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Ageing and multiple sclerosis
Open accessAbstract
The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection.
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“The efficacy of remyelination has been shown to depend on multiple factors such as, age, disease duration and lesion location.”
From BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis (2025) · cites this paper as [7]
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Metadata
- Authors
- Graves, J. S., Krysko, K. M., Hua, L. H., Absinta, M., Franklin, R. J. M., & Segal, B. M.
- Affiliations
- United States Department of Veterans Affairs (US)
- St. Michael's Hospital (CA)
- Cleveland Clinic (US)
- Johns Hopkins University (US)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- The Ohio State University (US)
- Corresponding author
- Graves, Jennifer S
- ORCID
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2023-01
- Volume
- 22
- Issue
- 1
- Pages
- 66-77
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W4303473149
- Cited by
- 260
- References
- 113
- Citations by year
- 2026: 74 · 2025: 84 · 2024: 68 · 2023: 33
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 162 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- The Lancet Neurology (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- National Institute of Neurological Disorders and Stroke
- Multiple Sclerosis Society (MS50)
- Conrad N. Hilton Foundation (17313)
- Fondazione Cariplo (1677)
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Fondazione per la Ricerca Biomedica (1750327)
- Ohio State University
- Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge (203151/Z/16/Z)
- Wellcome Trust
- National Eye Institute
- National Institutes of Health (R01EY028350, R01EY029159, R01NS105385)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Keywords
- multiple sclerosis, aging, age of onset, relapsing-remitting multiple sclerosis, progressive multiple sclerosis, disability progression, immunosenescence, disease-modifying therapy, adverse drug reactions, reproductive aging, cellular senescence, senolytics, remyelination, neuroprotection
- MeSH terms
- Aging, Disabled Persons, Persons with Disabilities, Humans, Multiple Sclerosis, Disease Progression, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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