Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

Shevchenko, A., Wilm, M. S., Vorm, O., & Mann, M. (1996) · Analytical Chemistry · doi:10.1021/ac950914h · Cited by 8,996

Current protocols in molecular biology

Sargent, T. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90147-9 · Cited by 7,281

Getting started with yeast

Sherman, F. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94004-v · Cited by 4,078

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Heterologous modules for efficient and versatile PCR-based gene targeting inSchizosaccharomyces pombe

Bähler, J., Wu, J., Longtine, M. S., Shah, N. G., Mckenzie, A., Steever, A. B., Wach, A., Philippsen, P., & Pringle, J. R. (1998) · Yeast · doi:10.1002/(sici)1097-0061(199807)14:10 · Cited by 2,208

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

Heitman, J., Movva, N. R., & Hall, M. N. (1991) · Science · doi:10.1126/science.1715094 · Cited by 2,010

TOR, a Central Controller of Cell Growth

Schmelzle, T., & Hall, M. N. (2000) · Cell · doi:10.1016/s0092-8674(00)00117-3 · Cited by 1,914

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810

The Tandem Affinity Purification (TAP) Method: A General Procedure of Protein Complex Purification

Puig, Ó., Caspary, F., Rigaut, G., Rutz, B., Bouveret, E., Bragado‐Nilsson, E., Wilm, M. S., & Séraphin, B. (2001) · Methods · doi:10.1006/meth.2001.1183 · Cited by 1,784

Regulation of translation initiation by FRAP/mTOR

Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545

Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

Yoshida, S., Pacitto, R., Yao, Y., Inoki, K., & Swanson, J. A. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201504097 · Cited by 105

The ever-evolving role of mTOR in translation

Fonseca, B. D., Smith, E. M., Yelle, N., Alain, T., Bushell, M., & Pause, A. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.014 · Cited by 110

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

Ryskalin, L., Limanaqi, F., Frati, A., Busceti, C. L., & Fornai, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082226 · Cited by 110

The TOR Pathway Modulates the Structure of Cell Walls in Arabidopsis

Leiber, R.-M., John, F., Verhertbruggen, Y., Diet, A., Knox, J. P., & Ringli, C. (2010) · The Plant Cell · doi:10.1105/tpc.109.073007 · Cited by 105

Phosphoinositide 3-kinases as drug targets in cancer

Stephens, L., WILLIAMS, R., & Hawkins, P. T. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.03.002 · Cited by 105

The 3.2-Å resolution structure of human mTORC2

Scaiola, A., Mangia, F., Imseng, S., Boehringer, D., Berneiser, K., Shimobayashi, M., Stuttfeld, E., Hall, M. N., Ban, N., & Maier, T. (2020) · Science Advances · doi:10.1126/sciadv.abc1251 · Cited by 105

Oncosuppressive Functions of Autophagy

Morselli, E., Galluzzi, L., Kepp, O., Mariño, G., Michaud, M., Vitale, I., Maiuri, M. C., & Kroemer, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3478 · Cited by 112

hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

Nobukuni, T., Kozma, S. C., & Thomas, G. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.019 · Cited by 105

Mechanisms of amino acid sensing in mTOR signaling pathway

Kim, E. (2009) · Nutrition Research and Practice · doi:10.4162/nrp.2009.3.1.64 · Cited by 104

Raptor, a binding partner of target of rapamycin

Yonezawa, K., Tokunaga, C., Oshiro, N., & Yoshino, K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.07.018 · Cited by 104

Autophagy and polyglutamine diseases

Jiménez-Sánchez, M., Thomson, F., Zavodszky, E., & Rubinsztein, D. C. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.013 · Cited by 105

COVID-19 and diabetes mellitus: how one pandemic worsens the other

Azar, W. S., Njeim, R., Fares, A. H., Azar, N. S., Azar, S. T., Sayed, M. J. E., & Eid, A. A. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09573-6 · Cited by 109

Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases

Huynh, C. Q., Ryu, J., Lee, J., Inoki, A., & Inoki, K. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00648-y · Cited by 109

