Cited by 324Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Fear Conditioning Occludes LTP-Induced Presynaptic Enhancement of Synaptic Transmission in the Cortical Pathway to the Lateral Amygdala

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Tsvetkov, Evgeny, Carlezon, William A., Benes, Francine M., Kandel, Eric R., Bolshakov, Vadim Y.·2002·Neuron

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Abstract

Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electrically induced long-term potentiation (LTP). Quantal analysis of the expression of LTP in this pathway reveals a significant presynaptic component reflected in an increase in probability of transmitter release. Conditioned fear also is accompanied by the enhancement in transmitter release at this cortico-amygdala synapse. These results indicate that the synaptic projections from the auditory cortex to the lateral amygdala are modified during the acquisition and expression of fear to auditory stimulation, thus further strengthening the proposed link between LTP in the auditory pathways to the amygdala and learned fear.

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Authors: Tsvetkov, E., Carlezon, W. A., Benes, F. M., Kandel, E. R., & Bolshakov, V. Y.
Affiliations: Harvard University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Bolshakov, Vadim Y.
ORCID: Tsvetkov, Evgeny
Carlezon, William A.
Benes, Francine M.
Kandel, Eric R.
Bolshakov, Vadim Y.
Venue: Neuron
Publisher: Elsevier BV
Published: 2002-04
Volume: 34
Issue: 2
Pages: 289-300
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(02)00645-1
OpenAlex: W2040002918
Cited by: 321
References: 51
Citations by year: 2026: 2 · 2025: 10 · 2024: 9 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 16 · 2016: 7 · 2015: 19 · 2014: 21 · 2013: 22 · 2012: 10
FWCI: 8.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4125 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (R01DA012736, DA12736)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: fear conditioning, long-term potentiation, lateral amygdala, auditory cortex, medial geniculate body, synaptic transmission, emotional learning, auditory fear
MeSH terms: Amygdala, Animals, Cerebral Cortex, Conditioning, Psychological, Electrophysiology, Fear, Neural Pathways, Synaptic Transmission, Synapses, Rats, Sprague-Dawley, Presynaptic Terminals, Long-Term Potentiation, Rats, In Vitro Techniques

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Fear Conditioning Occludes LTP-Induced Presynaptic Enhancement of Synaptic Transmission in the Cortical Pathway to the Lateral Amygdala

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