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Keynote review: Intestinal Peyer's patch M cells and oral vaccine targeting
Abstract
Specialized M cells in the follicle-associated epithelium of intestinal Peyer's patches serve as portals for diverse particulates. Following antigen handover to dome lymphocytes, a protective mucosal antibody secretion ensues. One approach to oral vaccine delivery is to mimic the entry pathways of pathogens via M cells. The paucity of human tissue for in vitro investigation has hampered the discovery of M-cell pathogen receptors; however an in vitro human M like-cell culture model displays many expected phenotypic features. Comparative studies using microarrays reveal several novel M-cell surface receptors that could be used to potentially target orally delivered antigens.
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“As α-L fucose and GM1 are both highly expressed on M-cells [34,35], NA might represent a promising tool not only to enhance the residence time on intestinal epithelial cells but also to target M-cells directly leading to an enhanced transepithelial uptake of allergen loaded”
From Characterization of Vibrio cholerae neuraminidase as an immunomodulator for novel formulation of oral allergy immunotherapy (2018) · cites this paper as [34]
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Metadata
- Authors
- Brayden, D. J., Jepson, M. A., & Baird, A. W.
- Affiliations
- University College Dublin (IE)
- University of Bristol (GB)
- Corresponding author
- Brayden, David J.
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 10
- Issue
- 17
- Pages
- 1145-1157
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2018689770
- Cited by
- 224
- References
- 107
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 13 · 2022: 8 · 2021: 18 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 15 · 2016: 7 · 2015: 5 · 2014: 10 · 2013: 10 · 2012: 15
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- follicle-associated epithelium, oral vaccine delivery, mucosal immunity, antigen sampling
- MeSH terms
- Administration, Oral, Animals, Antigens, Humans, Intestinal Mucosa, Peyer's Patches, Receptors, Cell Surface, Vaccines, Immunity, Mucosal
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