Molecular Cloning and Characterization of a Novel Histone Deacetylase HDAC10

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

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Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

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A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

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Three proteins define a class of human histone deacetylases related to yeast Hda1p

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Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation

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Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

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A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

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Regulation of activity of the transcription factor GATA-1 by acetylation

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Regulation of E2F1 activity by acetylation

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p300/CBP‐mediated p53 acetylation is commonly induced by p53‐activating agents and inhibited by MDM2

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Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

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Histone acetylation: chromatin in action

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Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family

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Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repressionPreprint

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Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

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Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

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A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

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Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

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Sin Meets NuRD and Other Tails of Repression

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Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor

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FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.

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Cloning and characterization of a histone deacetylase, HDAC9

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Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasm

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Acetylation of importin-α nuclear import factors by CBP/p300

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hOGG1 polymorphism and loss of heterozygosity (LOH): Significance for lung cancer susceptibility in a caucasian population

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The Modular Nature of Histone Deacetylase HDAC4 Confers Phosphorylation-dependent Intracellular Trafficking

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Chemoprevention of carcinogen-induced mammary tumorigenesis by the hybrid polar cytodifferentiation agent, suberanilohydroxamic acid (SAHA).

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Tip60 and HDAC7 Interact with the Endothelin Receptor A and May Be Involved in Downstream Signaling

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Histone deacetylases (HDACs): characterization of the classical HDAC family

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The many roles of histone deacetylases in development and physiology: implications for disease and therapy

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HDAC6 is a microtubule-associated deacetylase

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HDAC2 negatively regulates memory formation and synaptic plasticity

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The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

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Inhibition of Histone Deacetylase Activity by Butyrate

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Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis

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50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

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HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

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In vivo destabilization of dynamic microtubules by HDAC6‐mediated deacetylation

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Histone Deacetylases: Unique Players in Shaping the Epigenetic Histone Code

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Class II histone deacetylases: versatile regulators

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CLINICAL DEVELOPMENT OF HISTONE DEACETYLASE INHIBITORS AS ANTICANCER AGENTS

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Histone deacetylases as regulators of inflammation and immunity

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The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin

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Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation

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Recent developments of HDAC inhibitors: Emerging indications and novel molecules

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Class II Histone Deacetylases: from Sequence to Function, Regulation, and Clinical Implication

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The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress responsePreprint

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Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy

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HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination

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Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics

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The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

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Isoform-selective histone deacetylase inhibitors

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Regulation of histone deacetylase activities

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Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

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Runx2 (Cbfa1, AML-3) Interacts with Histone Deacetylase 6 and Represses the p21 CIP1/WAF1 Promoter

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Histone deacetylase inhibitors: from target to clinical trials

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Histone Deacetylase Inhibitors Promote Osteoblast Maturation

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Class IIa histone deacetylases: regulating the regulators

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Histone Deacetylase 3 Interacts with Runx2 to Repress the Osteocalcin Promoter and Regulate Osteoblast Differentiation

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Targeting histone deacetylase in cancer therapy

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Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6

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Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases?

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Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review

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Histone deacetylase 10 promotes autophagy-mediated cell survival

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From 1957 to Nowadays: A Brief History of Epigenetics

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Histone deacetylase inhibitors as therapeutics for polyglutamine disorders

Butler, R. K., & Bates, G. P. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1989 · Cited by 212 · see citing works

Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

Kumar, V., Kundu, S., Singh, A., & Singh, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x19666210609160017 · Cited by 210 · see citing works

A Limited Group of Class I Histone Deacetylases Acts To Repress Human Immunodeficiency Virus Type 1 Expression

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Histone deacetylase HDAC8 associates with smooth muscle α‐actin and is essential for smooth muscle cell contractility

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Histone deacetylase 10 structure and molecular function as a polyamine deacetylase

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Class II (IIa)-Selective Histone Deacetylase Inhibitors. 1. Synthesis and Biological Evaluation of Novel (Aryloxopropenyl)pyrrolyl Hydroxyamides

Mai, A., Massa, S., Pezzi, R., Simeoni, S., Rotili, D., Nebbioso, A., Scognamiglio, A., Altucci, L., Loidl, P., & Brosch, G. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm049002a · Cited by 185 · see citing works

Down-regulation of Histone Deacetylases Stimulates Adipocyte Differentiation

Yoo, E. J., Chung, J.-J., Choe, S. S., Kim, K. H., & Kim, J. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508982200 · Cited by 184 · see citing works

Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain

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Class II Histone Deacetylases Are Directly Recruited by BCL6 Transcriptional Repressor

Lemercier, C., Brocard, M.-P., Puvion-dutilleul, F., Kao, H., Albagli, O., & Khochbin, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201736200 · Cited by 172 · see citing works

Targeting Histone Deacetylases for Cancer Therapy: From Molecular Mechanisms to Clinical Implications

Li, Z., & Zhu, W. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.9067 · Cited by 160 · see citing works

Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy

Verza, F. A., Das, U., Fachin, A. L., Dimmock, J. R., & Marins, M. (2020) · Cancers · doi:10.3390/cancers12061664 · Cited by 147 · see citing works

The Histone Deacetylase 9 Gene Encodes Multiple Protein Isoforms

Petrie, K. R., Guidez, F., Howell, L., Healy, L. E., Waxman, S., Greaves, M. F., & Zelent, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212935200 · Cited by 146 · see citing works

Characterization of the two catalytic domains in histone deacetylase 6

Zou, H., Wu, Y., Navre, M., & Sang, B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.144 · Cited by 144 · see citing works

Mechanisms Regulating Adipocyte Expression of Resistin

Hartman, H. B., Hu, X., Tyler, K. X., Dalal, C. K., & Lazar, M. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201451200 · Cited by 145 · see citing works

Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect

Dickinson, M. J., Johnstone, R. W., & Prince, H. M. (2010) · Investigational New Drugs · doi:10.1007/s10637-010-9596-y · Cited by 145 · see citing works

Regulation of the HIF-1α stability by histone deacetylases

Kim, S. H., Jeong, J.-W., Park, J. Y., Lee, J., Seo, J., Jung, B., Bae, M., & Kim, K. (2007) · Oncology Reports · doi:10.3892/or.17.3.647 · Cited by 144 · see citing works

The Tale of Protein Lysine Acetylation in the Cytoplasm

Sadoul, K., Wang, J., Diagouraga, B., & Khochbin, S. (2010) · BioMed Research International · doi:10.1155/2011/970382 · Cited by 140 · see citing works

Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes

Perišić, T., Zimmermann, N., Kirmeier, T., Asmus, M., Tuorto, F., Uhr, M., Holsboer, F., Rein, T., & Zschocke, J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.188 · Cited by 132 · see citing works

Expression of Histone Deacetylase 8, a Class I Histone Deacetylase, Is Restricted to Cells Showing Smooth Muscle Differentiation in Normal Human Tissues

Waltregny, D., de Leval, L., Glénisson, W., Tran, S. L., North, B. J., Bellahcène, A., Weidle, U. H., Verdin, E. M., & Castronovo, V. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63320-2 · Cited by 131 · see citing works

Deactylase Inhibitors Disrupt Cellular Complexes Containing Protein Phosphatases and Deacetylases

Brush, M., Guardiola, A. R., Connor, J. H., Yao, T., & Shenolikar, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310997200 · Cited by 129 · see citing works

Targeting Histone Deacetylases in Diseases: Where Are We?

Benedetti, R., Conte, M., & Altucci, L. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5776 · Cited by 127 · see citing works

HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer.

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Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment

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Strategies To Design Selective Histone Deacetylase Inhibitors

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Histone Deacetylase 7 Promotes Toll-like Receptor 4-dependent Proinflammatory Gene Expression in Macrophages

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Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824

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Activation of the Growth-Differentiation Factor 11 Gene by the Histone Deacetylase (HDAC) Inhibitor Trichostatin A and Repression by HDAC3

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Will broad-spectrum histone deacetylase inhibitors be superseded by more specific compounds?

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Histone Deacetylase Inhibitors for Cancer Therapy

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Chemical Genetic Modifier Screens

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Histone Deacetylase 7 Promotes PML Sumoylation and Is Essential for PML Nuclear Body Formation

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Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) α and β messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells

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Kinetics and Comparative Reactivity of Human Class I and Class IIb Histone Deacetylases

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Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition

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Medicinal chemistry updates of novel HDACs inhibitors (2020 to present)

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Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner

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The use of diversity profiling to characterize chemical modulators of the histone deacetylases

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Corepressor Recruitment by Agonist-Bound Nuclear Receptors

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HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities

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Rice histone deacetylase 10 and Arabidopsis histone deacetylase 14 genes encode N ‐acetylserotonin deacetylase, which catalyzes conversion of N ‐acetylserotonin into serotonin, a reverse reaction for melatonin biosynthesis in plants

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Human MI-ER1 Alpha and Beta Function as Transcriptional Repressors by Recruitment of Histone Deacetylase 1 to Their Conserved ELM2 Domain

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Evolution of the arginase fold and functional diversity

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Histone Deacetylase Inhibitors: The Epigenetic Therapeutics That Repress Hypoxia‐Inducible Factors

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Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells.

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Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7–HMGA2–Cyclin A2 Pathway

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The Role of Histone Acetylation-/Methylation-Mediated Apoptotic Gene Regulation in Hepatocellular Carcinoma

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Modulation of antigen‐presenting cells by HDAC inhibitors: implications in autoimmunity and cancer

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Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease

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Valproic acid: how it works. Or not

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Isolation and Characterization of Mammalian HDAC10, a Novel Histone Deacetylase

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Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain

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Isolation and Characterization of a Novel Class II Histone Deacetylase, HDAC10

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Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors

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Two Catalytic Domains Are Required for Protein Deacetylation

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