Preparation and characterization of hydrophobic polymeric films that are thromboresistant via nitric oxide release
Abstract
The preparation of hydrophobic polymer films (polyurethane and poly(vinyl chloride)) containing nitric oxide (NO)-releasing diazeniumdiolate functions is reported as a basis for improving the thromboresistivity of such polymeric materials for biomedical applications. Several different approaches for preparing NO-releasing polymer films are presented, including: (1) dispersion of diazeniumdiolate molecules within the polymer matrix; (2) covalent attachment of the diazeniumdiolate to the polymer backbone; and (3) ion-pairing of a diazeniumdiolated heparin species to form an organic soluble complex that can be blended into the polymer. Each approach is characterized in terms of NO release rates and in vitro biocompatibility. Results presented indicate that the polymer films prepared by each approach release NO for variable periods of time (10-72 h), although they differ in the mechanism, location and amount of NO released. In vitro platelet adhesion studies demonstrate that the localized NO release may prove to be an effective strategy for improving blood compatibility of polymer materials for a wide range of medical devices.
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Meyerhoff and coworkers were among the first to link NO donors to particle fillers or to polymer backbones such as PVC, polyurethane, and silicone rubber.
“Meyerhoff and coworkers were among the first to link these NO donors to particle fillers (such as fumed silica particles236) or to the polymer backbone of polymers such as PVC,34,237 polyurethane (PU),34,110,233 and silicone rubber (SR).238”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [34]
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- Authors
- Mowery, K. A., H. Schoenfisch, M., Saavedra, J. E., Keefer, L. K., & Meyerhoff, M. E.
- Affiliations
- University of Michigan (US)
- National Cancer Institute (US)
- Frederick National Laboratory for Cancer Research (US)
- Corresponding author
- Meyerhoff, Mark E.
- ORCID
- Meyerhoff, Mark E.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 21
- Issue
- 1
- Pages
- 9-21
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2092155814
- Cited by
- 219
- References
- 3
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 2 · 2017: 12 · 2016: 11 · 2015: 12 · 2014: 11 · 2013: 13 · 2012: 11
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm056991-02, n01co056000-057)
- National Cancer Institute (N01 CO 56000)
- National Institute of General Medical Sciences (GM56991)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- nitric oxide release, diazeniumdiolates, thromboresistance, hydrophobic polymer films, polyurethane, polyvinyl chloride, heparin, ion pairing, covalent binding, platelet adhesion, hemocompatibility, medical devices, biocompatibility
- MeSH terms
- Animals, Biocompatible Materials, Kinetics, Membranes, Artificial, Nitric Oxide, Platelet Adhesiveness, Polyurethanes, Polyvinyl Chloride, Sheep, Surface Properties, Thrombosis, Nitric Oxide Donors
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