Oral probiotics can resolve urogenital infections
Open accessAbstract
We report the first clinical evidence that probiotic lactobacilli can be delivered to the vagina following oral intake. In 10 women with a history of recurrent yeast vaginitis, bacterial vaginosis (BV) and urinary tract infections, strains Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14 suspended in skim milk and given twice daily for 14 days, were recovered from the vagina and identified by morphology and molecular typing within 1 week of commencement of therapy. In six cases of asymptomatic BV or intermediate BV (based upon Nugent scoring) was resolved within 1 week of therapy.
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Evidence supports translocation of gastrointestinal Lactobacillus strains to the vagina (gut-vagina axis), suggesting oral probiotic intake may be directly linked with improved vaginal microbiota balance and local immune responses.
“Evidence supports the translocation of gastrointestinal Lactobacillus strains to the vagina (gut-vagina axis), suggesting that oral probiotic intake may be directly linked with improved vaginal microbiota balance and local immune responses [55].”
From Women's health is a team effort: probiogenomics supports the development of a multi-species vaginal probiotic (2026) · cites this paper as [55]
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“Keywords: Probiotics; Urogenital ; Bacterial vaginosis ; Infection”
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- Authors
- Reid, G., Bruce, A. W., Fraser, N., Heinemann, C., Owen, J., & Henning, B.
- Affiliations
- Western University (CA)
- Lawson Research Institute (CA)
- Corresponding author
- Reid, Gregor
- ORCID
- Reid, Gregor
- Venue
- FEMS Immunology & Medical Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02
- Volume
- 30
- Issue
- 1
- Pages
- 49-52
- ISSN
- 0928-8244 (ISSN-L)
- 1574-695X
- OpenAlex
- W2130187365
- Cited by
- 464
- References
- 20
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 14 · 2023: 32 · 2022: 19 · 2021: 24 · 2020: 15 · 2019: 19 · 2018: 12 · 2017: 22 · 2016: 22 · 2015: 14 · 2014: 27 · 2013: 33 · 2012: 24
- FWCI
- 30.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Immunology & Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Keywords
- oral probiotics, vaginal lactobacilli, Lactobacillus rhamnosus GR-1, bacterial vaginosis, urinary tract infection, urogenital infections, Nugent score
- MeSH terms
- Administration, Oral, Bacterial Infections, Female, Humans, Lactobacillus, Vagina, Probiotics, Female Urogenital Diseases
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