Identification of a Novel Cortactin SH3 Domain-Binding Protein and Its Localization to Growth Cones of Cultured Neurons
Open accessAbstract
Cortactin is an actin-binding protein that contains several potential signaling motifs including a Src homology 3 (SH3) domain at the distal C terminus. Translocation of cortactin to specific cortical actin structures and hyperphosphorylation of cortactin on tyrosine have been associated with the cortical cytoskeleton reorganization induced by a variety of cellular stimuli. The function of cortactin in these processes is largely unknown in part due to the lack of information about cellular binding partners for cortactin. Here we report the identification of a novel cortactin-binding protein of approximately 180 kDa by yeast two-hybrid interaction screening. The interaction of cortactin with this 180-kDa protein was confirmed by both in vitro and in vivo methods, and the SH3 domain of cortactin was found to direct this interaction. Since this protein represents the first reported natural ligand for the cortactin SH3 domain, we designated it CortBP1 for cortactin-binding protein 1. CortBP1 contains two recognizable sequence motifs within its C-terminal region, including a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. Northern and Western blot analysis indicated that CortBP1 is expressed predominately in brain tissue. Immunofluorescence studies revealed colocalization of CortBP1 with cortactin and cortical actin filaments in lamellipodia and membrane ruffles in fibroblasts expressing CortBP1. Colocalization of endogenous CortBP1 and cortactin was also observed in growth cones of developing hippocampal neurons, implicating CortBP1 and cortactin in cytoskeleton reorganization during neurite outgrowth.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The Shank complex can be linked to proteins regulating actin cytoskeleton dynamics, including β-Pix, Abp1, and cortactin.
“Furthermore, the Shank complex could be linked to several other proteins regulating actin cytoskeleton dynamics, such as β-Pix, a guanine nucleotide exchange factor for Rac1 and cdc42 small GTPases;18 Abp1, a member of the Arp2/3 complex;17 and cortactin.35”
From SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism (2012) · cites this paper as [35]
Shank and cortactin are enriched within the lamellipodia of motile cells and in neuronal growth cones.
“Shank and cortactin are enriched within the lamellipodia of motile cells and in neuronal growth cones.12, 35”
From SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism (2012) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A novel genetic system to detect protein–protein interactions
Fields, S., & Song, O.-K. (1989) · Nature · doi:10.1038/340245a0 · Cited by 6,152 · see citing works
Rho GTPases and the Actin Cytoskeleton
Hall, A. (1998) · Science · doi:10.1126/science.279.5350.509 · Cited by 6,138 · see citing works
Smith, D. B., & Johnson, K. S. (1988) · Gene · doi:10.1016/0378-1119(88)90005-4 · Cited by 5,974 · see citing works
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651 · see citing works
The scanning model for translation: an update.
Kozak, M. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.2.229 · Cited by 3,485 · see citing works
A comprehensive genetic map of the human genome based on 5,264 microsatellites
Dib, C., Fauré, S., Fizames, C., Samson, D. S., Drouot, N., Alain Vignal, A., Millasseau, P., Marc, S., Kazan, J., Seboun, E., et al. (1996) · Nature · doi:10.1038/380152a0 · Cited by 2,927 · see citing works
The establishment of polarity by hippocampal neurons in culture.
Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862 · see citing works
On the Crawling of Animal Cells
Stossel, T. P. (1993) · Science · doi:10.1126/science.8493552 · Cited by 1,015 · see citing works
Modular binding domains in signal transduction proteins
Cohen, G. B., Ren, R., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90406-9 · Cited by 951 · see citing works
Feng, S., Chen, J., Yu, H., Simon, J. A., & Schreiber, S. L. (1994) · Science · doi:10.1126/science.7526465 · Cited by 799 · see citing works
Sequence identification of 2,375 human brain genes
Adams, M. D., Dubnick, M., Kerlavage, A. R., Moreno, R., Kelley, J. M., Utterback, T. R., Nagle, J. W., Fields, C., & Venter, J. C. (1992) · Nature · doi:10.1038/355632a0 · Cited by 754 · see citing works
Chevray, P. M., & Nathans, D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5789 · Cited by 526 · see citing works
Mechanisms and Molecules that Control Growth Cone Guidance
Goodman, C. S. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.002013 · Cited by 521 · see citing works
Wu, H. G., & Parsons, J. T. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.6.1417 · Cited by 513 · see citing works
Self-citationKanner, S. B., Reynolds, A. B., Vines, R. R., & Parsons, J. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.9.3328 · Cited by 471 · see citing works
Self-citationGietz, R. D., & Schiestl, R. H. (1991) · Yeast · doi:10.1002/yea.320070307 · Cited by 441 · see citing works
Tarone, G., Cirillo, D. M., Giancotti, F. G., Comoglio, P. M., & Marchisio, P. C. (1985) · Experimental Cell Research · doi:10.1016/s0014-4827(85)80044-6 · Cited by 436 · see citing works
Identification and characterization of a novel cytoskeleton-associated pp60src substrate.
