Treatment and prevention of antibiotic associated diarrhea
Abstract
Mild or severe episodes of antibiotic-associated diarrhea (AAD) are common side effects of antibiotic therapy. The incidence of AAD differs with the antibiotic and varies from 5 to 25%. The major form of intestinal disorders is the pseudomembranous colitis associated with Clostridium difficile which occurs in 10-20% of all AAD. In most cases of AAD discontinuation or replacement of the inciting antibiotic by another drug with lower AAD risk can be effective. For more severe cases involving C. difficile, the treatment of diarrhea requires an antibiotic treatment, with glycopeptides (vancomycin) or metronidazole. Another approach to AAD treatment or prevention is based on the use of non-pathogenic living organisms, capable of re-establishing the equilibrium of the intestinal ecosystem. Several organisms have been used in treatment or prophylaxis of AAD such as selected strains of Lactobacillus acidophilus, L. bulgaricus, Bifidobacterium longum, and Enterococcus faecium. Another biotherapeutic agent, a non-pathogenic yeast, Saccharomyces boulardii has been used. In animal models of C. difficile colitis initiated by clindamycin, animals treated with S. boulardii (at end of vancomycin therapy) had a significant decrease in C. difficile colony-forming units, and of toxin B production. In several clinical randomised trials (versus placebo), S. boulardii has demonstrated its effectiveness by decreasing significantly the occurrence of C. difficile colitis and preventing the pathogenic effects of toxins A and B of C. difficile. It has been shown to be a safe and effective therapy in relapses of C. difficile colitis. A good response has been seen in children with AAD, treated by S. boulardii only. In ICUs prevention of AAD remains based on limitation of antibiotic overuse and spread of C. difficile or other agents of AAD should be prevented by improved hygiene measures (single rooms, private bathrooms for patients, use of gloves and hand washing for personnel). In addition the increasing use of biotherapeutic agents such as S. boulardii should permit the prevention of the major side effect of antibiotics, i.e. AAD in at risk patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia
Bartlett, J. G., Chang, T. W., Gurwith, M., Gorbach, S. L., & Onderdonk, A. B. (1978) · New England Journal of Medicine · doi:10.1056/nejm197803092981003 · Cited by 1,374 · see citing works
McFarland, L. V. (1994) · JAMA · doi:10.1001/jama.1994.03510480037031 · Cited by 862 · see citing works
Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: A prospective study
Surawicz, C. M., Elmer, G. W., Speelman, P., McFarland, L. V., Chinn, J., & van Belle, G. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)91613-2 · Cited by 570 · see citing works
SUCCESSFUL TREATMENT OF RELAPSING CLOSTRIDIUM DIFFICILE COLITIS WITH LACTOBACILLUS GG
Gorbach, S., Chang, T., & Goldin, B. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92646-8 · Cited by 467 · see citing works
Castagliuolo, I., Riegler, M. F., Valenick, L. V., LaMont, J. T., & Pothoulakis, C. (1999) · Infection and Immunity · doi:10.1128/iai.67.1.302-307.1999 · Cited by 408 · see citing works
Recurrent Clostridium Difficile Disease: Epidemiology and Clinical Characteristics
McFarland, L. V., Surawicz, C. M., Rubin, M., Fekety, R., Elmer, G. W., & Greenberg, R. N. (1999) · Infection Control and Hospital Epidemiology · doi:10.1086/501553 · Cited by 353 · see citing works
Mechanisms and Management of Antibiotic‐Associated Diarrhea
Hogenauer, C., Hammer, H. F., Krejs, G. J., & Reisinger, E. C. (1998) · Clinical Infectious Diseases · doi:10.1086/514958 · Cited by 348 · see citing works
Prevention of beta-lactam-associated diarrhea by Saccharomyces boulardii compared with placebo.
