The DOI matches its Crossref record; 104 of the 107 references it cites were found in a registry or an index.
Keynote review: Intestinal Peyer's patch M cells and oral vaccine targeting
Abstract
Specialized M cells in the follicle-associated epithelium of intestinal Peyer's patches serve as portals for diverse particulates. Following antigen handover to dome lymphocytes, a protective mucosal antibody secretion ensues. One approach to oral vaccine delivery is to mimic the entry pathways of pathogens via M cells. The paucity of human tissue for in vitro investigation has hampered the discovery of M-cell pathogen receptors; however an in vitro human M like-cell culture model displays many expected phenotypic features. Comparative studies using microarrays reveal several novel M-cell surface receptors that could be used to potentially target orally delivered antigens.
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“As α-L fucose and GM1 are both highly expressed on M-cells [34,35], NA might represent a promising tool not only to enhance the residence time on intestinal epithelial cells but also to target M-cells directly leading to an enhanced transepithelial uptake of allergen loaded”
From Characterization of Vibrio cholerae neuraminidase as an immunomodulator for novel formulation of oral allergy immunotherapy (2018) · cites this paper as [34]
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des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Homayun, B., Lin, X., & Choi, H.-J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030129 · Cited by 837
Advances in Oral Drug Delivery
Alqahtani, M. S., Kazi, M., Alsenaidy, M. A., & Ahmad, M. Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.618411 · Cited by 945
Formulation, stabilisation and encapsulation of bacteriophage for phage therapy
Malik, D. J., Sokolov, I. J., Vinner, G. K., Mancuso, F., Cinquerrui, S., Vladisavljevic, G. T., Clokie, M. R. J., Garton, N. J., Stapley, A. G. F., & Kirpichnikova, A. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.05.014 · Cited by 594
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Metadata
- Authors
- Brayden, D. J., Jepson, M. A., & Baird, A. W.
- Affiliations
- University College Dublin (IE)
- University of Bristol (GB)
- Corresponding author
- Brayden, David J.
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 10
- Issue
- 17
- Pages
- 1145-1157
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2018689770
- Cited by
- 224
- References
- 107
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 13 · 2022: 8 · 2021: 18 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 15 · 2016: 7 · 2015: 5 · 2014: 10 · 2013: 10 · 2012: 15
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- follicle-associated epithelium, oral vaccine delivery, mucosal immunity, antigen sampling
- MeSH terms
- Administration, Oral, Animals, Antigens, Humans, Intestinal Mucosa, Peyer's Patches, Receptors, Cell Surface, Vaccines, Immunity, Mucosal
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