Wu, H., Reynolds, A. B., Kanner, S. B., Vines, R. R., & Parsons, J. T. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.5113 · Cited by 435 · see citing works
Self-citation[16] Analyzing protein-protein interactions using two-hybrid system
Bartel, P. L., & Fields, S. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(95)54018-0 · Cited by 364 · see citing works
Harte, M. T., Hildebrand, J. D., Burnham, M. R., Bouton, A. H., & Parsons, J. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13649 · Cited by 361 · see citing works
Self-citationBartlett, W., & Banker, G. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-08-01944.1984 · Cited by 348 · see citing works
Sparks, A. B., Rider, J. E., Hoffman, N. G., Fowlkes, D. M., Quillam, L. A., & Kay, B. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1540 · Cited by 348 · see citing works
Hildebrand, J. D., Taylor, J. M., & Parsons, J. T. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.3169 · Cited by 344 · see citing works
Self-citationClerc, P., & Sansonetti, P. J. (1987) · Infection and Immunity · doi:10.1128/iai.55.11.2681-2688.1987 · Cited by 332 · see citing works
Serra‐Pagès, C., Kedersha, N. L., Fazikas, L., Medley, Q., Debant, A., & Streuli, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07282.x · Cited by 321 · see citing works
Schuuring, E., Verhoeven, E., Mooi, W. J., & Michalides, R. J. A. M. (1992) · PubMed · Cited by 317 · see citing works
Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I
Drubin, D. G., Mulholland, J., Zhu, Z., & Botstein, D. (1990) · Nature · doi:10.1038/343288a0 · Cited by 309 · see citing works
SAM as a protein interaction domain involved in developmental regulation
Schultz, J., Peer Bork, B., Ponting, C. P., & Hofmann, K. (1997) · Protein Science · doi:10.1002/pro.5560060128 · Cited by 300 · see citing works
Microfilament Structure and Function in the Cortical Cytoskeleton
Bretscher, A. P. (1991) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.07.110191.002005 · Cited by 276 · see citing works
Dai, Z., & Pendergast, A. M. (1995) · Genes & Development · doi:10.1101/gad.9.21.2569 · Cited by 272 · see citing works
Chang, J. H., Gill, S. R., Settleman, J. E., & Parsons, S. J. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.2.355 · Cited by 256 · see citing works
Greene, L. A., Aletta, J. M., Rukenstein, A., et al. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(87)47111-5 · Cited by 245 · see citing works
Marcus, S., Polverino, A. J., Barr, M. M., & Wigler, M. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7762 · Cited by 242 · see citing works
Durieu-Trautmann, O., Chaverot, N., Cazaubon, S. M., Strosberg, A. D., & Couraud, P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99908-4 · Cited by 237 · see citing works
Differential Inhibition of Signaling Pathways by Dominant-Negative SH2/SH3 Adapter Proteins
Tanaka, M., Gupta, R., & Mayer, B. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6829 · Cited by 230 · see citing works
Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3
Lehmann, J. M., Riethmüller, G., & Johnson, J. P. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.4.1048 · Cited by 210 · see citing works
Olson, M. F., Pasteris, N. G., Gorski, J. L., et al. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70786-0 · Cited by 208 · see citing works
Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1
Weed, S. A., Du, Y., & Parsons, J. T. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.16.2433 · Cited by 204 · see citing works
Self-citationSH3 Domains: Minding your p's and q's
Mayer, B. J., & Eck, M. J. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00073-x · Cited by 202 · see citing works
Nakanishi, H., Obaishi, H., Satoh, A., Wada, M., Mandai, K., Satoh, K., Nishioka, H., Matsuura, Y., Mizoguchi, A., & Takai, Y. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.4.951 · Cited by 193 · see citing works
c-src gene product in developing rat brain is enriched in nerve growth cone membranes.
