Cited by 830Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

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Insulin and neurodegenerative disease: shared and specific mechanisms

Craft, Suzanne, Stennis Watson, G·2004·The Lancet Neurology

DOI 10.1016/s1474-4422(04)00681-7

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Abstract

Insulin has functions in the brain and dysregulation of these functions may contribute to the expression of late-life neurodegenerative disease. We provide a brief summary of research on the influence of insulin on normal brain function. We then review evidence that perturbation of this role may contribute to the symptoms and pathogenesis of various neurodegenerative disorders, such as Alzheimer's disease, vascular dementia, Parkinson's disease, and Huntington's disease. We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms.

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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988–1994
Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703
Diabetes mellitus and the risk of dementia: The Rotterdam Study
Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175
Parkinson's Disease
Lang, A. E., & Lozano, A. M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810083391506 · Cited by 2,072
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E. A., Frosch, M. P., Eckman, C. B., Tanzi, R. E., Selkoe, D. J., & Guénette, S. Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0230450100 · Cited by 1,526
The Endocrine Regulation of Aging by Insulin-like Signals
Tatar, M., Bartke, A., & Antebi, A. (2003) · Science · doi:10.1126/science.1081447 · Cited by 1,327
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.661 · Cited by 1,258
Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies
Peila, R., Rodriguez, B. L., & Launer, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1256 · Cited by 1,207
Insulin receptors are widely distributed in the central nervous system of the rat
Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116
Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes
Rulifson, E. J., Kim, S. K., & Nusse, R. (2002) · Science · doi:10.1126/science.1070058 · Cited by 1,064

Show all 145 references

Research works printed but not linked: 1

Schobotz, 1976, Fatty acid patterns and glucose tolerance in Huntington's chorea, Res Exp Med (Berl), 167, 203

