Cited by 125Cystic Fibrosis Research Advancesinterferon and immune responsesImmunodeficiency and Autoimmune Disorders

The DOI matches its Crossref record; 81 of the 82 references it cites were found in a registry or an index.

Impaired Innate Host Defense Causes Susceptibility to Respiratory Virus Infections in Cystic Fibrosis

Open access

Zheng, Shuo, De, Bishnu P, Choudhary, Suresh, Comhair, Suzy A.A, Goggans, Tannishia, Slee, Roger, Williams, Bryan R.G, Pilewski, Joseph, Haque, S.Jaharul, Erzurum, Serpil C·2003·Immunity

DOI 10.1016/s1074-7613(03)00114-6

Open this paper in CoChat — free account

Abstract

Viral infection is the primary cause of respiratory morbidity in cystic fibrosis (CF) infants. Here, we identify that host factors allow increased virus replication and cytokine production, providing a mechanism for understanding the severity of virus disease in CF. Increased virus is due to lack of nitric oxide synthase 2 (NOS2) and 2', 5' oligoadenylate synthetase (OAS) 1 induction in response to virus or IFNgamma. This can be attributed to impairment of activation of signal transducer and activator of transcription (STAT)1, a fundamental component to antiviral defense. NO donor or NOS2 overexpression provides protection from virus infection in CF, suggesting that NO is sufficient for antiviral host defense in the human airway and is one strategy for antiviral therapy in CF children.