Maness, P. F., Aubry, M., Shores, C. G., Frame, L., & Pfenninger, K. H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5001 · Cited by 191 · see citing works
DeCamillis, M. A., Cheng, N. S., Pierre, D., & Brock, H. W. (1992) · Genes & Development · doi:10.1101/gad.6.2.223 · Cited by 191 · see citing works
Schuuring, E., Verhoeven, E., van Tinteren, H., Peterse, J. L., Boeser‐Nunnink, B., Thunnissen, E., Devilee, P., Cj, C., van de Vijver, M. J., & Mooi, W. J. (1992) · PubMed · Cited by 189 · see citing works
Function of Myosin-V in Filopodial Extension of Neuronal Growth Cones
Wang, F.-S., Wolenski, J. S., Cheney, R. E., Mooseker, M. S., & Jay, D. G. (1996) · Science · doi:10.1126/science.273.5275.660 · Cited by 183 · see citing works
Absence of persistent spreading, branching, and adhesion in GAP-43-depleted growth cones.
Aigner, L., & Caroni, P. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.128.4.647 · Cited by 183 · see citing works
Cytoskeletal events in growth cone steering
Bentley, D., & O’Connor, T. P. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90030-2 · Cited by 181 · see citing works
Membrane ruffling and signal transduction
Ridley, A. J. (1994) · BioEssays · doi:10.1002/bies.950160506 · Cited by 180 · see citing works
Dehio, C., Prévost, M. C., & Sansonetti, P. J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07244.x · Cited by 179 · see citing works
Cytoskeletal reorganization underlying growth cone motility
Lin, C., Thompson, C. A., & Forscher, P. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90004-3 · Cited by 167 · see citing works
Local degradation of fibronectin at sites of expression of the transforming gene product pp60src
Chen, W., Chen, J.-M., Parsons, S. J., et al. (1985) · Nature · doi:10.1038/316156a0 · Cited by 159 · see citing works
Schuuring, E., Verhoeven, E., Litvinov, S. V., & Michalides, R. J. A. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.2891 · Cited by 158 · see citing works
Cao, L. G., & Wang, Y. L. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.4.1089 · Cited by 157 · see citing works
SAM: A novel motif in yeast sterile anddrosophilapolyhomeotic proteins
Ponting, C. P. (1995) · Protein Science · doi:10.1002/pro.5560040927 · Cited by 152 · see citing works
Meredith, S. D., Levine, P. A., Burns, J. A., et al. (1995) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1995.01890070076016 · Cited by 151 · see citing works
Kitamura, D., Kaneko, H., Miyagoe, Y., Ariyasu, T., & Watanabe, T. (1989) · Europe PMC (PubMed Central) · Cited by 146 · see citing works
Membrane interactions with the actin cytoskeleton
Hitt, A. L., & Luna, E. J. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90125-2 · Cited by 136 · see citing works
Pandey, A., Duan, H., & Dixit, V. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.33.19201 · Cited by 131 · see citing works
Chromosome 11Q13 Amplification in Head and Neck Squamous Cell Carcinoma
Williams, M. E., Gaffey, M. J., Weiss, L. M., Wilczynski, S. P., Schuuring, E., & Levine, P. A. (1993) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1993.01880230084013 · Cited by 130 · see citing works
Mahone, M., Saffman, E. E., & Lasko, P. F. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.4152 · Cited by 130 · see citing works
Downing, & Ab, R. (1991) · PubMed · Cited by 127 · see citing works
Taniuchi, I., Kitamura, D., Maekawa, Y., Fukuda, T., Kishi, H., & Watanabe, T. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00036.x · Cited by 123 · see citing works
Localized Bicaudal‐C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1.
