Insulin and neurodegenerative disease: shared and specific mechanisms

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126

Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988–1994

Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703

Diabetes mellitus and the risk of dementia: The Rotterdam Study

Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175

Parkinson's Disease

Lang, A. E., & Lozano, A. M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810083391506 · Cited by 2,072

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E. A., Frosch, M. P., Eckman, C. B., Tanzi, R. E., Selkoe, D. J., & Guénette, S. Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0230450100 · Cited by 1,526

The Endocrine Regulation of Aging by Insulin-like Signals

Tatar, M., Bartke, A., & Antebi, A. (2003) · Science · doi:10.1126/science.1081447 · Cited by 1,327

Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function

Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.661 · Cited by 1,258

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

Peila, R., Rodriguez, B. L., & Launer, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1256 · Cited by 1,207

Insulin receptors are widely distributed in the central nervous system of the rat

Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116

Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes

Rulifson, E. J., Kim, S. K., & Nusse, R. (2002) · Science · doi:10.1126/science.1070058 · Cited by 1,064

Potential drug interactions associated with treatments for Type 2 diabetes and its comorbidities: a clinical pharmacology review

Freeman, J. S., & Gross, B. (2011) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.11.64 · Cited by 29

Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats

Nampoothiri, M., Kumar, N., Ramalingayya, G. V., Kutty, N. G., Nandakumar, K., & Rao, C. M. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000799 · Cited by 29

Course of bipolar illness worsens after onset of insulin resistance

Cairns, K., McCarvill, T., Růžičková, M., & Calkin, C. V. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.03.006 · Cited by 29

Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease

Caldwell, C. C., Petzinger, G. M., Jakowec, M. W., & Cadenas, E. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108907 · Cited by 29

Association between exenatide use and incidence of Alzheimer's disease

Zhou, B., Zissimopoulos, J., Nadeem, H., Crane, M. A., Goldman, D. P., & Romley, J. A. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12139 · Cited by 28

Potential Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration

Mehan, S., Bhalla, S., Siddiqui, E. M., Sharma, N., Shandilya, A., & Khan, A. (2022) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s247153 · Cited by 29

Induction of Brain Insulin Resistance and Alzheimer’s Molecular Changes by Western Diet

Mietelska‐Porowska, A., Domańska, J. M., Want, A., Więckowska‐Gacek, A., Chutorański, D., Koperski, M., & Wojda, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094744 · Cited by 29

Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice

Chan, E. S., Chen, C., Cole, G. M., & Wong, B.-S. (2015) · Scientific Reports · doi:10.1038/srep13842 · Cited by 29

Mechanisms of action of brain insulin against neurodegenerative diseases

Ramalingam, M., & Kim, S. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-013-1147-1 · Cited by 30

Effect of Insulin on the Brain Activity Obtained during Visual and Memory Tasks in Healthy Human Subjects

Benedict, L. E., Nelson, C. A., Schunk, E., Sullwold, K., & Seaquist, E. R. (2006) · Neuroendocrinology · doi:10.1159/000093338 · Cited by 33

Association of geriatric conditions and cardiovascular diseases with disability in older adults with diabetes: Findings from a nationally representative survey

Li, C., Chiu, Y., Chang, H., Hsu, K., Bai, Y., & Wang, H. (2012) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2012.00935.x · Cited by 29

Glycemic load and risk of Alzheimer's disease.

Luchsinger, J. A., Tang, M. ‐., & Mayeux, R. P. (2007) · PubMed · Cited by 29

GIGYF2 mutation in late-onset Parkinson’s disease with cognitive impairment

Ruiz‐Martínez, J., Krebs, C. E., Makarov, V., Gorostidi, A., Martí-Massó, J. F., & Paisán‐Ruiz, C. (2015) · Journal of Human Genetics · doi:10.1038/jhg.2015.69 · Cited by 28

Memory advancement by intranasal insulin in type 2 diabetes (MemAID) randomized controlled clinical trial: Design, methods and rationale