Cryptotanshinone Inhibits Cancer Cell Proliferation by Suppressing Mammalian Target of Rapamycin–Mediated Cyclin D1 Expression and Rb Phosphorylation

Chen, W., Luo, Y., Liu, L., Zhou, H., Xu, B., Han, X., Shen, T., Liu, Z., Lu, Y., & Huang, S. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0020 · Cited by 103

Critical roles for the TSC-mTOR pathway in β-cell function

Mori, H., Inoki, K., Opland, D. M., Münzberg, H., Villanueva, E. C., Faouzi, M., Ikenoue, T., Kwiatkowski, D. J., MacDougald, O. A., Myers, M. G., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00262.2009 · Cited by 104

The control of growth

Nijhout, H. F. (2003) · Development · doi:10.1242/dev.00902 · Cited by 103

TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis

Shimobayashi, M., Oppliger, W., Moes, S., Jenö, P., & Hall, M. N. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-10-0753 · Cited by 102

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling

Shekhar-Guturja, T., Gunaherath, G. M. K. B., Wijeratne, E. M. K., Lambert, J.-P., Averette, A. F., Lee, S. C., Kim, T., Bahn, Y.-S., Tripodi, F., Ammar, R., et al. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2165 · Cited by 101

ERK7 is a negative regulator of protein secretion in response to amino‐acid starvation by modulating Sec16 membrane association

Zacharogianni, M., Kondylis, V., Tang, Y., Farhan, H., Xanthakis, D., Fuchs, F., Boutros, M., & Rabouille, C. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.253 · Cited by 104

Nutrient-Regulated Protein Kinases in Budding Yeast

Wilson, W. A., & Roach, P. J. (2002) · Cell · doi:10.1016/s0092-8674(02)01043-7 · Cited by 101

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

Zhou, X., Ikenoue, T., Chen, X., Li, L., Inoki, K., & Guan, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903621106 · Cited by 101

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

Zhang, C., Wendel, A. A., Keogh, M. R., Harris, T. E., Chen, J., & Coleman, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110730109 · Cited by 102

Macroautophagy Signaling and Regulation

Esclatine, A., Chaumorcel, M., & Codogno, P. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-00302-8_2 · Cited by 101

HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway

Chen, J., Chen, J., Huang, J., Li, Z., Gong, Y., Zou, B., Liu, X., Ding, L., Li, P., Zhu, Z., et al. (2019) · Aging · doi:10.18632/aging.102488 · Cited by 98

Regulation of mTORC1 by Upstream Stimuli

Melick, C. H., & Jewell, J. L. (2020) · Genes · doi:10.3390/genes11090989 · Cited by 104

Brain-restricted mTOR inhibition with binary pharmacology

Zhang, Z., Fan, Q.-W., Luo, X., Lou, K., Weiss, W. A., & Shokat, K. M. (2022) · Nature · doi:10.1038/s41586-022-05213-y · Cited by 102

Cross-talk between Sirtuin and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in the Regulation of S6 Kinase 1 (S6K1) Phosphorylation

Hong, S., Zhao, B., Lombard, D. B., Fingar, D. C., & Inoki, K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.520734 · Cited by 101

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment

Inoki, K., & Guan, K. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp032 · Cited by 101

Therapy for myeloproliferative neoplasms: when, which agent, and how?

Geyer, H. L., & Mesa, R. A. (2014) · Blood · doi:10.1182/blood-2014-05-577635 · Cited by 99

Signaling pathways in breast cancer: Therapeutic targeting of the microenvironment

Kamdje, A. H. N., Etet, P. F. S., Vecchio, L., Jm, M., Krampera, M., & Lukong, K. E. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.07.034 · Cited by 98

TORC1 Promotes Phosphorylation of Ribosomal Protein S6 via the AGC Kinase Ypk3 in Saccharomyces cerevisiae

González, A., Shimobayashi, M., Eisenberg, T., Merle, D. A., Pendl, T., Hall, M. N., & Moustafa, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120250 · Cited by 103

4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1

Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M.-Q., Wong, C. C. L., Wang, J., Xu, Y., et al. (2016) · Protein & Cell · doi:10.1007/s13238-016-0346-6 · Cited by 96