Integrity signals

Registry

Crossref · 10.1016/s1074-7613(03)00114-6

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Identification of the Cystic Fibrosis Gene: Genetic Analysis
Kerem, B.-S., Rommens, J. M., Buchanan, J. A., Markiewicz, D., Cox, T. K., Chakravarti, A., Buchwald, M., & Tsui, L.-C. (1989) · Science · doi:10.1126/science.2570460 · Cited by 4,142
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Self-citation
Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping
Rommens, J. M., Iannuzzi, M. C., Kerem, B.-S., Drumm, M. L., Melmer, G., Dean, M. C., Rozmahel, R. F., Cole, J. L., Kennedy, D., Hidaka, N., et al. (1989) · Science · doi:10.1126/science.2772657 · Cited by 3,301
Antiviral Actions of Interferons
Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743
High density synthetic oligonucleotide arrays
Lipshutz, R. J., Fodor, S. P. A., Gingeras, T., & Lockhart, D. J. (1999) · Nature Genetics · doi:10.1038/4447 · Cited by 2,204
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,539
Structure and Function of the CFTR Chloride Channel
Sheppard, D. N., & Welsh, M. J. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s23 · Cited by 1,025
Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems
García‐Sastre, A., Egorov, A., Matassov, D., Brandt, S., Levy, D. E., Durbin, J. E., Palese, P., & Muster, T. (1998) · Virology · doi:10.1006/viro.1998.9508 · Cited by 1,000
Functional classification of interferon-stimulated genes identified using microarrays
de Veer, M. J., Holko, M., Frevel, M. A. E., Walker, E. M., Der, S., Paranjape, J. M., Silverman, R. H., & Williams, B. R. G. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.6.912 · Cited by 902
Self-citation
Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages
Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843
Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase
Karupiah, G., Xie, Q. W., Buller, R. M. L., Nathan, C., Duarte, C. J., & MacMicking, J. D. (1993) · Science · doi:10.1126/science.7690156 · Cited by 810
Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
Seo, S. H., Hoffmann, E., & Webster, R. G. (2002) · Nature Medicine · doi:10.1038/nm757 · Cited by 652
Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities
Samuel, C. E. (1991) · Virology · doi:10.1016/0042-6822(91)90112-o · Cited by 608
Generation of cAMP-Activated Chloride Currents by Expression of CFTR
Anderson, M. P., Rich, D. P., Gregory, R. J., Smith, A. E., & Welsh, M. J. (1991) · Science · doi:10.1126/science.1704151 · Cited by 554
Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.
Guo, F. H., Raeve, H. R. D., Rice, T. W., Stuehr, D. J., Thunnissen, E., & ERZURUM, S. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7809 · Cited by 517
Self-citation
Identification of the cystic fibrosis gene.
Knight, R. A., & Hodson, M. E. (1990) · BMJ · doi:10.1136/bmj.300.6721.345 · Cited by 504
Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication.
Croen, K. D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116479 · Cited by 463
I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation
Grisham, M. B., Jourd’heuil, D., & Wink, D. A. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.2.g315 · Cited by 451
Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice
Karaghiosoff, M., Neubauer, H. J., Lassnig, C., Kovarik, P., Schindler, H., Pircher, H., McCoy, B., Bogdan, C., Decker, T., Brem, G., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00054-6 · Cited by 423
Virus interference. II. Some properties of interferon
Isaacs, A., Lindenmann, J.-M., & Valentine, R. C. (1957) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1957.0049 · Cited by 421
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.
Müller, M., Laxton, C., Briscoe, J., Schindler, C., Improta, T., Darnell, J. E., Stark, G. R., & Kerr, I. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06106.x · Cited by 411
Proteomic method identifies proteins nitrated in vivo during inflammatory challenge
Aulak, K. S., Miyagi, M., Yan, L., West, K. A., Massillon, D., Crabb, J. W., & Stuehr, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221269198 · Cited by 350
Inactivation of ribonucleotide reductase by nitric oxide
Lepoivre, M., Fieschi, F., Covès, J., Thelander, L., & Fontecave, M. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91390-x · Cited by 329
Inhibition of Interferon-Mediated Antiviral Responses by Influenza A Viruses and Other Negative-Strand RNA Viruses
