Ultraviolet A radiation-induced biological effects in human skin: Relevance for photoaging and photodermatosis
Abstract
There is increasing evidence that longwave ultraviolet (UV) radiation (UVA; 320-400 nm) plays an important role in the pathogenesis of photodermatoses such as polymorphous light eruption as well as photoaging. In order to fully understand these detrimental effects it is critical to analyze the photobiological and molecular mechanisms by which UVA radiation affects the function of human skin cells. In this review, our current knowledge about the signal transduction pathway involved in UVA radiation-induced expression of proinflammatory genes relevant to the pathogenesis of polymorphous light eruption will be summarized. In addition, recent studies on the role of mitochondrial DNA mutations in UVA radiation-induced photoaging of human skin will be discussed. For both biological endpoints the UVA radiation-induced generation of singlet oxygen within human skin appears to be of critical importance. These studies are of enormous clinical relevance because they indicate that prevention of the generation of singlet oxygen or inhibition of singlet oxygen-induced signaling pathways may prove to be critical for effective protection of human skin against UVA radiation-induced damage.
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Both UVB and UVA radiation contribute to freckling, skin wrinkling and the development of skin cancers.
“In fact, both UVB and UVA radiation contribute to freckling, skin wrinkling and the development of skin cancers [13,14].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [13]
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- Authors
- Krutmann, J.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Krutmann, Jean
- ORCID
- Krutmann, Jean
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 23
- Pages
- S22-S26
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W2086371894
- Cited by
- 248
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 15 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 8 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 10 · 2013: 16 · 2012: 9
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- ultraviolet A radiation, photoaging, photodermatosis, polymorphous light eruption, pro-inflammatory gene expression, signal transduction, mitochondrial DNA mutations, singlet oxygen, skin damage, photoprotection
- MeSH terms
- DNA, Mitochondrial, Humans, Mutation, Oxygen, Photosensitivity Disorders, Skin, Ultraviolet Rays, Signal Transduction, Skin Aging, Keratinocytes, Gene Expression, Cytokines, Intercellular Adhesion Molecule-1, Singlet Oxygen
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