Targeting mTOR for fighting diseases: A revisited review of mTOR inhibitors

Xu, T., Sun, D., Chen, Y., & Ouyang, L. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112391 · Cited by 97

Nutrient Signaling Components Controlling Protein Synthesis in Striated Muscle ,

Vary, T. C., & Lynch, C. J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.8.1835 · Cited by 96

Focal malformations of cortical development: New vistas for molecular pathogenesis

Lim, K., & Crino, P. B. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.037 · Cited by 98

The m6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway

Zhang, Y., Liu, X., Wang, Y., Lai, S., Wang, Z., Yang, Y., Liu, W., Wang, H., & Tang, B. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01647-0 · Cited by 95

Probing the Membrane Environment of the TOR Kinases Reveals Functional Interactions between TORC1, Actin, and Membrane Trafficking inSaccharomyces cerevisiae

Aronova, S., Wedaman, K. P., Anderson, S., Yates, J. R., & Powers, T. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-03-0274 · Cited by 95

The CRB1 and adherens junction complex proteins in retinal development and maintenance

Alves, C. H., Pellissier, L. P., & Wijnholds, J. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.01.001 · Cited by 96

Nitrogen Regulates AMPK to Control TORC1 Signaling

Davie, E., Forte, G., & Petersen, J. (2015) · Current Biology · doi:10.1016/j.cub.2014.12.034 · Cited by 97

Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress

Hartmuth, S., & Petersen, J. (2009) · Journal of Cell Science · doi:10.1242/jcs.049387 · Cited by 95

Inhibitors of the mammalian target of rapamycin

Dancey, J. E. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.3.313 · Cited by 95

Antitumor Activity of Rapamycin in a Transgenic Mouse Model of ErbB2-Dependent Human Breast Cancer

Liu, M., Howes, A. L., Lesperance, J., Stallcup, W. B., Hauser, C. A., Kadoya, K., Oshima, R. G., & Abraham, R. T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4589 · Cited by 97

Metabolic features of macrophages in inflammatory diseases and cancer

Na, Y. R., Je, S., & Seok, S. H. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.10.044 · Cited by 96

Conventional and emerging roles of the energy sensor Snf1/AMPK in Saccharomyces cerevisiae

Coccetti, P., Nicastro, R., & Tripodi, F. (2018) · Microbial Cell · doi:10.15698/mic2018.11.655 · Cited by 99

The Tuberous Sclerosis Complex Genes in Tumor Development

Mak, B. C., & Yeung, R. S. W. (2004) · Cancer Investigation · doi:10.1081/cnv-200027144 · Cited by 94

Cell-free reconstitution of vacuole membrane fragmentation reveals regulation of vacuole size and number by TORC1

Mayer, L. M., Baars, T. L., & Mayer, A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-08-0703 · Cited by 95

Glucose- and nitrogen sensing and regulatory mechanisms in Saccharomyces cerevisiae

Rødkær, S. V., & Færgeman, N. J. (2014) · FEMS Yeast Research · doi:10.1111/1567-1364.12157 · Cited by 95

The multifaceted role of mTOR in cellular stress responses

Proud, C. G. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.012 · Cited by 95

The m TOR pathway and integrating immune regulation

Cobbold, S. P. (2013) · Immunology · doi:10.1111/imm.12162 · Cited by 95

PI3K/mTOR Pathway Inhibition: Opportunities in Oncology and Rare Genetic Diseases

Hillmann, P., & Fabbro, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225792 · Cited by 96

Impact of Acute Metal Stress in Saccharomyces cerevisiae

Hosiner, D., Gerber, S., Lichtenberg‐Fraté, H., Glaser, W., Schüller, C., & Klipp, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083330 · Cited by 92

Hmo1 Is Required for TOR-Dependent Regulation of Ribosomal Protein Gene Transcription

Berger, A. B., Decourty, L., Badis, G., Nehrbass, U., Jacquier, A., & Gadal, O. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01102-07 · Cited by 92

