Impaired Innate Host Defense Causes Susceptibility to Respiratory Virus Infections in Cystic Fibrosis

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418 · see citing works

Identification of the Cystic Fibrosis Gene: Genetic Analysis

Kerem, B.-S., Rommens, J. M., Buchanan, J. A., Markiewicz, D., Cox, T. K., Chakravarti, A., Buchwald, M., & Tsui, L.-C. (1989) · Science · doi:10.1126/science.2570460 · Cited by 4,142 · see citing works

HOW CELLS RESPOND TO INTERFERONS

Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932 · see citing works

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

Rommens, J. M., Iannuzzi, M. C., Kerem, B.-S., Drumm, M. L., Melmer, G., Dean, M. C., Rozmahel, R. F., Cole, J. L., Kennedy, D., Hidaka, N., et al. (1989) · Science · doi:10.1126/science.2772657 · Cited by 3,238 · see citing works

Antiviral Actions of Interferons

Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743 · see citing works

High density synthetic oligonucleotide arrays

Lipshutz, R. J., Fodor, S. P. A., Gingeras, T., & Lockhart, D. J. (1999) · Nature Genetics · doi:10.1038/4447 · Cited by 2,204 · see citing works

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656 · see citing works

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,522 · see citing works

Structure and Function of the CFTR Chloride Channel

Sheppard, D. N., & Welsh, M. J. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s23 · Cited by 1,025 · see citing works

Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems

García‐Sastre, A., Egorov, A., Matassov, D., Brandt, S., Levy, D. E., Durbin, J. E., Palese, P., & Muster, T. (1998) · Virology · doi:10.1006/viro.1998.9508 · Cited by 1,000 · see citing works

Functional classification of interferon-stimulated genes identified using microarrays

de Veer, M. J., Holko, M., Frevel, M. A. E., Walker, E. M., Der, S., Paranjape, J. M., Silverman, R. H., & Williams, B. R. G. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.6.912 · Cited by 902 · see citing works

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843 · see citing works

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

Karupiah, G., Xie, Q. W., Buller, R. M. L., Nathan, C., Duarte, C. J., & MacMicking, J. D. (1993) · Science · doi:10.1126/science.7690156 · Cited by 810 · see citing works

Lethal H5N1 influenza viruses escape host anti-viral cytokine responses

Seo, S. H., Hoffmann, E., & Webster, R. G. (2002) · Nature Medicine · doi:10.1038/nm757 · Cited by 652 · see citing works

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

Samuel, C. E. (1991) · Virology · doi:10.1016/0042-6822(91)90112-o · Cited by 608 · see citing works

Generation of cAMP-Activated Chloride Currents by Expression of CFTR

Anderson, M. P., Rich, D. P., Gregory, R. J., Smith, A. E., & Welsh, M. J. (1991) · Science · doi:10.1126/science.1704151 · Cited by 550 · see citing works

Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.

Guo, F. H., Raeve, H. R. D., Rice, T. W., Stuehr, D. J., Thunnissen, E., & ERZURUM, S. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7809 · Cited by 517 · see citing works

Identification of the cystic fibrosis gene.

Knight, R. A., & Hodson, M. E. (1990) · BMJ · doi:10.1136/bmj.300.6721.345 · Cited by 503 · see citing works

Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication.

Croen, K. D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116479 · Cited by 463 · see citing works

I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation

Grisham, M. B., Jourd’heuil, D., & Wink, D. A. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.2.g315 · Cited by 451 · see citing works

Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

Karaghiosoff, M., Neubauer, H. J., Lassnig, C., Kovarik, P., Schindler, H., Pircher, H., McCoy, B., Bogdan, C., Decker, T., Brem, G., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00054-6 · Cited by 422 · see citing works

Virus interference. II. Some properties of interferon

Isaacs, A., Lindenmann, J.-M., & Valentine, R. C. (1957) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1957.0049 · Cited by 415 · see citing works

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.

Müller, M., Laxton, C., Briscoe, J., Schindler, C., Improta, T., Darnell, J. E., Stark, G. R., & Kerr, I. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06106.x · Cited by 411 · see citing works

Proteomic method identifies proteins nitrated <i>in vivo</i> during inflammatory challenge

Aulak, K. S., Miyagi, M., Yan, L., West, K. A., Massillon, D., Crabb, J. W., & Stuehr, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221269198 · Cited by 350 · see citing works

Inactivation of ribonucleotide reductase by nitric oxide

Lepoivre, M., Fieschi, F., Covès, J., Thelander, L., & Fontecave, M. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91390-x · Cited by 329 · see citing works

Inhibition of Interferon-Mediated Antiviral Responses by Influenza A Viruses and Other Negative-Strand RNA Viruses

García‐Sastre, A. (2001) · Virology · doi:10.1006/viro.2000.0756 · Cited by 321 · see citing works

An Interferon-γ-activated Site (GAS) Is Necessary for Full Expression of the Mouse iNOS Gene in Response to Interferon-γ and Lipopolysaccharide

Gao, J., Morrison, D. C., Parmely, T. J., Russell, S. W., & Murphy, W. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.1226 · Cited by 303 · see citing works

Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle

Pavlovic, J., Haller, O., & Staeheli, P. (1992) · Journal of Virology · doi:10.1128/jvi.66.4.2564-2569.1992 · Cited by 297 · see citing works

p38 Mitogen-Activated Protein Kinase-Dependent and -Independent Signaling of mRNA Stability of AU-Rich Element-Containing Transcripts

Frevel, M. A. E., Bakheet, T. M., Silva, A. M., Hissong, J. G., Khabar, K. S. A., & Williams, B. R. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.425-436.2003 · Cited by 288 · see citing works

Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.

Zhu, Z., Tang, W., Ray, A., Wu, Y., Einarsson, O., Landry, M. L., Gwaltney, J., & Elias, J. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118431 · Cited by 282 · see citing works

Does Nitric Oxide Play a Critical Role in Viral Infections?

