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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control
Open accessAbstract
The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin-sensitive manner. TOR2 additionally regulates polarization of the actin cytoskeleton in a rapamycin-insensitive manner. We describe two functionally distinct TOR complexes. TOR Complex 1 (TORC1) contains TOR1 or TOR2, KOG1 (YHR186c), and LST8. TORC2 contains TOR2, AVO1 (YOL078w), AVO2 (YMR068w), AVO3 (YER093c), and LST8. FKBP-rapamycin binds TORC1, and TORC1 disruption mimics rapamycin treatment, suggesting that TORC1 mediates the rapamycin-sensitive, TOR-shared pathway. FKBP-rapamycin fails to bind TORC2, and TORC2 disruption causes an actin defect, suggesting that TORC2 mediates the rapamycin-insensitive, TOR2-unique pathway. Thus, the distinct TOR complexes account for the diversity, specificity, and selective rapamycin inhibition of TOR signaling. TORC1 and possibly TORC2 are conserved from yeast to man.
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“specifically, mTORC2 contains the mTOR, Rictor, LST8 and SIN1 proteins (Loewith et al., 2002).”
From Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities (2021) · cites this paper as Loewith et al., 2002
In the citing paper
“which was discovered after it was shown that rapamycin is able to inhibit mTORC1 via binding to the protein FKBP12 (REFS31,32).”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [31]
In the citing paper
“mTOR is present in two complexes, mTORC1 (associated with ‘raptor’) and mTORC2 (associated with ‘rictor’), accounting for the diversity, specificity and selectivity of rapamycin-mediated inhibition of TOR signalling”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [31]
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Cites
Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels
Shevchenko, A., Wilm, M. S., Vorm, O., & Mann, M. (1996) · Analytical Chemistry · doi:10.1021/ac950914h · Cited by 8,996
Current protocols in molecular biology
Sargent, T. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90147-9 · Cited by 7,281
Sherman, F. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94004-v · Cited by 4,078
Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051
Bähler, J., Wu, J., Longtine, M. S., Shah, N. G., Mckenzie, A., Steever, A. B., Wach, A., Philippsen, P., & Pringle, J. R. (1998) · Yeast · doi:10.1002/(sici)1097-0061(199807)14:10 · Cited by 2,208
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
Heitman, J., Movva, N. R., & Hall, M. N. (1991) · Science · doi:10.1126/science.1715094 · Cited by 2,010
Self-citationTOR, a Central Controller of Cell Growth
Schmelzle, T., & Hall, M. N. (2000) · Cell · doi:10.1016/s0092-8674(00)00117-3 · Cited by 1,914
Self-citationRaptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action
Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810
The Tandem Affinity Purification (TAP) Method: A General Procedure of Protein Complex Purification
Puig, Ó., Caspary, F., Rigaut, G., Rutz, B., Bouveret, E., Bragado‐Nilsson, E., Wilm, M. S., & Séraphin, B. (2001) · Methods · doi:10.1006/meth.2001.1183 · Cited by 1,784
Regulation of translation initiation by FRAP/mTOR
Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545
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Meyer, V., Arentshorst, M., Flitter, S. J., Nitsche, B. M., Kwon, M. J., Reynaga‐Peña, C. G., Bartnicki-Garcı́a, S., van den Hondel, C. A. M. J. J., & Ram, A. F. J. (2009) · Eukaryotic Cell · doi:10.1128/ec.00050-09 · Cited by 52
Crespo, J. L., Helliwell, S. B., Niederhauser-Wiederkehr, C., Demougin, P., Fowler, B., Primig, M., & Hall, M. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407372200 · Cited by 52
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Magri, L., & Galli, R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1196-x · Cited by 52
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Tan, H. K., Moad, A. I. H., & Tan, M. L. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.16.6463 · Cited by 51