Targeting the mTOR Signaling Pathway in Neuroendocrine Tumors

Chan, J. A., & Kulke, M. H. (2014) · Current Treatment Options in Oncology · doi:10.1007/s11864-014-0294-4 · Cited by 92

Autophagy as a Potential Therapy for Malignant Glioma

Escamilla-Ramírez, Á., Castillo‐Rodríguez, R. A., Zavala-Vega, S., Jiménez‐Farfán, D., Anaya‐Rubio, I., Briseño, E., Palencia, G., Guevara, P., Cruz-Salgado, A., Sotelo, J., et al. (2020) · Pharmaceuticals · doi:10.3390/ph13070156 · Cited by 94

Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action

Chen, J., Wu, S., Shi, Z.-M., & Hu, B. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00719-7 · Cited by 93

Yeast protein expression profile during acetic acid‐induced apoptosis indicates causal involvement of the TOR pathway

Almeida, B., Ohlmeier, S., Almeida, A. J., Madeo, F., Leão, C., Rodrigues, F. J. S., & Ludovico, P. (2009) · PROTEOMICS · doi:10.1002/pmic.200700816 · Cited by 91

mTOR Signaling in T Cell Immunity and Autoimmunity

Liu, Y., Zhang, D., & Liu, X. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.933957 · Cited by 94

Mammalian target of rapamycin as a therapeutic target in oncology

Abraham, R. T., & Eng, C. H. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.2.209 · Cited by 92

Roles for PI(3,5)P2 in nutrient sensing through TORC1

Jin, N., Mao, K., Jin, Y., Tevzadze, G. G., Kauffman, E. J., Park, S., Bridges, D., Loewith, R., Saltiel, A. R., Klionsky, D. J., et al. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-01-0021 · Cited by 95

Recent advances in the regulation of the TOR pathway by insulin and nutrients

Avruch, J., Lin, Y., Long, X., Murthy, S., & Ortiz-Vega, S. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200501000-00010 · Cited by 91

The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis

Russo, E., Citraro, R., Constanti, A., & Sarro, G. D. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8314-5 · Cited by 91

Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation

Scarpin, M. R., Leiboff, S., & Brunkard, J. O. (2020) · eLife · doi:10.7554/elife.58795 · Cited by 94

Stimulation of Signal Transducer and Activator of Transcription-1 (STAT1)-dependent Gene Transcription by Lipopolysaccharide and Interferon-γ Is Regulated by Mammalian Target of Rapamycin

Kristof, A. S., Marks-Kończalik, J., Billings, E. M., & Moss, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301053200 · Cited by 92

Rapamycin and Interleukin-1β Impair Brain-derived Neurotrophic Factor-dependent Neuron Survival by Modulating Autophagy

Smith, E. D., Prieto, G. A., Tong, L., Sears‐Kraxberger, I., Rice, J. D., Steward, O., & Cotman, C. W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.568659 · Cited by 94

Potential for therapeutic manipulation of the UPR in disease

Park, S. W., & Özcan, U. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0370-z · Cited by 92

A critical role for mTORC1 in erythropoiesis and anemia

Knight, Z. A., Schmidt, S. F., Birsoy, K., Tan, K., & Friedman, J. M. (2014) · eLife · doi:10.7554/elife.01913 · Cited by 93

The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing

Díaz-González, R., Kuhlmann, F. M., Galan-Rodriguez, C., da Silva, L. M., Saldivia, M., Karver, C. E., Rodrı́guez, A., Beverley, S. M., Navarro, M., & Pollastri, M. P. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001297 · Cited by 90

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors

Ducker, G. S., Atreya, C. E., Simko, J. P., Hom, Y. K., Matli, M. R., Benes, C. H., Hann, B. C., Nakakura, E. K., Bergsland, E. K., Donner, D. B., et al. (2013) · Oncogene · doi:10.1038/onc.2013.92 · Cited by 91

A Tour of TOR Complex Signaling in Plants

Burkart, G. M., & Brandizzí, F. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.11.004 · Cited by 89

The interplay between autophagy and apoptosis: its implication in lung cancer and therapeutics