García‐Sastre, A. (2001) · Virology · doi:10.1006/viro.2000.0756 · Cited by 321
Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle
Pavlovic, J., Haller, O., & Staeheli, P. (1992) · Journal of Virology · doi:10.1128/jvi.66.4.2564-2569.1992 · Cited by 301
An Interferon-γ-activated Site (GAS) Is Necessary for Full Expression of the Mouse iNOS Gene in Response to Interferon-γ and Lipopolysaccharide
Gao, J., Morrison, D. C., Parmely, T. J., Russell, S. W., & Murphy, W. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.1226 · Cited by 300
p38 Mitogen-Activated Protein Kinase-Dependent and -Independent Signaling of mRNA Stability of AU-Rich Element-Containing Transcripts
Frevel, M. A. E., Bakheet, T. M., Silva, A. M., Hissong, J. G., Khabar, K. S. A., & Williams, B. R. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.425-436.2003 · Cited by 290
Self-citation
Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.
Zhu, Z., Tang, W., Ray, A., Wu, Y., Einarsson, O., Landry, M. L., Gwaltney, J., & Elias, J. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118431 · Cited by 282
Does Nitric Oxide Play a Critical Role in Viral Infections?
Reiss, C. S., & Komatsu, T. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.4547-4551.1998 · Cited by 272
2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A
Dong, B., & Silverman, R. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4133 · Cited by 261
Molecular Mechanisms of Increased Nitric Oxide (NO) in Asthma: Evidence for Transcriptional and Post-Translational Regulation of NO Synthesis
Guo, F. H., COMHAIR, S. A. A., Zheng, S., Dweik, R. A., Eissa, N. T., Thomassen, M. J., Calhoun, W. J., & ERZURUM, S. C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.5970 · Cited by 258
Self-citation
Nasal and Bronchoalveolar Lavage Fluid Cytokines in Early Cystic Fibrosis
Noah, T. L., Black, H. R., Cheng, P., Wood, R. E., & Leigh, M. W. (1997) · The Journal of Infectious Diseases · doi:10.1093/infdis/175.3.638 · Cited by 250
An Antiviral Mechanism of Nitric Oxide
Saura, M., Zaragoza, C., McMillan, A., Quick, R. A., Hohenadl, C., Lowenstein, J. M., & Lowenstein, C. J. (1999) · Immunity · doi:10.1016/s1074-7613(00)80003-5 · Cited by 245
Interferon Action in Triply Deficient Mice Reveals the Existence of Alternative Antiviral Pathways
Zhou, A., Paranjape, J. M., Der, S. D., Williams, B. R. G., & Silverman, R. H. (1999) · Virology · doi:10.1006/viro.1999.9738 · Cited by 244
Self-citation
Initial and innate responses to viral infections — pattern setting in immunity or disease
Biron, C. A. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)80066-6 · Cited by 239
Association of Respiratory Viral Infections with Pulmonary Deterioration in Patients with Cystic Fibrosis
Wang, E. E. L., Prober, C. G., Manson, B., Corey, M. L., & Levison, H. (1984) · New England Journal of Medicine · doi:10.1056/nejm198412273112602 · Cited by 235
Decreased SLIM1 Expression and Increased Gelsolin Expression in Failing Human Hearts Measured by High-Density Oligonucleotide Arrays
Yang, J., Moravec, C. S., Sussman, M. A., DiPaola, N. R., Fu, D., Hawthorn, L., Mitchell, C. A., Young, J. B., Francis, G. S., McCarthy, P. M., et al. (2000) · Circulation · doi:10.1161/01.cir.102.25.3046 · Cited by 222
The interferon antiviral response: from viral invasion to evasion
Grandvaux, N., tenOever, B. R., Servant, M. J., & Hiscott, J. B. (2002) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200206000-00008 · Cited by 216
Effects of Viral Lower Respiratory Tract Infection on Lung Function in Infants With Cystic Fibrosis
Hiatt, P., Grace, S. C., Kozinetz, C. A., RABOUDI, S. H., Treece, D. G., Taber, L. H., & Piedra, P. A. (1999) · PEDIATRICS · doi:10.1542/peds.103.3.619 · Cited by 215
Paramyxoviridae Use Distinct Virus-Specific Mechanisms to Circumvent the Interferon Response
Young, D. F., Didcock, L., Goodbourn, S., & Randall, R. E. (2000) · Virology · doi:10.1006/viro.2000.0240 · Cited by 196
Severe viral respiratory infections in infants with cystic fibrosis
Armstrong, D., Grimwood, K., Carlin, J. B., Carzino, R., Hull, J., Olinsky, A., & Phelan, P. D. (1998) · Pediatric Pulmonology · doi:10.1002/(sici)1099-0496(199812)26:6 · Cited by 196
Nitric Oxide Inhibits Rhinovirus-Induced Cytokine Production and Viral Replication in a Human Respiratory Epithelial Cell Line
Sanders, S. P., Siekierski, E. S., Porter, J. D., Richards, S. M., & Proud, D. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.934-942.1998 · Cited by 195