Reiss, C. S., & Komatsu, T. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.4547-4551.1998 · Cited by 272 · see citing works

2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A

Dong, B., & Silverman, R. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4133 · Cited by 261 · see citing works

Molecular Mechanisms of Increased Nitric Oxide (NO) in Asthma: Evidence for Transcriptional and Post-Translational Regulation of NO Synthesis

Guo, F. H., COMHAIR, S. A. A., Zheng, S., Dweik, R. A., Eissa, N. T., Thomassen, M. J., Calhoun, W. J., & ERZURUM, S. C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.5970 · Cited by 258 · see citing works

Nasal and Bronchoalveolar Lavage Fluid Cytokines in Early Cystic Fibrosis

Noah, T. L., Black, H. R., Cheng, P., Wood, R. E., & Leigh, M. W. (1997) · The Journal of Infectious Diseases · doi:10.1093/infdis/175.3.638 · Cited by 250 · see citing works

An Antiviral Mechanism of Nitric Oxide

Saura, M., Zaragoza, C., McMillan, A., Quick, R. A., Hohenadl, C., Lowenstein, J. M., & Lowenstein, C. J. (1999) · Immunity · doi:10.1016/s1074-7613(00)80003-5 · Cited by 245 · see citing works

Interferon Action in Triply Deficient Mice Reveals the Existence of Alternative Antiviral Pathways

Zhou, A., Paranjape, J. M., Der, S. D., Williams, B. R. G., & Silverman, R. H. (1999) · Virology · doi:10.1006/viro.1999.9738 · Cited by 244 · see citing works

Initial and innate responses to viral infections — pattern setting in immunity or disease

Biron, C. A. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)80066-6 · Cited by 239 · see citing works

Association of Respiratory Viral Infections with Pulmonary Deterioration in Patients with Cystic Fibrosis

Wang, E. E. L., Prober, C. G., Manson, B., Corey, M. L., & Levison, H. (1984) · New England Journal of Medicine · doi:10.1056/nejm198412273112602 · Cited by 235 · see citing works

Decreased SLIM1 Expression and Increased Gelsolin Expression in Failing Human Hearts Measured by High-Density Oligonucleotide Arrays

Yang, J., Moravec, C. S., Sussman, M. A., DiPaola, N. R., Fu, D., Hawthorn, L., Mitchell, C. A., Young, J. B., Francis, G. S., McCarthy, P. M., et al. (2000) · Circulation · doi:10.1161/01.cir.102.25.3046 · Cited by 222 · see citing works

The interferon antiviral response: from viral invasion to evasion

Grandvaux, N., tenOever, B. R., Servant, M. J., & Hiscott, J. B. (2002) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200206000-00008 · Cited by 216 · see citing works

Effects of Viral Lower Respiratory Tract Infection on Lung Function in Infants With Cystic Fibrosis

Hiatt, P., Grace, S. C., Kozinetz, C. A., RABOUDI, S. H., Treece, D. G., Taber, L. H., & Piedra, P. A. (1999) · PEDIATRICS · doi:10.1542/peds.103.3.619 · Cited by 215 · see citing works

Nitric Oxide Inhibits Rhinovirus-Induced Cytokine Production and Viral Replication in a Human Respiratory Epithelial Cell Line

Sanders, S. P., Siekierski, E. S., Porter, J. D., Richards, S. M., & Proud, D. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.934-942.1998 · Cited by 197 · see citing works

Paramyxoviridae Use Distinct Virus-Specific Mechanisms to Circumvent the Interferon Response

Young, D. F., Didcock, L., Goodbourn, S., & Randall, R. E. (2000) · Virology · doi:10.1006/viro.2000.0240 · Cited by 196 · see citing works

Severe viral respiratory infections in infants with cystic fibrosis

Armstrong, D., Grimwood, K., Carlin, J. B., Carzino, R., Hull, J., Olinsky, A., & Phelan, P. D. (1998) · Pediatric Pulmonology · doi:10.1002/(sici)1099-0496(199812)26:6 · Cited by 196 · see citing works

Kinase‐negative mutants of JAK1 can sustain interferon‐gamma‐inducible gene expression but not an antiviral state.

Briscoe, J., Rogers, N. C., Witthuhn, B. A., Watling, D., Harpur, A. G., Wilks, A. F., Stark, G. R., Ihle, J. N., & Kerr, I. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00415.x · Cited by 194 · see citing works

Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.

Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588 · Cited by 192 · see citing works

Interferon Consensus sequence-Binding Protein, a Member of the Interferon Regulatory Factor Family, Suppresses Interferon-Induced Gene Transcription

Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588-599.1993 · Cited by 192 · see citing works

Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.

Guo, F. H., Uetani, K., Haque, S. J., Williams, B. R. G., Dweik, R. A., Thunnissen, E., Calhoun, W. J., & ERZURUM, S. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119598 · Cited by 185 · see citing works

RESPIRATORY INFECTIONS IN CYSTIC FIBROSIS PATIENTS CAUSED BY VIRUS, CHLAMYDIA AND MYCOPLASMA–POSSIBLE SYNERGISM WITH PSEUDOMONAS AERUGINOSA

Petersen, N., Høiby, N., Mordhorst, C. H., Lind, K., Flensborg, E. W., & Bruun, B. (1981) · Acta Paediatrica · doi:10.1111/j.1651-2227.1981.tb05757.x · Cited by 184 · see citing works

Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus

Xiang, Y., CONDIT, R. C., Vijaysri, S., Jacobs, B. L., Williams, B. R. G., & Silverman, R. H. (2002) · Journal of Virology · doi:10.1128/jvi.76.10.5251-5259.2002 · Cited by 177 · see citing works

Degradation of STAT1 and STAT2 by the V Proteins of Simian Virus 5 and Human Parainfluenza Virus Type 2, Respectively: Consequences for Virus Replication in the Presence of Alpha/Beta and Gamma Interferons

Andrejeva, J., Young, D. F., Goodbourn, S., & Randall, R. E. (2002) · Journal of Virology · doi:10.1128/jvi.76.5.2159-2167.2002 · Cited by 166 · see citing works

Expression of IL-6, IL-8, and RANTES on human bronchial epithelial cells, NCI-H292, induced by influenza virus A

Matsukura, S., Kokubu, F., Noda, H., Tokunaga, H., & Adachi, M. (1996) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(96)80195-3 · Cited by 160 · see citing works

Regulation of IFN-alpha/beta, MxA, 2',5'-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells

Ronni, T., Matikainen, S., Sareneva, T., Melén, K., Pirhonen, J., Keskinen, P., & Julkunen, I. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.2363 · Cited by 155 · see citing works

Characterization of the Solution Complex between the Interferon-induced, Double-stranded RNA-activated Protein Kinase and HIV-I Trans-activating Region RNA

Carpick, B. W., Graziano, V., Schneider, D. K., Maitra, R. K., Lee, X., & Williams, B. R. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.9510 · Cited by 128 · see citing works

Signal transduction in the interferon system.

