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Cited by 533Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyMemory and Neural Mechanisms

Modulation of AMPA receptor unitary conductance by synaptic activity

Benke, Tim A., Lüthi, Andreas, Isaac, John T. R., Collingridge, Graham L.·1998·Nature
DOI 10.1038/31709
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Abstract

Activity-dependent alteration in synaptic strength is a fundamental property of the vertebrate central nervous system and is thought to underlie learning and memory. The most extensively studied model of activity-dependent synaptic plasticity is long-term potentiation (LTP) of glutamate-responsive (glutamatergic) synapses, a widespread phenomenon involving multiple mechanisms. The best characterized form of LTP occurs in the CA1 region of the hippocampus, in which LTP is initiated by transient activation of NMDA (N-methyl-D-aspartate) receptors and is expressed as a persistent increase in synaptic transmission through AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate) receptors. This increase is due, at least in part, to a postsynaptic modification of AMPA-receptor function; this modification could be caused by an increase in the number of receptors, their open probability, their kinetics or their single-channel conductance. Here we show that the induction of LTP in the CA1 region of the hippocampus is often associated with an increase in single-channel conductance of AMPA receptors. This shows that elementary channel properties can be rapidly modified by synaptic activity and provides an insight into one molecular mechanism by which glutamatergic synapses can alter their strength.

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Crossref · 10.1038/31709

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  • Our implementation of plasticity through changes in individual memristors is analogous to individual plasticity of synaptic connections between a pair of biological neurons, which is also true for individual ion channels of a synaptic connection.

    “Furthermore, our implementation of plasticity through changes in the individual memristors is analogous to individual plasticity of the synaptic connections between a pair of biological neurons55, which is also true for the individual ion channels of a synaptic connection55,56.”

    From Neuromorphic computing with multi-memristive synapses (2018) · cites this paper as [56]

  • Phosphorylation of AMPAR subunits can cause an increase in the conductance of the AMPAR channel, another postsynaptic mechanism that contributes to at least the early phase of LTP.

    “The phosphorylation of AMPAR subunits can cause an increase in the conductance of the AMPAR channel (Benke et al. 1998), another postsynaptic mechanism that contributes to at least the early phase of LTP.”

    From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Benke et al. 1998

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Authors
Benke, T. A., Lüthi, A., Isaac, J. T. R., & Collingridge, G. L.
Affiliations
  • Baylor College of Medicine (US)
  • University of Zurich (CH)
  • University of Bristol (GB)
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1998-06
Volume
393
Issue
6687
Pages
793-797
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/31709
OpenAlex
W1641016126
Cited by
533
References
1
Citations by year
2026: 4 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 11 · 2020: 9 · 2019: 16 · 2018: 19 · 2017: 24 · 2016: 12 · 2015: 18 · 2014: 28 · 2013: 12 · 2012: 18
FWCI
13.74
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
AMPA receptors, single-channel conductance, long-term potentiation, synaptic plasticity, hippocampal CA1, NMDA receptor, glutamatergic synapses
MeSH terms
Animals, Electric Conductivity, Electrophysiology, Hippocampus, Synapses, Long-Term Potentiation, Pyramidal Cells, Receptors, AMPA, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques

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