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Cited by 743

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice

Open access
Haziot, Alain, Ferrero, Enza, Köntgen, Frank, Hijiya, Naoki, Yamamoto, Shunsuke, Silver, Jack, Stewart, Colin L, Goyert, Sanna M·1996·Immunity
DOI 10.1016/s1074-7613(00)80254-x
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Abstract

Endotoxin shock is the result of activation of the immune system by endotoxin/LPS, a component of Gram-negative bacteria. CD14, a GPI-anchored glycoprotein expressed strongly by monocyte/macrophages, is one of several receptors for endotoxin/LPS. The role of CD14 in bacterial-induced and LPS-induced shock was tested in CD14-deficient mice produced by gene targeting in embryonic stem cells. CD14-deficient mice were found to be highly resistant to shock induced by either live Gram-negative bacteria or LPS; however, at very high concentrations of LPS or bacteria, responses through non-CD14 receptors could be detected. Surprisingly, CD14-deficient mice also showed dramatically reduced levels of bacteremia, suggesting an unexpected role for CD14 in the dissemination of Gram-negative bacteria.

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Metadata

Authors
Haziot, A., Ferrero, E., Köntgen, F., Hijiya, N., Yamamoto, S., Silver, J., Stewart, C. L., & Goyert, S. M.
Venue
Immunity
Publisher
Elsevier BV
Published
1996-04
Volume
4
Issue
4
Pages
407-414
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/s1074-7613(00)80254-x
OpenAlex
W1991109223
Cited by
743
References
2
FWCI
16.19
Type
journal article
Language
en
Open access
hybrid

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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