Mendez, B. G., Trevino, J. A., McGlinchey, R. E., Fortier, C. B., Lioutas, V., Novák, P., Mantzoros, C. S., Ngo, L. H., & Novak, V. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.105934 · Cited by 29

Diabetes, insulin and new therapeutic strategies for Parkinson’s disease: Focus on glucagon-like peptide-1 receptor agonists

Labandeira, C. M., Bau, A. F., Ron, D. A., Muñoz, A., Losada, G. A., Koukoulis, A., Romero-López, J., & Rodriguez-Perez, A. I. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100914 · Cited by 28

Novel Insights into the Distribution and Functional Aspects of the Calcium Binding Protein Secretagogin from Studies on Rat Brain and Primary Neuronal Cell Culture

Maj, M. A., Milenković, I., Bauer, J., Berggård, T., Veit, M., Ilhan‐Mutlu, A., Wagner, L., & Tretter, V. E. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00084 · Cited by 28

Mouse Models of Alzheimer’s Dementia: Current Concepts and New Trends

Torres‐Alemán, I. (2008) · Endocrinology · doi:10.1210/en.2008-0905 · Cited by 28

Cognitive decline associated with dementia and type 2 diabetes: the interplay of risk factors

Messier, C., & Gagnon, M. (2009) · Diabetologia · doi:10.1007/s00125-009-1533-2 · Cited by 28

Glycation in Huntington’s Disease: A Possible Modifier and Target for Intervention

Brás, I. C., König, A., & Outeiro, T. F. (2019) · Journal of Huntington s Disease · doi:10.3233/jhd-190366 · Cited by 29

The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review

Giuffrè, M., Merli, N., Pugliatti, M., & Moretti, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063337 · Cited by 29

Intranasal Insulin: a Treatment Strategy for Addiction

Kashyap, B., Hanson, L. R., & Frey, W. H. (2020) · Neurotherapeutics · doi:10.1007/s13311-019-00822-4 · Cited by 27

Altered insulin pathway compromises mitochondrial function and quality control both in in vitro and in vivo model systems

Galizzi, G., Palumbo, L., Amato, A., Conigliaro, A., Nuzzo, D., Terzo, S., Caruana, L., Picone, P., Alessandro, R., Mulè, F., et al. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.08.014 · Cited by 28

Neuroprotective Role of DPP-4 Inhibitor Linagliptin Against Neurodegeneration, Neuronal Insulin Resistance and Neuroinflammation Induced by Intracerebroventricular Streptozotocin in Rat Model of Alzheimer’s Disease

Siddiqui, N., Ali, J., Parvez, S., Najmi, A. K., & Akhtar, M. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03924-w · Cited by 30

Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency

Poirier, R., Fernandez, A. M., Torres‐Alemán, I., & Metzger, F. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2011.12.048 · Cited by 27

Ida-1, the Caenorhabditis elegans Orthologue of Mammalian Diabetes Autoantigen IA-2, Potentially Acts as a Common Modulator between Parkinson’s Disease and Diabetes: Role of Daf-2/Daf-16 Insulin Like Signalling Pathway

Fatima, S., Haque, R., Jadiya, P., Shamsuzzama, S., Kumar, L., & Nazir, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113986 · Cited by 27

Cardiovascular Dementia - A Different Perspective

Kumari, U., & Heese, K. (2010) · The Open Biochemistry Journal · doi:10.2174/1874091x01004010029 · Cited by 27

Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer’s disease and normalized by treatment with anti-diabetic agents

Katsel, P., Roussos, P., Beeri, M. S., Gama-Sosa, M. A., Gandy, S., Khan, S., & Haroutunian, V. H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206547 · Cited by 29

Does physical activity reduce risk for Alzheimer's disease through interaction with the stress neuroendocrine system?

