UV modulation of subcutaneous fat metabolism
Open accessAbstract
Adipose tissue is not a homogeneous organ. Visceral fat accumulation is associated with atherosclerosis and metabolic syndrome, but peripheral subcutaneous (SC) fat accumulation may be protective. Human skin is continuously exposed to UV light. UV can penetrate the epidermis and into the mid-dermis, but not into the SC fat tissue of human skin. However, we here show that SC fat tissue in chronically sun-damaged skin contains less fat than naturally aged skin, and even a single UV exposure of human skin reduced lipid synthesis in the underlying SC fat tissue through transcriptional regulation of the lipogenic enzymes, acetyl CoA carboxylase, fatty acid synthase, and stearoyl CoA desaturase, of their transcription activator sterol regulatory element-binding protein-1 (SREBP-1), and of two key adipogenic transcription factors, CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ. The cytokines IL-6, IL-8, monocyte chemoattractant protein-3 (MCP-3), and placenta growth factor, produced by keratinocytes and fibroblasts in response to UV, may be responsible for the reduction of SC fat, and these cytokines, except MCP-3, may act by upregulation of suppressor of cytokine signaling-3 expression. Our data demonstrate the inhibitory effects of UV light on SC lipid synthesis and provide proof of concept for targeting cytokines for SC fat tissue modification.
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UV radiation significantly affects SWAT metabolism, reducing free fatty acid and triglyceride amounts in sun-exposed skin compared with sun-protected skin.
“The amounts of free fatty acid and triglycerides in the SWAT of the photoaged forearm (sun-exposed skin) were significantly less than those in the buttocks (sun-protected skin) of the same elderly individuals [48].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [48]
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- Authors
- Kim, E. J., Kim, Y. K., Kim, J. E., Kim, S., Kim, M.-K., Park, C.-H., & Chung, J. H.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Chung, Jin Ho
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 131
- Issue
- 8
- Pages
- 1720-1726
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2032272551
- Cited by
- 79
- References
- 38
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health and Welfare (A060160)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- ultraviolet radiation, subcutaneous adipose tissue, adipose tissue, lipogenesis, SREBP1, C/EBPα, PPARγ, acetyl-CoA carboxylase, fatty acid synthase, stearoyl-CoA desaturase, keratinocytes, fibroblasts, cytokines, interleukin-6, interleukin-8, MCP-3, placental growth factor, SOCS3, skin aging, sun damage, adipogenesis
- MeSH terms
- Placenta Growth Factor, Epidermal Cells, Adult, Aged, Cell Communication, Cells, Cultured, Epidermis, Female, Fibroblasts, Humans, Male, Pregnancy Proteins, Ultraviolet Rays, Signal Transduction, Skin Aging, Keratinocytes, Interleukin-6, Interleukin-8, Adipocytes, Subcutaneous Fat, Lipid Metabolism, Chemokine CCL7, Young Adult
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