NUMB controls p53 tumour suppressor activity

p53 Mutations in Human Cancers

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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Mdm2 promotes the rapid degradation of p53

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Regulation of p53 stability by Mdm2

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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A Randomized Comparison of Sentinel-Node Biopsy with Routine Axillary Dissection in Breast Cancer

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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Tumor surveillance via the ARF–p53 pathwayPreprint

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The INK4A/ARF locus and its two gene products.

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Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

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Telomeres, stem cells, senescence, and cancer

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The Endocytic Protein α-Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila

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Numb Is an Endocytic Protein

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Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis

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P53 and Prognosis

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Asymmetric cell division

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Molecular mechanisms of coupled monoubiquitination

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The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb

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Numb and α‐Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs

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Negative Regulation of dE2F1 by Cyclin-Dependent Kinases Controls Cell Cycle Timing

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Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status

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Evidence That Dynamin-2 Functions as a Signal-Transducing Gtpase

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Concomitant expression of p16INK4a and p14ARF in primary breast cancer and analysis of inactivation mechanisms

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Requirement of clathrin heavy chain for p53-mediated transcriptionPreprint

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Immortal DNA Strand Cosegregation Requires p53/IMPDH–Dependent Asymmetric Self-renewal Associated with Adult Stem Cells

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Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics.

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Analysis of genetic and epigenetic processes that influence p14ARF expression in breast cancer

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p14ARF expression in invasive breast cancers and ductal carcinoma in situ– relationships to p53 and Hdm2

Vestey, S. B., Sen, C., Calder, C. J., Perks, C. M., Pignatelli, M. N., & Winters, Z. (2004) · Breast Cancer Research · doi:10.1186/bcr912 · Cited by 20 · see citing works

Notch signaling pathway: architecture, disease, and therapeutics

Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., & Chu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00934-y · Cited by 1,145 · see citing works

Notch signaling: simplicity in design, versatility in function

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Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

Pece, S., Tosoni, D., Confalonieri, S., Mazzarol, G., Vecchi, M., Ronzoni, S., Bernard, L., Viale, G., Pelicci, P. G., & Fiore, P. P. D. (2010) · Cell · doi:10.1016/j.cell.2009.12.007 · Cited by 946 · see citing works

Notch signalling in solid tumours: a little bit of everything but not all the time

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Derailed endocytosis: an emerging feature of cancer

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The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

Cicalese, A., Bonizzi, G., Pasi, C. E., Faretta, M., Ronzoni, S., Giulini, B., Brisken, C., Minucci, S., Fiore, P. P. D., & Pelicci, P. G. (2009) · Cell · doi:10.1016/j.cell.2009.06.048 · Cited by 695 · see citing works

Asymmetric cell division: recent developments and their implications for tumour biology

Knoblich, J. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3010 · Cited by 568 · see citing works

Non-histone protein methylation as a regulator of cellular signalling and function

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Not(ch) just development: Notch signalling in the adult brain

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The p53 orchestra: Mdm2 and Mdmx set the tone

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The endocytic matrix

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Neural stem cells: balancing self-renewal with differentiation

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Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancerPreprint

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Alterations of the Notch pathway in lung cancer

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From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

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Targeting the MDM2-p53 Interaction for Cancer Therapy

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Mdm2-mediated ubiquitylation: p53 and beyond

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Regulation of myeloid leukaemia by the cell-fate determinant Musashi

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Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan

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A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

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Epidermal Notch signalling: differentiation, cancer and adhesion

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The Origins and Evolution of the p53 Family of GenesPreprint

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γ-Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

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Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

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Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals

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An alkaline lake in the Late Paleozoic Ice Age (LPIA): A review and new insights into paleoenvironment and petroleum geology

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Drug Resistance in Non-Small Cell Lung Cancer: A Potential for NOTCH Targeting?

