The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord
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Neurons of the dorsal horn integrate and relay sensory information and arise during development in the dorsal spinal cord, the alar plate. Class A and B neurons emerge in the dorsal and ventral alar plate, differ in their dependence on roof plate signals for specification, and settle in the deep and superficial dorsal horn, respectively. We show here that the basic helix-loop-helix (bHLH) gene Olig3 is expressed in progenitor cells that generate class A (dI1-dI3) neurons and that Olig3 is an important factor in the development of these neuronal cell types. In Olig3 mutant mice, the development of class A neurons is impaired; dI1 neurons are generated in reduced numbers, whereas dI2 and dI3 neurons are misspecified and assume the identity of class B neurons. Conversely, Olig3 represses the emergence of class B neurons in the chick spinal cord. We conclude that Olig3 expression distinguishes the two major classes of progenitors in the dorsal spinal cord and determines the distinct specification program of class A neurons.
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Olig3 is expressed in the three most dorsal progenitor domains, dp1-dp3.
“we first examined Olig3, which is expressed in the three most dorsal progenitor domains, dp1-dp3 (Müller et al., 2005).”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Müller et al., 2005
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Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685 · cited 1× · see citing works
“Dorsal horn neurons integrate sensory information, relay it to the brainstem and thalamus, and modulate spinal cord reflexes (for review, see Gillespie and Walker 2001; Julius and Basbaum 2001).”
BackgroundNeuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089 · see citing works
The cytoarchitectonic organization of the spinal cord in the cat
Rexed, B. (1952) · The Journal of Comparative Neurology · doi:10.1002/cne.900960303 · Cited by 1,633 · see citing works
Briscoe, J., Pierani, A., Jessell, T. M., & Ericson, J. (2000) · Cell · doi:10.1016/s0092-8674(00)80853-3 · Cited by 1,111 · see citing works
Lu, Q. R., Sun, T., Zhu, Z.-M., Ma, N., García, M., Stiles, C., & Rowitch, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,064 · see citing works
The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Zhou, Q., & Anderson, D. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00677-3 · Cited by 1,059 · cited 5× · see citing works
“Olig2 is expressed in a progenitor domain of the ventral spinal cord that generates initially motoneurons and, subsequently, oligodendrocytes, and is required for the specification of both cell types (Novitch et al. 2001; Zhou et al. 2001; Lu et al. 2002; Takebayashi et al. 2002a; Zhou and Anderson 2002).”
BackgroundInfluentialHomeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
Briscoe, J., Sussel, L., Serup, P., Hartigan-O'Connor, D., Jessell, T., Rubenstein, J., & Ericson, J. (1999) · Nature · doi:10.1038/19315 · Cited by 807 · see citing works
Zhou, Q., Wang, S., & Anderson, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)80898-3 · Cited by 789 · see citing works
Triezenberg, S., Kingsbury, R., & McKnight, S. (1988) · Genes & Development · doi:10.1101/gad.2.6.718 · Cited by 785 · see citing works
Schmidt, D., Ovitt, C., Anlag, K., Fehsenfeld, S., Gredsted, L., Treier, A.-C., & Treier, M. (2004) · Development · doi:10.1242/dev.00969 · Cited by 740 · see citing works
Self-citationMolecular basis of mechanosensory transduction
Gillespie, P. G., & Walker, R. G. (2001) · Nature · doi:10.1038/35093011 · Cited by 708 · see citing works
Zhou, Q., Choi, G. B., & Anderson, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00414-7 · Cited by 625 · see citing works