McFarland, L. V., Surawicz, C. M., Greenberg, R. N., Elmer, G. W., Moyer, K. A., Melcher, S. A., Bowen, K., & Cox, J. L. (1995) · PubMed · Cited by 338 · see citing works
Effect ofLactobacillusGG Yoghurt in Prevention of Antibiotic Associated Diarrhoea
Siitonen, S., Vapaatalo, H., Salminen, S., Gordin, A., Saxelin, M., Wikberg, R., & Kirkkola, A.-L. (1990) · Annals of Medicine · doi:10.3109/07853899009147243 · Cited by 326 · see citing works
Elmer, G. W. (1996) · JAMA · doi:10.1001/jama.275.11.870 · Cited by 326 · see citing works
Epidemiology, Risk Factors and Treatments for Antibiotic-Associated Diarrhea
McFarland, L. V. (1998) · Digestive Diseases · doi:10.1159/000016879 · Cited by 310 · see citing works
HL-A ANTIGENS IN MYASTHENIA GRAVIS
Fritze, D., Herrmann, C., Naeim, F., Smith, G., & Walford, R. L. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91370-1 · Cited by 296 · see citing works
Treatment of Recurrent Clostridium difficile Colitis With Lactobacillus GG
Biller, J. A., Katz, A. J., Flores, A. F., Buie, T. M., & Gorbach, S. L. (1995) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199508000-00016 · Cited by 283 · see citing works
YOGHURT WITH BIFIDOBACTERIUM LONGUM REDUCES ERYTHROMYCIN-INDUCED GASTROINTESTINAL EFFECTS
Colombel, J., Cortot, A., Neut, C., & Romond, C. (1987) · The Lancet · doi:10.1016/s0140-6736(87)93078-9 · Cited by 197 · see citing works
Tankanow, R. M., Ross, M. B., Ertel, I. J., Dickinson, D. G., McCormick, L. S., & GARFINKEL, J. (1990) · DICP · doi:10.1177/106002809002400408 · Cited by 140 · see citing works
Saccharomyces boulardii for Clostridium difficile-Associated Enteropathies in Infants
Buts, J., Corthier, G., & Delmée, M. (1993) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199305000-00013 · Cited by 131 · see citing works
McFarland, L. V. (1994) · JAMA · doi:10.1001/jama.271.24.1913 · Cited by 116 · see citing works
Pseudomembranous Colitis: Causes and Cures
Surawicz, C. M., & McFarland, L. V. (1999) · Digestion · doi:10.1159/000007633 · Cited by 114 · see citing works
Review article: treatment of Clostridium difficile infection
Zimmerman, M. J., Bąk, A., & Sutherland, L. R. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.00269.x · Cited by 37 · see citing works
Antibiotic-Associated Diarrhoea,Clostridium difficile, and Short-Chain Fatty Acids
Hove, H., Tvede, M., & Mortensen, P. B. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609009151 · Cited by 32 · see citing works
Prevention of antibiotic-associated diarrhea utilizing Lactobacillus GG
Young, R. J., Whitney, D., Hanner, T. L., Antonson, D. L., Lupo, J. V., & Vanderhoof, J. A. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)81762-9 · Cited by 24 · see citing works
Living in the ‘post-antibiotic era’: could the use of probiotics be an effective strategy?
Hamilton-Miller, J. M. T. (1997) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.1997.tb00242.x · Cited by 20 · see citing works
Bergogne-Bérézin, E. (1995) · PubMed · Cited by 18 · see citing works
Self-citationCarbon, C., Richard, A. M., & Bons, B. (1994) · PubMed · Cited by 11 · see citing works
Flagged first, then by citations
3 of the 27 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Hickson, M., D'Souza, A. L., Muthu, N., Rogers, T. R., Want, S., Rajkumar, C., & Bulpitt, C. J. (2007) · BMJ · doi:10.1136/bmj.39231.599815.55 · Cited by 599 · see citing works
Health benefits of probiotics: are mixtures more effective than single strains?
