Cited by 857Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationAxon Guidance and Neuronal Signaling

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Tbr1 Regulates Differentiation of the Preplate and Layer 6

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Hevner, Robert F, Shi, Limin, Justice, Nick, Hsueh, Yi-Ping, Sheng, Morgan, Smiga, Susan, Bulfone, Alessandro, Goffinet, André M, Campagnoni, Anthony T, Rubenstein, John L.R·2001·Neuron

DOI 10.1016/s0896-6273(01)00211-2

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Abstract

During corticogenesis, early-born neurons of the preplate and layer 6 are important for guiding subsequent neuronal migrations and axonal projections. Tbr1 is a putative transcription factor that is highly expressed in glutamatergic early-born cortical neurons. In Tbr1-deficient mice, these early-born neurons had molecular and functional defects. Cajal-Retzius cells expressed decreased levels of Reelin, resulting in a reeler-like cortical migration disorder. Impaired subplate differentiation was associated with ectopic projection of thalamocortical fibers into the basal telencephalon. Layer 6 defects contributed to errors in the thalamocortical, corticothalamic, and callosal projections. These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development.

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Authors: Hevner, R. F., Shi, L., Justice, N., Hsueh, Y.-P., Sheng, M., Smiga, S., Bulfone, A., Goffinet, A. M., Campagnoni, A. T., & Rubenstein, J. L. R.
Affiliations: University of California, San Francisco (US)
Howard Hughes Medical Institute (US)
University of California, Los Angeles (US)
Corresponding author: Rubenstein, John L.R
ORCID: Hevner, Robert F
Shi, Limin
Hsueh, Yi-Ping
Sheng, Morgan
Goffinet, André M
Rubenstein, John L.R
Venue: Neuron
Publisher: Elsevier BV
Published: 2001-02
Volume: 29
Issue: 2
Pages: 353-366
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(01)00211-2
OpenAlex: W2029245198
Cited by: 857
References: 53
Citations by year: 2026: 20 · 2025: 36 · 2024: 21 · 2023: 29 · 2022: 38 · 2021: 41 · 2020: 41 · 2019: 33 · 2018: 31 · 2017: 36 · 2016: 42 · 2015: 38 · 2014: 40 · 2013: 39 · 2012: 38
FWCI: 5.95
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4580 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (submittedVersion)
Funders: National Institutes of Health (2k02mh001046-06, 7k08ns001973-06)
National Institute of Mental Health (K02MH01046)
National Institute of Neurological Disorders and Stroke (NS01973, R01NS034661)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords: Tbr1, cortical development, preplate, layer 6, glutamatergic neurons, Cajal-Retzius cells, reelin, subplate, thalamocortical connections, corticothalamic projections, callosal projections, neuronal migration, transcription factors
MeSH terms: Reelin Protein, Animals, Cell Movement, DNA-Binding Proteins, Germ Layers, Lac Operon, Mice, Mutant Strains, Mice, Transgenic, Mutation, Nerve Tissue Proteins, Neural Pathways, Synaptic Transmission, Neurons, Serine Endopeptidases, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Cell Death, Gene Expression Regulation, Developmental, Neocortex, T-Box Domain Proteins, Mice

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Tbr1 Regulates Differentiation of the Preplate and Layer 6

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