Novitch, B. G., Chen, A. I., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00407-x · Cited by 615 · see citing works
Liem, K. F., Tremml, G., & Jessell, T. M. (1997) · Cell · doi:10.1016/s0092-8674(01)80015-5 · Cited by 591 · see citing works
Specification of neuronal fates in the ventral neural tube
Briscoe, J., & Ericson, J. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00172-0 · Cited by 548 · see citing works
Transcriptional Codes and the Control of Neuronal Identity
Shirasaki, R., & Pfaff, S. L. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142916 · Cited by 522 · see citing works
Takebayashi, H., Nabeshima, Y., Yoshida, S., Chisaka, O., Ikenaka, K., & Nabeshima, Y. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00926-0 · Cited by 500 · see citing works
Mizuguchi, R., Sugimori, M., Takebayashi, H., Kosako, H., Nagao, M., Yoshida, S., Nabeshima, Y., Shimamura, K., & Nakafuku, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00413-5 · Cited by 471 · see citing works
Lo, L., Johnson, J. E. B., Wuenschell, C. W., Saito, T., & Anderson, D. J. (1991) · Genes & Development · doi:10.1101/gad.5.9.1524 · Cited by 435 · see citing works
Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord
Gross, M. K., Dottori, M., & Goulding, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00690-6 · Cited by 396 · see citing works
Control of Interneuron Fate in the Developing Spinal Cord by the Progenitor Homeodomain Protein Dbx1
Pierani, A., Moran-Rivard, L., Sunshine, M. J., Littman, D. R., Goulding, M., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00212-4 · Cited by 379 · see citing works
Müller, T., Brohmann, H., Pierani, A., Heppenstall, P. A., Lewin, G. R., Jessell, T. M., & Birchmeier, C. (2002) · Neuron · doi:10.1016/s0896-6273(02)00689-x · Cited by 368 · see citing works
Self-citationSpecification of dorsal spinal cord interneurons
Helms, A. W., & Johnson, J. E. B. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00010-2 · Cited by 357 · see citing works
Control of oligodendrocyte differentiation by theNkx2.2homeodomain transcription factor
Qi, Y. B., Cai, J., Wu, Y., Wu, R., Lee, J. D., Fu, H. Q., Rao, M. S., Sussel, L., Rubenstein, J. L. R., & Qiu, M. S. (2001) · Development · doi:10.1242/dev.128.14.2723 · Cited by 356 · see citing works
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
Cheng, L., Arata, A., Mizuguchi, R., Qian, Y., Karunaratne, A., Gray, P. A., Arata, S., Shirasawa, S., Bouchard, M., Luo, P., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1221 · Cited by 350 · see citing works
Lee, K. J., Mendelsohn, M. M., & Jessell, T. M. (1998) · Genes & Development · doi:10.1101/gad.12.21.3394 · Cited by 341 · see citing works
Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification
Lee, K. J., Dietrich, P., & Jessell, T. M. (2000) · Nature · doi:10.1038/35001507 · Cited by 310 · see citing works
Proprioceptor Pathway Development Is Dependent on MATH1
Bermingham, N. A., Hassan, B. A., Wang, V. Y., Fernandez, M., Banfi, S., Bellen, H. J., Fritzsch, B., & Zoghbi, H. Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00305-1 · Cited by 304 · see citing works
Crossinhibitory Activities of Ngn1 and Math1 Allow Specification of Distinct Dorsal Interneurons
Gowan, K., Helms, A. W., Hunsaker, T., Collisson, T., Ebert, P. J., Odom, R., & Johnson, J. E. B. (2001) · Neuron · doi:10.1016/s0896-6273(01)00367-1 · Cited by 302 · see citing works
The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS
Millonig, J. H., Millen, K. J., & Hatten, M. E. (2000) · Nature · doi:10.1038/35001573 · Cited by 292 · see citing works
Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cordPreprint
Muroyama, Y., Fujihara, M., Ikeya, M., Kondoh, H., & Takada, S. (2002) · Genes & Development · doi:10.1101/gad.937102 · Cited by 288 · see citing works
Vallstedt, A., Muhr, J., Pattyn, A., Pierani, A., Mendelsohn, M., Sander, M., Jessell, T., & Ericson, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00412-3 · Cited by 288 · see citing works
