Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea
Open accessAbstract
AIM: To investigate the effect of Lactobacillus-containing commercially available probiotic formulations in Germany during antibiotic treatment with an analysis of cost-efficiency. METHODS: In an observational study, we analyzed the frequency of bowel movements from 258 patients with infections in a primary care hospital in western Germany; 107 of the patients were offered a probiotic drink containing at least 10 billion cultures of Lactobacillus casei DN 114001 b.i.d. The economic analysis was based on the costs of patient isolation vs preventive intake of probiotics. In a second pilot study, two commercially available probiotic drinks with different Lactobacillus casei strains were directly compared in 60 patients in a randomized controlled fashion. RESULTS: In the first study, the incidence of antibiotic-associated diarrhea (AAD) was significantly reduced in the intervention group (6.5% vs 28.4%), and the duration of AAD in days was significantly shorter (1.7 ± 1.1 vs 3.1 ± 2.1). Higher age and creatinine and lower albumin were identified as risk factors for AAD. Ampicillin was the antibiotic with the highest rate of AAD (50%) and with the greatest AAD reduction in the probiotic group (4.2%, relative risk reduction 92%). The economic analysis showed a cost advantage of nearly 60000 €/year in a department of this size. The second study confirmed the preventive effect of the drink with Lactobacillus casei DN114001; however, there were no advantages found for the other tested probiotic drink containing Lactobacillus casei Shirota. CONCLUSION: In contrast to a drink containing Lactobacillus casei Shirota, a commercially available probiotic drink containing Lactobacillus casei DN 114001 cost-efficiently reduces the prevalence of AAD during antibiotic treatment.
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In the one study comparing two strains of the same probiotic species, L. casei DN-114001 was significantly more effective for preventing antibiotic-associated diarrhoea than L. casei Shirota.
“In this study L. casei DN-114001 was significantly more effective for preventing AAD than L. casei Shirota.”
From Probiotics for the prevention of antibiotic-associated diarrhoea: A systematic review and meta-analysis (2021) · cites this paper as [34]
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Environmental pH controls antimicrobial production by human probiotic Streptococcus salivarius
Nguyen, D. L., Saha, S., Thacharodi, A., Singh, B. B., Mitra, S., Do, H., & Kumaraswami, M. (2025) · Journal of Bacteriology · doi:10.1128/jb.00059-25 · Cited by 5 · see citing works
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Probiotics and prebiotics in the Brazilian dairy sector: An integrative review
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Lactic acid bacteria–based beverages in the promotion of gastrointestinal tract health
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Development of a Probiotics Practice E-Reference Database for Health Care Professionals
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An Overview of Probiotic Research
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- Authors
- Dietrich, C. G.
- Affiliations
- Bethlehem Gesundheitszentrum Stolberg (DE)
- Corresponding author
- Dietrich, Christoph G
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 20
- Issue
- 42
- Pages
- 15837
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4229551
- OpenAlex
- W2047262491
- Cited by
- 90
- References
- 26
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 11 · 2022: 11 · 2021: 12 · 2020: 11 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 5
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- World Journal of Gastroenterology
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, Lactobacillus casei Shirota, antibiotic-associated diarrhea, probiotic beverages, cost efficiency, ampicillin, risk factors, primary hospitals
- MeSH terms
- Administration, Oral, Aged, Aged, 80 and over, Anti-Bacterial Agents, Beverages, Cost-Benefit Analysis, Diarrhea, Female, Germany, Humans, Lacticaseibacillus casei, Male, Middle Aged, Pilot Projects, Retrospective Studies, Time Factors, Incidence, Treatment Outcome, Health Care Costs, Probiotics
About these checks
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