Valbuena, N., Rozalén, A. E., & Moreno, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.105395 · Cited by 51
Prizant, R. L., & Barash, I. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21904 · Cited by 51
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Gao, W. Z., Zhao, Y., Li, X. O., Sun, Y., Cai, M., Cao, W., Liu, Z., Tong, L., Cui, G., & Tang, B. (2017) · Chemical Science · doi:10.1039/c7sc03582a · Cited by 51
Emerging Role of mTOR Signaling‐Related miRNAs in Cardiovascular Diseases
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Wu, C., & Storey, K. B. (2021) · Biomolecules · doi:10.3390/biom11050681 · Cited by 54
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Tan, B. S. N., Lonic, A., Morris, M. B., Rathjen, P. D., & Rathjen, J. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00235.2010 · Cited by 50
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Martı́n, H., Shales, M., Fernández-Piñar, P., Wei, P., Molina, M., Fiedler, D., Shokat, K. M., Beltrão, P., Lim, W. A., & Krogan, N. J. (2015) · Molecular Systems Biology · doi:10.15252/msb.20145606 · Cited by 52
Odaka, Y., Xu, B., Luo, Y., Shen, T., Shang, C., Wu, Y., Zhou, H., & Huang, S. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt277 · Cited by 50
Cortéz, C., Real, F., & Yoshida, N. (2015) · Cellular Microbiology · doi:10.1111/cmi.12548 · Cited by 50
Chen, B. W., Chen, W., Liang, H., Liu, H., Liang, C., Zhi, X., Hu, L.-Q., Yu, X.-Z., Wei, T., Ma, T., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0029 · Cited by 50
Breitenbach, M., Laun, P., & Jazwinski, S. M. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2561-4 · Cited by 55
Jiang, X., & Yeung, R. S. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4510 · Cited by 51
Ohji, G., Sujuti, H., Nakashima, A., Tokunaga, C., Oshiro, N., Yoshino, K., Yokono, K., Kikkawa, U., & Yonezawa, K. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj008 · Cited by 50
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Díaz‐Troya, S., Pérez‐Pérez, M. E., Pérez-Martín, M., Moes, S., Jenö, P., Florencio, F. J., & Crespo, J. L. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.179861 · Cited by 51
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Martino, M. C. D., van Koetsveld, P. M., Feelders, R. A., Sprij-Mooij, D. M., Waaijers, M., Lamberts, S. W. J., de Herder, W. W., Colao, A., Pivonello, R., & Hofland, L. J. (2012) · Endocrine Related Cancer · doi:10.1530/erc-11-0270 · Cited by 48
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Liu, D., Li, P., Song, S., Liu, Y., Wang, Q., Chang, Y., Wu, Y., Chen, J., Zhao, W., Zhang, L., et al. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.026 · Cited by 45
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Zimmermann, C., Santos, A. X. S., Gable, K. S., Epstein, S., Gururaj, C. S., Chymkowitch, P., Pultz, D., Rødkær, S. V., Clay, L., Bjørås, M., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.024 · Cited by 44
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Metadata
- Authors
- Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Hall, Michael N.
- ORCID
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 10
- Issue
- 3
- Pages
- 457-468
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2152600551
- Cited by
- 1,886
- References
- 59
- Citations by year
- 2026: 37 · 2025: 47 · 2024: 68 · 2023: 65 · 2022: 75 · 2021: 79 · 2020: 70 · 2019: 76 · 2018: 76 · 2017: 100 · 2016: 68 · 2015: 115 · 2014: 97 · 2013: 103 · 2012: 135
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- TOR signaling, TOR1, TOR2, rapamycin sensitivity, cell growth regulation, LST8, Saccharomyces cerevisiae
- MeSH terms
- Actins, Animals, Antifungal Agents, Cell Line, Cytoskeleton, Fungal Proteins, Glycogen, Humans, Protein Binding, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Tissue Distribution, Signal Transduction, Phosphotransferases (Alcohol Group Acceptor), Genes, Reporter, Cell Cycle Proteins, Phosphatidylinositol 3-Kinases, Sirolimus, Tacrolimus Binding Proteins, Drug Resistance, Fungal, Saccharomyces cerevisiae Proteins, Macromolecular Substances
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