Smith, S. T., & Jaynes, J. B. (1996) · Development · doi:10.1242/dev.122.10.3141 · Cited by 284 · see citing works
Progenitors of dorsal commissural interneurons are defined by MATH1 expression
Helms, A. W., & Johnson, J. E. B. (1998) · Development · doi:10.1242/dev.125.5.919 · Cited by 279 · see citing works
Sander, M., Paydar, S., Ericson, J., Briscoe, J., Berber, E., German, M., Jessell, T. M., & Rubenstein, J. L. R. (2000) · Genes & Development · doi:10.1101/gad.820400 · Cited by 270 · see citing works
Evx1 Is a Postmitotic Determinant of V0 Interneuron Identity in the Spinal Cord
Moran-Rivard, L., Kagawa, T., Saueressig, H., Gross, M. K., Burrill, J. D., & Goulding, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00213-6 · Cited by 261 · see citing works
The specification of neuronal identity by graded sonic hedgehog signalling
Briscoe, J., & Ericson, J. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0295 · Cited by 256 · see citing works
The role of Lbx1 in migration of muscle precursor cells
Brohmann, H., Jagla, K., & Birchmeier, C. (2000) · Development · doi:10.1242/dev.127.2.437 · Cited by 228 · see citing works
Self-citationPatterning cell types in the dorsal spinal cord: what the mouse mutants say
Caspary, T., & Anderson, K. V. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1073 · Cited by 187 · see citing works
An ‘oligarchy’ rules neural development
Rowitch, D. H., Lu, Q. R., Kessaris, N., & Richardson, W. D. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02201-4 · Cited by 181 · see citing works
REVIEW ARTICLE THE DORSAL HORN OF THE SPINAL CORD
Brown, A. G. (1982) · Quarterly Journal of Experimental Physiology · doi:10.1113/expphysiol.1982.sp002630 · Cited by 139 · see citing works
Chen, Z., Rebelo, S., White, F. A., Malmberg, A. B., Baba, H., Lima, D., Woolf, C. J., Basbaum, A. I., & Anderson, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00341-5 · Cited by 133 · see citing works
The formation of sensorimotor circuits.
Goulding, M. D., Lanuza, G. M., Sapir, T., & Narayan, S. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00371-9 · Cited by 125 · see citing works
Nakada, Y., Hunsaker, T., Henke, R. M., & Johnson, J. E. B. (2004) · Development · doi:10.1242/dev.01008 · Cited by 108 · see citing works
Ding, Y., Yin, J., Kania, A., Zhao, Z.-Q., Johnson, R. L., & Chen, Z. (2004) · Development · doi:10.1242/dev.01250 · Cited by 106 · see citing works
Qian, Y., Shirasawa, S., Chen, C.-L., Cheng, L., & Ma, Q. (2002) · Genes & Development · doi:10.1101/gad.982802 · Cited by 104 · see citing works
Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube
Takebayashi, H., Ohtsuki, T., Uchida, T., Kawamoto, S., Okubo, K., Ikenaka, K., Takeichi, M., Chisaka, O., & Nabeshima, Y. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00021-7 · Cited by 76 · see citing works
Flagged first, then by citations
1 of the 48 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Grigoryan, T., Wend, P., Klaus‐Bergmann, A., & Birchmeier, W. (2008) · Genes & Development · doi:10.1101/gad.1686208 · Cited by 558 · see citing works
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
Plenge, R. M., Cotsapas, C. J., Davies, L. R. L., Price, A. L., de Bakker, P. I. W., Maller, J., Pe’er, I., Burtt, N. P., Blumenstiel, B. S., DeFelice, M., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.27 · Cited by 550 · see citing works
Delile, J., Rayon, T., Melchionda, M., Edwards, A., Briscoe, J., & Sagner, A. (2019) · Development · doi:10.1242/dev.173807 · Cited by 356 · see citing works
Spinal Circuits for Touch, Pain, and Itch
Koch, S. C., Acton, D. G., & Goulding, M. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034303 · Cited by 248 · see citing works
bHLH transcription factors in neural development, disease, and reprogramming.