Kinase‐negative mutants of JAK1 can sustain interferon‐gamma‐inducible gene expression but not an antiviral state.
Briscoe, J., Rogers, N. C., Witthuhn, B. A., Watling, D., Harpur, A. G., Wilks, A. F., Stark, G. R., Ihle, J. N., & Kerr, I. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00415.x · Cited by 194
Interferon Consensus sequence-Binding Protein, a Member of the Interferon Regulatory Factor Family, Suppresses Interferon-Induced Gene Transcription
Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588-599.1993 · Cited by 192
Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.
Guo, F. H., Uetani, K., Haque, S. J., Williams, B. R. G., Dweik, R. A., Thunnissen, E., Calhoun, W. J., & ERZURUM, S. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119598 · Cited by 185
Self-citation
RESPIRATORY INFECTIONS IN CYSTIC FIBROSIS PATIENTS CAUSED BY VIRUS, CHLAMYDIA AND MYCOPLASMA–POSSIBLE SYNERGISM WITH PSEUDOMONAS AERUGINOSA
Petersen, N., Høiby, N., Mordhorst, C. H., Lind, K., Flensborg, E. W., & Bruun, B. (1981) · Acta Paediatrica · doi:10.1111/j.1651-2227.1981.tb05757.x · Cited by 184
Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus
Xiang, Y., CONDIT, R. C., Vijaysri, S., Jacobs, B. L., Williams, B. R. G., & Silverman, R. H. (2002) · Journal of Virology · doi:10.1128/jvi.76.10.5251-5259.2002 · Cited by 177
Self-citation
Degradation of STAT1 and STAT2 by the V Proteins of Simian Virus 5 and Human Parainfluenza Virus Type 2, Respectively: Consequences for Virus Replication in the Presence of Alpha/Beta and Gamma Interferons
Andrejeva, J., Young, D. F., Goodbourn, S., & Randall, R. E. (2002) · Journal of Virology · doi:10.1128/jvi.76.5.2159-2167.2002 · Cited by 166
Expression of IL-6, IL-8, and RANTES on human bronchial epithelial cells, NCI-H292, induced by influenza virus A
Matsukura, S., Kokubu, F., Noda, H., Tokunaga, H., & Adachi, M. (1996) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(96)80195-3 · Cited by 164
Regulation of IFN-alpha/beta, MxA, 2',5'-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells
Ronni, T., Matikainen, S., Sareneva, T., Melén, K., Pirhonen, J., Keskinen, P., & Julkunen, I. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.2363 · Cited by 155
Characterization of the Solution Complex between the Interferon-induced, Double-stranded RNA-activated Protein Kinase and HIV-I Trans-activating Region RNA
Carpick, B. W., Graziano, V., Schneider, D. K., Maitra, R. K., Lee, X., & Williams, B. R. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.9510 · Cited by 128
Self-citation
Signal transduction in the interferon system.
Haque, S. J., & Williams, B. (1998) · PubMed · Cited by 126
Self-citation
Inflammatory Response in Airway Epithelial Cells Isolated from Patients with Cystic Fibrosis
Aldallal, N., McNaughton, E. E., Manzel, L. J., Richards, A. M., Zabner, J., Ferkol, T. W., & Look, D. C. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200206-627oc · Cited by 125
Inhibition of Influenza Virus Replication by Nitric Oxide
Rimmelzwaan, G. F., Baars, M. M. J. W., de Lijster, P., Fouchier, R. A. M., & Osterhaus, A. D. M. E. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8880-8883.1999 · Cited by 120
Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites.
Karupiah, G., & Harris, N. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2171 · Cited by 104
Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA
ERZURUM, S. C., Lemarchand, P., Rosenfeld, M. A., Yoo, J.-H., & Crystal, R. G. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.7.1607 · Cited by 103
Self-citation
Activation of NF-κB by Double-Stranded RNA (dsRNA) in the Absence of Protein Kinase R and RNase L Demonstrates the Existence of Two Separate dsRNA-Triggered Antiviral Programs
Iordanov, M. S., Wong, J. W., Bell, J. C., & Magun, B. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.61-72.2001 · Cited by 101
Central Role of Double-Stranded RNA-Activated Protein Kinase in Microbial Induction of Nitric Oxide Synthase
Uetani, K., Der, S. D., Zamanian-Daryoush, M., de la Motte, C., Lieberman, B. Y., Williams, B. R. G., & Erzurum, S. C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.988 · Cited by 100
Self-citation
Nitric oxide inhibition of coxsackievirus replication in vitro.
Zaragoza, C., Ocampo, C. J., Saura, M., McMillan, A., & Lowenstein, C. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119702 · Cited by 91
Exhaled nitric oxide is reduced in infants with cystic fibrosis
Elphick, H. (2001) · Thorax · doi:10.1136/thorax.56.2.151 · Cited by 81
