Steroid sulfation
Abstract
Formation of steroid sulfates is catalyzed by sulfotransferase enzymes that are widely distributed and frequently of high specificity. Steroid sulfates cannot be described as being active hormones, but some serve in tissue sites as precursors of active steroids formed by enzymic cleavage of the sulfate group by sulfatase enzymes. There is increasing evidence that intracellular sulfation and desulfation can play a role in regulating the availability of active steroid hormones near target sites. There are strong indications for this regulation in the uterine compartment, in the liver, and in mammary cancer cells.
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Once transported across the plasma membrane, a steroid sulfate ester is hydrolysed by STS, with maintenance of stereo configuration yielding the respective hydroxysteroid that is subsequently accessible for enzymatic conversions or can exert biological functions.
“Once transported across the plasma membrane, a steroid sulfate ester is hydrolysed by steroid sulfatase (STS), with maintenance of stereo configuration yielding the respective hydroxysteroid that is subsequently accessible for enzymatic conversions or can exert biological functions (Hobkirk, 1993).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Hobkirk, 1993
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- Authors
- Hobkirk, R.
- Affiliations
- Western University (CA)
- Corresponding author
- Hobkirk, Ronald
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 1993-03
- Volume
- 4
- Issue
- 2
- Pages
- 69-74
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W32525469
- Cited by
- 113
- References
- 42
- Citations by year
- 2025: 3 · 2024: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 4 · 2013: 4 · 2012: 3
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- steroid sulfation, sulfotransferase, steroid sulfates, sulfatase, steroid hormone metabolism, mammary cancer cells
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