Probiotic Yogurt for the Prevention of Antibiotic-associated Diarrhea in Adults: A Randomized Double-blind Placebo-controlled Trial
Open accessAbstract
GOAL: To evaluate the effect of yogurt supplemented with probiotic bacteria on the prevention of antibiotic-associated diarrhea (AAD) in hospitalized patients. BACKGROUND: Diarrhea following antibiotic administration is a frequent clinical problem. The usefulness of probiotics for the prevention of AAD in the hospitalized adult population remains unclear. STUDY: A randomized, double-blind, placebo-controlled clinical trial was conducted in hospitalized patients who started antibiotic treatment. Patients were randomized (2:2:1) to receive a daily amount of 200 mL of placebo-yogurt (Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus), 200 mL of probiotic yogurt (previous plus Lactobacillus acidophilus La-5, Bifidobacterium animalis subsp. lactis Bb-12 and Lactobacillus casei subsp. casei Lc-01 or no yogurt (unblinded control) within 48 hours of beginning the antibiotic therapy and up to 5 days after stopping the antibiotic. Patients were followed up with for 1 month to determine occurrence of diarrhea. RESULTS: We included 314 patients, mean age 76 years. The rate of diarrhea was 23.0% in the probiotic group versus 17.6% in the placebo group, absolute risk reduction -5.35% (95% confidence interval, -15.4% to 4.7%; P=0.30). Rate of diarrhea was similar in the unblinded external control and in the blinded study groups combined (20.9% vs. 20.2% respectively; P=0.91). There was no difference in the duration of diarrhea, maximum number of bowel movements or prolonged admission because of diarrhea among the groups. All-cause mortality did not differ between groups. CONCLUSIONS: The combined probiotic strains LA-5, BB-12, and LC-01 do not have an effect in the prevention of AAD in hospitalized patients.
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Another included study commented that their probiotic milk was less well tolerated than their placebo milk.
“and another commented that their probiotic milk was less well tolerated than their placebo milk.27”
From Probiotics for the prevention of antibiotic-associated diarrhoea: A systematic review and meta-analysis (2021) · cites this paper as [27]
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- Authors
- Velasco, M., Requena, T., Delgado-Iribarren, A., Peláez, C., & Guijarro, C.
- Affiliations
- Infectious Diseases Section, Internal Medicine
- Consejo Superior de Investigaciones Científicas (ES)
- Microbiology Department, Hospital Universitario Fundación Alcorcón, Alcorcón
- Corresponding author
- Velasco, María
- Guijarro, Carlos
- Venue
- Journal of Clinical Gastroenterology
- Published
- 2019-11
- Volume
- 53
- Issue
- 10
- Pages
- 717-723
- ISSN
- 0192-0790 (ISSN-L)
- OpenAlex
- W2926690288
- Cited by
- 25
- References
- 25
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 1
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotic yogurt, antibiotic-associated diarrhea, probiotics, Lactobacillus acidophilus LA-5, Bifidobacterium animalis subsp. lactis BB-12, Streptococcus thermophilus, Lactobacillus bulgaricus, hospitalized patients, antibiotic therapy, diarrhea prevention
- MeSH terms
- Aged, Anti-Bacterial Agents, Diarrhea, Double-Blind Method, Female, Humans, Male, Prospective Studies, Yogurt, Treatment Outcome, Probiotics
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