Dennis, D. J., Han, S., & Schuurmans, C. (2019) · Brain Research · doi:10.1016/j.brainres.2018.03.013 · Cited by 207 · see citing works
Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn
Glasgow, S. M., Henke, R. M., MacDonald, R. J., Wright, C. V. E., & Johnson, J. E. (2005) · Development · doi:10.1242/dev.02167 · Cited by 225 · see citing works
Ueno, M., Nakamura, Y., Li, J., Gu, Z., Niehaus, J. K., Maezawa, M., Crone, S. A., Goulding, M., Baccei, M. L., & Yoshida, Y. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.137 · Cited by 222 · see citing works
Normal and abnormal coding of somatosensory stimuli causing pain
Prescott, S. A., Ma, Q., & De Koninck, Y. (2014) · Nature Neuroscience · doi:10.1038/nn.3629 · Cited by 210 · see citing works
Motor antagonism exposed by spatial segregation and timing of neurogenesis
Tripodi, M., Stepien, A. E., & Arber, S. (2011) · Nature · doi:10.1038/nature10538 · Cited by 203 · see citing works
Molecular and cellular development of spinal cord locomotor circuitry
Lu, D. C.-T., Niu, T., & Alaynick, W. A. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00025 · Cited by 193 · see citing works
Cheng, L., Samad, O. A., Xu, Y., Mizuguchi, R., Luo, P., Shirasawa, S., Goulding, M., & Ma, Q. (2005) · Nature Neuroscience · doi:10.1038/nn1569 · Cited by 198 · see citing works
Making sense out of spinal cord somatosensory development
Lai, H. C., Seal, R. P., & Johnson, J. E. (2016) · Development · doi:10.1242/dev.139592 · Cited by 188 · see citing works
Li, H., Lu, Y., Smith, H., & Richardson, W. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4456-07.2007 · Cited by 180 · see citing works
Battiste, J. D., Helms, A. W., Kim, E. J., Savage, T. K., Lagace, D. C., Mandyam, C. D., Eisch, A. J., Miyoshi, G., & Johnson, J. E. B. (2006) · Development · doi:10.1242/dev.02727 · Cited by 178 · see citing works
BMP-Smad 1/5/8 signalling in the development of the nervous system
Hegarty, S. V., O’Keeffe, G. W., & Sullivan, A. M. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.07.002 · Cited by 171 · see citing works
Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2
Meijer, D., Kane, M., Mehta, S., Liu, H.-Y., Harrington, E. P., Taylor, C. M., Stiles, C., & Rowitch, D. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3386 · Cited by 166 · see citing works
Huang, T., Liu, Y., Huang, M., Zhao, X., & Cheng, L. (2010) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq008 · Cited by 173 · see citing works
Pereira, J. D., DuBreuil, D. M., Devlin, A., Held, A., Sapir, Y., Berezovski, E., Hawrot, J., Dorfman, K., Chander, V., & Wainger, B. J. (2021) · Nature Communications · doi:10.1038/s41467-021-24776-4 · Cited by 155 · see citing works
Characterization of progenitor domains in the developing mouse thalamus
Vue, T. Y., Aaker, J., Taniguchi, A., Kazemzadeh, C., Skidmore, J. M., Martin, D. M., Martin, J. F., Treier, M., & Nakagawa, Y. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21467 · Cited by 144 · see citing works
Self-citationHindbrain Rhombic Lip Is Comprised of Discrete Progenitor Cell Populations Allocated by Pax6
Landsberg, R. L., Awatramani, R. B., Hunter, N. L., Farago, A. F., DiPietrantonio, H. J., Rodríguez, C. I., & Dymecki, S. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.11.031 · Cited by 149 · see citing works
Briscoe, J., & Novitch, B. G. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.2012 · Cited by 162 · see citing works
Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly
Ross, S. E., McCord, A. E., Jung, C., Atan, D., Mok, S. I., Hemberg, M., Kim, T.-K., Salogiannis, J., Hu, L., Cohen, S., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.09.035 · Cited by 137 · see citing works
Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons
Helms, A. W., Battiste, J. D., Henke, R. M., Nakada, Y., Simplicio, N., Guillemot, F., & Johnson, J. E. B. (2005) · Development · doi:10.1242/dev.01859 · Cited by 126 · see citing works
Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways
D’Autréaux, F., Coppola, E., Hirsch, M., Birchmeier, C., & Brunet, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110416108 · Cited by 123 · see citing works
Self-citationCho, L. T. Y., Wamaitha, S. E., Tsai, I. J., Artus, J., Sherwood, R. I., Pedersen, R. A., Hadjantonakis, A., & Niakan, K. K. (2012) · Development · doi:10.1242/dev.078519 · Cited by 106 · see citing works
Wildner, H., Gierl, M. S., Strehle, M., Pla, P., & Birchmeier, C. (2007) · Development · doi:10.1242/dev.011783 · Cited by 110 · see citing works
Self-citationNakatani, T., Minaki, Y., Kumai, M., & Ono, Y. (2007) · Development · doi:10.1242/dev.02870 · Cited by 108 · see citing works
Borromeo, M. D., Meredith, D., Castro, D. S., Chang, J. C., Tung, K.-C., Guillemot, F., & Johnson, J. E. (2014) · Development · doi:10.1242/dev.105866 · Cited by 97 · see citing works
Storm, R., Cholewa-Waclaw, J., Reuter, K., Bröhl, D., Sieber, M., Treier, M., Müller, T., & Birchmeier, C. (2009) · Development · doi:10.1242/dev.027193 · Cited by 94 · see citing works
Self-citationBMP4 patterns Smad activity and generates stereotyped cell fate organization in spinal organoids
Duval, N., Vaslin, C., Barata, T. C., Frarma, Y., Contremoulins, V., Baudin, X., Nedelec, S., & Ribes, V. C. (2019) · Development · doi:10.1242/dev.175430 · Cited by 93 · see citing works
The dorsal spinal cord and hindbrain: From developmental mechanisms to functional circuits.
