A vector for expressing foreign genes in the brains and hearts of transgenic mice

Borchelt, David R.; Davis, Janine; Fischer, Marek; Lee, Micheal K.; Slunt, Hilda H.; Ratovitsky, Tamara; Regard, Jean; Copeland, Neal G.; Jenkins, Nancy A.; Sisodia, Sangram S.; Price, Donald L.

doi:10.1016/s1050-3862(96)00167-2

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A vector for expressing foreign genes in the brains and hearts of transgenic mice

Borchelt, David R., Davis, Janine, Fischer, Marek, Lee, Micheal K., Slunt, Hilda H., Ratovitsky, Tamara, Regard, Jean, Copeland, Neal G., Jenkins, Nancy A., Sisodia, Sangram S., Price, Donald L.·1996·Genetic Analysis: Biomolecular Engineering

DOI 10.1016/s1050-3862(96)00167-2

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In all BRI-Aβ lines, BRI-Aβ mRNA was expressed in a pattern characteristic of the MoPrP promoter, with highest expression in cerebellar granule cells and hippocampus, followed by cortex, pons, thalamus, and midbrain.
“In all lines, BRI-Aβ mRNA was expressed in a pattern characteristic of the MoPrP promoter (Borchelt et al., 1996); with highest expression in the cerebellar granule cells and hippocampus, followed by the cortex, pons, thalamus, and midbrain (Figures S1A and S1B).”
From Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice (2005) · cites this paper as Borchelt et al., 1996
The pattern of amyloid deposition in BRI-Aβ42 mice generally followed the expression pattern of the PrP transgene and was similar to Tg2576 pathology except for the presence of a large number of plaques in the cerebellum.
“The pattern of amyloid deposition in BRI-Aβ42 mice generally followed the expression pattern of the PrP transgene (Borchelt et al., 1996) and was similar to Tg2576 pathology except for the presence of a large number of plaques in the cerebellum of BRI-Aβ42 mice.”
From Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice (2005) · cites this paper as Borchelt et al., 1996

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Authors: Borchelt, D. R., Davis, J., Fischer, M., Lee, M. K., Slunt, H. H., Ratovitsky, T., Regard, J., Copeland, N. G., Jenkins, N. A., Sisodia, S. S., & Price, D. L.
Venue: Genetic Analysis: Biomolecular Engineering
Publisher: Elsevier BV
Published: 1996-12
Volume: 13
Issue: 6
Pages: 159-163
ISSN: 1050-3862
DOI: 10.1016/s1050-3862(96)00167-2
Cited by: 317
References: 4
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 2438 d)

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A vector for expressing foreign genes in the brains and hearts of transgenic mice

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