Mahone, M., Saffman, E. E., & Lasko, P. F. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07196.x · Cited by 123 · see citing works
Devarajan, P., Stabach, P. R., Matteis, M. A. D., & Morrow, J. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10711 · Cited by 122 · see citing works
Identification and Characterization of a Novel Cytoskeleton-Associated pp60src Substrate
Wu, H. G., Reynolds, A. B., Kanner, S. B., Vines, R. R., & Parsons, J. T. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.5113-5124.1991 · Cited by 115 · see citing works
Self-citationp80/85 Cortactin Associates with the Src SH2 Domain and Colocalizes with v-Src in Transformed Cells
Okamura, H., & Resh, M. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26613 · Cited by 112 · see citing works
Zhan, X., Hu, X., Hampton, B., Burgess, W. H., Friesel, R. E., & Maciag, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80543-2 · Cited by 110 · see citing works
Anderson, R., & Vaudenay, S. (1996) · Lecture notes in computer science · doi:10.1007/bfb0034832 · Cited by 108 · see citing works
Goslin, K., Birgbauer, E., Banker, G. A., & Solomon, F. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.4.1621 · Cited by 106 · see citing works
Associations among PH and SH3 domain-containing proteins and Rho-type GTPases in Yeast.
Bender, L. B., Lo, H. S., Lee, H., Kokojan, V., Peterson, V., & Bender, A. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.4.879 · Cited by 99 · see citing works
Functional analysis of point mutations in the AAUAAA motif of the SV40 late polyadenylation signal
Wilus, J., Pettine, S. M., & Shenk, T. E. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.10.3899 · Cited by 88 · see citing works
Barr, M. M., Tu, H., Aelst, L. V., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5597 · Cited by 80 · see citing works
Actin, its associated proteins and metastasis
Button, E., Shapland, C., & Lawson, D. (1995) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970300402 · Cited by 77 · see citing works
Wong, S. T. C., Ab, R., & Papkoff, J. (1992) · PubMed · Cited by 77 · see citing works
Growth cone enrichment and cytoskeletal association of non‐receptor tyrosine kinases
Helmke, S. M., & Pfenninger, K. H. (1995) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970300304 · Cited by 60 · see citing works
Patel, A. M., Incognito, L., Schechter, G. L., et al. (1996) · PubMed · Cited by 55 · see citing works
Gelsolin is localized in neuronal growth cones
Tanaka, J., Kira, M., & Sobue, K. (1993) · Developmental Brain Research · doi:10.1016/0165-3806(93)90217-x · Cited by 54 · see citing works
Miglarese, M. R., Mannion-Henderson, J., Wu, H., et al. (1994) · PubMed · Cited by 41 · see citing works
Schuuring, E., Verhoeven, E., Litvinov, S. V., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.2891-2898.1993 · Cited by 38 · see citing works
Cook, S. J., & McCormick, F. P. (1994) · Nature · doi:10.1038/369361a0 · Cited by 31 · see citing works
Association of cortactin with developing neuromuscular specializations
Peng, H. B., Xie, H. M., & Dai, Z. (1997) · Journal of Neurocytology · doi:10.1023/a:1018545827369 · Cited by 29 · see citing works
Molecular Cloning and Characterization of Mouse HS1
Kitamura, D., Kaneko, H., Taniuchi, I., et al. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1452 · Cited by 28 · see citing works
Faivre‐Sarrailh, C., Léna, J.-Y., Had‐Aissouni, L., Vignes, M., & Lindberg, U. (1993) · Journal of Neurocytology · doi:10.1007/bf01235749 · Cited by 23 · see citing works
13 Cortical Cytoskeleton of the Xenopus Oocyte, Egg, and Early Embryo
Larabell, C. A. (1996) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60235-5 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., & Sheng, M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80809-0 · Cited by 1,009 · see citing works
Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797 · see citing works
Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
Sala, C., Piëch, V., Wilson, N. R., Passafaro, M., Liu, G., & Sheng, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00339-7 · Cited by 716 · see citing works
Bozdagi, O., Sakurai, T., Papapetrou, D., Wang, X., Dickstein, D. L., Takahashi, N., Kajiwara, Y., Yang, M., Katz, A. M., Scattoni, M. L., et al. (2010) · Molecular Autism · doi:10.1186/2040-2392-1-15 · Cited by 584 · see citing works