Hernandez-Miranda, L. R., Müller, T., & Birchmeier, C. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2016.10.008 · Cited by 88 · see citing works
Self-citationFrancius, C., Harris, A., Rucchin, V., Hendricks, T. J., Stam, F. J., Barber, M., Kurek, D., Grosveld, F. G., Pierani, A., Goulding, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070325 · Cited by 97 · see citing works
A model of early molecular regionalization in the chicken embryonic pretectum
Ferrán, J. L., Sánchez‐Arrones, L., Sandoval, J. E., & Puelles, L. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21493 · Cited by 95 · see citing works
Bröhl, D., Strehle, M., Wende, H., Hori, K., Bormuth, I., Nave, K., Müller, T. H., & Birchmeier, C. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.08.002 · Cited by 90 · see citing works
Self-citationDelays in neuronal differentiation in Mash1/Ascl1 mutants
Pattyn, A., Guillemot, F., & Brunet, J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.03.008 · Cited by 90 · see citing works
Zechner, D., Müller, T. H., Wende, H., Walther, I., Taketo, M. M., Crenshaw, E. B., Treier, M., Birchmeier, W., & Birchmeier, C. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.045 · Cited by 90 · see citing works
Self-citationDréau, G. L., García‐Campmany, L., Rabadán, M. A., Ferronha, T., Tozer, S., Briscoe, J., & Martı́, E. (2011) · Development · doi:10.1242/dev.074948 · Cited by 86 · see citing works
Wildner, H., Müller, T. H., Cho, S., Bröhl, D., Cepko, C. L., Guillemot, F., & Birchmeier, C. (2006) · Development · doi:10.1242/dev.02345 · Cited by 84 · see citing works
Self-citationSasai, N., Kutejova, E., & Briscoe, J. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001907 · Cited by 76 · see citing works
Li, Y., & Begovich, A. B. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.04.002 · Cited by 81 · see citing works
Simionato, E., Kerner, P., Dray, N., Gouar, M. L., Ledent, V., Arendt, D., & Vervoort, M. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-170 · Cited by 64 · see citing works
Rheumatoid arthritis: a view of the current genetic landscape
Coenen, M. J. H., & Gregersen, P. K. (2008) · Genes and Immunity · doi:10.1038/gene.2008.77 · Cited by 76 · see citing works
Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube
Tozer, S., Dréau, G. L., Martı́, E., & Briscoe, J. (2013) · Development · doi:10.1242/dev.090118 · Cited by 75 · see citing works
Genetic identification of a hindbrain nucleus essential for innate vocalization
Hernandez-Miranda, L. R., Ruffault, P.-L., Bouvier, J., Murray, A., Morin‐Surun, M., Zampieri, N., Cholewa-Waclaw, J., Ey, E., Brunet, J., Champagnat, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702893114 · Cited by 65 · see citing works
Self-citationOntogeny of Excitatory Spinal Neurons Processing Distinct Somatic Sensory Modalities
Xu, Y., Lopes, C., Wende, H., Guo, Z., Cheng, L., Birchmeier, C., & Ma, Q. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5512-12.2013 · Cited by 63 · see citing works
Self-citationLewis, K. E. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1778 · Cited by 63 · see citing works
Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system
Dai, J., Hu, Z., Shi, M., Guo, C., & Ding, Y. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21759 · Cited by 62 · see citing works
Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling
Skaggs, K., Martin, D. M., & Novitch, B. G. (2011) · Development · doi:10.1242/dev.057281 · Cited by 60 · see citing works
Evolution of the CNS myelin gene regulatory program
Li, H., & Richardson, W. (2015) · Brain Research · doi:10.1016/j.brainres.2015.10.013 · Cited by 53 · see citing works
Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons
Candelas, M., Reynders, A., Arango-Lievano, M., Neumayer, C., Fruquière, A., Demes, E., Hamid, J., Lemmers, C., Bernat, C., Monteil, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39703-3 · Cited by 57 · see citing works