Haque, S. J., & Williams, B. (1998) · PubMed · Cited by 126 · see citing works

Inflammatory Response in Airway Epithelial Cells Isolated from Patients with Cystic Fibrosis

Aldallal, N., McNaughton, E. E., Manzel, L. J., Richards, A. M., Zabner, J., Ferkol, T. W., & Look, D. C. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200206-627oc · Cited by 125 · see citing works

Inhibition of Influenza Virus Replication by Nitric Oxide

Rimmelzwaan, G. F., Baars, M. M. J. W., de Lijster, P., Fouchier, R. A. M., & Osterhaus, A. D. M. E. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8880-8883.1999 · Cited by 120 · see citing works

Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites.

Karupiah, G., & Harris, N. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2171 · Cited by 104 · see citing works

Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA

ERZURUM, S. C., Lemarchand, P., Rosenfeld, M. A., Yoo, J.-H., & Crystal, R. G. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.7.1607 · Cited by 103 · see citing works

Activation of NF-κB by Double-Stranded RNA (dsRNA) in the Absence of Protein Kinase R and RNase L Demonstrates the Existence of Two Separate dsRNA-Triggered Antiviral Programs

Iordanov, M. S., Wong, J. W., Bell, J. C., & Magun, B. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.61-72.2001 · Cited by 102 · see citing works

Central Role of Double-Stranded RNA-Activated Protein Kinase in Microbial Induction of Nitric Oxide Synthase

Uetani, K., Der, S. D., Zamanian-Daryoush, M., de la Motte, C., Lieberman, B. Y., Williams, B. R. G., & Erzurum, S. C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.988 · Cited by 100 · see citing works

Nitric oxide inhibition of coxsackievirus replication in vitro.

Zaragoza, C., Ocampo, C. J., Saura, M., McMillan, A., & Lowenstein, C. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119702 · Cited by 91 · see citing works

Exhaled nitric oxide is reduced in infants with cystic fibrosis

Elphick, H. (2001) · Thorax · doi:10.1136/thorax.56.2.151 · Cited by 81 · see citing works

A Specific Isozyme of 2′-5′ Oligoadenylate Synthetase Is a Dual Function Proapoptotic Protein of the Bcl-2 Family

Ghosh, A., Sarkar, S. N., Rowe, T. M., & Sen, G. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100496200 · Cited by 80 · see citing works

Cystic Fibrosis Transmembrane Conductance Regulator–Dependent Regulation of Epithelial Inducible Nitric Oxide Synthase Expression

Steagall, W. K., Elmer, H. L., Brady, K. G., & Kelley, T. J. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.22.1.3789 · Cited by 80 · see citing works

In vivo antioxidant gene expression in human airway epithelium of normal individuals exposed to 100% O2

ERZURUM, S. C., Danel, C. J., Gillissen, A., Chu, C. S., Trapnell, B. C., & Crystal, R. G. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1256 · Cited by 78 · see citing works

Innate Immune Responses to Cytomegalovirus Infection in the Developing Mouse Brain and Their Evasion by Virus-Infected Neurons

Kosugi, I., Kawasaki, H., Arai, Y., & Tsutsui, Y. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64252-6 · Cited by 73 · see citing works

Prolonged STAT1 Activation Is Associated with Interferon-γ Priming for Interleukin-1-induced Inducible Nitric-oxide Synthase Expression by Islets of Langerhans

Heitmeier, M. R., Scarim, A. L., & Corbett, J. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29266 · Cited by 73 · see citing works

Identification ofNitric Oxide Synthase 2as an Innate Resistance Locus against Ectromelia Virus Infection

Karupiah, G., Chen, J.-H., Nathan, C., Mahalingam, S., & MacMicking, J. D. (1998) · Journal of Virology · doi:10.1128/jvi.72.9.7703-7706.1998 · Cited by 65 · see citing works

Role of Nitric Oxide Synthase Type 2 in Acute Infection with Murine Cytomegalovirus

Noda, S., TANAKA, K. A., Sawamura, S., Sasaki, M., Matsumoto, T., Mikami, K., Aiba, Y., Hasegawa, H., Kawabe, N., & Koga, Y. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3533 · Cited by 61 · see citing works

Cellular protein kinase C isoform zeta regulates human parainfluenza virus type 3 replication.

De, B. P., Gupta, S., Gupta, S., & Banerjee, A. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.5204 · Cited by 61 · see citing works

Role of cellular actin in human parainfluenza virus type 3 genome transcription.