Iglesias, V. S., Giuranno, L., Dubois, L. J., Theys, J., & Vooijs, M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00267 · Cited by 230 · see citing works

Reciprocal repression between P53 and TCTP

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p53-family proteins and their regulators: hubs and spokes in tumor suppression

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Polo-like kinase 1 (PLK1) signaling in cancer and beyond

Iliaki, S., Beyaert, R., & Afonina, I. S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114747 · Cited by 203 · see citing works

The multiple functions of Numb

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Crosstalk of Notch with p53 and p63 in cancer growth control

Dotto, G. P. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2675 · Cited by 189 · see citing works

The molecular programme of tumour reversion: the steps beyond malignant transformation

Telerman, A., & Amson, R. B. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2589 · Cited by 185 · see citing works

The role of ubiquitin modification in the regulation of p53

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Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation

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Asymmetric cell division of stem and progenitor cells during homeostasis and cancer

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p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome

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Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

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Hedgehog signalling in breast cancer

Kasper, M., Jaks, V., Fiaschi, M., & Toftgård, R. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp048 · Cited by 147 · see citing works

NUMB-ing down cancer by more than just a NOTCH

Pece, S., Confalonieri, S., Romano, P. R., & Fiore, P. P. D. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.10.001 · Cited by 147 · see citing works

Methylation multiplicity and its clinical values in cancer

Dai, X., Ren, T., Zhang, Y., & Nan, N. (2021) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2021.4 · Cited by 143 · see citing works

Notch signaling in the mammalian respiratory system, specifically the trachea and lungs, in development, homeostasis, regeneration, and disease

Kiyokawa, H., & Morimoto, M. (2019) · Development Growth & Differentiation · doi:10.1111/dgd.12628 · Cited by 133 · see citing works

Fusobacterium nucleatum and colorectal cancer: From phenomenon to mechanism

Ou, S., Wang, H., Tao, Y., Luo, K., Ye, J., Ran, S., Guan, Z., Wang, Y., Hu, H., & Huang, R. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1020583 · Cited by 136 · see citing works

miR-146a Enhances the Oncogenicity of Oral Carcinoma by Concomitant Targeting of the IRAK1, TRAF6 and NUMB Genes

Hung, P.-S., Liu, C., Chou, C.-S., Kao, S., Yang, C., Chang, K., Chiu, T.-H., & Lin, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079926 · Cited by 128 · see citing works

The cytoplasmic side of p53's oncosuppressive activities

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Endocytosis and Cancer: an ‘Insider’ Network with Dangerous Liaisons

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Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

Kusko, R. L., Brothers, J. F., Tedrow, J. R., Pandit, K. V., Huleihel, L., Perdomo, C., Liu, G., Juan-Guardela, B. M., Kass, D. J., Zhang, S., et al. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201510-2026oc · Cited by 118 · see citing works

Notch Signalling in Breast Development and Cancer

Edwards, A., & Brennan, K. R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.692173 · Cited by 116 · see citing works

Dynamic Methylation of Numb by Set8 Regulates Its Binding to p53 and Apoptosis

Dhami, G. K., Liu, H., Galka, M., Voss, C., Wei, R., Muranko, K., Kaneko, T., Cregan, S. P., Li, L., & Li, S. S. ‐. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.04.028 · Cited by 117 · see citing works

Numb regulates cell–cell adhesion and polarity in response to tyrosine kinase signalling

Wang, Z., Sandiford, S. D. E., Wu, C., & Li, S. S. ‐. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.190 · Cited by 115 · see citing works

TPT1/ TCTP-regulated pathways in phenotypic reprogramming

Amson, R. B., Pece, S., Marine, J., Fiore, P. P. D., & Telerman, A. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.10.002 · Cited by 116 · see citing works

Advancing a clinically relevant perspective of the clonal nature of cancer

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Novel Dyskerin-Mediated Mechanism of p53 Inactivation through Defective mRNA Translation

Montanaro, L., Calienni, M., Bertoni, S., Rocchi, L., Sansone, P., Storci, G., Santini, D., Ceccarelli, C., Taffurelli, M., Carnicelli, D., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4024 · Cited by 110 · see citing works

Notch signalling in cancer stem cells

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NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer

Belle, V. A., McDermott, N., Meunier, A., & Marignol, L. H. (2014) · Nature Reviews Urology · doi:10.1038/nrurol.2014.195 · Cited by 106 · see citing works

Numb controls E-cadherin endocytosis through p120 catenin with aPKC

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The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1

Li, P., Fu, Z.-Y., Zhang, Y., Zhang, J., Xu, C., Ma, Y.-T., Li, B.-L., & Song, B. (2013) · Nature Medicine · doi:10.1038/nm.3417 · Cited by 103 · see citing works

