The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Fear Conditioning Occludes LTP-Induced Presynaptic Enhancement of Synaptic Transmission in the Cortical Pathway to the Lateral Amygdala
Open accessAbstract
Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electrically induced long-term potentiation (LTP). Quantal analysis of the expression of LTP in this pathway reveals a significant presynaptic component reflected in an increase in probability of transmitter release. Conditioned fear also is accompanied by the enhancement in transmitter release at this cortico-amygdala synapse. These results indicate that the synaptic projections from the auditory cortex to the lateral amygdala are modified during the acquisition and expression of fear to auditory stimulation, thus further strengthening the proposed link between LTP in the auditory pathways to the amygdala and learned fear.
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“Tsvetkov et al. [345] found that 3 days of fear conditioning resulted in a profound suppression of LTP in the cortico-amygdala circuit”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Tsvetkov et al. [345]
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Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
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Metadata
- Authors
- Tsvetkov, E., Carlezon, W. A., Benes, F. M., Kandel, E. R., & Bolshakov, V. Y.
- Affiliations
- Harvard University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bolshakov, Vadim Y.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 34
- Issue
- 2
- Pages
- 289-300
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2040002918
- Cited by
- 321
- References
- 51
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 9 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 16 · 2016: 7 · 2015: 19 · 2014: 21 · 2013: 22 · 2012: 10
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R01DA012736, DA12736)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- fear conditioning, long-term potentiation, lateral amygdala, auditory cortex, medial geniculate body, synaptic transmission, emotional learning, auditory fear
- MeSH terms
- Amygdala, Animals, Cerebral Cortex, Conditioning, Psychological, Electrophysiology, Fear, Neural Pathways, Synaptic Transmission, Synapses, Rats, Sprague-Dawley, Presynaptic Terminals, Long-Term Potentiation, Rats, In Vitro Techniques
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