Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field
Abstract
In this work we have studied the effect of a low-frequency alternating magnetic field (LF-AMF) on the permeability of magnetoliposomes, i.e. liposomes including magnetic nanoparticles within their water pool. Large unilamellar liposomes loaded with magnetic cobalt ferrite nanoparticles (CoFe2O4) have been prepared and characterized. Structural characterization of the liposomal dispersion has been performed by dynamic light scattering (DLS). The enhancement of liposome permeability upon exposure to LF-AMF has been measured as the self-quenching decrease of a fluorescent hydrophilic molecule (carboxyfluorescein, CF) entrapped in the liposome pool. Liposome leakage has been monitored as a function of field frequency, time of exposure and concentration, charge and size of the embedded nanoparticles. The results show that CF release from magnetoliposomes is strongly promoted by LF-AMF, reasonably as a consequence of nanoparticle motions in the liposome pool at the applied frequency. CF release as a function of time in magnetoliposomes unexposed to magnetic field follows Fickian diffusion, while samples exposed to LF-AMF show zero-order kinetics, consistently with an anomalous transport, due to an alteration of the bilayer permeability. These preliminary results open up new perspectives in the use of these systems as carriers in targeted and controlled release of drugs.
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Iron oxide nanoparticles can be entrapped inside vesicles like liposomes or polymeric micelles.
“Iron oxide nanoparticles can be entrapped inside of vesicles like liposomes [94–97] or polymeric micelles [98–101].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [95]
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New developments in liposomal drug delivery
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- Authors
- Nappini, S., Bombelli, F. B., Bonini, M., Nordèn, B., & Baglioni, P.
- Affiliations
- Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (IT)
- Corresponding author
- Baglioni, Piero
- Venue
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 6
- Issue
- 1
- Pages
- 154-162
- ISSN
- 1744-683X (ISSN-L)
- 1744-6848
- OpenAlex
- W2004520855
- Cited by
- 113
- References
- 50
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Soft Matter (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
- Chalmers Research (Chalmers University of Technology) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- magnetoliposomes, low-frequency alternating magnetic field, controlled drug release, liposome permeability, cobalt ferrite nanoparticles, carboxyfluorescein leakage, nanoparticle motion, bilayer permeability, anomalous transport, Fickian diffusion, targeted drug delivery, magnetic nanoparticles
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