β-TrCP-Mediated Ubiquitination and Degradation of PHLPP1 Are Negatively Regulated by Akt

Li, X., Liu, J., & Gao, T. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00681-09 · Cited by 98 · see citing works

A Double-Edged Sword: How Oncogenes and Tumor Suppressor Genes Can Contribute to Chromosomal Instability

Orr, B., & Compton, D. A. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00164 · Cited by 98 · see citing works

Loss of Tumor Suppressor RPL5/RPL11 Does Not Induce Cell Cycle Arrest but Impedes Proliferation Due to Reduced Ribosome Content and Translation Capacity

Teng, T., Mercer, C. A., Hexley, P., Thomas, G., & Fumagalli, S. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01174-13 · Cited by 98 · see citing works

microRNAs (miRNAs) in Glioblastoma Multiforme (GBM)—Recent Literature Review

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Aberrant regulation of FBW7 in cancer

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Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells

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p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

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Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF–triggered granulopoiesis

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Notch, Apoptosis and Cancer

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Genomic Analyses of Musashi1 Downstream Targets Show a Strong Association with Cancer-related Processes

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Numb Depletion Promotes Drp1-Mediated Mitochondrial Fission and Exacerbates Mitochondrial Fragmentation and Dysfunction in Acute Kidney Injury

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The RNA-Binding Protein Musashi1 Affects Medulloblastoma Growth via a Network of Cancer-Related Genes and Is an Indicator of Poor Prognosis

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Numb is required to prevent p53-dependent senescence following skeletal muscle injury

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Notch1 Is Regulated by Chorionic Gonadotropin and Progesterone in Endometrial Stromal Cells and Modulates Decidualization in Primates

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Msx1-Positive Progenitors in the Retinal Ciliary Margin Give Rise to Both Neural and Non-neural Progenies in Mammals

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Notch Signaling and Breast Cancer

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The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB

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The ubiquitin–proteasome system and signal transduction pathways regulating Epithelial Mesenchymal transition of cancer

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Cell Polarity in Motion: Redefining Mammary Tissue Organization Through EMT and Cell Polarity Transitions

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Molecular Oncology of Breast Cancer

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Molecular mechanisms of asymmetric divisions in mammary stem cells

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Fusobacterium nucleatum Promotes Colorectal Cancer Cell to Acquire Stem Cell‐Like Features by Manipulating Lipid Droplet‐Mediated Numb Degradation

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Cancer Stemness: p53 at the Wheel

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Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer

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Targeting the MDM2-p53 protein–protein interaction for new cancer therapeutics

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Smoking Dysregulates the Human Airway Basal Cell Transcriptome at COPD Risk Locus 19q13.2

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Regulation of the p53 pathway by ubiquitin and related proteins

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MiR-31-5p promotes the cell growth, migration and invasion of colorectal cancer cells by targeting NUMB

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E3 ubiquitin ligases as drug targets and prognostic biomarkers in melanoma

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NUMB phosphorylation destabilizes p53 and promotes self‐renewal of tumor‐initiating cells by a NANOG‐dependent mechanism in liver cancer

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The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells

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NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling

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Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy

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Biological Effects of Mammalian Translationally Controlled Tumor Protein (TCTP) on Cell Death, Proliferation, and Tumorigenesis

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Moving Breast Cancer Therapy up a Notch

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HMGA1 silencing restores normal stem cell characteristics in colon cancer stem cells by increasing p53 levels

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hSSB1 regulates both the stability and the transcriptional activity of p53

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Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase Activity

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Cooperation of Musashi‐2, Numb, MDM2, and P53 in drug resistance and malignant biology of pancreatic cancer

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The New Faces of Endocytosis in Signaling

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Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation

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Insights of Endocytosis Signaling in Health and Disease

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Fearful Symmetry: Subversion of Asymmetric Division in Cancer Development and Progression

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A role for Numb in p53 stabilization

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Progress in the research of p53 tumour suppressor activity controlled by Numb in triple‐negative breast cancer

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Research progress on Numb protein inhibiting tumorigenesis

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A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer

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RELEVANCE OF NUMB ISOFORMS IN BREAST CANCER

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