038/nature12647 · Cited by 531
Interleukin-1β Promotes Repair of the CNS
Mason, J. L., Suzuki, K., Chaplin, D. D., & Matsushima, G. K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07046.2001 · Cited by 502
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency
Shen, S., Sandoval, J., Swiss, V. A., Li, J., Dupree, J. L., Franklin, R. J. M., & Casaccia‐Bonnefil, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2172 · Cited by 499
Axonal pathology in multiple sclerosis: relationship to neurologic disability
Trapp, B. D., Ransohoff, R. M., & Rudick, R. A. (1999) · Current Opinion in Neurology · doi:10.1097/00019052-199906000-00008 · Cited by 475
The life, death, and replacement of oligodendrocytes in the adult CNS
McTigue, D. M., & Tripathi, R. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05570.x · Cited by 474
bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS
Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D. (2004) · Science · doi:10.1126/science.1103709 · Cited by 416
Huperzine A and tacrine attenuate ?-amyloid peptide-induced oxidative injury
Xiao, X., Wang, R., & Tang, X. C. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000901)61:5 · Cited by 101
Spinal cord injury is accompanied by chronic progressive demyelination
Totoiu, M. O., & Keirstead, H. S. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20517 · Cited by 372
Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter
Káradóttir, R. T., Hamilton, N. B., Bakiri, Y., & Attwell, D. (2008) · Nature Neuroscience · doi:10.1038/nn2060 · Cited by 385
A functional role for EGFR signaling in myelination and remyelination
Aguirre, A. A., Dupree, J. L., Mangin, J., & Gallo, V. (2007) · Nature Neuroscience · doi:10.1038/nn1938 · Cited by 352
The link between excitotoxic oligodendroglial death and demyelinating diseases
Matute, C., Alberdi, E. M., Domercq, M., Pérez‐Cerdá, F., Pérez‐Samartín, A., & Sánchez‐Gómez, M. V. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01746-x · Cited by 346
Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination
Woodruff, R. H., Fruttiger, M., Richardson, W. D., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.10.014 · Cited by 335
Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression
Kotter, M. R., Zhao, C., van Rooijen, N., & Franklin, R. J. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.019 · Cited by 331
Astrocytes in multiple sclerosis: A product of their environment
Nair, A., Frederick, T., & Miller, S. D. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8059-5 · Cited by 323
Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS
Fancy, S. P. J., Zhao, C., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.06.015 · Cited by 302
Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis
Scolding, N. J. (1998) · Brain · doi:10.1093/brain/121.12.2221 · Cited by 293
Glial Progenitors in Adult White Matter Are Driven to Form Malignant Gliomas by Platelet-Derived Growth Factor-Expressing Retroviruses
Assanah, M., Lochhead, R. A., Ogden, A. T., Bruce, J., Goldman, J. E., & Canoll, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0514-06.2006 · Cited by 289
Self-citation
Activation and Proliferation of Endogenous Oligodendrocyte Precursor Cells during Ethidium Bromide-Induced Demyelination
Levine, J. M., & Reynolds, R. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7224 · Cited by 282
Functional Recovery in Traumatic Spinal Cord Injury after Transplantation of Multineurotrophin-Expressing Glial-Restricted Precursor Cells
Cao, Q., Xu, X., DeVries, W. H., Enzmann, G. U., Ping, P., Tsoulfas, P., Wood, P. M., Bunge, M. B., & Whittemore, S. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1065-05.2005 · Cited by 281
NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease
Tripathi, R. B., Rivers, L. E., Young, K. M., Jamen, F., & Richardson, W. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3411-10.2010 · Cited by 277
Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis
Ben‐Hur, T., Einstein, O., Mizrachi‐Kol, R., Menachem-Zidon, O. B., Reinhartz, E., Karussis, D. M., & Abramsky, O. (2002) · Glia · doi:10.1002/glia.10159 · Cited by 272
Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord
Wolswijk, G. (2002) · Brain · doi:10.1093/brain/awf031 · Cited by 268
Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices
Miron, V. E., Ludwin, S. K., Darlington, P. J., Jarjour, A. A., Soliven, B. C., Kennedy, T. E., & Antel, J. P. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091234 · Cited by 273
Glial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain
Dimou, L., & Götz, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2013 · Cited by 285
Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion
Watanabe, M., Toyama, Y., & Nishiyama, A. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10338 · Cited by 261
NG 2‐glia and their functions in the central nervous system
Dimou, L., & Gallo, V. (2015) · Glia · doi:10.1002/glia.22859 · Cited by 275
The adult oligodendrocyte can participate in remyelination
Duncan, I. D., Radcliff, A. B., Heidari, M., Kidd, G., August, B. K., & Wierenga, L. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808064115 · Cited by 259
Identification, Isolation, and Promoter-Defined Separation of Mitotic Oligodendrocyte Progenitor Cells from the Adult Human Subcortical White Matter
Roy, N. S., Wang, S., Harrison‐Restelli, C., Benraiss, A., Fraser, R. A. R., Gravel, M., Braun, P. E., & Goldman, S. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09986.1999 · Cited by 259
FTY720 modulates human oligodendrocyte progenitor process extension and survival
Miron, V. E., Jung, C., Kim, H. J., Kennedy, T. E., Soliven, B. C., & Antel, J. P. (2007) · Annals of Neurology · doi:10.1002/ana.21227 · Cited by 255
Stem cell repair of central nervous system injury
Cao, Q., Benton, R. L., & Whittemore, S. R. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10240 · Cited by 254
Cells of the oligodendroglial lineage, myelination, and remyelination
Miron, V. E., Kuhlmann, T., & Antel, J. P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.09.010 · Cited by 249
Visual system of the stalk-eyed fly,Cyrtodiopsis quinqueguttata (Diopsidae, Diptera): an anatomical investigation of unusual eyes
Buschbeck, E. K., & Hoy, R. R. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19981115)37:3 · Cited by 29
Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
Cai, W., Yang, T., Liu, H., Han, L., Zhang, K., Hu, X., Zhang, X., Yin, K., Gao, Y., Bennett, M. V. L., et al. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.002 · Cited by 240
Insulin-Like Growth Factor-1 Inhibits Mature Oligodendrocyte Apoptosis during Primary Demyelination
Mason, J. L., Ye, P., Suzuki, K., D'Ercole, A. J., & Matsushima, G. K. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05703.2000 · Cited by 237
Cell migration in the normal and pathological postnatal mammalian brain
Cayre, M., Canoll, P., & Goldman, J. E. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.02.001 · Cited by 254
Self-citation
White Matter Plasticity and Enhanced Remyelination in the Maternal CNS
Gregg, C., Shikar, V., Larsen, P. H., Mak, G. K., Chojnacki, A. K., Yong, V. W., & Weiss, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4441-06.2007 · Cited by 234
Myelin damage and repair in pathologic CNS: challenges and prospects
Alizadeh, A., Dyck, S. M., & Karimi‐Abdolrezaee, S. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00035 · Cited by 246
NG2‐expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system
Polito, A., & Reynolds, R. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00454.x · Cited by 231
Disease-associated oligodendrocyte responses across neurodegenerative diseases
Pandey, S., Shen, K., Lee, S.-H., Shen, Y.-A. A., Wang, Y., Otero-García, M., Kotova, N., Vito, S. T., Laufer, B. I., Newton, D. F., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111189 · Cited by 227
Marrow stromal cell transplantation in stroke and traumatic brain injury
Li, Y., & Chopp, M. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2008.03.096 · Cited by 222
Distinctive Patterns of PDGF-A, FGF-2, IGF-I, and TGF-β1 Gene Expression during Remyelination of Experimentally-Induced Spinal Cord Demyelination
Hinks, G. L., & Franklin, R. J. M. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0771 · Cited by 226
Purification and Characterization of Adult Oligodendrocyte Precursor Cells from the Rat Optic Nerve
Shi, J., Marinovich, A. M., & Barres, B. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04627.1998 · Cited by 220
Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity
Zhang, S., Ge, B., & Duncan, I. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4089 · Cited by 217
