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Cited by 131Microtubule and mitosis dynamicsProtein Structure and DynamicsAdvanced Fluorescence Microscopy Techniques

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Conformational changes during kinesin motility

Schief, William R, Howard, Jonathon·2001·Current Opinion in Cell Biology
DOI 10.1016/s0955-0674(00)00169-1
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Abstract

Nucleotide-dependent movements of the head and neck of kinesin have been visualized by cryoelectron microscopy and have been inferred from single-molecule studies. Key predictions of the hand-over-hand model for dimeric kinesin have been confirmed, and a novel processivity mechanism for the one-headed, kinesin-related motor KIF1A has been discovered.

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Research works printed but not linked: 58

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Metadata

Authors
Schief, W. R., & Howard, J.
Affiliations
University of Washington (US)
Corresponding author
  • Schief, William R
  • Howard, Jonathon
ORCID
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2001-02
Volume
13
Issue
1
Pages
19-28
ISSN
0955-0674 (ISSN-L)
DOI
10.1016/s0955-0674(00)00169-1
OpenAlex
W2170893640
Cited by
131
References
0
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 5
FWCI
1.19
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Current Opinion in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
Keywords
kinesin, conformational change, KIF1A, motor processivity, single-molecule analysis, cryo-electron microscopy
MeSH terms
Animals, Models, Molecular, Protein Conformation, Kinesins, Molecular Motor Proteins

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