Tortosa‐Martínez, J., & Clow, A. (2012) · Stress · doi:10.3109/10253890.2011.629323 · Cited by 29

The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-α/JNK/IRS signaling

Ma, X., Fang, F., Song, M., & Ma, S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.07.081 · Cited by 26

Regional cortical thickness and subcortical volume changes in patients with metabolic syndrome

Song, S.-W., Chung, J., Rho, J. S., Lee, Y.-A., Lim, H. K., Kang, S. G., Kim, H.-N., Kim, J. E., & Kim, S. (2014) · Brain Imaging and Behavior · doi:10.1007/s11682-014-9311-2 · Cited by 26

Managing psychiatric disorders with antidiabetic agents: translational research and treatment opportunities

McIntyre, R. S., Soczynska, J. K., Lewis, G. F., MacQUEEN, G. M., Konarski, J. Z., & Kennedy, S. H. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.7.10.1305 · Cited by 26

Prevention of progression to dementia in the elderly: Rationale and proposal for a health-promoting memory consultation (an IANA task force)

Guyonnet, S., van Kan, G. A., Andrieu, S., Aquino, J. P. R., Arbus, C., Becq, J.-P., Berr, C., Bismuth, S., Chamontin, B., DANTOINE, T. F., et al. (2008) · The journal of nutrition health & aging · doi:10.1007/bf02983204 · Cited by 26

Diabetes and the elderly brain: sweet memories?

Samaras, K., & Sachdev, P. S. (2012) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018812469645 · Cited by 28

Machine learning techniques to discover genes with potential prognosis role in Alzheimer’s disease using different biological sources

Martínez-Ballesteros, M., García-Heredia, J. M., Nepomuceno-Chamorro, I. A., & Riquelme, J. C. (2016) · Information Fusion · doi:10.1016/j.inffus.2016.11.005 · Cited by 24

The role of melatonin in the onset and progression of type 3 diabetes

Song, J., Whitcomb, D. J., & Kim, B. C. (2017) · Molecular Brain · doi:10.1186/s13041-017-0315-x · Cited by 28

DPP4 Inhibitors Can Be a Drug of Choice for Type 3 Diabetes: A Mini Review

Chalichem, N. S. S., Gonugunta, C., Krishnamurthy, P. T., & Basavan, D. (2017) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317517722005 · Cited by 26

Association between Parkinson’s disease and cardiovascular disease mortality: a prospective population-based study from NHANES

Li, K., Zhao, L., Xing, W., & Tang, Q. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02200-2 · Cited by 25

The Interaction of Age and Type 2 Diabetes on Executive Function and Memory in Persons Aged 35 Years or Older

van Eersel, M. E. A., Joosten, H., Gansevoort, R. T., Dullaart, R. P. F., Slaets, J. P. J., & Izaks, G. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082991 · Cited by 28

Combined immunotherapy with “anti-insulin resistance” therapy as a novel therapeutic strategy against neurodegenerative diseases

Takamatsu, Y., Ho, G. J., Koike, W., Sugama, S., Takenouchi, T., Waragai, M., Wei, J., Sekiyama, K., & Hashimoto, M. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-016-0001-1 · Cited by 26

Mens sana in corpore sano: Does the Glycemic Index Have a Role to Play?

Carneiro, L., & Leloup, C. (2020) · Nutrients · doi:10.3390/nu12102989 · Cited by 29

Fluid dynamics in aging-related dementias

Bah, T. M., Siler, D. A., Ibrahim, A. H., Cetas, J. S., & Alkayed, N. J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105986 · Cited by 26

Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer’s Disease

Adem, M. A., Decourt, B., & Sabbagh, M. N. (2024) · Biomedicines · doi:10.3390/biomedicines12010099 · Cited by 30

The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion

Jin, H., Kim, J., Lee, S., Kim, K., Go, M. J., Lee, J., Lee, H., Song, J., Jeon, B. T., Roh, G. S., et al. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.031 · Cited by 26

Reprint of: ‘Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes’

McNay, E. C., & Recknagel, A. K. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.11.001 · Cited by 26

Enhancement of select cognitive domains with rosiglitazone implicates dorsal hippocampus circuitry sensitive to PPARγ agonism in an Alzheimer's mouse model

Cortez, I., Hernandez, C. M., & Dineley, K. T. (2020) · Brain and Behavior · doi:10.1002/brb3.1973 · Cited by 23

