Cited by 113Nanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesLipid Membrane Structure and Behavior

Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field

Nappini, Silvia, Bombelli, Francesca Baldelli, Bonini, Massimo, Nordèn, Bengt, Baglioni, Piero·2010·Soft Matter

Abstract

In this work we have studied the effect of a low-frequency alternating magnetic field (LF-AMF) on the permeability of magnetoliposomes, i.e. liposomes including magnetic nanoparticles within their water pool. Large unilamellar liposomes loaded with magnetic cobalt ferrite nanoparticles (CoFe2O4) have been prepared and characterized. Structural characterization of the liposomal dispersion has been performed by dynamic light scattering (DLS). The enhancement of liposome permeability upon exposure to LF-AMF has been measured as the self-quenching decrease of a fluorescent hydrophilic molecule (carboxyfluorescein, CF) entrapped in the liposome pool. Liposome leakage has been monitored as a function of field frequency, time of exposure and concentration, charge and size of the embedded nanoparticles. The results show that CF release from magnetoliposomes is strongly promoted by LF-AMF, reasonably as a consequence of nanoparticle motions in the liposome pool at the applied frequency. CF release as a function of time in magnetoliposomes unexposed to magnetic field follows Fickian diffusion, while samples exposed to LF-AMF show zero-order kinetics, consistently with an anomalous transport, due to an alteration of the bilayer permeability. These preliminary results open up new perspectives in the use of these systems as carriers in targeted and controlled release of drugs.

Integrity signals

Registry

Crossref · 10.1039/b915651h

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Nappini, S., Bombelli, F. B., Bonini, M., Nordèn, B., & Baglioni, P.
Affiliations
Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (IT)
Corresponding author
Baglioni, Piero
Venue
Soft Matter
Published
2010
Volume
6
Issue
1
Pages
154-162
ISSN
  • 1744-683X (ISSN-L)
  • 1744-6848
OpenAlex
W2004520855
Cited by
113
References
50
Citations by year
2026: 3 · 2025: 8 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 8 · 2012: 7
FWCI
3.08
Type
journal article
Language
en
Open access
closed
Locations
  • Soft Matter (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
  • Chalmers Research (Chalmers University of Technology) (submittedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
magnetoliposomes, low-frequency alternating magnetic field, controlled drug release, liposome permeability, cobalt ferrite nanoparticles, carboxyfluorescein leakage, nanoparticle motion, bilayer permeability, anomalous transport, Fickian diffusion, targeted drug delivery, magnetic nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review