Role of epithelial nitric oxide in airway viral infection
Open accessAbstract
The airway mucosal epithelium is the first site of virus contact with the host, and the main site of infection and inflammation. Nitric oxide (NO) produced by the airway epithelium is vital to antiviral inflammatory and immune defense in the lung. Multiple mechanisms function coordinately to support high-level basal NO synthesis in healthy airway epithelium and further induction of NO synthesis in the infected airway of normal hosts. Hosts deficient in NO synthesis, such as those patients with cystic fibrosis, have impaired antiviral defense and may benefit from therapies to augment NO levels in the airways.
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NO is an important element in the control of viruses such as rhinovirus, cytomegalovirus, herpesvirus, and vaccinia virus.
“NO is also an important element in the control of viruses such as rhinovirus, cytomegalovirus, herpesvirus, vaccinia virus, etc. [133].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [133]
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- Authors
- Xu, W., Zheng, S., Dweik, R. A., & Erzurum, S. C.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Xu, Weiling
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 41
- Issue
- 1
- Pages
- 19-28
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC7127628
- OpenAlex
- W1998513784
- Cited by
- 85
- References
- 148
- Citations by year
- 2026: 1 · 2025: 6 · 2023: 5 · 2022: 12 · 2021: 9 · 2020: 6 · 2019: 2 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-68863, HL-60917, R37HL060917, R01HL060917, K23HL068863)
- National Institute of Allergy and Infectious Diseases (AI70649)
- National Center for Research Resources (M01RR018390)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- nitric oxide production, antiviral defense, airway inflammation, cystic fibrosis
- MeSH terms
- Animals, Cystic Fibrosis, Epithelium, Humans, Lung Diseases, Nitric Oxide, Signal Transduction, Nitric Oxide Synthase
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