Control of Precerebellar Neuron Development byOlig3bHLH Transcription Factor
Liu, Z., Li, H., Hu, X., Yu, L. L., Liu, H., Han, R., Colella, R., Mower, G. D., Chen, Y., & Qiu, M. S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3769-08.2008 · Cited by 56 · see citing works
Jacob, J., Storm, R., Castro, D. S., Milton, C. I., Pla, P., Guillemot, F., Birchmeier, C., & Briscoe, J. (2009) · Development · doi:10.1242/dev.034546 · Cited by 54 · see citing works
Self-citationKriks, S., Lanuza, G. M., Mizuguchi, R., Nakafuku, M., & Goulding, M. (2005) · Development · doi:10.1242/dev.01878 · Cited by 52 · see citing works
Silencing neurotransmission with membrane-tethered toxins
Auer, S., Stürzebecher, A., Jüttner, R., Santos‐Torres, J., Hanack, C., Frahm, S., Liehl, B., & Ibáñez-Tallon, I. (2010) · Nature Methods · doi:10.1038/nmeth.1425 · Cited by 53 · see citing works
Transcriptional regulation of neuronal phenotype in mammals
Ma, Q. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113449 · Cited by 50 · see citing works
Wildner, H., Gupta, R. D. D., Bröhl, D., Heppenstall, P., Zeilhofer, H., & Birchmeier, C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0491-13.2013 · Cited by 48 · see citing works
Self-citationDorsal–ventral patterning: a view from the top
Zhuang, B., & Sockanathan, S. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.11.001 · Cited by 48 · see citing works
Bonner, J., Gribble, S. L., Veien, E. S., Nikolaus, O. B., Weidinger, G., & Dorsky, R. I. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.10.041 · Cited by 48 · see citing works
Zika Virus Causes Persistent Infection in Porcine Conceptuses and may Impair Health in Offspring
Darbellay, J., Cox, B., Lai, K., Delgado-Ortega, M., Wheler, C. L., Wilson, D. W. L., Walker, S., Starrak, G. S., Hockley, D. K., Huang, Y., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.021 · Cited by 49 · see citing works
Meredith, D., Masui, T., Swift, G. H., MacDonald, R. J., & Johnson, J. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2303-09.2009 · Cited by 52 · see citing works
Detailed Expression Analysis of Regulatory Genes in the Early Developing Human Neural Tube
Marklund, U., Alekseenko, Z., Andersson, E., Falci, S. P., Westgren, M., Perlmann, T., Graham, A., Sundström, E., & Ericson, J. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0309 · Cited by 42 · see citing works
Horner, V. L., & Caspary, T. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.04.019 · Cited by 44 · see citing works
John, A., Wildner, H., & Britsch, S. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20568 · Cited by 43 · see citing works
Self-citationRepression by PRDM13 is critical for generating precision in neuronal identity
Mona, B., Urueña, A., Kollipara, R., Ma, Z., Borromeo, M. D., Chang, J. C., & Johnson, J. E. (2017) · eLife · doi:10.7554/elife.25787 · Cited by 44 · see citing works
Torres‐Machorro, A. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312855 · Cited by 40 · see citing works
Espana, A., & Clotman, F. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.04.002 · Cited by 42 · see citing works
Short‐term lineage analysis of dorsally derived Olig3 cells in the developing spinal cord
Ding, L., Takebayashi, H., Watanabe, K., Ohtsuki, T., Tanaka, K., Nabeshima, Y., Chisaka, O., Ikenaka, K., & Ono, K. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20545 · Cited by 43 · see citing works
Deriving Dorsal Spinal Sensory Interneurons from Human Pluripotent Stem Cells
Gupta, S. K., Sivalingam, D., Hain, S., Makkar, C., Sosa, E., Clark, A. T., & Butler, S. J. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.12.012 · Cited by 41 · see citing works
Dréau, G. L., Saade, M., Gutiérrez-Vallejo, I., & Martı́, E. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201307031 · Cited by 39 · see citing works
Guo, Z., Zhao, C., Huang, M.-G., Huang, T., Fan, M., Xie, Z., Chen, Y., Zhao, X., Xia, G., Geng, J., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6301-11.2012 · Cited by 39 · see citing works
