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NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development
Open accessAbstract
Activation of the transcription factor NF-kappa B and pre-T cell receptor (pre-TCR) expression is tightly correlated during thymocyte development. Inhibition of NF-kappa B in isolated thymocytes in vitro results in spontaneous apoptosis of cells expressing the pre-TCR, whereas inhibition of NF-kappa B in transgenic mice through expression of a mutated, superrepressor form of I kappa B alpha leads to a loss of beta-selected thymocytes. In contrast, the forced activation of NF-kappa B through expression of a dominant-active I kappa B kinase allows differentiation to proceed to the CD4(+)CD8(+) stage in a Rag1(-/-) mouse that cannot assemble the pre-TCR. Therefore, signals emanating from the pre-TCR are mediated at least in part by NF-kappa B, which provides a selective survival signal for developing thymocytes with productive beta chain rearrangements.
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Metadata
- Authors
- Voll, R. E., Jimi, E., Phillips, R. J., Barber, D. F., Rincon, M., Hayday, A. C., Flavell, R. A., & Ghosh, S.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 13
- Issue
- 5
- Pages
- 677-689
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1967059605
- Cited by
- 277
- References
- 0
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
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