The Shank family of scaffold proteins
Sheng, M., & Kim, E. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.1851 · Cited by 578 · see citing works
Hung, A. Y., Futai, K., Sala, C., Valtschanoff, J. G., Ryu, J., Woodworth, M. A., Kidd, F. L., Sung, C. C., Miyakawa, T., Bear, M. F., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3032-07.2008 · Cited by 350 · see citing works
Boeckers, T. M., Bockmann, J., Kreutz, M. R., & Gundelfinger, E. D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00931.x · Cited by 349 · see citing works
HDAC6 is a target for protection and regeneration following injury in the nervous system
Rivieccio, M. A., Brochier, C., Willis, D. E., Walker, B. A., D'Annibale, M. A., McLaughlin, K., Siddiq, A., Kozikowski, A. P., Jaffrey, S. R., Twiss, J. L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907935106 · Cited by 322 · see citing works
Durand, C. M., Perroy, J., Loll, F., Perrais, D., Fagni, L., Bourgeron, T., Montcouquiol, M., & Sans, N. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.57 · Cited by 316 · see citing works
Characterization of the Shank Family of Synaptic Proteins
Lim, S., Naisbitt, S., Yoon, J., Hwang, J.-I., Suh, P.-G., Sheng, M., & Kim, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29510 · Cited by 295 · see citing works
Sala, C., Futai, K., Yamamoto, K., Worley, P. F., Hayashi, Y., & Sheng, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06327.2003 · Cited by 288 · see citing works
Activity-Dependent Redistribution and Essential Role of Cortactin in Dendritic Spine Morphogenesis
Hering, H., & Sheng, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-37-11759.2003 · Cited by 269 · see citing works
Boeckers, T. M., Kreutz, M. R., Winter, C., Zuschratter, W., Smalla, K.-H., Sanmarti-Vila, L., Wex, H., Langnaese, K., Bockmann, J., Garner, C. C., et al. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06506.1999 · Cited by 257 · see citing works
The emerging role of <i>SHANK</i> genes in neuropsychiatric disorders
Guilmatre, A., Huguet, G., Delorme, R., & Bourgeron, T. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22128 · Cited by 237 · see citing works
Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies
Grabrucker, A. M., Schmeisser, M. J., Schoen, M., & Boeckers, T. M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.07.003 · Cited by 233 · see citing works
Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
Grabrucker, A. M., Knight, M. J., Proepper, C., Bockmann, J., Joubert, M., Rowan, M., Nienhaus, G. U., Garner, C. C., Bowie, J. U., Kreutz, M. R., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.336 · Cited by 228 · see citing works
Wöhr, M., Roullet, F. I., Hung, A. Y., Sheng, M., & Crawley, J. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020631 · Cited by 220 · see citing works
Boeckers, T. M., Winter, C., Smalla, K.-H., Kreutz, M. R., Bockmann, J., Seidenbecher, C., Garner, C. C., & Gundelfinger, E. D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1489 · Cited by 200 · see citing works
SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
Zaslavsky, K., Zhang, W.-B., McCready, F. P., Rodrigues, D. C., Deneault, E., Loo, C., Zhao, M., Ross, P. J., El Hajjar, J., Romm, A., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0365-8 · Cited by 174 · see citing works
Park, E., Na, M., Choi, J., Kim, S., Lee, J.-R., Yoon, J., Park, D., Sheng, M., & Kim, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301052200 · Cited by 175 · see citing works
Lim, S., Sala, C., Yoon, J., Park, S., Kuroda, S., Sheng, M., & Kim, E. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0940 · Cited by 151 · see citing works
Böckers, T. M., Segger-Junius, M., Iglauer, P., Bockmann, J., Gundelfinger, E. D., Kreutz, M. R., Richter, D., Kindler, S., & Kreienkamp, H.-J. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.01.009 · Cited by 149 · see citing works
Synaptic Scaffolding Proteins in Rat Brain
Böckers, T. M., Mameza, M. G., Kreutz, M. R., Bockmann, J., Weise, C., Buck, F., Richter, D., Gundelfinger, E. D., & Kreienkamp, H.-J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102454200 · Cited by 137 · see citing works
