Cited by 830Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.

Insulin and neurodegenerative disease: shared and specific mechanisms

Craft, Suzanne, Stennis Watson, G·2004·The Lancet Neurology

Abstract

Insulin has functions in the brain and dysregulation of these functions may contribute to the expression of late-life neurodegenerative disease. We provide a brief summary of research on the influence of insulin on normal brain function. We then review evidence that perturbation of this role may contribute to the symptoms and pathogenesis of various neurodegenerative disorders, such as Alzheimer's disease, vascular dementia, Parkinson's disease, and Huntington's disease. We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms.

Overview

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Crossref · 10.1016/s1474-4422(04)00681-7

Cites

145 of 145 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 145 references

Research works printed but not linked: 1

  1. Schobotz, 1976, Fatty acid patterns and glucose tolerance in Huntington's chorea, Res Exp Med (Berl), 167, 203

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Metadata

Authors
Craft, S., & Stennis Watson, G.
Affiliations
University of Washington (US)
Corresponding author
Craft, Suzanne
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2004-03
Volume
3
Issue
3
Pages
169-178
ISSN
1474-4422 (ISSN-L)
OpenAlex
W2145451941
Cited by
830
References
145
Citations by year
2026: 17 · 2025: 26 · 2024: 29 · 2023: 37 · 2022: 36 · 2021: 27 · 2020: 49 · 2019: 42 · 2018: 36 · 2017: 36 · 2016: 43 · 2015: 37 · 2014: 66 · 2013: 44 · 2012: 48
FWCI
3.57
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01-AG-10880, R01AG010880)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061606, DK61606)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
insulin, neurodegenerative diseases, brain insulin signaling, Alzheimer's disease, vascular dementia, Parkinson's disease, Huntington's disease, insulin dysregulation, late-life cognitive decline
MeSH terms
Animals, Brain, Cognition Disorders, Diabetes Mellitus, Energy Metabolism, Humans, Insulin, Receptor, Insulin, Signal Transduction, Neurodegenerative Diseases, Diabetes Complications

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