Cited by 353T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmune Response and Inflammation

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Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

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Taki, Shinsuke, Sato, Takeo, Ogasawara, Kouetsu, Fukuda, Taeko, Sato, Mitsuharu, Hida, Shigeaki, Suzuki, Gen, Mitsuyama, Masao, Shin, Eun-Hee, Kojima, Soumei, Taniguchi, Tadatsugu, Asano, Yoshihiro·1997·Immunity

DOI 10.1016/s1074-7613(00)80443-4

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Abstract

Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects in multiple cell types, namely impaired production of interleukin-12 by macrophages, hyporesponsiveness of CD4+ T cells to interleukin-12, and defective development of natural killer cells. These results indicate the involvement of IRF-1 in multiple stages of the Th1 limb of the immune response.

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Authors: Taki, S., Sato, T., Ogasawara, K., Fukuda, T., Sato, M., Hida, S., Suzuki, G., Mitsuyama, M., Shin, E.-H., Kojima, S., Taniguchi, T., & Asano, Y.
Affiliations: The University of Tokyo (JP)
National Institute of Radiological Sciences (JP)
Niigata University (JP)
Institute of Medical Science, The University of Tokyo (JP)
Corresponding author: Taniguchi, Tadatsugu
ORCID: Taki, Shinsuke
Sato, Takeo
Sato, Mitsuharu
Hida, Shigeaki
Shin, Eun-Hee
Taniguchi, Tadatsugu
Asano, Yoshihiro
Venue: Immunity
Publisher: Elsevier BV
Published: 1997-06
Volume: 6
Issue: 6
Pages: 673-679
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/s1074-7613(00)80443-4
OpenAlex: W1977795184
Cited by: 353
References: 58
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 12 · 2013: 10 · 2012: 13
FWCI: 13.09
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5890 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science
Ministry of Education, Culture, Sports, Science and Technology
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: IRF1, Th1 response, Th1/Th2 differentiation, T helper cell differentiation, IL-12, macrophages, CD4+ T cells, natural killer cell development, transcription factors
MeSH terms: Animals, Antigen-Presenting Cells, Cell Differentiation, DNA-Binding Proteins, Gene Expression Regulation, Killer Cells, Natural, Phosphoproteins, Transcription Factors, CD4-Positive T-Lymphocytes, Mice, Knockout, Th1 Cells, Th2 Cells, Interleukin-12, Interferon Regulatory Factor-1, Mice

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Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

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