De, B. P., Burdsall, A., & Banerjee, A. K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53375-5 · Cited by 59 · see citing works

A Critical Role for Inducible Nitric Oxide Synthase in Host Survival Following Coxsackievirus B4 Infection

Flodström‐Tullberg, M., Horwitz, M. S., Maday, A., Balakrishna, D., Rodriguez, E., & Sarvetnick, N. (2001) · Virology · doi:10.1006/viro.2000.0801 · Cited by 58 · see citing works

In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium

Kelley, T. J., & Elmer, H. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9560 · Cited by 53 · see citing works

Effects of acute viral respiratory tract infections in patients with cystic fibrosis

Hordvik, N. L., König, P., Hamory, B. H., Cooperstock, M. S., Kreutz, C., Gayer, D., & Barbero, G. J. (1989) · Pediatric Pulmonology · doi:10.1002/ppul.1950070406 · Cited by 45 · see citing works

Asthma, Viruses, and Nitric Oxide

Sanders, S. P. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-19.x · Cited by 43 · see citing works

Human Parainfluenza Virus Type 3 Up-Regulates Major Histocompatibility Complex Class I and II Expression on Respiratory Epithelial Cells: Involvement of a STAT1- and CIITA-Independent Pathway

Gao, J., De, B. P., & Banerjee, A. K. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1411-1418.1999 · Cited by 43 · see citing works

Role of NH 2 - and COOH-Terminal Domains of the P Protein of Human Parainfluenza Virus Type 3 in Transcription and Replication

De, B. P., Hoffman, M. A., Choudhary, S. K., Huntley, C. C., & Banerjee, A. K. (2000) · Journal of Virology · doi:10.1128/jvi.74.13.5886-5895.2000 · Cited by 39 · see citing works

Interferon Action against Human Parainfluenza Virus Type 3: Involvement of a Novel Antiviral Pathway in the Inhibition of Transcription

Choudhary, S. K., Gao, J., Leaman, D. W., & De, B. P. (2001) · Journal of Virology · doi:10.1128/jvi.75.10.4823-4831.2001 · Cited by 34 · see citing works

Yet Another Role for the Cystic Fibrosis Transmembrane Conductance Regulator

Widdicombe, J. H. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.22.1.f177 · Cited by 19 · see citing works

Evolution of airway microbiology in the infant with cystic fibrosis: role of nonpseudomonal and pseudomonal pathogens.

Rosenfeld, M., & Ramsey, B. W. (1992) · PubMed · Cited by 16 · see citing works

Complementation of an

Patton, D. A., Volrath, S., & Ward, E. R. (1996) · Molecular and General Genetics MGG · doi:10.1007/s004380050166 · Cited by 5 · see citing works

The airway epithelium: soldier in the fight against respiratory viruses

Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works

Cystic fibrosis: a mucosal immunodeficiency syndrome

Cohen, T. S., & Prince, A. S. (2012) · Nature Medicine · doi:10.1038/nm.2715 · Cited by 480 · see citing works

The innate immune function of airway epithelial cells in inflammatory lung disease

Hiemstra, P. S., McCray, P. B., & Bals, R. (2015) · European Respiratory Journal · doi:10.1183/09031936.00141514 · Cited by 425 · see citing works

Barrier function of airway tract epithelium

Ganesan, S., Comstock, A. T., & Sajjan, U. S. (2013) · Tissue Barriers · doi:10.4161/tisb.24997 · Cited by 347 · see citing works

The role of airway epithelial cells and innate immune cells in chronic respiratory disease

Holtzman, M. J., Byers, D. E., Alexander‐Brett, J. M., & Wang, X. (2014) · Nature reviews. Immunology · doi:10.1038/nri3739 · Cited by 240 · see citing works

DNA methylation in lung cells is associated with asthma endotypes and genetic risk

Nicodemus-Johnson, J., Myers, R. A., Sakabe, N. J., Sobreira, D. R., Hogarth, D. K., Naureckas, E. T., Sperling, A. I., Solway, J., White, S. R., Nobrega, M. A., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.90151 · Cited by 180 · see citing works

Novel antiviral properties of azithromycin in cystic fibrosis airway epithelial cells

Schögler, A., Kopf, B. S., Edwards, M. R., Johnston, S. L., Casaulta, C., Kieninger, E., Jung, A., Mœller, A., Geiser, T., Regamey, N., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00102014 · Cited by 167 · see citing works

Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens

Holtzman, M. J. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60325 · Cited by 164 · see citing works

Developing animal models for polymicrobial diseases

Bakaletz, L. O. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro928 · Cited by 158 · see citing works

Nitric oxide and reactive nitrogen species in airway epithelial signaling and inflammation

Bove, P. F., & van der Vliet, A. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.011 · Cited by 158 · see citing works

Chronic Inflammation in the Cystic Fibrosis Lung: Alterations in Inter- and Intracellular Signaling

Nichols, D. P., Chmiel, J. F., & Berger, M. (2007) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-007-8039-9 · Cited by 142 · see citing works

Viral respiratory infections in cystic fibrosis

van Ewijk, B. E., van der Zalm, M. M., Wolfs, T. F. W., & van der Ent, C. K. (2005) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2005.05.011 · Cited by 98 · see citing works

Innate and Adaptive Immunity in Cystic Fibrosis

Bruscia, E. M., & Bonfield, T. L. (2015) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2015.11.010 · Cited by 89 · see citing works

Respiratory Epithelial Gene Expression in Patients with Mild and Severe Cystic Fibrosis Lung Disease

Wright, J. M., Merlo, C. A., Reynolds, J. B., Zeitlin, P. L., Garcia, J. G. N., Guggino, W. B., & Boyle, M. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0359oc · Cited by 87 · see citing works

Viruses exacerbating chronic pulmonary disease: the role of immune modulation

Singanayagam, A., Joshi, P. V., Mallia, P., & Johnston, S. L. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-27 · Cited by 86 · see citing works

Challenging and emerging pathogens in cystic fibrosis

de Vrankrijker, A. M. M., Wolfs, T. F. W., & van der Ent, C. K. (2010) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2010.07.003 · Cited by 87 · see citing works

Role of epithelial nitric oxide in airway viral infection

Xu, W., Zheng, S., Dweik, R. A., & Erzurum, S. C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.037 · Cited by 85 · see citing works

High Rhinovirus Burden in Lower Airways of Children With Cystic Fibrosis

Kieninger, E., Singer, F., Tapparel, C., Alves, M. P., Latzin, P., Tan, H., Bossley, C. J., Casaulta, C., Bush, A., Davies, J. C., et al. (2013) · CHEST Journal · doi:10.1378/chest.12-0954 · Cited by 82 · see citing works

