Ageing and multiple sclerosis

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

Horvath, S., & Raj, K. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0004-3 · Cited by 3,095

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

Montalban, X., Hauser, S. L., Kappos, L., Arnold, D. L., Bar-Or, A., Comi, G., de Seze, J., Giovannoni, G., Hartung, H.-P., Hemmer, B., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1606468 · Cited by 1,905

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

Blackburn, E. H., Epel, E. S., & Lin, J. (2015) · Science · doi:10.1126/science.aab3389 · Cited by 1,596

Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology

Magliozzi, R., Howell, O. W., Vora, A., Serafini, B., Nicholas, R. S., Puopolo, M., Reynolds, R., & Aloisi, F. (2006) · Brain · doi:10.1093/brain/awm038 · Cited by 1,486

Microglial control of astrocytes in response to microbial metabolites

Rothhammer, V., Borucki, D. M., Tjon, E. C., Takenaka, M. C., Chao, C.-C., Ardura-Fabregat, A., de Lima, K. A., Gutiérrez-Vázquez, C., Hewson, P., Staszewski, O., et al. (2018) · Nature · doi:10.1038/s41586-018-0119-x · Cited by 1,051

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Kappos, L., Bar-Or, A., Cree, B. A. C., Fox, R. J., Giovannoni, G., Gold, R., Vermersch, P., Arnold, D. L., Arnould, S., Scherz, T., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30475-6 · Cited by 942

Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine

Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.-H., May, C., Wilck, N., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.007 · Cited by 927

Review: microglia of the aged brain: primed to be activated and resistant to regulation

Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792

A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

Absinta, M., Maric, D., Gharagozloo, M., Garton, T., Smith, M. D., Jin, J., Fitzgerald, K. C., Song, A., Liu, P., Lin, J.-P., et al. (2021) · Nature · doi:10.1038/s41586-021-03892-7 · Cited by 768

A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: Overview

Marrie, R., Cohen, J., Stüve, O., Trojano, M., Sørensen, P., Reingold, S., Cutter, G., & Reider, N. (2015) · Multiple Sclerosis · doi:10.1177/1352458514564491 · Cited by 762

Subpial Demyelination in the Cerebral Cortex of Multiple Sclerosis Patients

Bø, L., Vedeler, C. A., Nyland, H. I., Trapp, B. D., & Mørk, S. J. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.7.723 · Cited by 757

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

Frischer, J. M., Weigand, S. D., Guo, Y., Kale, N., Parisi, J. E., Pirko, I., Mandrekar, J., Bramow, S., Metz, I., Brück, W., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24497 · Cited by 728

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

Mogilenko, D. A., Shpynov, O., Andhey, P. S., Arthur, L., Swain, A., Esaulova, E., Brioschi, S., Shchukina, I., Kerndl, M., Bambouskova, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2020.11.005 · Cited by 683

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

Duscha, A., Gisevius, B., Hirschberg, S., Yissachar, N., Stangl, G. I., Dawin, E., Bader, V., Haase, S., Kaisler, J., David, C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.035 · Cited by 654

Rejuvenation of Regeneration in the Aging Central Nervous System

Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.019 · Cited by 649

Regenerating CNS myelin — from mechanisms to experimental medicines

Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647

The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625

Defective cholesterol clearance limits remyelination in the aged central nervous system

Cantuti-Castelvetri, L., Fitzner, D., Bosch-Queralt, M., Weil, M.-T., Su, M., Sen, P., Ruhwedel, T., Mitkovski, M., Trendelenburg, G., Lütjohann, D., et al. (2018) · Science · doi:10.1126/science.aan4183 · Cited by 586

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Kaufmann, T., van der Meer, D., Doan, N. T., Schwarz, E., Lund, M. J., Agartz, I., Alnæs, D., Barch, D. M., Baur‐Streubel, R., Bertolino, A., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0471-7 · Cited by 575

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Khalil, M., Pirpamer, L., Hofer, E., Voortman, M. M., Barro, C., Leppert, D., Benkert, P., Ropele, S., Enzinger, C., Fazekas, F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14612-6 · Cited by 572

Retinoid X receptor gamma signaling accelerates CNS remyelination

Huang, J. K., Jarjour, A. A., Nait Oumesmar, B., Kerninon, C., Williams, A., Krezel, W., Kagechika, H., Bauer, J., Zhao, C., Evercooren, A. B.-V., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2702 · Cited by 547

Age at disability milestones in multiple sclerosis

Confavreux, C., & Vukusic, S. (2006) · Brain · doi:10.1093/brain/awh714 · Cited by 544

Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo

Absinta, M., Sati, P., Masuzzo, F., Nair, G., Sethi, V., Kolb, H., Ohayon, J., Wu, T., Cortese, I. C. M., & Reich, D. S. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2399 · Cited by 534

Regulatory T cells promote myelin regeneration in the central nervous system

Dombrowski, Y., O'Hagan, T., Dittmer, M., Penalva, R., Mayoral, S. R., Bankhead, P., Fleville, S., Eleftheriadis, G., Zhao, C., Naughton, M., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4528 · Cited by 533

Niche stiffness underlies the ageing of central nervous system progenitor cells

Segel, M., Neumann, B., Hill, M. F. E., Weber, I. P., Viscomi, C., Zhao, C., Young, A., Agley, C. C., Thompson, A. J., