Cited by 85Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsAsthma and respiratory diseases

Role of epithelial nitric oxide in airway viral infection

Open access
Xu, Weiling, Zheng, Shuo, Dweik, Raed A., Erzurum, Serpil C.·2006·Free Radical Biology and Medicine

Abstract

The airway mucosal epithelium is the first site of virus contact with the host, and the main site of infection and inflammation. Nitric oxide (NO) produced by the airway epithelium is vital to antiviral inflammatory and immune defense in the lung. Multiple mechanisms function coordinately to support high-level basal NO synthesis in healthy airway epithelium and further induction of NO synthesis in the infected airway of normal hosts. Hosts deficient in NO synthesis, such as those patients with cystic fibrosis, have impaired antiviral defense and may benefit from therapies to augment NO levels in the airways.

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Registry

Crossref · 10.1016/j.freeradbiomed.2006.01.037

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  • NO is an important element in the control of viruses such as rhinovirus, cytomegalovirus, herpesvirus, and vaccinia virus.

    “NO is also an important element in the control of viruses such as rhinovirus, cytomegalovirus, herpesvirus, vaccinia virus, etc. [133].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [133]

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Authors
Xu, W., Zheng, S., Dweik, R. A., & Erzurum, S. C.
Affiliations
Cleveland Clinic (US)
Corresponding author
Xu, Weiling
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2006-07
Volume
41
Issue
1
Pages
19-28
ISSN
0891-5849 (ISSN-L)
OpenAlex
W1998513784
Cited by
85
References
148
Citations by year
2026: 1 · 2025: 6 · 2023: 5 · 2022: 12 · 2021: 9 · 2020: 6 · 2019: 2 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 5
FWCI
0.54
Type
journal article
Language
en
Open access
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL-68863, HL-60917, R37HL060917, R01HL060917, K23HL068863)
  • National Institute of Allergy and Infectious Diseases (AI70649)
  • National Center for Research Resources (M01RR018390)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
nitric oxide production, antiviral defense, airway inflammation, cystic fibrosis
MeSH terms
Animals, Cystic Fibrosis, Epithelium, Humans, Lung Diseases, Nitric Oxide, Signal Transduction, Nitric Oxide Synthase

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