Convergent Molecular Pathways in Type 2 Diabetes Mellitus and Parkinson’s Disease: Insights into Mechanisms and Pathological Consequences

Sandeep, X. X. X. X., Ahmad, M. H., Rani, L., & Mondal, A. C. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02867-7 · Cited by 24

Association of Plasma Neurofilament Light Chain With Glycaemic Control and Insulin Resistance in Middle-Aged Adults

Thota, R. N., Chatterjee, P., Pedrini, S., Hone, E., Ferguson, J. J. A., Garg, M. L., & Martins, R. N. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.915449 · Cited by 26

Mammalian Target of Rapamycin at the Crossroad Between Alzheimer’s Disease and Diabetes

Liang, H., Nie, J., Skike, C. E. V., Valentine, J. M., & Orr, M. E. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_10 · Cited by 24

Impact of diabetes mellitus and chronic liver disease on the incidence of dementia and all-cause mortality among patients with dementia

Kim, H. M., Lee, Y., Han, K., Lee, B., Kang, E. S., Kim, J., & Soo, B. (2017) · Medicine · doi:10.1097/md.0000000000008753 · Cited by 23

Are Tanycytes the Missing Link Between Type 2 Diabetes and Alzheimer’s Disease?

Raikwar, S. P., Bhagavan, S., Ramaswamy, S. B., Thangavel, R., Dubova, I., Selvakumar, G. P., Ahmed, M. E., Kempuraj, D., Zaheer, S. A., Iyer, S. S., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1123-8 · Cited by 24

Zinc determines dynamical properties and aggregation kinetics of human insulin

Pounot, K., Grime, G. W., Longo, A., Zamponi, M., Noferini, D., Cristiglio, V., Seydel, T., Garman, E. F., Weik, M., Foderà, V., et al. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2020.11.2280 · Cited by 23

Mutant Huntingtin Impairs Pancreatic β-cells by Recruiting IRS-2 and Disturbing the PI3K/AKT/FoxO1 Signaling Pathway in Huntington’s Disease

Li, L., Sun, Y. T., Zhang, Y., Wang, W., & Ye, C. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01869-9 · Cited by 23

Diet quality and Parkinson’s disease: Potential strategies for non-motor symptom management

Kwon, D., Folle, A. D., Rosario, I. D., Zhang, K., Paul, K. C., Keener, A. M., Bronstein, J. M., & Ritz, B. R. (2023) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2023.105816 · Cited by 23

Cerebrospinal fluid biomarkers of Alzheimer’s disease in cognitively healthy elderly

Glodzik, L. (2013) · Frontiers in bioscience · doi:10.2741/4170 · Cited by 25

Permanent impairment of insulin resistance from pregnancy to adulthood: The primary basic risk factor of chronic Western diseases

Melnik, B. C. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.04.047 · Cited by 23

Hyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer’s Disease?

Hegde, V. K., Dhurandhar, N. V., & Reddy, P. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190808 · Cited by 22

Rosiglitazone and cognitive function in clozapine-treated patients with schizophrenia: A pilot study

Yi, Z., Fan, X., Wang, J., Liu, D., Freudenreich, O., GOFF, D. C., & Henderson, D. C. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.05.020 · Cited by 23

Mutational analysis of GIGYF2, ATP13A2 and GBA genes in Brazilian patients with early-onset Parkinson's disease

dos Santos, A. V., Pestana, C. P., Diniz, K. R. D. S., Campos, M., Abdalla, C. B., de Rosso, A. L. Z., Pereira, J. S., Nicaretta, D. H., de Carvalho, W. L., dos Santos, J. M., et al. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.08.083 · Cited by 24

Cognitive dysfunction and its clinical and radiological determinants in patients with symptomatic arterial disease and diabetes

Tiehuis, A. M., Mali, W. P. T. M., van Raamt, A. F., Visseren, F. L. J., Biessels, G. J., van Zandvoort, M. J. E., Kappelle, L. J., & van der Graaf, Y. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.337 · Cited by 23