Oligodendrocytes and Progenitors Become Progressively Depleted within Chronically Demyelinated Lesions
Mason, J. L., Toews, A., Hostettler, J. D., Morell, P., Suzuki, K., Goldman, J. E., & Matsushima, G. K. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63726-1 · Cited by 212
Self-citation
Identity, distribution, and development of polydendrocytes: NG2-expressing glial cells
Nishiyama, A., Watanabe, M., Yang, Z., & Bu, J. (2002) · Journal of Neurocytology · doi:10.1023/a:1025783412651 · Cited by 219
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling
Baer, A. S., Syed, Y. A., Kang, S. U., Mitteregger, D., Vig, R., ffrench-Constant, C., Franklin, R. J. M., Altmann, F., Lubec, G., & Kotter, M. R. (2009) · Brain · doi:10.1093/brain/awn334 · Cited by 211
Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination
Zhang, Y., Argaw, A. T., Gurfein, B. T., Zameer, A., Snyder, B. J., Ge, C., Lu, Q. R., Rowitch, D. H., Raine, C. S., Brosnan, C. F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902834106 · Cited by 210
Experimental strategies to promote spinal cord regeneration—an integrative perspective
Schwab, J. M., Brechtel, K., Mueller, C.-A., Failli, V., Kaps, H.-P., Tuli, S. K., & Schluesener, H. J. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.12.004 · Cited by 213
Interleukin-10, interleukin-4, and transforming growth factor-? differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells
Ledeboer, A., Brev�, J. J. P., Poole, S., Tilders, F. J. H., & van Dam, A. (2000) · Glia · doi:10.1002/(sici)1098-1136(200004)30:2 · Cited by 233
Transplantation of Ciliary Neurotrophic Factor-Expressing Adult Oligodendrocyte Precursor Cells Promotes Remyelination and Functional Recovery after SpinalCord Injury
Cao, Q., He, Q., Wang, Y., Cheng, X., Howard, R. M., Zhang, Y., DeVries, W. H., Shields, C. B., Magnuson, D. S. K., Xu, X., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3174-09.2010 · Cited by 205
Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain
Tabar, V. S., Panagiotakos, G., Greenberg, E. D., Chan, B. K., Sadelain, M., Gutin, P. H., & Studer, L. (2005) · Nature Biotechnology · doi:10.1038/nbt1088 · Cited by 197
Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation
Sugawa, M., Sakurai, Y., Ishikawa-Ieda, Y., Suzuki, H., & Asou, H. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00161-x · Cited by 197
Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes
Talbott, J. F., Loy, D. N., Liu, Y., Qiu, M. S., Bunge, M. B., Rao, M. S., & Whittemore, S. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.038 · Cited by 195
Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury
Seo, J. H., Miyamoto, N., Hayakawa, K., Pham, L. D., Maki, T., Ayata, C., Kim, K., Lo, E. H., & Arai, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65863 · Cited by 196
The role of propriospinal interneurons in recovery from spinal cord injury
Flynn, J. R., Graham, B. A., Galea, M. P., & Callister, R. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.016 · Cited by 192
Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division
Hill, R., Patel, K. D., Gonçalves, C. M., Grutzendler, J., & Nishiyama, A. (2014) · Nature Neuroscience · doi:10.1038/nn.3815 · Cited by 198
Regenerative response following stab injury in the adult zebrafish telencephalon
März, M., Viales, R. R., Rastegar, S., & Strähle, U. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22710 · Cited by 199
Long-Term Impact of Radiation on the Stem Cell and Oligodendrocyte Precursors in the Brain
Panagiotakos, G., Al-Shamy, G., Chan, B., Abrams, R. M. C., Greenberg, E. D., Saxena, A., Bradbury, M. S., Edgar, M. A., Gutin, P. H., & Tabar, V. S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000588 · Cited by 184
Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum
Etxeberría, A., Mangin, J., Aguirre, A. A., & Gallo, V. (2010) · Nature Neuroscience · doi:10.1038/nn.2500 · Cited by 181
Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis
Stephenson, D. T., O'Neill, S. M., Narayan, S., Tiwari, A., Arnold, E., Samaroo, H. D., Du, F., Ring, R. H., Campbell, B., Pletcher, M., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-7 · Cited by 180
NG2 proteoglycan‐expressing cells of the adult rat brain: Possible involvement in the formation of glial scar astrocytes following stab wound
Alonso, G. (2004) · Glia · doi:10.1002/glia.20121 · Cited by 178
