The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.
Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1
Open accessAbstract
Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects in multiple cell types, namely impaired production of interleukin-12 by macrophages, hyporesponsiveness of CD4+ T cells to interleukin-12, and defective development of natural killer cells. These results indicate the involvement of IRF-1 in multiple stages of the Th1 limb of the immune response.
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“It was shown that ICSBP alone is able to activate mouse and human IL-12 p40 promoters.”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [45]
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Cites
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
The expanding universe of T-cell subsets: Th1, Th2 and more
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Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
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The Instructive Role of Innate Immunity in the Acquired Immune Response
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Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
Kaplan, M. H., Schindler, U., Smiley, S. T., & Grusby, M. J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80439-2 · Cited by 1,629
Essential role of Stat6 in IL-4 signalling
Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S.-I., Nakanishi, K., Yoshida, N., Kishimoto, T., & Akira, S. (1996) · Nature · doi:10.1038/380627a0 · Cited by 1,557
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,539
The Molecular Cell Biology of Interferon-Gamma and Its Receptor
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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
Shimoda, K., van Deursent, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A., Chu, C., Quelle, F. W., Nosaka, T., Vignali, D. A. A., et al. (1996) · Nature · doi:10.1038/380630a0 · Cited by 1,278
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Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
Honda, K., & Taniguchi, T. (2006) · Nature reviews. Immunology · doi:10.1038/nri1900 · Cited by 1,716
Self-citationIRF Family of Transcription Factors as Regulators of Host Defense
Taniguchi, T., Ogasawara, K., Takaoka, A., & Tanaka, N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.623 · Cited by 1,658
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Metadata
- Authors
- Taki, S., Sato, T., Ogasawara, K., Fukuda, T., Sato, M., Hida, S., Suzuki, G., Mitsuyama, M., Shin, E.-H., Kojima, S., Taniguchi, T., & Asano, Y.
- Affiliations
- The University of Tokyo (JP)
- National Institute of Radiological Sciences (JP)
- Niigata University (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Corresponding author
- Taniguchi, Tadatsugu
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 6
- Issue
- 6
- Pages
- 673-679
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1977795184
- Cited by
- 353
- References
- 58
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 12 · 2013: 10 · 2012: 13
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- IRF1, Th1 response, Th1/Th2 differentiation, T helper cell differentiation, IL-12, macrophages, CD4+ T cells, natural killer cell development, transcription factors
- MeSH terms
- Animals, Antigen-Presenting Cells, Cell Differentiation, DNA-Binding Proteins, Gene Expression Regulation, Killer Cells, Natural, Phosphoproteins, Transcription Factors, CD4-Positive T-Lymphocytes, Mice, Knockout, Th1 Cells, Th2 Cells, Interleukin-12, Interferon Regulatory Factor-1, Mice
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