Chapman, C. M. C., Gibson, G. R., & Rowland, I. R. (2011) · European Journal of Nutrition · doi:10.1007/s00394-010-0166-z · Cited by 476 · see citing works
Diarrhoea in children: an interface between developing and developed countries
Thapar, N., & Sanderson, I. R. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15599-2 · Cited by 406 · see citing works
Probiotics: potential pharmaceutical applications
Kaur, I. P., Chopra, K., & Saini, A. (2002) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(01)00209-3 · Cited by 392 · see citing works
Optical control of antibacterial activity
Velema, W. A., van der Berg, J. P., Hansen, M. J., Szymański, W., Driessen, A. J. M., & Feringa, B. L. (2013) · Nature Chemistry · doi:10.1038/nchem.1750 · Cited by 371 · see citing works
Health and growth of veal calves fed milk replacers with or without probiotics
Timmerman, H. M., Mulder, L., Everts, H., van Espen, D. C., van der Wal, E., Klaassen, G., Rouwers, S. M. G., Hartemink, R., Rombouts, F. M., & Beynen, A. C. (2005) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(05)72891-5 · Cited by 297 · see citing works
Mechanisms and therapeutic effectiveness of lactobacilli
Cerbo, A. D., Palmieri, B., Aponte, M., Morales‐Medina, J. C., & Iannitti, T. (2015) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2015-202976 · Cited by 264 · see citing works
Characterization of the normal microbiota of the ocular surface
Willcox, M. D. P. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.06.003 · Cited by 259 · see citing works
Probiotics and gastrointestinal diseases
Sullivan, Å., & Nord, C. E. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01410.x · Cited by 202 · see citing works
Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis
Harnoss, J. C., Zelienka, I., Probst, P., Grummich, K., Müller-Lantzsch, C., Harnoss, J. M., Ulrich, A. B., Büchler, M. W., & Diener, M. K. (2016) · Annals of Surgery · doi:10.1097/sla.0000000000002039 · Cited by 184 · see citing works
Probiotics and intestinal health effects: a clinical perspective
Marteau, P. R., Seksik, P., & Jian, R. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002629 · Cited by 183 · see citing works
Fecal Flora Reconstitution for Recurrent Clostridium difficile Infection: Results and Methodology
Rohlke, F., Surawicz, C. M., & Stollman, N. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181dadb10 · Cited by 165 · see citing works
Varankovich, N. V., Nickerson, M. T., & Korber, D. R. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00685 · Cited by 164 · see citing works
Hölzel, C. S., Tetens, J. L., & Schwaiger, K. (2018) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2018.2501 · Cited by 159 · see citing works
Elia, M., Engfer, M., GREEN, C., & Silk, D. B. A. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03544.x · Cited by 151 · see citing works
Robustness trade‐offs and host–microbial symbiosis in the immune system
Kitano, H., & Oda, K. (2006) · Molecular Systems Biology · doi:10.1038/msb4100039 · Cited by 145 · see citing works
Deep discovery informs difficult deployment in plant microbiome science
Russ, D., Fitzpatrick, C. R., Teixeira, P. J. P. L., & Dangl, J. L. (2023) · Cell · doi:10.1016/j.cell.2023.08.035 · Cited by 143 · see citing works
Pharmacokinetic and Pharmacodynamic Issues in the Treatment of Bacterial Infectious Diseases
McKinnon, P. S., & Davis, S. L. (2004) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-004-1107-7 · Cited by 117 · see citing works
The place of probiotics in human intestinal infections
Sullivan, Å., & Nord, C. E. (2002) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(02)00199-1 · Cited by 112 · see citing works
Probiotic microorganisms: how they affect intestinal pathophysiology
Heyman, M., & Ménard, S. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8494-7 · Cited by 109 · see citing works
Lacombe, A., Wu, V. C. H., White, J. S., Tadepalli, S., & Andre, E. E. (2011) · Food Microbiology · doi:10.1016/j.fm.2011.10.006 · Cited by 109 · see citing works
Role of Lactobacillus in the Prevention of Antibiotic‐Associated Diarrhea: A Meta‐analysis