Generation of oligodendroglial progenitors in acute inflammatory demyelinating lesions of the rat brain stem is associated with demyelination rather than inflammation
di Bello, I. C., Dawson, M. R. L., Levine, J. M., & Reynolds, R. (1999) · Journal of Neurocytology · doi:10.1023/a:1007069815302 · Cited by 178
Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination
Mason, J. L., Xuan, S., Dragatsis, I., Efstratiadis, A., & Goldman, J. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07710.2003 · Cited by 177
Self-citation
Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery
Nissen, J. C., Thompson, K. K., West, B. L., & Tsirka, S. E. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.05.021 · Cited by 168
The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS
Reynolds, R., Dawson, M., Papadopoulos, D., Polito, A., di Bello, I. C., Pham-Dinh, D., & Levine, J. (2002) · Journal of Neurocytology · doi:10.1023/a:1025747832215 · Cited by 175
Untitled work
(1999) · doi:10.1002/(sici)1097-4547(19990815)57:4
Self-citation
Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre
Mason, J. L., Langaman, C., Morell, P., Suzuki, K., & Matsushima, G. K. (2001) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2001.00301.x · Cited by 172
Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells
Setzu, A., Lathia, J. D., Zhao, C., Wells, K., Rao, M. S., ffrench‐Constant, C., & Franklin, R. J. M. (2006) · Glia · doi:10.1002/glia.20371 · Cited by 172
Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination
Samanta, J., Grund, E. M., Silva, H. M., Lafaille, J. J., Fishell, G., & Salzer, J. L. (2015) · Nature · doi:10.1038/nature14957 · Cited by 170
Neurorestorative Therapy for Stroke
Chen, J., Venkat, P., Zacharek, A., & Chopp, M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00382 · Cited by 169
A role for CXCL12 (SDF-1α) in the pathogenesis of multiple sclerosis: Regulation of CXCL12 expression in astrocytes by soluble myelin basic protein
Calderon, T. M., Eugenín, E. A., Lopez, L., Kumar, S. S., Hesselgesser, J., Raine, C. S., & Berman, J. W. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.05.003 · Cited by 166
Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor
González-Pérez, Ó., & Álvarez-Buylla, A. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.01.001 · Cited by 176
Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
Windrem, M. S., Roy, N. S., Wang, J., Nunes, M. C., Benraiss, A., Goodman, R., McKhann, G. M., & Goldman, S. A. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10397 · Cited by 168
Exercise reverses ethanol inhibition of neural stem cell proliferation
Crews, F. T., Nixon, K., & Wilkie, M. E. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.04.005 · Cited by 165
In VivoAnalysis of Ascl1 Defined Progenitors Reveals Distinct Developmental Dynamics during Adult Neurogenesis and Gliogenesis
Kim, E. J., Leung, C. T., Reed, R. R., & Johnson, J. E. B. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3178-07.2007 · Cited by 172
Spatial and temporal expression of S100B in cells of oligodendrocyte lineage
Hachem, S., Aguirre, A. A., Vives, V., Marks, A., Gallo, V., & Legraverend, C. (2005) · Glia · doi:10.1002/glia.20184 · Cited by 169

Authors: Gensert, J. M., & Goldman, J. E.
Affiliations: Columbia University Irving Medical Center (US)
Columbia University (US)
Corresponding author: Gensert, JoAnn M
ORCID: Goldman, James E
Venue: Neuron
Publisher: Elsevier BV
Published: 1997-07
Volume: 19
Issue: 1
Pages: 197-203
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)80359-1
OpenAlex: W2005578607
Cited by: 544
References: 40
Citations by year: 2026: 3 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 12 · 2018: 23 · 2017: 15 · 2016: 17 · 2015: 25 · 2014: 23 · 2013: 29 · 2012: 21
FWCI: 5.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1380 d)
Locations: Neuron (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS17125, R01NS017125)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: remyelination, demyelination, oligodendrocyte precursor cells, myelinating oligodendrocytes, white matter, retroviral labeling, subcortical white matter, multiple sclerosis, CNS repair, adult neurogenesis
MeSH terms: Animals, Axons, Central Nervous System, Demyelinating Diseases, Female, Lysophosphatidylcholines, Stem Cells, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks