Cited by 830Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

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Insulin and neurodegenerative disease: shared and specific mechanisms

Craft, Suzanne, Stennis Watson, G·2004·The Lancet Neurology

DOI 10.1016/s1474-4422(04)00681-7

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Abstract

Insulin has functions in the brain and dysregulation of these functions may contribute to the expression of late-life neurodegenerative disease. We provide a brief summary of research on the influence of insulin on normal brain function. We then review evidence that perturbation of this role may contribute to the symptoms and pathogenesis of various neurodegenerative disorders, such as Alzheimer's disease, vascular dementia, Parkinson's disease, and Huntington's disease. We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms.

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Authors: Craft, S., & Stennis Watson, G.
Affiliations: University of Washington (US)
Corresponding author: Craft, Suzanne
ORCID: Craft, Suzanne
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2004-03
Volume: 3
Issue: 3
Pages: 169-178
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(04)00681-7
OpenAlex: W2145451941
Cited by: 830
References: 145
Citations by year: 2026: 17 · 2025: 26 · 2024: 29 · 2023: 37 · 2022: 36 · 2021: 27 · 2020: 49 · 2019: 42 · 2018: 36 · 2017: 36 · 2016: 43 · 2015: 37 · 2014: 66 · 2013: 44 · 2012: 48
FWCI: 3.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01-AG-10880, R01AG010880)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061606, DK61606)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: insulin, neurodegenerative diseases, brain insulin signaling, Alzheimer's disease, vascular dementia, Parkinson's disease, Huntington's disease, insulin dysregulation, late-life cognitive decline
MeSH terms: Animals, Brain, Cognition Disorders, Diabetes Mellitus, Energy Metabolism, Humans, Insulin, Receptor, Insulin, Signal Transduction, Neurodegenerative Diseases, Diabetes Complications

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Insulin and neurodegenerative disease: shared and specific mechanisms

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