Biswas, U., Roy, R., Ghosh, S., & Chakrabarti, G. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216662 · Cited by 93

mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics

Zhang, H., Xiao, X., Pan, Z., & Dokudovskaya, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02493-4 · Cited by 94

Retrograde Response to Mitochondrial Dysfunction Is Separable from TOR1/2 Regulation of Retrograde Gene Expression

Giannattasio, S., Liu, Z., Thornton, J., & Butow, R. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509187200 · Cited by 89

mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice

Chen, X., Wang, Y., Tao, J., Shi, Y.-Z., Gai, X., Huang, F., Ma, Q., Zhou, Z., Chen, H., Zhang, H., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.005 · Cited by 89

TOR Signaling Is a Determinant of Cell Survival in Response to DNA Damage

Shen, C., Lancaster, C. S., Shi, B., Guo, H., Thimmaiah, P., & Bjornsti, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00290-07 · Cited by 89

SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling

Kim, Y.-M., Stone, M., Hwang, T. H., Kim, Y.-G., Dunlevy, J. R., Griffin, T. J., & Kim, D.-H. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.007 · Cited by 88

Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication

Pilar-Cuéllar, F., Vidal, R., Díaz, Á., Castro, E., Dos-Anjos, S., Pascual-Brazo, J., Linge, R., Vargas, V. I., Blanco, H., Martínez‐Villayandre, B., et al. (2013) · Neural Plasticity · doi:10.1155/2013/537265 · Cited by 90

Ectopic expression of Arabidopsis Target of Rapamycin (AtTOR) improves water-use efficiency and yield potential in rice

Bakshi, A., Moin, M., Kumar, M. U., Reddy, A. B. M., Ren, M., Datla, R. S. S., Siddiq, E. A., & Kirti, P. B. (2017) · Scientific Reports · doi:10.1038/srep42835 · Cited by 88

Inositol Pyrophosphates Regulate Cell Growth and the Environmental Stress Response by Activating the HDAC Rpd3L

Worley, J., Luo, X., & Capaldi, A. P. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.043 · Cited by 89

TOR Is Required for the Retrograde Regulation of Synaptic Homeostasis at the Drosophila Neuromuscular Junction

Penney, J., Tsurudome, K., Liao, E. H., Elazzouzi, F., Livingstone, M., González, M., Sonenberg, N., & Haghighi, A. P. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.030 · Cited by 90

Efficient Tor Signaling Requires a Functional Class C Vps Protein Complex in Saccharomyces cerevisiae

Zurita-Martinez, S. A., Puria, R., Pan, X., Boeke, J. D., & Cardenas, M. E. (2007) · Genetics · doi:10.1534/genetics.107.072835 · Cited by 88

TOR kinase complexes and cell migration

Liu, L., & Parent, C. A. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102090 · Cited by 87

Current Scientific Rationale for the Use of Somatostatin Analogs and mTOR Inhibitors in Neuroendocrine Tumor Therapy

Bousquet, C., Lasfargues, C., Chalabi‐Dchar, M., Moatassim-Billah, S., Susini, C., Vezzosi, D., Caron, P. J., & Pyronnet, S. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2088 · Cited by 87

Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control

Ikeda, K., Morigasaki, S., Tatebe, H., Tamanoi, F., & Shiozaki, K. (2008) · Cell Cycle · doi:10.4161/cc.7.3.5245 · Cited by 87

Structure of TOR and Its Complex with KOG1

Adami, A., García‐Álvarez, B., Arias‐Palomo, E., Barford, D., & Llorca, Ó. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.040 · Cited by 92

TORC1 Inhibition Induces Lipid Droplet Replenishment in Yeast

Madeira, J. B., Masuda, C. A., Maya‐Monteiro, C. M., Matos, G. S., Montero-Lomelı́, M., & Bozaquel-Morais, B. L. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01314-14 · Cited by 89

TORC2 Signaling Pathway Guarantees Genome Stability in the Face of DNA Strand Breaks