A Specific Isozyme of 2′-5′ Oligoadenylate Synthetase Is a Dual Function Proapoptotic Protein of the Bcl-2 Family
Ghosh, A., Sarkar, S. N., Rowe, T. M., & Sen, G. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100496200 · Cited by 80
Cystic Fibrosis Transmembrane Conductance Regulator–Dependent Regulation of Epithelial Inducible Nitric Oxide Synthase Expression
Steagall, W. K., Elmer, H. L., Brady, K. G., & Kelley, T. J. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.22.1.3789 · Cited by 80
In vivo antioxidant gene expression in human airway epithelium of normal individuals exposed to 100% O2
ERZURUM, S. C., Danel, C. J., Gillissen, A., Chu, C. S., Trapnell, B. C., & Crystal, R. G. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1256 · Cited by 78
Self-citation
Innate Immune Responses to Cytomegalovirus Infection in the Developing Mouse Brain and Their Evasion by Virus-Infected Neurons
Kosugi, I., Kawasaki, H., Arai, Y., & Tsutsui, Y. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64252-6 · Cited by 73
Prolonged STAT1 Activation Is Associated with Interferon-γ Priming for Interleukin-1-induced Inducible Nitric-oxide Synthase Expression by Islets of Langerhans
Heitmeier, M. R., Scarim, A. L., & Corbett, J. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29266 · Cited by 73
Identification ofNitric Oxide Synthase 2as an Innate Resistance Locus against Ectromelia Virus Infection
Karupiah, G., Chen, J.-H., Nathan, C., Mahalingam, S., & MacMicking, J. D. (1998) · Journal of Virology · doi:10.1128/jvi.72.9.7703-7706.1998 · Cited by 65
Role of Nitric Oxide Synthase Type 2 in Acute Infection with Murine Cytomegalovirus
Noda, S., TANAKA, K. A., Sawamura, S., Sasaki, M., Matsumoto, T., Mikami, K., Aiba, Y., Hasegawa, H., Kawabe, N., & Koga, Y. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3533 · Cited by 61
Cellular protein kinase C isoform zeta regulates human parainfluenza virus type 3 replication.
De, B. P., Gupta, S., Gupta, S., & Banerjee, A. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.5204 · Cited by 61
Self-citation
Role of cellular actin in human parainfluenza virus type 3 genome transcription.
De, B. P., Burdsall, A., & Banerjee, A. K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53375-5 · Cited by 59
Self-citation
A Critical Role for Inducible Nitric Oxide Synthase in Host Survival Following Coxsackievirus B4 Infection
Flodström‐Tullberg, M., Horwitz, M. S., Maday, A., Balakrishna, D., Rodriguez, E., & Sarvetnick, N. (2001) · Virology · doi:10.1006/viro.2000.0801 · Cited by 58
In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium
Kelley, T. J., & Elmer, H. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9560 · Cited by 53
Effects of acute viral respiratory tract infections in patients with cystic fibrosis
Hordvik, N. L., König, P., Hamory, B. H., Cooperstock, M. S., Kreutz, C., Gayer, D., & Barbero, G. J. (1989) · Pediatric Pulmonology · doi:10.1002/ppul.1950070406 · Cited by 45
Asthma, Viruses, and Nitric Oxide
Sanders, S. P. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-19.x · Cited by 43
Human Parainfluenza Virus Type 3 Up-Regulates Major Histocompatibility Complex Class I and II Expression on Respiratory Epithelial Cells: Involvement of a STAT1- and CIITA-Independent Pathway
Gao, J., De, B. P., & Banerjee, A. K. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1411-1418.1999 · Cited by 43
Self-citation
Role of NH 2 - and COOH-Terminal Domains of the P Protein of Human Parainfluenza Virus Type 3 in Transcription and Replication
De, B. P., Hoffman, M. A., Choudhary, S. K., Huntley, C. C., & Banerjee, A. K. (2000) · Journal of Virology · doi:10.1128/jvi.74.13.5886-5895.2000 · Cited by 39
Self-citation
Interferon Action against Human Parainfluenza Virus Type 3: Involvement of a Novel Antiviral Pathway in the Inhibition of Transcription
Choudhary, S. K., Gao, J., Leaman, D. W., & De, B. P. (2001) · Journal of Virology · doi:10.1128/jvi.75.10.4823-4831.2001 · Cited by 34
Self-citation
Yet Another Role for the Cystic Fibrosis Transmembrane Conductance Regulator
Widdicombe, J. H. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.22.1.f177 · Cited by 19
Evolution of airway microbiology in the infant with cystic fibrosis: role of nonpseudomonal and pseudomonal pathogens.
Rosenfeld, M., & Ramsey, B. W. (1992) · PubMed · Cited by 16
Complementation of an
Patton, D. A., Volrath, S., & Ward, E. R. (1996) · Molecular and General Genetics MGG · doi:10.1007/s004380050166 · Cited by 5

