The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Insulin and neurodegenerative disease: shared and specific mechanisms
Abstract
Insulin has functions in the brain and dysregulation of these functions may contribute to the expression of late-life neurodegenerative disease. We provide a brief summary of research on the influence of insulin on normal brain function. We then review evidence that perturbation of this role may contribute to the symptoms and pathogenesis of various neurodegenerative disorders, such as Alzheimer's disease, vascular dementia, Parkinson's disease, and Huntington's disease. We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The localization of insulin receptors in the hippocampus and medial temporal cortex suggests that insulin and glucose homeostasis play a role in physiological memory functions through their effect on synaptic plasticity and cellular survival [110].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [110]
Citations
Cites
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703
Diabetes mellitus and the risk of dementia: The Rotterdam Study
Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175
Lang, A. E., & Lozano, A. M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810083391506 · Cited by 2,072
Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E. A., Frosch, M. P., Eckman, C. B., Tanzi, R. E., Selkoe, D. J., & Guénette, S. Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0230450100 · Cited by 1,526
The Endocrine Regulation of Aging by Insulin-like Signals
Tatar, M., Bartke, A., & Antebi, A. (2003) · Science · doi:10.1126/science.1081447 · Cited by 1,327
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.661 · Cited by 1,258
Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies
Peila, R., Rodriguez, B. L., & Launer, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1256 · Cited by 1,207
Insulin receptors are widely distributed in the central nervous system of the rat
Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116
Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes
Rulifson, E. J., Kim, S. K., & Nusse, R. (2002) · Science · doi:10.1126/science.1070058 · Cited by 1,064
Research works printed but not linked: 1
- Schobotz, 1976, Fatty acid patterns and glucose tolerance in Huntington's chorea, Res Exp Med (Berl), 167, 203
Cited by
Sorted by citations
Items 801–828 of 828
Épidémiologie descriptive et étiologique
Elbaz, A., Artaud, F., Domenighetti, C., Hajji, M., Nguyen, T. T. H., Portugal, B., & Moisan, F. (2025) · Elsevier eBooks · doi:10.1016/b978-2-294-78712-6.00002-6
Yin, K., Gu, X., Yu, J., Su, W., Yang, W., Duan, Q., He, S., Shen, C., Lu, S., Chi, L., et al. (2025) · Movement Disorders · doi:10.1002/mds.70010
Chen, L., Yin, Y., Gou, M., Pan, S., Tong, J., Zhou, Y., Xie, T., Yu, T. Y., Li, Y., Cui, Y., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07458-z · Cited by 1
Astaxanthin: A promising nutraceutical for cardiovascular health
Daoud, M. S. (2025) · Journal of King Saud University - Science · doi:10.25259/jksus_512_2025
Risk of dementia in diabetes mellitus: a mechanistic endeavor
Samanta, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33355-2.00029-3
Transcriptome analysis of Alzheimer's disease identifies links to cardiovascular disease
Ray, M. (2008) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7jw8c4j
Exploring the Association Between Depression and Obesity Among Alzheimer's Patients
Clugstone, S. (2014) · Scholar Commons (University of South Carolina)
Nasiri, E., Sankowski, R., Dietrich, H., Oikonomidi, A., Huerta, P. T., Popp, J., Al-Abed, Y., & Bacher, M. (2020) · Figshare · doi:10.6084/m9.figshare.12150948
The Role of Nutraceuticals in the Treatment of Neurodegenerative Diseases
Kumari, L., Datta, A., Sen, P., Dhara, S., & Badwaik, H. R. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898812553125010009
Long-term fasting insulin variability and cognitive function: Insights from the CARDIA study
Huang, B.-S., Huang, Z., Zeng, Y.-H., Bai, K.-H., Guo, J., Weng, J., Li, Z. H., & Hao, Q.-Y. (2026) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2026.100487
POTENTIAL EFFECTS OF SGLT-2 INHIBITORS ON PARKINSON DISEASE
Baskın, V. (2026) · TOGÜ Sağlık Bilimleri Dergisi · doi:10.52369/togusagbilderg.1652318
Cho, Y. E., Kim, A., Lee, H. M., Oh, J. W., Son, S. J., Roh, H. W., Jung, Y.-S., Hong, C. H., Lee, S. Y., & Kim, K. P. (2026) · Molecular Brain · doi:10.1186/s13041-026-01294-2
Papazoglou, I. (2013) · theses.fr (ABES) · doi:10.70675/06d278b5zf0a0z456dz9c4cz9dc680b45fd3 · Cited by 1
Dynamics of pathological aggregates and fibers
Pounot, K. (2020) · theses.fr (ABES) · doi:10.70675/b306d45azfd69z4b88z80c0z948cf17c885c
Nowakowski, D., Zańko, A., Pawłowski, M., & Milewski, R. J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27135876
Yousef, A. I., El-Twab, S. M. A., Khadrawy, S. M., Abdel‐Moneim, A., & Khalil, R. G. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01925-6
Gao, P., Su, J., Ma, X., Ma, X., Chen, Y., Shen, J., Wu, Y., Shi, C., & Li, J. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71044
WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signalingPreprint
Jaykumar, A. B., Binns, D. D., Taylor, C. A., Anselmo, A. N., Kankanamalage, S. G., Birnbaum, S. G., Huber, K. M., & Cobb, M. H. (2026) · eLife · doi:10.7554/elife.100097.3
Safety and tolerability of intranasal insulin in Parkinson’s disease
Johnson, J. C., Kashyap, B., Gustafson, S. K., O’Brien, M., Frey, W. H., Svitak, A. L., & Hanson, L. R. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1875165
Macesic, M. V., Lalic, K. S., Lukić, L., Milicic, T. J., Stojmenović, G. M., Stojković, T., Gajović, J. S., Stoiljkovic, M. M., Milin-Lazovic, J. S., Milovancevic, M. M., et al. (2026) · Diabetology · doi:10.3390/diabetology7090186
elaaty, T. A., Badrah, M., Elnily, D., & NAWAR, A. A. K. (2026) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-026-00732-w
Retinal microvascular abnormalities and cognitive function in older people with type 2 diabetes
Ding, J. (2010) · Edinburgh Research Archive (University of Edinburgh)
Doctor of Nursing Practice portfolio of Rodica Malos
Malos, R. (2009) · doi:10.6083/m4513wz5
Metadata
- Authors
- Craft, S., & Stennis Watson, G.
- Affiliations
- University of Washington (US)
- Corresponding author
- Craft, Suzanne
- ORCID
- Craft, Suzanne
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 3
- Issue
- 3
- Pages
- 169-178
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2145451941
- Cited by
- 830
- References
- 145
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 29 · 2023: 37 · 2022: 36 · 2021: 27 · 2020: 49 · 2019: 42 · 2018: 36 · 2017: 36 · 2016: 43 · 2015: 37 · 2014: 66 · 2013: 44 · 2012: 48
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01-AG-10880, R01AG010880)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061606, DK61606)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- insulin, neurodegenerative diseases, brain insulin signaling, Alzheimer's disease, vascular dementia, Parkinson's disease, Huntington's disease, insulin dysregulation, late-life cognitive decline
- MeSH terms
- Animals, Brain, Cognition Disorders, Diabetes Mellitus, Energy Metabolism, Humans, Insulin, Receptor, Insulin, Signal Transduction, Neurodegenerative Diseases, Diabetes Complications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review