Cited by 251Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

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Synaptic Transmission and Plasticity in the Absence of AMPA Glutamate Receptor GluR2 and GluR3

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Meng, Yanghong, Zhang, Yu, Jia, Zhengping·2003·Neuron

DOI 10.1016/s0896-6273(03)00368-4

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Abstract

The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of both GluR2 and GluR3. We show here that the double knockout mice are severely impaired in basal synaptic transmission, demonstrating that GluR2/3 are essential to maintain adequate synaptic transmission in vivo. However, these mutant mice are competent in establishing several forms of long-lasting synaptic changes in the CA1 region of the hippocampus, including LTD, long-term potentiation (LTP), depotentiation, and dedepression, indicating the presence of GluR2/3-independent mechanisms of LTD expression and suggesting that AMPA receptor GluR1 alone is capable of various forms of synaptic plasticity.

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Authors: Meng, Y., Zhang, Y., & Jia, Z.
Affiliations: University of Toronto (CA)
Hospital for Sick Children (CA)
Corresponding author: Jia, Zhengping
ORCID: Zhang, Yu
Jia, Zhengping
Venue: Neuron
Publisher: Elsevier BV
Published: 2003-07
Volume: 39
Issue: 1
Pages: 163-176
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(03)00368-4
OpenAlex: W2056366478
Cited by: 251
References: 56
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 2 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 6 · 2014: 11 · 2013: 13 · 2012: 12
FWCI: 5.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3669 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: AMPA receptors, GluR2, GluR3, GluR1, synaptic transmission, synaptic plasticity, long-term depression, long-term potentiation, depotentiation, hippocampal CA1, knockout mice, synaptic targeting
MeSH terms: Animals, Electrophysiology, Female, Hippocampus, Immunohistochemistry, Male, Microscopy, Electron, Synaptic Transmission, Neuronal Plasticity, Organ Culture Techniques, Immunoblotting, Long-Term Potentiation, Receptors, AMPA, Mice, Knockout, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Mice

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Synaptic Transmission and Plasticity in the Absence of AMPA Glutamate Receptor GluR2 and GluR3

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