Prophylaxis against respiratory syncytial virus in young children with cystic fibrosis

Giebels, K., Marcotte, J.-É., Podoba, J., Rousseau, C., Denis, M., Fauvel, V., & Laberge, S. (2007) · Pediatric Pulmonology · doi:10.1002/ppul.20751 · Cited by 79 · see citing works

Reactive oxygen and nitrogen species during viral infections

Molteni, C. G., Principi, N., & Esposito, S. (2014) · Free Radical Research · doi:10.3109/10715762.2014.945443 · Cited by 79 · see citing works

Airway Epithelial versus Immune Cell Stat1 Function for Innate Defense against Respiratory Viral Infection

Shornick, L. P., Wells, A. G., Zhang, Y., Patel, A. C., Huang, G., Takami, K., Sosa, M., Shukla, N. A., Agapov, E. V., & Holtzman, M. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3319 · Cited by 76 · see citing works

Nitric oxide metabolism in asthma pathophysiology

Ghosh, S., & ERZURUM, S. C. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.06.009 · Cited by 77 · see citing works

Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational study

Bain, R., Cosgriff, R., Zampoli, M., Elbert, A., Burgel, P., Carr, S. B., Castaños, C., Colombo, C., Corvol, H., Faro, A., et al. (2020) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2020.11.021 · Cited by 75 · see citing works

Impaired nitric oxide synthase-2 signaling pathway in cystic fibrosis airway epithelium

Zheng, S., Xu, W., Bose, S., Banerjee, A. K., Haque, S. J., & ERZURUM, S. C. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00039.2004 · Cited by 69 · see citing works

Induction of Type I Interferon Signaling by Pseudomonas aeruginosa Is Diminished in Cystic Fibrosis Epithelial Cells

Parker, D., Cohen, T. S., Alhede, M., Harfenist, B. S., Martin, F. J., & Prince, A. S. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0080oc · Cited by 68 · see citing works

Repair and remodeling of airway epithelium after injury in chronic obstructive pulmonary disease

Ganesan, S., & Sajjan, U. S. (2013) · Current Respiratory Care Reports · doi:10.1007/s13665-013-0052-2 · Cited by 67 · see citing works

Pseudomonas aeruginosa Suppresses Interferon Response to Rhinovirus Infection in Cystic Fibrosis but Not in Normal Bronchial Epithelial Cells

Chattoraj, S. S., Ganesan, S., Faris, A. N., Comstock, A. T., Lee, W.-M., & Sajjan, U. S. (2011) · Infection and Immunity · doi:10.1128/iai.05120-11 · Cited by 68 · see citing works

Nitric oxide and the common cold

Proud, D. (2005) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200502000-00008 · Cited by 64 · see citing works

Specific Engagement of TLR4 or TLR3 Does Not Lead to IFN-β-Mediated Innate Signal Amplification and STAT1 Phosphorylation in Resident Murine Alveolar Macrophages

Punturieri, A., Alviani, R. S., Polak, T., Copper, P., Sonstein, J., & Curtis, J. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1033 · Cited by 63 · see citing works

Current concepts: host–pathogen interactions in cystic fibrosis airways disease

Tang, A., Turvey, S. E., Alves, M. P., Regamey, N., Tümmler, B., & Hartl, D. (2014) · European Respiratory Review · doi:10.1183/09059180.00006113 · Cited by 57 · see citing works

Nitric oxide in cystic fibrosis

Groot, K. M. D. W., & van der Ent, C. K. (2005) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2005.05.008 · Cited by 57 · see citing works

Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency

Drutman, S. B., Mansouri, D., Mahdaviani, S. A., Neehus, A., Hum, D., Bryk, R., Hernandez, N., Belkaya, S., Rapaport, F., Bigio, B., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1910640 · Cited by 56 · see citing works

SARS-CoV-2 (COVID-19) and cystic fibrosis

Stanton, B. A., Hampton, T. H., & Ashare, A. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00225.2020 · Cited by 51 · see citing works

Inflammatory Levels of Nitric Oxide Inhibit Airway Epithelial Cell Migration by Inhibition of the Kinase ERK1/2 and Activation of Hypoxia-inducible Factor-1α

Bove, P. F., Hristova, M., Wesley, U. V., Olson, N. C., Lounsbury, K. M., & van der Vliet, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709914200 · Cited by 47 · see citing works

Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections

Bath, P. M., Coleman, C. M., Gordon, A. L., Lim, W. S., & Webb, A. J. (2021) · F1000Research · doi:10.12688/f1000research.51270.2 · Cited by 46 · see citing works

Viruses in cystic fibrosis patients’ airways

Billard, L., Berre, R. L., Pilorgé, L., Payan, C., Héry-Arnaud, G., & Vallet, S. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2017.1297763 · Cited by 44 · see citing works

Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability

Looi, K., Troy, N. M., Garratt, L. W., Iosifidis, T., Bosco, A., Buckley, A. G., Ling, K., Martinovich, K. M., Kicic‐Starcevich, E., Shaw, N. C., et al. (2016) · Experimental Lung Research · doi:10.1080/01902148.2016.1235237 · Cited by 42 · see citing works

Neutrophilic Inflammation as a Major Determinant in the Progression of Cystic Fibrosis

Tirouvanziam, R. M. (2006) · Drug News & Perspectives · doi:10.1358/dnp.2006.19.10.1068008 · Cited by 42 · see citing works

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma

Wang, Z., DiDonato, J. A., Buffa, J. A., COMHAIR, S. A. A., Aronica, M. A., Dweik, R. A., Lee, N. A., Lee, J. J., Thomassen, M. J., Kavuru, M. S., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.750034 · Cited by 41 · see citing works

Cystic Fibrosis and Normal Human Airway Epithelial Cell Response to Influenza A Viral Infection.