Kale-Pradhan, P. B., Jassaly, H. K., & Wilhelm, S. M. (2010) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.30.2.119 · Cited by 102 · see citing works
Duman, D., Bor, S., ??z??temiz, ?., ahin, T. L., uz, D. O., tan, F. I., Vural, T., Sandkci, M., ksal, F. I., ek, L. I., et al. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200512000-00015 · Cited by 104 · see citing works
Managing antibiotic associated diarrhoea: Probiotics may help in prevention
Barbut, F., & Meynard, J. L. (2002) · BMJ · doi:10.1136/bmj.324.7350.1345 · Cited by 100 · see citing works
Shi, X., Gong, E., Gao, D., Zhang, B., Zheng, J., Gao, Z., Zhong, Y., Zou, W.-Z., Wu, B., Fang, W., et al. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40377.x · Cited by 99 · see citing works
Lei, V., Friis, H., & Michaelsen, K. F. (2006) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2006.04.022 · Cited by 97 · see citing works
Dietrich, C. G. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i42.15837 · Cited by 90 · see citing works
Host-Microbiota Interactions in the Pathogenesis of Antibiotic-Associated Diseases
Lichtman, J. S., Ferreyra, J. A., Ng, K. M., Smits, S. A., Sonnenburg, J. L., & Elias, J. E. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.009 · Cited by 82 · see citing works
Nasiri, M. J., Goudarzi, M., Hajikhani, B., Ghazi, M., Goudarzi, H., & Pouriran, R. (2018) · Anaerobe · doi:10.1016/j.anaerobe.2018.01.011 · Cited by 80 · see citing works
Wong, S., Jamous, A., O’Driscoll, J., Sekhar, R., Weldon, M., Yau, C. Y., Hirani, S. P., GRIMBLE, G. K., & Forbes, A. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002973 · Cited by 79 · see citing works
Trejo, F. M., Minnaard, J., Pérez, P. F., & Antoni, G. L. D. (2006) · Anaerobe · doi:10.1016/j.anaerobe.2006.03.004 · Cited by 76 · see citing works
Chen, M., Su, C., Yang, J., Lu, C., Hou, Y., Wu, J., & Hsu, Y. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14372 · Cited by 75 · see citing works
Qu, Q., Fang, Y., Zhao, C., Liu, X., Yang, P., Li, Z., Han, L., & Shi, X. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113594 · Cited by 75 · see citing works
Shan, L.-S., Hou, P., Wang, Z.-J., Liu, F.-R., Chen, N., Shu, L.-H., Zhang, H., Han, X.-H., Han, X.-X., Cai, X., et al. (2013) · Beneficial Microbes · doi:10.3920/bm2013.0008 · Cited by 76 · see citing works
A Review of Clostridioides difficile Infection and Antibiotic-Associated Diarrhea
Abad, C. L. R., & Safdar, N. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.02.010 · Cited by 72 · see citing works
Lactobacillus GG and Tributyrin Supplementation Reduce Antibiotic‐Induced Intestinal Injury
Cresci, G., Nagy, L. E., & Ganapathy, V. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113486809 · Cited by 66 · see citing works
Ehrhardt, S., Guo, N., Hinz, R., Schoppen, S., May, J., Reiser, M., Schroeder, M. P., Schmiedel, S., Keuchel, M., Reisinger, E. C., et al. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw011 · Cited by 67 · see citing works
Probiotics: Delineation of Prophylactic and Therapeutic Benefits
Kaur, I. P., Kuhad, A., Garg, A., & Chopra, K. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2007.0544 · Cited by 66 · see citing works
Lee, Y.-J., Yu, W.-K., & Heo, T. (2003) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(02)00389-8 · Cited by 62 · see citing works
Antibiotic-Associated Hemorrhagic Colitis Caused by Cytotoxin-Producing Klebsiella oxytoca
Hoffmann, K. M., Deutschmann, A. J., Weitzer, C., Joainig, M. M., Zechner, E. L., Högenauer, C., & Hauer, A. C. (2010) · PEDIATRICS · doi:10.1542/peds.2009-1751 · Cited by 66 · see citing works
Ghert, M. A., Deheshi, B. M., Holt, G. E., Randall, R. L., Ferguson, P. C., Wunder, J. S., TURCOTTE, R. E., Werier, J. A., Clarkson, P. W., Damron, T. A., et al. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-002197 · Cited by 59 · see citing works
Prinzipien der Antibiotikabehandlung bei periprothetischen Infektionen
Frommelt, L. (2004) · Der Orthopäde · doi:10.1007/s00132-004-0677-5 · Cited by 58 · see citing works
Influence of pH conditions on the viability of Saccharomyces boulardii yeast