Qualmann, B., Boeckers, T. M., Jeromin, M., Gundelfinger, E. D., & Kessels, M. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5479-03.2004 · Cited by 134 · see citing works
Santini, E., & Klann, E. (2014) · Science Signaling · doi:10.1126/scisignal.2005832 · Cited by 118 · see citing works
Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan, Z., Kim, E., Datta, D., Lewis, D. A., & Soderling, S. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2360-16.2016 · Cited by 120 · see citing works
Boeckers, T. M., Liedtke, T., Spilker, C., Dresbach, T., Bockmann, J., Kreutz, M. R., & Gundelfinger, E. D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02910.x · Cited by 113 · see citing works
Scaffolding proteins at the postsynaptic density: shank as the architectural framework
Kreienkamp, H. J. (2008) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-72843-6_15 · Cited by 105 · see citing works
Chen, Y.-K., & Hsueh, Y.-P. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4405-11.2012 · Cited by 90 · see citing works
Quitsch, A., Berhörster, K., Liew, C. W., Richter, D., & Kreienkamp, H.-J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2699-04.2005 · Cited by 95 · see citing works
Synapse structure: glutamate receptors connected by the shanks
Ehlers, M. D. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80043-3 · Cited by 93 · see citing works
Haeckel, A., Ahuja, R., Gundelfinger, E. D., Qualmann, B., & Kessels, M. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0336-08.2008 · Cited by 85 · see citing works
DNA methylation regulates tissue‐specific expression of Shank3
Beri, S., Tonna, N., Menozzi, G., Bonaglia, M. C., Sala, C., & Giorda, R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04539.x · Cited by 74 · see citing works
Activity induced changes in the distribution of Shanks at hippocampal synapses
Tao-Cheng, J. H., Dosemeci, A., Gallant, P. E., Smith, C., & Reese, T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.041 · Cited by 61 · see citing works
Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells
McWILLIAMS, R. R., GIDEY, E., FOUASSIER, L., WEED, S. A., & DOCTOR, R. B. (2004) · Biochemical Journal · doi:10.1042/bj20031577 · Cited by 63 · see citing works
Self-citationVessey, J. P., & Karra, D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04662.x · Cited by 44 · see citing works
Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats
Jacot-Descombes, S., Keshav, N. U., Dickstein, D. L., Wicinski, B., Janssen, W. G. M., Hiester, L. L., Sarfo, E. K., Warda, T., Fam, M. M., Harony-Nicolas, H., et al. (2020) · Molecular Autism · doi:10.1186/s13229-020-00393-8 · Cited by 41 · see citing works
Molecular organization and assembly of the postsynaptic density of excitatory brain synapses.
Kim, E., & Ko, J. (2006) · Results and Problems in Cell Differentiation · doi:10.1007/400_011 · Cited by 11 · see citing works
- Authors
- Du, Y., Weed, S. A., Xiong, W.-C., Marshall, T. D., & Parsons, J. T.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Parsons, J. Thomas
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1998-10-01
- Volume
- 18
- Issue
- 10
- Pages
- 5838-5851
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC109170
- OpenAlex
- W1832262637
- Cited by
- 254
- References
- 83
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 12 · 2019: 5 · 2018: 10 · 2017: 4 · 2016: 7 · 2015: 12 · 2014: 10 · 2013: 6 · 2012: 8
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health (CA29243)
- National Cancer Institute (CA40042, R37CA029243, CA 29243, R01CA029243, F32 CA75695-01, P01CA040042, F32CA075695)
- National Institute of Neurological Disorders and Stroke (F32NS009918)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- cortactin, SH3 domain, actin cytoskeleton remodeling, growth cones, hippocampal neurons, neurite outgrowth, lamellipodia, ruffles, sterile alpha motif, protein-protein interaction
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, Cell Differentiation, Cells, Cultured, Cloning, Molecular, Fibroblasts, Hippocampus, Male, Microfilament Proteins, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Proteins, Rabbits, Subcellular Fractions, Tissue Distribution, 3T3 Cells, Rats, Sprague-Dawley, DNA, Complementary, src Homology Domains, Growth Cones, Adaptor Proteins, Signal Transducing, Cortactin, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review