Preparation and characterization of diazeniumdiolate releasing ethylcellulose films
Abstract
A monolayer and trilayer membrane configuration of ethylcellulose were doped with a new synthesized diazeniumdiolate GAGS/NO (glutaraldehyde modification of glucosamine/NO adduct) and DETA/NO as the NO donor species, which can be used for altering the time course of nitric oxide donor release and targeting it to tissues with which the polymers are in physical contact. The NO donor release profiles show that the average release rate of DETA/NO can be controlled from 0.2 to 9 x 10(-10)mol cm(-2) min(-1) for at least 7 day and up to 30 day under physiological condition. The average release rate of GAGS/NO is varied from 0.1 to 0.5 x 10(-10)mol cm(-2) min(-1) for up to 94 day. The trilayer configuration effectively eliminates the burst release in the initial stage, and notably increases the NO donor release time. The trilayer films of DETA/NO can release 5% of the total NO donors over 69 h. In comparison, the trilayer films of GAGS/NO only release 2.5% of the total NO donors over 69 h. The results suggest that this nitric oxide donor releasing polymer may hold considerable promise for reducing the risk of restenosis following angioplasty and other interventional procedures for vascular repair.
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Hydroxyl groups in the donor molecule or its matrix can hydrogen-bond with diazeniumdiolates.
“It has also been reported that hydroxyl groups within the donor molecule, or the matrix it is within, can also contribute to the hydrogen bonding with the diazeniumdiolates.149,150”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [149]
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- Authors
- Wan, A., Gao, Q., & Li, H.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Tongji University (CN)
- Corresponding author
- Wan, Ajun
- Li, Huili
- Venue
- Journal of Materials Science: Materials in Medicine
- Published
- 2008-09-20
- Volume
- 20
- Issue
- 1
- Pages
- 321-327
- ISSN
- 0957-4530 (ISSN-L)
- 1573-4838
- OpenAlex
- W2070082851
- Cited by
- 14
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2017: 1 · 2016: 2 · 2013: 4
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Materials Science Materials in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Physical Sciences › Engineering › Biomedical Engineering › Polymer-Based Agricultural Enhancements
- Keywords
- diazeniumdiolates, nitric oxide donors, controlled release, DETA/NO, burst release, restenosis prevention, angioplasty, polymeric drug delivery
- MeSH terms
- Azo Compounds, Biocompatible Materials, Cellulose, Delayed-Action Preparations, Drug Carriers, Glucosamine, Glutaral, Materials Testing, Membranes, Artificial, Spectrophotometry, Ultraviolet, Triazenes, Molecular Structure, Spectroscopy, Fourier Transform Infrared, Nitric Oxide Donors, Hydrophobic and Hydrophilic Interactions
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