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Self-citation
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Diabetes Mellitus and Neurocognitive Dysfunction
Ryan, C. M. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00095-4 · Cited by 2
Aging: Thromboembolic Disease, Metabolic Syndrome, Type 2 Diabetes Mellitus, and Alzheimer’s Disease
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Underlying biological substrates associated with cognitive dysfunction in major depressive disorder
(2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139860567.012 · Cited by 2
Symposium Summaries
(2018) · Pediatric Pulmonology · doi:10.1002/ppul.24151 · Cited by 1
Obesity may Increase the Prevalence of Parkinson's Disease while Parkinson's may Reduce Obesity Index in Patients
Kehinde, A. M., Ehianeta, T., Abdulraman, S. M. S., Liuyi, L., Mahmud, A.-N., Kanton, A. G., & Taiye, M. A. (2019) · International Journal of Neurodegenerative Disorders · doi:10.23937/2643-4539/1710012 · Cited by 2
Diabetic female rats exhibit defensive aggression during mating
Hernández-Munive, A., Rebolledo-Solleiro, D., & Fernández‐Guasti, A. (2020) · Salud Mental · doi:10.17711/sm.0185-3325.2020.005 · Cited by 2
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Olawale, A. S., Ezekiel, I., Eze, E. D., Oluwamayowa, I., Adams, M. D., Rabiu, K. M., & Ajeka, P. O. (2020) · American Journal of Biomedical Sciences · doi:10.5099/aj200100037 · Cited by 2
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Vrahatis, A. G., Kotsireas, I., & Vlamos, P. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-32622-7_38 · Cited by 2
Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice
Hara, T., Toyama, H., Ohata, Y., Ikeuchi, T., Nakamura, S., Joh, T., & Ohtsubo, K. (2022) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbac125 · Cited by 2
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Troshneva, A. Y., & As, A. (2022) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202212211212 · Cited by 2
Synthesis of benzylidene-benzofuranone derivatives as probes for detection of amyloid fibrils in cells
Tavakoli, M., Ghadami, S. A., Adibi, H., & Gülcan, H. O. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2184635 · Cited by 2
Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study
Drummen, M., Heinecke, A., Dorenbos, E., Vreugdenhil, A. C. E., Raben, A., Westerterp‐Plantenga, M. S., & Adam, T. C. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.06.017 · Cited by 2
Joint Effect of ABCA7 rs4147929 and Body Mass Index on Progression from Mild Cognitive Impairment to Alzheimer’s Disease: The Shanghai Aging Study
Xi, J., Ding, D., Zhao, Q., Liang, X., Zheng, L., Guo, Q., Hong, Z., Fu, H., Xu, J., & Xiao, Q. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200317095608 · Cited by 2
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Kerppers, I. I., Hosni, A. P., Miri, A. L., Cordeiro, M. E. R., Kerppers, F. K., de Lima, M. M. S. V., Bini, A. C. D., Moreira, F. F., Suckow, P. P. T., Fonseca, E. G. D. J., et al. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97081 · Cited by 2
Etiopathogenesis of vitiligo in the light of our studies.
Chorazak, T., & Rzempołuch, E. (1968) · PubMed · Cited by 2
Risk factors associated with Parkinson’s disease: An 11-year population-based South Korean studyPreprint
Kim, H. S., Lee, H.-J., Cha, J., Kwon, J., & Lim, H. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/253690 · Cited by 2
Dopaminergic regulation of insulin secretion from the pancreatic islet
Ustione, A. (2012) · Cited by 2
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Intergenerational Transmission of BMI and Educational Outcomes in Children and Adolescents
Alrouh, H., van Bergen, E., Dolan, C. V., & Boomsma, D. I. (2023) · Twin Research and Human Genetics · doi:10.1017/thg.2023.18 · Cited by 1
An oral glucose tolerance test does not affect cerebral blood flow: role of NOS
Carter, K. J., Ward, A. T., Al‐Subu, A. M., Wilson, A. D., Zevin, E. L., Serlin, R. C., Eldridge, M. W., Wieben, O. E., & Schrage, W. G. (2023) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00169.2022 · Cited by 1
Impact of type 2 diabetes mellitus on differential cerebellar volume reduction in Alzheimer's disease trajectory
Kim, S., Wang, S., Kang, D. W., Kim, S., Jeong, J., Yoon, H., Lim, H. K., & Um, Y. H. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251352208 · Cited by 1
The interplay between obesity and triglyceride-glucose index in modulating Parkinson's disease risk: A cross-sectional NHANES study of middle-aged and young adults
Ma, J., Li, M.-M., & Lei, Z. (2025) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2025.108070 · Cited by 1
Effectiveness of antidiabetic drugs to prevent dementia in people with diabetes
Palui, R., & Ray, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33355-2.00010-4 · Cited by 1
Targeting neuroplasticity in old brain: restoring synapse with cognitive strategies
Kopalli, S. R., Kale, M. B., Yadav, A., Alshahrani, S., Mohammed, A., Oirdi, M. E., Farhan, M., Taksande, B. G., Upaganlawar, A. B., Umekar, M. J., et al. (2026) · Biogerontology · doi:10.1007/s10522-026-10408-1 · Cited by 2
Repurposing Antidiabetic Medications for Parkinson’s Disease: Focus on Biomarker Strategies for Disease Modification
Yelleswarapu, N. K., & Sidiropoulos, C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062560 · Cited by 1
Genetic Risk Factors: Their Function and Comorbidities in Alzheimer′s Disease
Hiltunen, M. O., Bertram, L., & Saunders, A. J. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/925362 · Cited by 1
Identification of Common Target Proteins for Multiple Neurodegenerative Disorders and Reconstruction of Disease Pathway
Ahmad, K., Baig, M. H., Srivastava, A., & Khan, S. A. (2013) · Cited by 1

Authors: Craft, S., & Stennis Watson, G.
Affiliations: University of Washington (US)
Corresponding author: Craft, Suzanne
ORCID: Craft, Suzanne
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2004-03
Volume: 3
Issue: 3
Pages: 169-178
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(04)00681-7
OpenAlex: W2145451941
Cited by: 830
References: 145
Citations by year: 2026: 17 · 2025: 26 · 2024: 29 · 2023: 37 · 2022: 36 · 2021: 27 · 2020: 49 · 2019: 42 · 2018: 36 · 2017: 36 · 2016: 43 · 2015: 37 · 2014: 66 · 2013: 44 · 2012: 48
FWCI: 3.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01-AG-10880, R01AG010880)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061606, DK61606)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: insulin, neurodegenerative diseases, brain insulin signaling, Alzheimer's disease, vascular dementia, Parkinson's disease, Huntington's disease, insulin dysregulation, late-life cognitive decline
MeSH terms: Animals, Brain, Cognition Disorders, Diabetes Mellitus, Energy Metabolism, Humans, Insulin, Receptor, Insulin, Signal Transduction, Neurodegenerative Diseases, Diabetes Complications

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Insulin and neurodegenerative disease: shared and specific mechanisms

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