Graff, S., Chaumeil, J., Boy, P., Lai–Kuen, R., & Charrueau, C. (2008) · The Journal of General and Applied Microbiology · doi:10.2323/jgam.54.221 · Cited by 53 · see citing works
Analysis of treatment effects on the microbial ecology of the human intestine
Engelbrektson, A. L., Korzenik, J. R., Sanders, M. E., Clement, B., Leyer, G. J., Klaenhammer, T. R., & Kitts, C. L. (2006) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2006.00112.x · Cited by 51 · see citing works
Development of a Regional Model of Care for Ambulatory Total Shoulder Arthroplasty
Gallay, S. H., Lobo, J. J. A., Baker, J., Smith, K., & Patel, K. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-007-0083-5 · Cited by 49 · see citing works
Adverse drug reactions to treatments for ocular toxoplasmosis: A retrospective chart review
Iaccheri, B., Fiore, T., Papadaki, T., Androudi, S. N., Janjua, S., Bhaila, I., & Foster, C. S. (2008) · Clinical Therapeutics · doi:10.1016/j.clinthera.2008.10.021 · Cited by 46 · see citing works
Blanquet, S., Meunier, J.-P., Minekus, M., Marol-Bonnin, S., & Alric, M. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.5.2884-2892.2003 · Cited by 46 · see citing works
Susick, E., Putnam, M., Bermudez, D. M., & Thakur, S. (2011) · Veterinary Microbiology · doi:10.1016/j.vetmic.2011.12.017 · Cited by 41 · see citing works
Biological robustness in complex host-pathogen systems
Kitano, H. (2007) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7567-6_10 · Cited by 39 · see citing works
Zhou, F., Wu, S., Klena, J. D., & Huang, H. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2132-9 · Cited by 38 · see citing works
Móricz, Á. M., Ott, P. G., Yüce, I., Darcsi, A., Béni, S., & Morlock, G. E. (2017) · Journal of Chromatography A · doi:10.1016/j.chroma.2017.12.034 · Cited by 38 · see citing works
Antibiotic-associated diarrhoea
Coté, G. A., & Buchman, A. L. (2006) · Expert Opinion on Drug Safety · doi:10.1517/14740338.5.3.361 · Cited by 37 · see citing works
Probiotics in paediatric gastrointestinal diseases
Lemberg, D. A., Ooi, C. Y., & Day, A. S. (2007) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2007.01076.x · Cited by 37 · see citing works
Mangin, I., Lévêque, C., Magne, F., Suau, A., & Pochart, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050257 · Cited by 35 · see citing works
Lactoferrin for the Prevention of Post-antibiotic Diarrhoea
Laffan, A. M., McKenzie, R., Forti, J., Conklin, D. R., Marcinko, R., Shrestha, R., Bellantoni, M. F., & Greenough, W. B. (2012) · Journal of Health Population and Nutrition · doi:10.3329/jhpn.v29i6.9889 · Cited by 35 · see citing works
Surawicz, C. M. (2005) · Chemotherapy · doi:10.1159/000081993 · Cited by 35 · see citing works
Bravo, M. V., Bunout, D. C., Leiva, L., de la Maza, M. P., Barrera, G., de la Maza, J., & Hirsch, S. (2008) · PubMed · Cited by 34 · see citing works
Nutrition economic evaluation of a probiotic in the prevention of antibiotic-associated diarrhea
Lenoir‐Wijnkoop, I., Nuijten, M. J. C., Craig, J., & Butler, C. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00013 · Cited by 34 · see citing works
Wang, Y., Li, J., Liu, J., Mehmood, K., Wangdui, B., Shi, H., Luo, X., Zhang, H., & Li, J. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.04.020 · Cited by 33 · see citing works
Self-Extending Symbiosis: A Mechanism for Increasing Robustness Through Evolution
Kitano, H., & Oda, K. (2006) · Biological Theory · doi:10.1162/biot.2006.1.1.61 · Cited by 33 · see citing works
Wang, F. (2011) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp11.164 · Cited by 32 · see citing works
Role of probiotics in the treatment of intestinal infections and inflammation
Dunne, C. P., & Shanahan, F. (2002) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200201000-00007 · Cited by 30 · see citing works
Bacterial diversity in intestinal mucosa of antibiotic-associated diarrhea mice
Xie, G., Tan, K., Peng, M., Long, C., Li, D., & Tan, Z. (2019) · 3 Biotech · doi:10.1007/s13205-019-1967-2 · Cited by 29 · see citing works
Li, J., Jiang, X., Wang, Y., Zhang, L., Zhang, H., Mehmood, K., Li, Z., Waqas, M., & Li, J. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.12.031 · Cited by 28 · see citing works
