Synapse structure: glutamate receptors connected by the shanks
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A family of proteins has been identified whose members, the Shanks, physically link two major receptor complexes at excitatory synapses - NMDA receptors and metabotropic glutamate receptors.
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Shanks interact directly or indirectly with all major glutamate receptor types-NMDA receptors, AMPA receptors, and mGluRs-via different domains.
“Concentrated at glutamatergic synapses, Shanks interact directly or indirectly with all major types of glutamate receptors – NMDA receptors, AMPA receptors, and mGluRs – via different domains (Ehlers, 1999; Naisbitt et al., 1999; Tu et al., 1999; Uchino et al., 2006; Verpelli et al., 2011).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Ehlers, 1999
Shanks are scaffolding proteins that interact with many synaptic proteins in the postsynaptic density.
“Shanks are scaffolding proteins that interact with many synaptic proteins in the PSD (Ehlers, 1999; Gundelfinger et al., 2006; Kreienkamp, 2008; Sheng and Kim, 2000).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Ehlers, 1999
Cites
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Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
Sala, C., Piëch, V., Wilson, N. R., Passafaro, M., Liu, G., & Sheng, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00339-7 · Cited by 716 · see citing works
Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
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Tsai, G., & Coyle, J. T. (2002) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.082701.160735 · Cited by 577 · see citing works
Modeling Autism by SHANK Gene Mutations in Mice
Jiang, Y.-H., & Ehlers, M. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.016 · Cited by 488 · see citing works
Self-citationGlutamate and Depression: Clinical and Preclinical Studies
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Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators
Duffney, L. J., Zhong, P., Wei, J., Matas, E., Cheng, J., Qin, L., Ma, K., Dietz, D. M., Kajiwara, Y., Buxbaum, J. D., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.064 · Cited by 281 · see citing works
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Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism
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- Authors
- Ehlers, M. D.
- Affiliations
- Duke Medical Center (US)
- Corresponding author
- Ehlers, Michael D.
- ORCID
- Ehlers, Michael D.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 9
- Issue
- 22
- Pages
- R848-R850
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2021880358
- Cited by
- 93
- References
- 10
- Citations by year
- 2026: 2 · 2025: 2 · 2022: 4 · 2021: 6 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- shank, synaptic scaffolding proteins, NMDA receptor, metabotropic glutamate receptors, excitatory synapses, synaptic structure
- MeSH terms
- Homer Scaffolding Proteins, SAP90-PSD95 Associated Proteins, Animals, Carrier Proteins, Humans, Microfilament Proteins, Models, Molecular, Models, Neurological, Nerve Tissue Proteins, Neuropeptides, Synapses, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Protein Structure, Tertiary, Receptors, Metabotropic Glutamate, Two-Hybrid System Techniques, Macromolecular Substances, Adaptor Proteins, Signal Transducing, Cortactin
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