Shimada, K., Filipuzzi, I., Ståhl, M., Helliwell, S. B., Studer, C., Hoepfner, D., Seeber, A., Loewith, R., Movva, N. R., & Gasser, S. M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.019 · Cited by 89

mTOR-Dependent Cell Proliferation in the Brain

Ryskalin, L., Lazzeri, G., Flaibani, M., Biagioni, F., Gambardella, S., Frati, A., & Fornai, F. (2017) · BioMed Research International · doi:10.1155/2017/7082696 · Cited by 86

mTOR, A New Therapeutic Target in Acute Myeloid Leukemia

Récher, C., Santos, C. D., Demur, C., & Payrastre, B. (2005) · Cell Cycle · doi:10.4161/cc.4.11.2159 · Cited by 89

Dual targeting of AKT and mammalian target of rapamycin: A potential therapeutic approach for malignant peripheral nerve sheath tumor

Zou, C., Smith, K. D., Zhu, Q.-S., Liu, J., McCutcheon, I. E., Slopis, J. M., Meric‐Bernstam, F., Peng, Z., Bornmann, W. G., Mills, G. B., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1008 · Cited by 88

Nitrogen Availability and TOR Regulate the Snf1 Protein Kinase in Saccharomyces cerevisiae

Orlova, M., Kanter, E., Krakovich, D., & Kuchin, S. (2006) · Eukaryotic Cell · doi:10.1128/ec.00110-06 · Cited by 86

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways

Rispal, D., Eltschinger, S., Ståhl, M., Vaga, S., Bodenmiller, B., Abraham, Y., Filipuzzi, I., Movva, N. R., Aebersold, R. H., Helliwell, S. B., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.627794 · Cited by 85

PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease

Fan, J., Zhang, X., Zhang, J., Zhao, T., Burley, S. K., & Zheng, X. F. S. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116811 · Cited by 86

The proteome and phosphoproteome of Neurospora crassa in response to cellulose, sucrose and carbon starvation

Xiong, Y. B., Coradetti, S. T., Li, X., Gritsenko, M. A., Clauss, T. R., Petyuk, V., Camp, D., Smith, R. D., Cate, J. H. D., Yang, F., et al. (2014) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2014.05.005 · Cited by 85

Plant target of rapamycin signaling network: Complexes, conservations, and specificities

Liu, Y., & Xiong, Y. (2021) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13212 · Cited by 86

TOR signalling in plants

Rexin, D., Meyer, C., Robaglia, C., & Veit, B. (2015) · Biochemical Journal · doi:10.1042/bj20150505 · Cited by 88

Metastatic Potential of 21T Human Breast Cancer Cells Depends on Akt/Protein Kinase B Activation

Qiao, M., Iglehart, J. D., & Pardee, A. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0877 · Cited by 84

Non‐canonical functions of the tuberous sclerosis complex‐Rheb signalling axis

Neuman, N. A., & Henske, E. P. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100131 · Cited by 87

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe

Ikai, N., Nakazawa, N., Hayashi, T., & Yanagida, M. (2011) · Open Biology · doi:10.1098/rsob.110007 · Cited by 83

Biosynthesis and possible functions of inositol pyrophosphates in plants

Williams, S. P., Gillaspy, G. E., & Perera, I. Y. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00067 · Cited by 83

The Role of Autophagy in Genome Stability through Suppression of Abnormal Mitosis under Starvation

Matsui, A., Kamada, Y., & Matsuura, A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003245 · Cited by 83

Characterization of TOR complex 2 (TORC2) in "Saccharomyces cerevisiae"

Wullschleger, S. (2004) · edoc (University of Basel) · doi:10.5451/unibas-003679624

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., & Hall, M. N. (2004) · Nature Cell Biology · doi:10.1038/ncb1183 · Cited by 2,097

TOR signalling in yeast

Šimek, J. (2013) · Digital Repository (National Repository of Grey Literature)

Fission Yeast TOR and Rapamycin

Weisman, R. (2010) · The Enzymes · doi:10.1016/s1874-6047(10)27013-0 · Cited by 10

TORC2 downstream signaling in Saccharomyces cerevisiae

Eltschinger, S. (2015) · Archive ouverte UNIGE (University of Geneva) · doi:10.13097/archive-ouverte/unige:77570