Cui, M., Wang, Y., Elango, J., Wu, J., Liu, K., & Jin, Y. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.751992 · Cited by 27 · see citing works
Sana, T. G., & Monack, D. M. (2016) · Nature · doi:10.1038/nature18449 · Cited by 27 · see citing works
Allen, S. J., Wareham, K., Bradley, C., Harris, W., Dhar, A., Brown, H., Foden, A. P., Cheung, W., Gravenor, M. B., Plummer, S. F., et al. (2012) · BMC Infectious Diseases · doi:10.1186/1471-2334-12-108 · Cited by 26 · see citing works
Velasco, M., Requena, T., Delgado-Iribarren, A., Peláez, C., & Guijarro, C. (2019) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001131 · Cited by 25 · see citing works
Burdet, C., Sayah‐Jeanne, S., Nguyen, T. T., Hugon, P., Sablier-Gallis, F., Saint-Lu, N., Corbel, T., Ferreira, S., Pulse, M., Weiss, W., et al. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00925-18 · Cited by 25 · see citing works
McQuade, E. T. R., Westreich, D. J., Becker‐Dreps, S., Adair, L. S., Sandler, R. S., Sarkar, R., Kattula, D., Ward, H., Meshnick, S. R., & Kang, G. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv040 · Cited by 25 · see citing works
Graul, T., Cain, A. M., & Karpa, K. D. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.02.026 · Cited by 25 · see citing works
Preclinical and Clinical Pharmacology of Biotherapeutic Agents:Saccharomyces boulardii
Periti, P., & Tonelli, F. (2001) · Journal of Chemotherapy · doi:10.1179/joc.2001.13.5.473 · Cited by 25 · see citing works
Vasa, C. V., & Glatt, A. E. (2003) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(02)05895-1 · Cited by 24 · see citing works
Rego, R. T. T., Watson, S., Alam, M. A. U., Abdullah, S. A., Yunus, M., Alam, I. T., Chowdhury, A. S. M. H. K., Haider, A., Faruque, A., Khan, A. I., et al. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.101205 · Cited by 19 · see citing works
Bhatia, S. S., Spector, S. A., Echenique, A., Froud, T., Suthar, R. R., Lawson, I., Dalal, R., Dinh, V., Yrizarry, J. M., & Narayanan, G. (2014) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-014-1020-0 · Cited by 23 · see citing works
Burden of acute gastrointestinal illness in the Metropolitan region, Chile, 2008
THOMAS, M. K., PEREZ, E., MAJOWICZ, S. E., REID-SMITH, R., OLEA, A., DIAZ, J., SOLARI, V., & McEWEN, S. A. (2011) · Epidemiology and Infection · doi:10.1017/s0950268810001160 · Cited by 22 · see citing works
Darong, H., Chen, Y., Chen, H., Deng, X., Huang, J., Lu, S., Li, P., & Du, B. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09906-8 · Cited by 22 · see citing works
Wawruch, M., Bozeková, L., Krcmery, S., & Kriška, M. (2002) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/bf03656554 · Cited by 22 · see citing works
Impact of antibiotics on the microcirculation in local and systemic inflammation
Al-Banna, N., Pavlović, D., Gründling, M., Zhou, J., Kelly, M. E. M., Whynot, S., Hung, O. R., Johnston, B., Issekutz, T. B., Kern, H., et al. (2013) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2012-1583 · Cited by 21 · see citing works
Probiotics: Microbial Therapy for Health Modulation
Goel, A. K., Dilbaghi, N., Kamboj, D. V., & Singh, L. (2006) · Defence Science Journal · doi:10.14429/dsj.56.1917 · Cited by 20 · see citing works
Controlled Gene Expression in Bifidobacteria by Use of a Bile-Responsive Element
Ruíz, L., Álvarez‐Martín, P., Mayo, B., Reyes‐Gavilán, C. G. D. L., Gueimonde, M., & Margollés, A. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.06611-11 · Cited by 20 · see citing works
McGorum, B. C., & Pirie, R. S. (2009) · Equine Veterinary Education · doi:10.2746/095777309x4710 · Cited by 20 · see citing works
Diarrhées associées aux antibiotiques chez le sujet âgé
Kaltenbach, G., & Heitz, D. (2003) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2003.10.002 · Cited by 19 · see citing works
Bravo, M. V., Bunout, D. C., Leiva, L., de la Maza, M. P., Barrera, G., de la Maza, J., & Hirsch, S. (2008) · Revista médica de Chile · doi:10.4067/s0034-98872008000800004 · Cited by 19 · see citing works
Clostridium perfringens in the Intestine: Innocent Bystander or Serious Threat?