Human immunodeficiency virus (HIV) modulates the associations between insulin resistance and cognition in the current combination antiretroviral therapy (cART) era: a study of the Women’s Interagency HIV Study (WIHS)

Valcour, V., Rubin, L. H., Tien, P. C., Anastos, K., Young, M., Mack, W. J., Cohen, M. H., Golub, E. T., Crystal, H., & Maki, P. M. (2015) · Journal of NeuroVirology · doi:10.1007/s13365-015-0330-6 · Cited by 22

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor inC. elegansmodel of Parkinson’s disease

Haque, R., Shamsuzzama, S., Kumar, L., Sharma, T., Fatima, S., Jadiya, P., Siddiqi, M. I., & Nazir, A. (2020) · Oncotarget · doi:10.18632/oncotarget.27366 · Cited by 23

Association Between Leptin, Cognition, and Structural Brain Measures Among “Early” Middle-Aged Adults: Results from the Framingham Heart Study Third Generation Cohort

Sanborn, V. E., Preis, S. R., Ang, T. F. A., Devine, S., Mez, J., DeCarli, C. S., Au, R., Alosco, M. L., & Gunstad, J. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191247 · Cited by 22

Diabetes Exacerbates Sepsis-Induced Neuroinflammation and Brain Mitochondrial Dysfunction

Stork, S. D. S., Hübner, M., Biehl, E., Danielski, L. G., Bonfante, S., Joaquim, L. D. S., Denicol, T. L., Cidreira, T., Pacheco, A., Bagio, É., et al. (2022) · Inflammation · doi:10.1007/s10753-022-01697-y · Cited by 22

Type 2 diabetes mellitus, cognition and brain in aging: A brief review.

Kumar, R., Looi, J. C., & Raphael, B. (2009) · PubMed Central · Cited by 22

Clinical trials of intranasal delivery for treating neurological disorders – a critical review

Liu, X. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.633508 · Cited by 24

Intranasal insulin treatment improves memory and learning in a rat amyloid-beta model of Alzheimer’s disease

Farzampour, S., Majdi, A., & Sadigh‐Eteghad, S. (2016) · Physiology International · doi:10.1556/2060.103.2016.3.7 · Cited by 22

Diabesity and Brain Energy Metabolism: The Case of Alzheimer’s Disease

Cardoso, S., Seiça, R. M. F., & Moreira, P. I. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_5 · Cited by 24

Prefrontal cortex brain damage and glycemic control in patients with type 2 diabetes

CHOI, S. E., Roy, B., Freeby, M., MULLUR, R. S., Woo, M. A., & Kumar, R. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.13019 · Cited by 22

Effects of Exercise and Nutrition on Memory in Japanese Americans With Impaired Glucose Tolerance

Watson, G. S., Reger, M. A., Baker, L. D., McNeely, M. J., Fujimoto, W. Y., Kahn, S. E., Boyko, E. J., Leonetti, D. L., & Craft, S. (2006) · Diabetes Care · doi:10.2337/diacare.29.01.06.dc05-1889 · Cited by 22

Fuel for Thought? A Systematic Review of Neuroimaging Studies into Glucose Enhancement of Cognitive Performance

Peters, R., White, D., Cleeland, C., & Scholey, A. B. (2020) · Neuropsychology Review · doi:10.1007/s11065-020-09431-x · Cited by 21

Frontotemporal Dementia and Glucose Metabolism

Garrett, L. R., & Niccoli, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.812222 · Cited by 20

The role of transforming growth factor β1 /Smad pathway in Alzheimer’s disease inflammation pathology

Yang, C., & Xu, P. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07951-8 · Cited by 22

Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors

Tu, X., Jain, A., Parra-Bueno, P., Decker, H., Liu, X., & Yasuda, R. (2023) · Science Advances · doi:10.1126/sciadv.adg0666 · Cited by 22

METABOLIC SYNDROME AND PSYCHIATRIC ILLNESS

Mendelson, S. D. (2008) · Elsevier eBooks · doi:10.1016/b978-012374240-7.50006-1 · Cited by 21

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: The Role of GSK-3β in the Maintenance of Steady-State Levels of Insulin Receptor Signaling Molecules and Nav1.7 Sodium Channel in Adrenal Chromaffin Cells

Nemoto, T., Yanagita, T., Kanai, T., & Wada, A. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08r20fm · Cited by 21

Current View from Alzheimer Disease to Type 2 Diabetes Mellitus

Rasool, M., Malik, A., Qazi, A. M., SHEIKH, I. A., Manan, A., Shaheen, S., Qazi, M. H., Chaudhary, A., Abuzenadah, A. M., Asif, M., et al. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660167 · Cited by 20

Reestablishment of the hyperglycemia to the normal levels seems not to be essential to the anxiolytic-like effect induced by insulin

Gambeta, E., de Souza, C. P., Morais, H., & Zanoveli, J. M. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9770-1 · Cited by 23

Effect of pioglitazone and simvastatin in lipopolysaccharide-induced amyloidogenesis and cognitive impairment in mice: possible role of glutamatergic pathway and oxidative stress

Ekladious, S. T., & Sayed, N. S. E. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000407 · Cited by 21

Basal Insulin: Beyond Glycemia

Niswender, K. D. (2011) · Postgraduate Medicine · doi:10.3810/pgm.2011.07.2301 · Cited by 20

Insulin resistance: Genetic associations with depression and cognition in population based cohorts

Frangou, S., Shirali, M., Adams, M. J., Howard, D. M., Gibson, J., Hall, L. S., Smith, B. H., Padmanabhan, S., Murray, A. D., Porteous, D. J., et al. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.04.001 · Cited by 19

Insulin, Insulin-Like Growth Factors??and Incretins

McIntyre, R. S., Vagic, D., Swartz, S. A., Soczynska, J. K., Woldeyohannes, H. O., Voruganti, L. P., & Konarski, J. Z. (2008) · CNS Drugs · doi:10.2165/00023210-200822060-00001 · Cited by 20

Maternal high-fat feeding leads to alterations of brain glucose metabolism in the offspring: positron emission tomography study in a porcine model

Sanguinetti, E., Liistro, T., Mainardi, M., Pardini, S., Salvadori, P. A., Vannucci, A., Burchielli, S., & Iozzo, P. (2016) · Diabetologia · doi:10.1007/s00125-015-3848-5 · Cited by 22

Shared pathological pathways of Alzheimer's disease with specific comorbidities: current perspectives and interventions

Nday, C. M., Eleftheriadou, D., & Jackson, G. E. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14256 · Cited by 21

Faster progression from MCI to probable AD for carriers of a single-nucleotide polymorphism associated with type 2 diabetes

Girard, H., Potvin, O., Nugent, S., Dallaire‐Théroux, C., Cunnane, S. C., & Duchesne, S. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.11.013 · Cited by 20

Protection of brain and pancreas from high-fat diet: Effects of catechin and caffeine

Unno, K., Yamamoto, H., Maeda, K., Takabayashi, F., Yoshida, H., Kikunaga, N., Takamori, N., Asahina, S., Iguchi, K., Sayama, K., et al. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.10.009 · Cited by 20

Parkinson disease: Associated disorders in the Norwegian population based incident ParkWest study

SKEIE, G. O., Müller, B. P., Haugarvoll, K., Larsen, J. O., & Tysnes, O. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.07.003 · Cited by 20

Deciphering the role of premicellar and micellar concentrations of sodium dodecyl benzenesulfonate surfactant in insulin fibrillation at pH 2.0

Khan, J. M., Malik, A., Sen, P., Ahmad, A., Ahmed, A., & Atiya, A. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.01.215 · Cited by 20

DPP-4 inhibition by linagliptin ameliorates age-related mild cognitive impairment by regulating microglia polarization in mice

Zhuge, F., Zheng, L., Pan, Y., Ni, L., Fu, Z., Shi, J., & Ni, Y. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114689 · Cited by 19

Heat shock response and insulin-associated neurodegeneration

Urban, M. J., Dobrowsky, R. T., & Blagg, B. S. J. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.11.001 · Cited by 19

