The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
PKC downregulation upon rapamycin treatment attenuates mitochondrial disease
Published version of a preprint
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Inhibition of mTORC2 signaling extends the lifespan of C. elegans under certain temperatures and dietary conditions111,112, has anti-tumor effects 128–131, is beneficial in mouse models of mitochondrial disease132,133, and has been shown to inhibit or reverse senescence in human cells 134,135.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [133]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886
Geiger, T., Wehner, A., Schaab, C., Cox, J., & Mann, M. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.014050 · Cited by 797
Hung, V., Zou, P., Rhee, H.-W., Udeshi, N. D., Cracan, V., Svinkina, T., Carr, S. A., Mootha, V. K., & Ting, A. Y. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.003 · Cited by 517
A cannabinoid link between mitochondria and memory
Hebert-Chatelain, E., Desprez, T., Serrat, R., Bellocchio, L., Soria-Gomez, E., Busquets-Garcia, A., Pagano Zottola, A. C., Delamarre, A., Cannich, A., Vincent, P., et al. (2016) · Nature · doi:10.1038/nature20127 · Cited by 434
Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease
Distelmaier, F., Koopman, W. J. H., van den Heuvel, L. P., Rodenburg, R. J., Mayatepek, E., Willems, P. H. G. M., & Smeitink, J. A. M. (2008) · Brain · doi:10.1093/brain/awp058 · Cited by 310
Research works printed but not linked: 42
- Rich, P. Chemiosmotic coupling: the cost of living. Nature 421, 583 (2003). · DOI
- Darin, N., Oldfors, A., Moslemi, A. R., Holme, E. & Tulinius, M. The incidence of mitochondrial encephalomyopathies in childhood: clinical features and morphological, biochemical, and DNA abnormalities. Ann. Neurol. 49, 377–383 (2001). · DOI
- Quintana, A., Kruse, S. E., Kapur, R. P., Sanz, E. & Palmiter, R. D. Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome. Proc. Natl Acad. Sci. USA 107, 10996–11001 (2010). · DOI
- Johnson, S. C. et al. mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science 342, 1524–1528 (2013). · DOI · Paper page
- Ising, C. et al. Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol. Med. 7, 275–287 (2015). · DOI
- Khan, N. A. et al. mTORC1 regulates mitochondrial integrated stress response and mitochondrial myopathy progression. Cell Metab. 26, 419–428.e5 (2017). · DOI
- Jacinto, E. et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122–1128 (2004). · DOI
- Sarbassov, D. D. et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22, 159–168 (2006). · DOI · Paper page
- Lamming, D. W. et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335, 1638–1643 (2012). · DOI · Paper page
- Sarbassov, D. D. et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296–1302 (2004). · DOI · Paper page
- Guertin, D. A. et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCɑ, but not S6K1. Dev. Cell. 11, 859–871 (2006). · DOI
- Gould, C. M. & Newton, A. C. The life and death of protein kinase C. Curr. Drug Targets 9, 614–625 (2008). · DOI
- Wang, Y. et al. Sequential posttranslational modifications regulate PKC degradation. Mol. Biol. Cell 27, 410–420 (2016). · DOI
- Ikenoue, T. et al. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signaling. EMBO J. 27, 1919–1931 (2008). · DOI
- Moon, J.-S. et al. mTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation. Cell Rep. 12, 102–115 (2015). · DOI
- Savaskan, N. E., Bräuer, A. U. & Nitsch, R. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Eur. J. Neurosci. 19, 212–220 (2004). · DOI
- Shibuya, N. et al. 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid. Redox Signal. 11, 703–714 (2009). · DOI
- Wesseling, H., Elgersma, Y. & Bahn, S. A brain proteomic investigation of rapamycin effects in the Tsc1+/− mouse model. Mol. Autism 8, 41 (2017). · DOI
- Peretti, D. et al. RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration. Nature 518, 236–239 (2015). · DOI
- Zhu, X., Bührer, C. & Wellmann, S. Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold. Cell. Mol. Life Sci. 73, 3839–3859 (2016). · DOI
- Wu, R. et al. A large-scale method to measure absolute protein phosphorylation stoichiometries. Nat. Methods 8, 677–683 (2011). · DOI
- Niemi, N. M. et al. Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis. Nat. Commun. 10, 3197 (2019). · DOI
- Hijazi, M. et al. Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring. Nat. Biotechnol. 38, 493–502 (2020). · DOI
- Ochoa, D. et al. An atlas of human kinase regulation. Mol. Syst. Biol. 12, 888 (2016). · DOI
- Zhou, X., Yang, W. & Li, J. Ca2+- and protein kinase C-dependent signaling pathway for nuclear factor-κB activation, inducible nitric-oxide synthase expression, and tumor necrosis factor-ɑ production in lipopolysaccharide-stimulated rat peritoneal macrophages. J. Biol. Chem. 281, 31337–31347 (2006). · DOI
- Lieu, Q. et al. Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway. J. Neuroinflammation 16, 10 (2019).
- Leitges, M. et al. Immunodeficiency in protein kinase Cβ-deficient mice. Science 273, 788–791 (1996). · DOI
- Jope, R. S., Yuskaitis, C. J. & Beurel, E. Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem. Res. 32, 577–595 (2007). · DOI · Paper page
- Mochly-Rose, D., Das, K. & Grimes, K. V. Protein kinase C, an elusive therapeutic target? Nat. Rev. Drug Discov. 11, 937–957 (2012). · DOI
- Aiello, L. P. et al. Oral protein kinase C β inhibition using ruboxistaurin: efficacy, safety, and causes of vision loss among 813 patients (1,392 eyes) with diabetic retinopathy in the protein kinase C β inhibitor-diabetic retinopathy study and the protein kinase C β inhibitor-diabetic retinopathy study 2. Retina 31, 2084–2094 (2011). · DOI
- Jin, Z., Wei, W., Yang, M., Du, Y. & Wan, Y. Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization. Cell Metab. 20, 483–498 (2014). · DOI · Paper page
- Lamming, D. W. et al. Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. Aging Cell 13, 911–917 (2014). · DOI · Paper page
- Fang, Y. et al. Effects of rapamycin on growth hormone receptor knockout mice. Proc. Natl Acad. Sci. USA 115, E1495–E1503 (2018).
- Sage-Schwaede, A. et al. Exploring mTOR inhibition as treatment for mitochondrial disease. Ann. Clin. Transl. Neurol. 6, 1877–1881 (2019). · DOI
- Johnson, S. C. et al. mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases. Kidney Int. 95, 455–466 (2019). · DOI
- Cox, J. & Mann, M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat. Biotechnol. 26, 1367–1372 (2008). · DOI · Paper page
- Tyanova, S. et al. The Perseus computational platform for comprehensive analysis of (prote)omics data. Nat. Methods 13, 731–740 (2016). · DOI · Paper page
- Cox, J. & Mann, M. 1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data. BMC Bioinform. 13, S12 (2012). · DOI
- Calvo, S. E., Clauser, K. R. & Mootha, V. K. MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins. Nucleic Acids Res. 44, D1251–D1257 (2016). · DOI · Paper page
- Eden, E. et al. GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinform. 10, 48 (2009). · DOI · Paper page
- Hornbeck, P. V. et al. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Nucleic Acids Res. 43, D512–D520 (2015). · DOI · Paper page
- Schwartz, D. & Gygi, S. P. An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets. Nat. Biotechnol. 23, 1391–1398 (2005). · DOI
Cited by
Sorted by citations
Targeting the biology of aging with mTOR inhibitors
Mannick, J. B., & Lamming, D. W. (2023) · Nature Aging · doi:10.1038/s43587-023-00416-y · Cited by 372
Metadata
- Authors
- Martin-Perez, M., Grillo, A. S., Ito, T. K., Valente, A. S., Han, J., Entwisle, S. W., Huang, H. Z., Kim, D., Yajima, M., Kaeberlein, M., & Villén, J.
- ORCID
- Venue
- Nature Metabolism
- Published
- 2020-12-14
- Volume
- 2
- Issue
- 12
- Pages
- 1472-1481
- ISSN
- 2522-5812
- PMC
- PMC8017771
- Cited by
- 45
- References
- 5
- Language
- en
- Licence
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (F32 NS110109, R01 NS098329)
- MEXT | Japan Society for the Promotion of Science (postdoctoral fellowship)
- Uehara Memorial Foundation (postdoctoral fellowship)
- U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine (T32 LM012419)
- U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (T32 HG00035)
- Samuel and Althea Stroum Endowed Graduate Fellowships
- U.S. Department of Health & Human Services | NIH | National Institute on Aging (P30 AG013280)
- U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R35 GM119536)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: PKC downregulation upon rapamycin treatment attenuates mitochondrial disease. https://app.cochat.ai/papers/10.1038/s42255-020-00319-x
- The paper
- Martin-Perez, M., Grillo, A. S., Ito, T. K., Valente, A. S., Han, J., Entwisle, S. W., Huang, H. Z., Kim, D., Yajima, M., Kaeberlein, M., & Villén, J. (2020). PKC downregulation upon rapamycin treatment attenuates mitochondrial disease. Nature Metabolism. https://doi.org/10.1038/s42255-020-00319-x