Xu, W., Zheng, S., Goggans, T., Kiser, P. K., Quiñones‐Mateu, M. E., Janocha, A. J., COMHAIR, S. A. A., Slee, R. B., Williams, B. R. G., & ERZURUM, S. C. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.609 · Cited by 41 · see citing works

Mechanistic Similarities between Cultured Cell Models of Cystic Fibrosis and Niemann-Pick Type C

White, N. M. A., Corey, D. A., & Kelley, T. J. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0117oc · Cited by 41 · see citing works

DDAH2 suppresses RLR-MAVS–mediated innate antiviral immunity by stimulating nitric oxide–activated, Drp1-induced mitochondrial fission

Huang, S., Li, Z., Wu, Z., Liu, C., Yu, M., Wen, M., Zhang, L., & Wang, X. (2021) · Science Signaling · doi:10.1126/scisignal.abc7931 · Cited by 39 · see citing works

The physiologic aggresome mediates cellular inactivation of iNOS

Pandit, L. M., Kołodziejska, K. E., Zeng, S., & Eissa, N. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810968106 · Cited by 38 · see citing works

Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection

Schögler, A., Stokes, A. B., Casaulta, C., Regamey, N., Edwards, M. R., Johnston, S. L., Jung, A., Mœller, A., Geiser, T., & Alves, M. P. (2015) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2015.10.013 · Cited by 37 · see citing works

Lack of an exaggerated inflammatory response on virus infection in cystic fibrosis

Kieninger, E., Vareille-Delarbre, M., Kopf, B. S., Blank, F., Alves, M. P., Gisler, F. M., Latzin, P., Casaulta, C., Geiser, T., Johnston, S. L., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00054511 · Cited by 37 · see citing works

Airway Nitric Oxide in Patients With Cystic Fibrosis Is Associated With Pancreatic Function, Pseudomonas Infection, and Polyunsaturated Fatty Acids

Keen, C., Olin, A., Edentoft, A., Gronowitz, E., & Strandvik, B. (2007) · CHEST Journal · doi:10.1378/chest.06-2635 · Cited by 36 · see citing works

Dysfunctional Inflammation in Cystic Fibrosis Airways: From Mechanisms to Novel Therapeutic Approaches

Ghigo, A., Prono, G., Riccardi, E., & Rose, V. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041952 · Cited by 35 · see citing works

Influenza A(H1N1)pdm09 and Cystic Fibrosis Lung Disease: A Systematic Meta-Analysis

Renk, H., Regamey, N., & Hartl, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0078583 · Cited by 34 · see citing works

Nitrative stress through formation of 8-nitroguanosine: Insights into microbial pathogenesis

Akuta, T., Zaki, M. H., Yoshitake, J., Okamoto, T., & Akaike, T. (2005) · Nitric Oxide · doi:10.1016/j.niox.2005.10.004 · Cited by 32 · see citing works

Susceptibility to viral infections in chronic obstructive pulmonary disease

Sajjan, U. S. (2013) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e32835cef10 · Cited by 31 · see citing works

Glycosaminoglycans as Multifunctional Anti-Elastase and Anti-Inflammatory Drugs in Cystic Fibrosis Lung Disease

Voynow, J. A., Zheng, S., & Kummarapurugu, A. B. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01011 · Cited by 30 · see citing works

Exhaled nitric oxide is not reduced in infants with cystic fibrosis

Franklin, P., Hall, G. L., Mœller, A., Horak, F., Brennan, S., & Stick, S. M. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00071005 · Cited by 30 · see citing works

KLF6 and iNOS regulates apoptosis during respiratory syncytial virus infection

Mgbemena, V. E., Segovia, J. A., Chang, T.-H., & Bose, S. (2013) · Cellular Immunology · doi:10.1016/j.cellimm.2013.06.002 · Cited by 29 · see citing works

Spectrum of viral infections in patients with cystic fibrosis

Frickmann, H., Jungblut, S., Hirche, T. O., Groß, U., Kuhns, M., & Zautner, A. E. (2012) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi.2.2012.3.1 · Cited by 28 · see citing works

Airway Surface Liquid Has Innate Antiviral Activity That is Reduced in Cystic Fibrosis

Berkebile, A. R., Bartlett, J. A., Alaiwa, M. H. A., Varga, S. M., Power, U. F., & McCray, P. B. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0304oc · Cited by 25 · see citing works

Transactivation of Inducible Nitric Oxide Synthase Gene by Kruppel-like Factor 6 Regulates Apoptosis during Influenza A Virus Infection

Mgbemena, V. E., Segovia, J. A., Chang, T.-H., Tsai, S.-Y., Cole, G. T., Hung, C.-Y., & Bose, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102742 · Cited by 27 · see citing works

Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis

Ramirez, I. A., Caverly, L. J., Kalikin, L. M., Goldsmith, A. M., Lewis, T. C., Burke, D., LiPuma, J. J., Sajjan, U. S., & Hershenson, M. B. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201310-346oc · Cited by 26 · see citing works

Efficacy and long‐term outcomes of palivizumab prophylaxis to prevent respiratory syncytial virus infection in infants with cystic fibrosis in Northern Ireland

Groves, H. E., Jenkins, L., MacFarlane, M., Reid, A., Lynn, F. A., & Shields, M. D. (2016) · Pediatric Pulmonology · doi:10.1002/ppul.23376 · Cited by 24 · see citing works

Update on Innate and Adaptive Immunity in Cystic Fibrosis

Bruscia, E. M., & Bonfield, T. L. (2022) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2022.06.004 · Cited by 24 · see citing works

Reduced sputum expression of interferon-stimulated genes in severe COPD

Hilzendeger, C., da Silva, J., Henket, M. A., Schleich, F., Corhay, J. L., Kebadze, T., Edwards, M., Mallia, P., Johnston, S. L., & Louis, R. E. (2016) · International Journal of COPD · doi:10.2147/copd.s105948 · Cited by 24 · see citing works

Host epithelial–viral interactions as cause and cure for asthma

Holtzman, M. J., Patel, D. A., Zhang, Y., & Patel, A. C. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.05.010 · Cited by 22 · see citing works

Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections

Nakamura, H., Fujisawa, T., Suga, S., Taniguchi, K., Nagao, M., Ito, M., 落合, 仁., Konagaya, M., Hanaoka, N., & Fujimoto, T. (2018) · Journal of Medical Virology · doi:10.1002/jmv.25032 · Cited by 23 · see citing works

Molecular Epidemiology and Clinical Features Analysis of Respiratory Adenovirus Infections Reveals Correlations between Genotype, Inflammatory Biomarkers, and Disease Severity

Dai, H., Xi, H.-L., Huang, L., Yuan, Z., Liao, Y., Tang, Y., Liao, J., Min, L., & Yu, Z. (2020) · BioMed Research International · doi:10.1155/2020/4357910 · Cited by 22 · see citing works

S -nitrosothiols regulate cell-surface pH buffering by airway epithelial cells during the human immune response to rhinovirus

Carraro, S., Doherty, J., Zaman, K., Gainov, I., Turner, R. B., Vaughan, J., Hunt, J. F., Márquez, J., & Gaston, B. M. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00406.2005 · Cited by 21 · see citing works

Inflammation as a Regulator of the Airway Surface Liquid pH in Cystic Fibrosis

Rehman, T., & Welsh, M. J. (2023) · Cells · doi:10.3390/cells12081104 · Cited by 17 · see citing works

Rhinovirus‐associated pulmonary exacerbations show a lack of FEV 1 improvement in children with cystic fibrosis

Cousin, M., Molinari, N., Foulongne, V., Caimmi, D. P., Vachier, I., Abély, M., & Chiron, R. (2015) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12353 · Cited by 20 · see citing works

CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages

Gillan, J. L., Chokshi, M., Hardisty, G. R., Clohisey, S., Prasca-Chamorro, D., Robinson, N. J., Lasota, B., Clark, R. C., Murphy, L., Whyte, M. K. B., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg5128 · Cited by 20 · see citing works

Respiratory Virus Infection in Infants and Children

Hammond, S., Chenever, E., & Durbin, J. E. (2007) · Pediatric and Developmental Pathology · doi:10.2350/07-02-0238.1 · Cited by 18 · see citing works

Digging through the Obstruction: Insight into the Epithelial Cell Response to Respiratory Virus Infection in Patients with Cystic Fibrosis

Hendricks, M. R., & Bomberger, J. M. (2016) · Journal of Virology · doi:10.1128/jvi.01864-15 · Cited by 18 · see citing works

Progress in Model Systems of Cystic Fibrosis Mucosal Inflammation to Understand Aberrant Neutrophil Activity

Laucirica, D. R., Garratt, L. W., & Kicic, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00595 · Cited by 18 · see citing works

Lymphocytes in cystic fibrosis lung disease: a tale of two immunities

Moss, R. B. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2003.02389.x · Cited by 17 · see citing works

Respiratory Syncytial Virus-Induced Oxidative Stress in Lung Pathogenesis

Hosakote, Y. M., & Rayavara, K. (2019) · Springer eBooks · doi:10.1007/978-981-32-9366-3_13 · Cited by 16 · see citing works

Diabetes Induces a Transcriptional Signature in Bone Marrow–Derived CD34+ Hematopoietic Stem Cells Predictive of Their Progeny Dysfunction

D’Alessandra, Y., Chiesa, M., Vigorelli, V., Ricci, V., Rurali, E., Raucci, A., Colombo, G. I., Pompilio, G., & Vinci, M. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031423 · Cited by 16 · see citing works

Respiratory Syncytial Virus Infection Disrupts Monolayer Integrity and Function in Cystic Fibrosis Airway Cells

Kong, M. Y. F., Maeng, P., Hong, J. S., Szczesniak, R. D., Sorscher, E. J., Sullender, W. M., & Clancy, J. P. (2013) · Viruses · doi:10.3390/v5092260 · Cited by 16 · see citing works

Hypersusceptibility to Respiratory Viruses as a Shared Mechanism for Asthma, Chronic Obstructive Pulmonary Disease, and Cystic Fibrosis

Holtzman, M. J., Patel, D. A., Kim, H., You, Y., & Zhang, Y. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0120ed · Cited by 15 · see citing works

Novel Approaches to Multidrug-Resistant Infections in Cystic Fibrosis

Murray, T. S., Stanley, G., & Koff, J. L. (2022) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2022.06.008 · Cited by 15 · see citing works

Modulation of asthma pathogenesis by nitric oxide pathways and therapeutic opportunities

Ghosh, S., & ERZURUM, S. C. (2012) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2012.10.004 · Cited by 15 · see citing works

Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis

Gohy, S. T., Moeremans, A., Pilette, C., & Collin, A. M. (2021) · Cells · doi:10.3390/cells10123603 · Cited by 14 · see citing works

A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense

Svedin, E., Utorova, R., Hühn, M. H., Larsson, P. G., Stone, V. M., Garimella, M. G., Lind, K., Hägglöf, T., Pincikova, T., Laitinen, O. H., et al. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix474 · Cited by 13 · see citing works

Inflammatory epithelial cytokines afterin vitrorespiratory syncytial viral infection are associated with reduced lung function

Duan, W., Cen, Y., Lin, C., Ouyang, H., Du, K., Kumar, A. J., Wang, B., Avolio, J., Grasemann, H., & Moraes, T. J. (2021) · ERJ Open Research · doi:10.1183/23120541.00365-2021 · Cited by 13 · see citing works

Human rhinoviruses and severe respiratory infections: is it possible to identify at-risk patients early?