Kabayiza, K. U., Masgutova, G., Harris, A., Rucchin, V., Jacob, B., & Clotman, F. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00157 · Cited by 35 · see citing works
Olig3 regulates early cerebellar development
Lowenstein, E. D., Rusanova, A., Stelzer, J., Hernaiz-Llorens, M., Schroer, A. E., Epifanova, E., Bladt, F., Isik, E. G., Buchert, S., Jia, S., et al. (2021) · eLife · doi:10.7554/elife.64684 · Cited by 34 · see citing works
Stürzebecher, A., Hu, J., Smith, E. S. J., Frahm, S., Santos‐Torres, J., Kampfrath, B., Auer, S., Lewin, G. R., & Ibáñez-Tallon, I. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.187112 · Cited by 34 · see citing works
Miesegaes, G. R., Klisch, T. J., Christina Thaller, B., Ahmad, K. A., Atkinson, R. C., & Zoghbi, H. Y. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.12.016 · Cited by 34 · see citing works
Whittaker, D., Oleari, R., Gregory, L. C., Stabej, P. L. Q., Williams, H. J., GOSgene, Torpiano, J. G., Formosa, N., Cachia, M. J., Field, D., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci141587 · Cited by 31 · see citing works
Hoxb1 Controls Anteroposterior Identity of Vestibular Projection Neurons
Chen, Y., Takano‐Maruyama, M., Fritzsch, B., & Gaufo, G. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034762 · Cited by 30 · see citing works
Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord
Duval, N., Daubas, P., de Carbon, C. B., Cloment, C. S., Tinévez, J.-Y., Lopes, M. D., Ribes, V., & Robert, B. (2014) · Development · doi:10.1242/dev.099002 · Cited by 31 · see citing works
Context-Dependent Gait Choice Elicited by EphA4 Mutation in Lbx1 Spinal Interneurons
Satoh, D., Pudenz, C., & Arber, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.033 · Cited by 26 · see citing works
prdm1a and olig4 act downstream of Notch signaling to regulate cell fate at the neural plate border
Hernandez‐Lagunas, L., Powell, D. R., Law, J., Grant, K. A., & Artinger, K. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.06.005 · Cited by 26 · see citing works
Oyallon, J., Apitz, H., Miguel-Aliaga, I., Timofeev, K., Ferreira, L., & Salecker, I. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.06.027 · Cited by 26 · see citing works
Sonic Hedgehog Regulates Wnt Activity During Neural Circuit Formation
Wilson, N. H., & Stoeckli, E. T. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394622-5.00008-0 · Cited by 25 · see citing works
Lee, D.-G., Kim, Y.-K., & Baek, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213936 · Cited by 22 · see citing works
Iulianella, A., Sharma, M., Heuvel, G. B. V., & Trainor, P. A. (2009) · Development · doi:10.1242/dev.032128 · Cited by 24 · see citing works
Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase
Bonnet, F., Roussat, M., Molina, A., Azaïs, M., Bel-Vialar, S., Jacques Gautrais, A., Pituello, F., & Agius, E. (2018) · eLife · doi:10.7554/elife.32937 · Cited by 24 · see citing works
Liu, B., Liu, Z., Chen, T., Li, H., Qiang, B., Yuan, J., Peng, X., & Qiu, M. S. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21061 · Cited by 24 · see citing works
Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection
Skarlatou, S., Hérent, C., Toscano, E., Mendes, C. S., Bouvier, J., & Zampieri, N. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107741 · Cited by 23 · see citing works
Yajima, H., Suzuki, M., Ochi, H., Ikeda, K., Sato, S., Yamamura, K., Ogino, H., Ueno, N., & Kawakami, K. (2014) · BMC Biology · doi:10.1186/1741-7007-12-40 · Cited by 22 · see citing works
Bozzo, M., Lacalli, T. C., Obino, V., Caicci, F., Marcenaro, E., Bachetti, T., Manni, L., Pestarino, M., Schubert, M., & Candiani, S. (2021) · Glia · doi:10.1002/glia.23982 · Cited by 21 · see citing works
Gupta, S. K., Kawaguchi, R., Heinrichs, E., Gallardo, S., Castellanos, S., Mandric, I., Novitch, B. G., & Butler, S. J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111119 · Cited by 20 · see citing works