Can Yoga-Based Diabetes Management Studies Facilitate Integrative Medicine in India Current Status and Future Directions

Pal, D. K., Bhalla, A., Bammidi, S., Telles, S., Kohli, A., Kumar, S., Devi, P., Kaur, N., Sharma, K., Kumar, R., et al. (2017) · Integrative Medicine International · doi:10.1159/000479816 · Cited by 19

Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects

Valenza, S., Paciaroni, L., Paolini, S., Bonfigli, A. R., Rosa, M. D., Rabini, R. A., Tortato, E., Pelliccioni, P., & Pelliccioni, G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072055 · Cited by 19

Restless legs syndrome in hemodialysis patients

Jafari, M., Rafie, S., Azizi, M., Bahadoram, M., & Jafari, S. (2016) · Saudi Journal of Kidney Diseases and Transplantation · doi:10.4103/1319-2442.178553 · Cited by 19

Plasma levels of insulin and amyloid β42 are correlated in patients with amnestic Mild Cognitive Impairment

Odetti, P. R., Piccini, A., Giliberto, L., Borghi, R., Natale, A., Monacelli, F., Marchese, M., Assini, A., Colucci, M., Cammarata, S., et al. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8303 · Cited by 19

Caloric Intake, Dietary Lifestyles, Macronutrient Composition, and Alzheimer′ Disease Dementia

Pasinetti, G. M., Wang, J., Porter, S., & Ho, L. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/806293 · Cited by 19

Insulin Signaling in Alzheimer’s Disease: Association with Brain Insulin Resistance

Pliszka, M., & Szablewski, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031222 · Cited by 18

Combined caloric restriction and exercise provides greater metabolic and neurocognitive benefits than either as a monotherapy in obesity with or without estrogen deprivation

Pratchayasakul, W., Arunsak, B., Suparan, K., Sriwichaiin, S., Chunchai, T., Chattipakorn, N., & Chattipakorn, S. C. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109125 · Cited by 18

The development and benefits of metformin in various diseases

Dong, Y., Qi, Y., Jiang, H., Tian, M., Zhang, Y., Peng, C. S., Li, W.-C., Zhang, Y., Zhou, Y., Zang, Y., et al. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-0998-6 · Cited by 21

Determinants of Cognitive Development of Low SES Children in Chile: A Post-transitional Country with Rising Childhood Obesity Rates

Galván, M., Uauy, R. D., Corvalán, C., Rodríguez, G. L., & Kain, J. (2012) · Maternal and Child Health Journal · doi:10.1007/s10995-012-1121-9 · Cited by 18

Identification of TYW3/CRYZ and FGD4 as susceptibility genes for amyotrophic lateral sclerosis

Wei, L., Tian, Y., Chen, Y., Wei, Q., Chen, F., Cao, B., Wu, Y., Zhao, B., Chen, X., Xie, C., et al. (2019) · Neurology Genetics · doi:10.1212/nxg.0000000000000375 · Cited by 19

PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes

Johnson, W., Harris, S. E., Starr, J. M., Whalley, L. J., & Deary, I. J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.01.027 · Cited by 18

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Ghasemi, R., Dargahi, L., Haeri, A., Moosavi, M., Mohamed, Z., & Ahmadiani, A. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8404-z · Cited by 123

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

Kellar, D., & Craft, S. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30231-3 · Cited by 832

Mechanisms of action of brain insulin against neurodegenerative diseases

Ramalingam, M., & Kim, S. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-013-1147-1 · Cited by 30

Altered regulation of brain glucose metabolism as a cause of neurodegenerative disorders?

Blum-Degen, D., Frölich, L., Hoyer, S., & Riederer, P. F. (1995) · PubMed · Cited by 55

Role of Insulin in Brain: An Emphasis on Molecular Functions

Kundu, S., & Firdous, S. M. (2022) · INNOSC Theranostics and Pharmacological Sciences · doi:10.36922/itps.v4i2.43 · Cited by 1