Principi, N., Daleno, C., & Esposito, S. (2014) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2014.890048 · Cited by 13 · see citing works

Modulation of ENaC, CFTR , and iNOS expression in bronchial epithelial cells after stimulation with S taphylococcus epidermidis (94B080) and S taphylococcus aureus (90B083)

Hussain, R., Oliynyk, I., Roomans, G. M., & Björkqvist, M. (2013) · Apmis · doi:10.1111/apm.12138 · Cited by 10 · see citing works

Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise

Oza, P. P., & Kashfi, K. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.08.003 · Cited by 10 · see citing works

The Potential Role of Nitric Oxide in Substrate Switching in Eosinophil Peroxidase

Galijašević, S., Proteasa, G., Abdulhamid, I. B., & Abu‐Soud, H. M. (2006) · Biochemistry · doi:10.1021/bi061177u · Cited by 10 · see citing works

Immune response of polarized cystic fibrosis airway epithelial cells infected with Influenza A virus

Sofoluwe, A., Zoso, A., Bacchetta, M., Lemeille, S., & Chanson, M. (2020) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2020.08.012 · Cited by 9 · see citing works

Rhinovirus-induced anti-viral interferon secretion is not deficient and not delayed in sinonasal epithelial cells of patients with chronic rhinosinusitis with nasal polyp

Lee, S. H., Han, M. S., Lee, T., Lee, D. B., Park, J. H., Lee, S. H., & Kim, T. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1025796 · Cited by 9 · see citing works

Exhaled nitric oxide in pediatrics: what is new for practice purposes and clinical research in children?

PIACENTINI, G. L., Cattazzo, E., Tezza, G., & Peroni, D. G. (2012) · Journal of Breath Research · doi:10.1088/1752-7155/6/2/027103 · Cited by 9 · see citing works

Cystic Fibrosis: Fighting Together Against Coronavirus Infection

Manti, S., Parisi, G. F., Papale, M. R., Mulè, E., Aloisio, D., Rotolo, N., & Leonardi, S. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00307 · Cited by 9 · see citing works

Neutrophil elastase decreases SARS-CoV-2 spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomain from the epithelial surface

Kummarapurugu, A. B., Hawkridge, A. M., Ma, J., Osei, S., Martin, R., Zheng, S., & Voynow, J. A. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104820 · Cited by 7 · see citing works

Pivotal role of c-Fos in nitric oxide synthase 2 expression in airway epithelial cells

Chambellan, A., Leahy, R., Xu, W., Cruickshank, P. J., Janocha, A. J., Szabó, K., Cannady, S. B., COMHAIR, S. A. A., & ERZURUM, S. C. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.12.004 · Cited by 7 · see citing works

H1N1 Influenza Virus in Patients With Cystic Fibrosis: A Literature Review Examining Both Disease Entities and Their Association in Light of the 2009 Pandemic

Wiltshire, D. A., Vahora, I. S., Tsouklidis, N., Kumar, R., & Khan, S. (2020) · Cureus · doi:10.7759/cureus.9218 · Cited by 6 · see citing works

Novel Approaches to Multidrug-Resistant Infections in Cystic Fibrosis

Murray, T. S., Stanley, G., & Koff, J. L. (2024) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2023.12.002 · Cited by 6 · see citing works

Exacerbations of chronic respiratory diseases

Edwards, M. R., Ritchie, A. I., & Johnston, S. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816417-4.00006-8 · Cited by 6 · see citing works

Biology of Epithelial Cells

Proud, D. (2009) · Elsevier eBooks · doi:10.1016/b978-0-323-05659-5.00023-1 · Cited by 6 · see citing works

Influenza Virus Detection Following Administration of Live-Attenuated Intranasal Influenza Vaccine in Children With Cystic Fibrosis and Their Healthy Siblings

Boikos, C., Joseph, L., Martineau, C., Papenburg, J., Scheifele, D. W., Lands, L. C., Serres, G. D., Chilvers, M. A., & Quach, C. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw187 · Cited by 5 · see citing works

Impact of viral respiratory infections on pulmonary exacerbations in children with cystic fibrosis

Gonzalez‐Rosales, N., Kasi, A. S., McCracken, C., Silva, G. L., Starks, M., Stecenko, A. A., & Guglani, L. (2022) · Pediatric Pulmonology · doi:10.1002/ppul.26267 · Cited by 5 · see citing works

The clinical features and impact of SARS-CoV-2/COVID-19 infection in children with Cystic Fibrosis (CF): A Qatari experience

Hamad, S. G., Kammouh, H., Alamri, M., & Zahraldin, K. (2023) · Qatar medical journal · doi:10.5339/qmj.2023.19 · Cited by 4 · see citing works

Formation and biological role NO at an allergic inflammation

Kozina, O. V., & Ogorodova, L. M. (2009) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2009-3-95-104 · Cited by 4 · see citing works

Cystic Fibrosis and Defective Airway Innate Immunity

Bartlett, J. A., & McCray, P. B. (2012) · Springer eBooks · doi:10.1007/978-3-0348-0541-4_11 · Cited by 3 · see citing works

Impaired nitric oxide synthase-2 signaling pathway in cystic fibrosis airway epithelium

Zheng, S., Xu, W., Bose, S., Banerjee, A. K., Haque, S. J., & ERZURUM, S. C. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00039.2004 · Cited by 69 · see citing works

Role of epithelial nitric oxide in airway viral infection

Xu, W., Zheng, S., Dweik, R. A., & Erzurum, S. C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.037 · Cited by 85 · see citing works

Cystic Fibrosis and Normal Human Airway Epithelial Cell Response to Influenza A Viral Infection.

Xu, W., Zheng, S., Goggans, T., Kiser, P. K., Quiñones‐Mateu, M. E., Janocha, A. J., COMHAIR, S. A. A., Slee, R. B., Williams, B. R. G., & ERZURUM, S. C. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.609 · Cited by 41 · see citing works

Lack of an exaggerated inflammatory response on virus infection in cystic fibrosis

Kieninger, E., Vareille-Delarbre, M., Kopf, B. S., Blank, F., Alves, M. P., Gisler, F. M., Latzin, P., Casaulta, C., Geiser, T., Johnston, S. L., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00054511 · Cited by 37 · see citing works

CF airway epithelia display exaggerated host defense responses and prolonged cilia loss during RSV infection

Bartlett, J. A., Huntemann, E. D., Krishnamurthy, S., Hartwig, S. M., Pewa, A. D., Thurman, A. L., Chimenti, M. S., Taylor, E. B., Varga, S. M., & McCray, P. B. (2025) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2025.02.003 · Cited by 1 · see citing works