Ba, X., Jin, Y., Ning, X., Gao, Y., Liu, R., Li, Y., Wang, Y., & Zhou, J. (2024) · Microorganisms · doi:10.3390/microorganisms12081610 · Cited by 18 · see citing works
Protection of live bacteria from bile acid toxicity using bile acid adsorbing resins
Edwards, A. D., & Slater, N. K. H. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.04.006 · Cited by 18 · see citing works
Lee, K. S., Shin, W. G., Jang, M. K., Kim, H. S., Kim, H. S., Park, C. J., Lee, J. Y., Kim, K. H., Park, J. Y., Lee, J. H., et al. (2006) · Diseases of the Colon & Rectum · doi:10.1007/s10350-006-0694-z · Cited by 17 · see citing works
Probiotics - What They Are, Their Benefits and Challenges
Thantsha, M. S., Mamvura, C. I., & Booyens, J. (2012) · InTech eBooks · doi:10.5772/32889 · Cited by 18 · see citing works
Zhao, S., Wan, D., Zhong, Y., & Xu, X. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2058559 · Cited by 15 · see citing works
de Souza, D. N. P., & Jorge, M. T. (2012) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/s0037-86822012000100021 · Cited by 15 · see citing works
Probiotic bacteria in prevention and treatment of diarrhea
Samaržija, D., Tudor, M., Prtilo, T., Špehar, I. D., Zamberlin, Š., & Havranek, J. (2009) · Mljekarstvo/Mljekarstvo.com · Cited by 15 · see citing works
ANTIBACTERIAL RESISTANCE IN PATIENTS WITH HEMATOPOIETIC STEM CELL TRANSPLANTATION
Akova, M. (2016) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2017.002 · Cited by 15 · see citing works
Regulation of Gut Microbiota by Herbal Medicines
Shinde, Y. D., & Deokar, G. S. (2024) · Current Drug Metabolism · doi:10.2174/0113892002287336240328083220 · Cited by 13 · see citing works
Alhaj, O. A., Kanekanian, A. D., & Peters, A. C. (2007) · British Food Journal · doi:10.1108/00070700710753526 · Cited by 13 · see citing works
Bimler therapy. Part 1. Bimler cephalometric analysis.
Bimler, H. P. (1985) · PubMed · Cited by 13 · see citing works
Comparison of acute bloody and watery diarrhea: a case control study
Kuşkonmaz, B., Yurdakök, K., Yalçın, S. S., & Özmert, E. N. (2009) · The Turkish Journal of Pediatrics · doi:10.24953/turkjpediatr.2009.2274 · Cited by 13 · see citing works
Antidiarrheal Effect of Food Fermented by Various Strains of Lactobacillus
Shafi, A., Farooq, U., Akram, K., Jaskani, M., Siddique, F., & Tanveer, A. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12056 · Cited by 12 · see citing works
Milk‐derived Bioactive Components from Fermentation
Alhaj, O. A., & Kanekanian, A. D. (2014) · Wiley eBooks · doi:10.1002/9781118635056.ch8 · Cited by 13 · see citing works
Effects of Lactic Acid Bacteria Isolated from Equine on Salmonella-Infected Gut Mouse Model
Pei, L., Liu, J., Huang, Z., Iqbal, ·., & Shen, Y. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09841-0 · Cited by 11 · see citing works
Wong, S., Hirani, S. P., Forbes, A., Kumar, N., Hariharan, R., O’Driscoll, J., Viswanathan, A., Harvey, G., Sekhar, R., & Jamous, A. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.101098 · Cited by 10 · see citing works
- Authors
- Bergogne-Bérézin, E.
- Affiliations
- Université Paris Diderot (FR)
- Corresponding author
- Bergogne-Bérézin, E
- Venue
- International Journal of Antimicrobial Agents
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 16
- Issue
- 4
- Pages
- 521-526
- ISSN
- 0924-8579 (ISSN-L)
- OpenAlex
- W2065697342
- Cited by
- 174
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 6 · 2021: 7 · 2020: 1 · 2019: 4 · 2018: 8 · 2017: 8 · 2016: 6 · 2015: 5 · 2014: 13 · 2013: 14 · 2012: 8
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Antimicrobial Agents (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- antibiotic-associated diarrhea, Clostridium difficile, pseudomembranous colitis, Saccharomyces boulardii, probiotics, vancomycin, metronidazole, Lactobacillus, Bifidobacterium longum, Enterococcus faecium, clindamycin, antibiotic overuse, infection control, toxin A and B, childhood diarrhea
- MeSH terms
- Anti-Bacterial Agents, Diarrhea, Enterocolitis, Pseudomembranous, Humans, Intestines, Lacticaseibacillus casei, Risk Factors, Saccharomyces, Clostridioides difficile, Probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