Genetically identified spinal interneurons integrating tactile afferents for motor control
Bui, T. V., Stifani, N., Panek, I., & Farah, C. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00522.2015 · Cited by 19 · see citing works
Francius, C., Hidalgo‐Figueroa, M., Debrulle, S., Pelosi, B., Rucchin, V., Ronellenfitch, K., Panayiotou, E., Makrides, N., Misra, K., Harris, A., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00145 · Cited by 18 · see citing works
Alzate‐Correa, D., Liu, J. M., Jones, M., Silva, T. M., Alves, M. J., Burke, E. M., Zuniga, J. N., Kaya, B., Zaza, G., Aslan, M. T., et al. (2020) · Brain Pathology · doi:10.1111/bpa.12877 · Cited by 18 · see citing works
6q23 polymorphisms in rheumatoid arthritis Spanish patients
Perdigones, N., Lamas, J. R., Vigo, A., de la Concha, E. G., Jover, J. A., Urcelay, E., Gutierrez, B.-F., & Martinez, A. (2009) · Lara D. Veeken · doi:10.1093/rheumatology/kep053 · Cited by 18 · see citing works
The Olig family affects central nervous system development and disease
Tan, B.-T., Yu, J., Yin, Y., Jia, G.-W., Jiang, W., & Yu, L.-H. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.128232 · Cited by 18 · see citing works
Misexpression ofBREgene in the developing chick neural tube affects neurulation and somitogenesis
Wang, G., Li, Y., Wang, X., Chuai, M., Chan, J. Y.-H., Lei, J., Münsterberg, A., Lee, K. K., & Yang, X. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1144 · Cited by 17 · see citing works
Sox5 controls dorsal progenitor and interneuron specification in the spinal cord
Quiroga, A. C., Stolt, C. C., del Corral, R. D., Markov, S. D., Pérez‐Alcalá, S., Sock, E., Barbas, J. A., Wegner, M., & Morales, A. V. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22240 · Cited by 16 · see citing works
An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system
Zannino, D., & Sagerström, C. G. (2015) · Neural Development · doi:10.1186/s13064-015-0052-8 · Cited by 14 · see citing works
A refined map of early gene expression in the dorsal rhombomere 1 of mouse embryos
Liu, Z.-R., Shi, M., Hu, Z., Zheng, M., Du, F., Zhao, G., & Ding, Y. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.02.010 · Cited by 15 · see citing works
The olig family: phylogenetic analysis and early gene expression in Xenopus tropicalis
Bronchain, O. J., Pollet, N., Ymlahi-Ouazzani, Q., Dhorne‐Pollet, S., Helbling, J., Lecarpentier, J., Percheron, K., & Wegnez, M. R. (2007) · Development Genes and Evolution · doi:10.1007/s00427-007-0158-z · Cited by 16 · see citing works
Axonal Projection Patterns of the Dorsal Interneuron Populations in the Embryonic Hindbrain
Hirsch, D., Kohl, A., Wang, Y., & Sela‐Donenfeld, D. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.793161 · Cited by 15 · see citing works
- Authors
- Müller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M., & Birchmeier, C.
- Affiliations
- Max Delbrück Center (DE)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-03-15
- Volume
- 19
- Issue
- 6
- Pages
- 733-743
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC1065726
- OpenAlex
- W2038998122
- Cited by
- 150
- References
- 48
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 1 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 9 · 2012: 9
- Type
- posted content
- Language
- en
- Open access
- green
- dx.doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- bHLH transcription factors, dorsal horn neurons, spinal cord development, alar plate, neuronal specification, dorsal interneurons, progenitor cells, chick embryo
- MeSH terms
- Animals, Bromodeoxyuridine, Cell Differentiation, Chick Embryo, Fluorescent Antibody Technique, Genetic Vectors, Mutation, Spinal Cord, Stem Cells, Transcription Factors, Blotting, Southern, In Situ Hybridization, Gene Transfer Techniques, Electroporation, Reverse Transcriptase Polymerase Chain Reaction, Posterior Horn Cells, Mice, Basic Helix-Loop-Helix Proteins
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