Research works printed but not linked: 2

Cystic Fibrosis Foundation. (2000). Patient Registry 2000 Annual Report (Bethesda, Maryland, Cystic Fibrosis Foundation), pp. 1.
Rosenfeld, 1992, Evolution of airway microbiology in the infant with cystic fibrosis, Semin. Respir. Infect., 7, 158

Sorted by citations

The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Cystic fibrosis: a mucosal immunodeficiency syndrome
Cohen, T. S., & Prince, A. S. (2012) · Nature Medicine · doi:10.1038/nm.2715 · Cited by 506
The innate immune function of airway epithelial cells in inflammatory lung disease
Hiemstra, P. S., McCray, P. B., & Bals, R. (2015) · European Respiratory Journal · doi:10.1183/09031936.00141514 · Cited by 425
Barrier function of airway tract epithelium
Ganesan, S., Comstock, A. T., & Sajjan, U. S. (2013) · Tissue Barriers · doi:10.4161/tisb.24997 · Cited by 366
The role of airway epithelial cells and innate immune cells in chronic respiratory disease
Holtzman, M. J., Byers, D. E., Alexander‐Brett, J. M., & Wang, X. (2014) · Nature reviews. Immunology · doi:10.1038/nri3739 · Cited by 246

See all 125

Authors: Zheng, S., De, B. P., Choudhary, S., Comhair, S. A. A., Goggans, T., Slee, R., Williams, B. R. G., Pilewski, J., Haque, S. J., & Erzurum, S. C.
Affiliations: Cleveland Clinic (US)
University of Pittsburgh (US)
Corresponding author: Erzurum, Serpil C
ORCID: Zheng, Shuo
Choudhary, Suresh
Comhair, Suzy A.A
Williams, Bryan R.G
Pilewski, Joseph
Haque, S.Jaharul
Erzurum, Serpil C
Venue: Immunity
Publisher: Elsevier BV
Published: 2003-05
Volume: 18
Issue: 5
Pages: 619-630
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/s1074-7613(03)00114-6
OpenAlex: W2025877008
Cited by: 125
References: 82
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 1 · 2017: 4 · 2016: 7 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 11
FWCI: 5.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3730 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: Cystic Fibrosis Foundation
National Institutes of Health (P50 DK56490)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords: cystic fibrosis, respiratory viral infections, antiviral innate immunity, nitric oxide synthase 2, 2',5'-oligoadenylate synthetase, STAT1 signaling, interferon-gamma, nitric oxide, cytokine production, viral replication, airway immunity, antiviral therapy
MeSH terms: Antiviral Agents, Cystic Fibrosis, Disease Susceptibility, Humans, Immunity, Innate, Interferons, Parainfluenza Virus 3, Human, Respirovirus Infections, Transcription Factors, Nitric Oxide Synthase, Nitric Oxide Donors, Nitric Oxide Synthase Type II, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impaired Innate Host Defense Causes Susceptibility to Respiratory Virus Infections in Cystic Fibrosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks