Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

Shevchenko, A., Wilm, M. S., Vorm, O., & Mann, M. (1996) · Analytical Chemistry · doi:10.1021/ac950914h · Cited by 8,996

Current protocols in molecular biology

Sargent, T. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90147-9 · Cited by 7,281

Getting started with yeast

Sherman, F. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94004-v · Cited by 4,078

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Heterologous modules for efficient and versatile PCR-based gene targeting inSchizosaccharomyces pombe

Bähler, J., Wu, J., Longtine, M. S., Shah, N. G., Mckenzie, A., Steever, A. B., Wach, A., Philippsen, P., & Pringle, J. R. (1998) · Yeast · doi:10.1002/(sici)1097-0061(199807)14:10 · Cited by 2,208

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

Heitman, J., Movva, N. R., & Hall, M. N. (1991) · Science · doi:10.1126/science.1715094 · Cited by 2,010

TOR, a Central Controller of Cell Growth

Schmelzle, T., & Hall, M. N. (2000) · Cell · doi:10.1016/s0092-8674(00)00117-3 · Cited by 1,914

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810

The Tandem Affinity Purification (TAP) Method: A General Procedure of Protein Complex Purification

Puig, Ó., Caspary, F., Rigaut, G., Rutz, B., Bouveret, E., Bragado‐Nilsson, E., Wilm, M. S., & Séraphin, B. (2001) · Methods · doi:10.1006/meth.2001.1183 · Cited by 1,784

Regulation of translation initiation by FRAP/mTOR

Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

Wei, M., Fabrizio, P., Hu, J. H., Ge, H., Cheng, C., Li, L., & Longo, V. D. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040013 · Cited by 460

eIF4E – from translation to transformation

Mamane, Y., Petroulakis, E., Rong, L., Yoshida, K., Ler, L. W., & Sonenberg, N. (2004) · Oncogene · doi:10.1038/sj.onc.1207549 · Cited by 465

Targeting mTOR signaling for cancer therapy

Huang, S. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(03)00071-7 · Cited by 441

mTOR substrate phosphorylation in growth control

Battaglioni, S., Benjamin, D., Wälchli, M., Maier, T., & Hall, M. N. (2022) · Cell · doi:10.1016/j.cell.2022.04.013 · Cited by 443

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

Özcan, U., Özcan, L., Yılmaz, E., Düvel, K., Şahin, M., Manning, B. D., & Hotamışlıgil, G. S. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.023 · Cited by 449

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

Julien, L.-A., Carriere, A., Moreau, J., & Roux, P. P. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00601-09 · Cited by 452

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

Binda, M., Gulli, M., Bonfils, G., Panchaud, N., Urban, J., Sturgill, T. W., Loewith, R., & VIRGILIO, C. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.033 · Cited by 432

mTOR as a central regulator of lifespan and aging

Papadopoli, D. J., Boulay, K., Kazak, L., Pollak, M., Mallette, F. A., Topisirović, I., & Hulea, L. (2019) · F1000Research · doi:10.12688/f1000research.17196.1 · Cited by 447

mTOR and cancer: many loops in one pathway

Efeyan, A., & Sabatini, D. M. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.10.007 · Cited by 441

Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer

Liu, G., Pei, F., Yang, F., Li, L., Amin, A. D., Liu, S., Buchan, J. R., & Cho, W. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020367 · Cited by 430

Reduced TOR Signaling Extends Chronological Life Span via Increased Respiration and Upregulation of Mitochondrial Gene Expression

Bonawitz, N. D., Chatenay-Lapointe, M., Pan, Y., & Shadel, G. S. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.009 · Cited by 422

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting

Tintignac, L. A. J., Brenner, H.-R., & Rüegg, M. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00033.2014 · Cited by 449

Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1

Dibble, C. C., Asara, J. M., & Manning, B. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00735-09 · Cited by 433

Sensing the environment: lessons from fungi

Bahn, Y., Xue, C., Idnurm, A., Rutherford, J. C., Heitman, J., & Cardenas, M. E. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1578 · Cited by 416

mTORC2 Promotes Tumorigenesis via Lipid Synthesis

Guri, Y., Colombi, M., Dazert, E., Hindupur, S. K., Roszik, J., Moes, S., Jenoe, P., Heim, M. H., Riezman, I., Riezman, H., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.11.011 · Cited by 418

Nutrient signaling to mTOR and cell growth

Jewell, J. L., & Guan, K. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.01.004 · Cited by 420

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

Tzatsos, A., & Kandror, K. V. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.63-76.2006 · Cited by 399

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

Kwiatkowski, D. J., & Manning, B. D. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi260 · Cited by 332

Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

Corradetti, M. N., & Guan, K.-L. (2006) · Oncogene · doi:10.1038/sj.onc.1209885 · Cited by 396

Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability

Shiota, C., Woo, J., Lindner, J., Shelton, K. D., & Magnuson, M. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.08.013 · Cited by 387

Progeria syndromes and ageing: what is the connection?

Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386

Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38

Bai, X., Ma, D., Liu, A., Shen, X., Wang, Q. J., Liu, Y., & Jiang, Y. (2007) · Science · doi:10.1126/science.1147379 · Cited by 382

Amino acid regulation of TOR complex 1

Avruch, J., Long, X., Ortiz-Vega, S., Rapley, J., Papageorgiou, A., & Dai, N. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90645.2008 · Cited by 400

mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

Fraenkel, M., Ketzinel‐Gilad, M., Ariav, Y., Pappo, O., Karaca, M., Castel, J., Berthault, M., Magnan, C., Cerasi, E., Kaiser, N., et al. (2008) · Diabetes · doi:10.2337/db07-0922 · Cited by 386

A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

Kimura, N., Tokunaga, C., Dalal, S., Richardson, C., Yoshino, K., Hara, K., Kemp, B. E., Witters, L. A., Mimura, O., & Yonezawa, K. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00615.x · Cited by 372

Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement

Sasaki, A. T., Chun, C., Takeda, K., & Firtel, R. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200406177 · Cited by 363

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

Petit, C. S., Roczniak-Ferguson, A., & Ferguson, S. M. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201307084 · Cited by 355

Recent advances in the protein kinase B signaling pathway

Woodgett, J. R. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.010 · Cited by 352

Architecture of human mTOR complex 1

Aylett, C. H. S., Sauer, E., Imseng, S., Boehringer, D., Hall, M. N., Ban, N., & Maier, T. (2016) · Science · doi:10.1126/science.aaa3870 · Cited by 344

The TOR pathway comes of age

Stanfel, M. N., Shamieh, L. S., Kaeberlein, M. R., & Kennedy, B. K. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.007 · Cited by 347

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

Bonfils, G., Jaquenoud, M., Bontron, S., Ostrowicz, C. W., Ungermann, C., & VIRGILIO, C. D. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.02.009 · Cited by 338

Stress and mTORture signaling

Reiling, J. H., & Sabatini, D. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209889 · Cited by 311

The TOR and EGO Protein Complexes Orchestrate Microautophagy in Yeast

Dubouloz, F., Deloche, O., Wanke, V., Cameroni, E., & VIRGILIO, C. D. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.05.020 · Cited by 336

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor.Preprint

Fox, C., Hammerman, P., Cinalli, R. M., Master, S., Chodosh, L., & Thompson, C. (2003) · Genes & Development · doi:10.1101/gad.1105003 · Cited by 366

Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

Carrière, A., Cargnello, M., Julien, L.-A., Gao, H., Bonneil, É., Thibault, P., & Roux, P. P. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.078 · Cited by 348

Signaling by Target of Rapamycin Proteins in Cell Growth Control

Inoki, K., Ouyang, H., Li, Y., & Guan, K. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.1.79-100.2005 · Cited by 335

Regulation of Tissue Growth through Nutrient Sensing

Hietakangas, V., & Cohen, S. M. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134815 · Cited by 341

Common corruption of the mTOR signaling network in human tumors

Menon, S., & Manning, B. D. (2008) · Oncogene · doi:10.1038/onc.2009.352 · Cited by 345

mTOR, translational control and human disease

Tee, A. R., & Blenis, J. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.11.005 · Cited by 325

Nutrient-Sensing Mechanisms across Evolution

Chantranupong, L., Wolfson, R. L., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.02.041 · Cited by 324

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

Pan, Y., Schroeder, E. A., Ocampo, A., Barrientos, A., & Shadel, G. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.018 · Cited by 324

Dissociation of raptor from mTOR is a mechanism of rapamycin‐induced inhibition of mTOR function

Oshiro, N., Yoshino, K., Sujuti, H., Tokunaga, C., Hara, K., Eguchi, S., Avruch, J., & Yonezawa, K. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00727.x · Cited by 314

Nutrient regulates Tor1 nuclear localization and association with rDNA promoter

Li, H., Tsang, C. K., Watkins, M. P., Bertram, P. G., & Zheng, X.-F. (2006) · Nature · doi:10.1038/nature05020 · Cited by 299

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

Sparks, C. A., & Guertin, D. A. (2010) · Oncogene · doi:10.1038/onc.2010.139 · Cited by 299

Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

Avruch, J., Hara, K., Lin, Y., Liu, M., Long, X., Ortiz-Vega, S., & Yonezawa, K. (2006) · Oncogene · doi:10.1038/sj.onc.1209882 · Cited by 301

PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis

Thedieck, K., Polak, P., Kim, M. L., Molle, K. D., Cohen, A., Jenö, P., Arrieumerlou, C., & Hall, M. N. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001217 · Cited by 300

Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae

Strahl, T., & Thorner, J. W. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.01.015 · Cited by 304

New functions for amino acids: effects on gene transcription and translation

Kimball, S. R., & Jefferson, L. S. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.500s · Cited by 279

Rab1A Is an mTORC1 Activator and a Colorectal Oncogene

Thomas, J. D., Zhang, Y.-J., Wei, Y.-H., Cho, J.-H., Morris, L. E., Wang, H.-Y., & Zheng, X. F. S. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.008 · Cited by 278

TOR Is a Negative Regulator of Autophagy in Arabidopsis thaliana

Liu, Y., & Bassham, D. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011883 · Cited by 290

Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

Knutson, S. K., Chyla, B. J., Amann, J. M., Bhaskara, S., Huppert, S. S., & Hiebert, S. W. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.51 · Cited by 271

Bnip3 Mediates the Hypoxia-induced Inhibition on Mammalian Target of Rapamycin by Interacting with Rheb

Li, Y., Wang, Y., Kim, E., Beemiller, P., Wang, C. Y., Swanson, J. A., You, M., & Guan, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705231200 · Cited by 269

The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease

Goul, C., Peruzzo, R., & Zoncu, R. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00641-8 · Cited by 280

Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship

Jhanwar-Uniyal, M., Wainwright, J. V., Mohan, A. L., Tobias, M. E., Murali, R., Gandhi, C. D., & Schmidt, M. H. (2019) · Advances in Biological Regulation · doi:10.1016/j.jbior.2019.03.003 · Cited by 268

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

Carriere, A., Romeo, Y., Acosta-Jaquez, H. A., Moreau, J., Bonneil, E., Thibault, P., Fingar, D. C., & Roux, P. P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159046 · Cited by 268

Transient Sequestration of TORC1 into Stress Granules during Heat Stress

Takahara, T., & Maeda, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.019 · Cited by 276

The Role of mTOR Signaling as a Therapeutic Target in Cancer

Popova, N. V., & Jücker, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041743 · Cited by 273

mTOR: A pathogenic signaling pathway in developmental brain malformations

Crino, P. B. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.07.008 · Cited by 266

To Die or Not to Die: That is the Autophagic Question

Maiuri, M. C., Galluzzi, L., Vicencio, J. M., Kepp, O., Tasdemir, E., & Kroemer, G. (2008) · Current Molecular Medicine · doi:10.2174/156652408783769616 · Cited by 265

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)

Fonseca, B. D., Zakaria, C., Jia, J.-J., Graber, T. E., Svitkin, Y. V., Tahmasebi, S., Healy, D., Hoang, H., Jensen, J. M., Diao, I. T., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.621730 · Cited by 285

TOR complex 2: a signaling pathway of its own

Cybulski, N., & Hall, M. N. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.09.004 · Cited by 264

How to Live Long and Prosper: Autophagy, Mitochondria, and Aging

Yen, W.-L., & Klionsky, D. J. (2008) · Physiology · doi:10.1152/physiol.00013.2008 · Cited by 271

Functions and metabolism of sphingolipids in Saccharomyces cerevisiae

Dickson, R. C., Sumanasekera, C., & Lester, R. L. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.03.004 · Cited by 262

ATGGenes Involved in Non-Selective Autophagy are Conserved from Yeast to Man, but the Selective Cvt and Pexophagy Pathways also Require Organism-Specific Genes

Meijer, W. H., van der Klei, I. J., Marten Veenhuis, A., & Kiel, J. A. K. W. (2007) · Autophagy · doi:10.4161/auto.3595 · Cited by 267

Activation of the RAS/Cyclic AMP Pathway Suppresses a TOR Deficiency in Yeast

Schmelzle, T., Beck, T. W., Martin, D. E., & Hall, M. N. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.338-351.2004 · Cited by 261

Mechanisms through which sulfur amino acids control protein metabolism and oxidative status

Métayer, S., Seiliez, I., Collin, A., Duchêne, S., Mercier, Y., Geraert, P., & Tesseraud, S. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.05.006 · Cited by 260

The Rapamycin-sensitive Phosphoproteome Reveals That TOR Controls Protein Kinase A Toward Some But Not All Substrates

Soulard, A., Cremonesi, A., Moes, S., Schütz, F., Jenö, P., & Hall, M. N. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-03-0182 · Cited by 260

TOR Complex 1 Includes a Novel Component, Tco89p (YPL180w), and Cooperates with Ssd1p to Maintain Cellular Integrity in Saccharomyces cerevisiae

Reinke, A. W., Anderson, S., McCaffery, J. M., Yates, J. R., Aronova, S., Chu, S., Fairclough, S. R., Iverson, C., Wedaman, K. P., & Powers, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313062200 · Cited by 257

Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms

Dunlop, E. A., & Tee, A. R. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.01.012 · Cited by 263

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

Sos, M. L., Fischer, S., Ullrich, R. T., Peifer, M., Heuckmann, J. M., Koker, M., Heynck, S., Stückrath, I., Weiss, J. M., Fischer, F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907325106 · Cited by 258

Emerging role of autophagy in kidney function, diseases and aging

Huber, T. B., Edelstein, C. L., Hartleben, B., Inoki, K., Jiang, M., Koya, D., Kume, S., Lieberthal, W., Pallet, N., Quiroga, A., et al. (2012) · Autophagy · doi:10.4161/auto.19821 · Cited by 261

mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation

Hong, F., Larrea, M. D., Doughty, C. A., Kwiatkowski, D. J., Squillace, R. M., & Slingerland, J. M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.027 · Cited by 259

Leucine nutrition in animals and humans: mTOR signaling and beyond

Li, F., Yin, Y., Tan, B., Kong, X., & Wu, G. (2011) · Amino Acids · doi:10.1007/s00726-011-0983-2 · Cited by 256

Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex

Sarbassov, D. D., & Sabatini, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506096200 · Cited by 248

The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System

Roa, J., García-Galiano, D., Varela, L., Sanchez-Garrido, M. A., Pineda, R., Castellano, J. M., Ruíz-Pino, F., Romero, M., Aguilar, E., López, M., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0096 · Cited by 247

Target of Rapamycin Signaling Regulates Metabolism, Growth, and Life Span in Arabidopsis

Ren, M., Venglat, P., Qiu, S., Feng, L., Cao, Y., Wang, E., Xiang, D., Wang, J., Alexander, D. C., Subbaiah, C. C., et al. (2012) · The Plant Cell · doi:10.1105/tpc.112.107144 · Cited by 257

The Mammalian Target of Rapamycin Signaling Pathway: Twists and Turns in the Road to Cancer Therapy

Abraham, R. T., & Gibbons, J. J. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2798 · Cited by 244

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

Mohi, G., Boulton, C. L., Gu, T., Sternberg, D., Neuberg, D. S., Griffin, J. D., Gilliland, D. G., & Neel, B. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400063101 · Cited by 241

Mutations in the Arabidopsis Homolog of LST8/GβL, a Partner of the Target of Rapamycin Kinase, Impair Plant Growth, Flowering, and Metabolic Adaptation to Long Days

Moreau, M., Azzopardi, M., Clément, G., Dobrenel, T., Marchive, C., Renne, C., Martin‐Magniette, M., Soubigou‐Taconnat, L., Renou, J., Robaglia, C., et al. (2012) · The Plant Cell · doi:10.1105/tpc.111.091306 · Cited by 238

Protein Kinase A and Sch9 Cooperatively Regulate Induction of Autophagy inSaccharomyces cerevisiae

Yorimitsu, T., Zaman, S., Broach, J. R., & Klionsky, D. J. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0485 · Cited by 237

Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

Hoeffer, C. A., Tang, W., Wong, H., Santillan, A., Patterson, R. J., Martinez, L. A., Tejada-Simon, M. V., Paylor, R. E., Hamilton, S. L., & Klann, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.037 · Cited by 240

The role of mTOR signaling in Alzheimer disease

Oddo, S. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s310 · Cited by 243

Amino Acid Signaling in TOR Activation

Kim, J., & Guan, K. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062209-094414 · Cited by 239

Multifaceted Roles of GSK‐3 in Cancer and Autophagy‐Related Diseases

Mancinelli, R., Carpino, G., Petrungaro, S., Mammola, C. L., Tomaipitinca, L., Filippini, A., Facchiano, A., Ziparo, E., & Giampietri, C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4629495 · Cited by 242

TOR Signaling

Harris, T. E., & Lawrence, J. C. (2003) · Science s STKE · doi:10.1126/stke.2122003re15 · Cited by 239

The essence of yeast quiescence

VIRGILIO, C. D. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00287.x · Cited by 248

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

Buckmaster, P., Ingram, E. A., & Wen, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4179-08.2009 · Cited by 239

Tor Kinases Are in Distinct Membrane-associated Protein Complexes inSaccharomyces cerevisiae

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Valcourt, J. R., Lemons, J. M. S., Haley, E. M., Kojima, M. L., Demuren, O. O., & Coller, H. A. (2012) · Cell Cycle · doi:10.4161/cc.19879 · Cited by 240

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Šimek, J. (2013) · Digital Repository (National Repository of Grey Literature)

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