Cited by 184Estrogen and related hormone effectsReceptor Mechanisms and SignalingAdrenal Hormones and Disorders

Nongenomic membrane actions of glucocorticoids in vertebrates

Borski, Russell J.·2000·Trends in Endocrinology & Metabolism

Abstract

For decades, it was widely assumed that glucocorticoids (GCs) work solely through changes in gene expression to exert their physiological actions, a process that normally takes several hours to occur. However, recent evidence indicates that GCs might also act at the membrane through specific receptors to exert multiple rapid effects on various tissues and cells. GCs modulate hormone secretion, neuronal excitability, behavior, cell morphology, carbohydrate metabolism and other processes within seconds or minutes. These early actions occur independent of the genome and are transduced by the same biochemical effector pathways responsible for mediating rapid responses to neurotransmitters. The biological significance of most rapid GC effects are not well understood, but many might be related to the important functions that this hormone plays in modulating stress responses.

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Registry

Crossref · 10.1016/s1043-2760(00)00325-8

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Authors
Borski, R. J.
Affiliations
North Carolina State University (US)
Corresponding author
Borski, Russell J.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2000-12
Volume
11
Issue
10
Pages
427-436
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2135070639
Cited by
184
References
77
Citations by year
2026: 3 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 10 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 8
FWCI
1.47
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
glucocorticoids, non-genomic steroid action, membrane steroid receptors, stress response, neuronal excitability, behavior, carbohydrate metabolism, hormone secretion, cell morphology
MeSH terms
Animals, Glucocorticoids, Humans, Membranes, Vertebrates

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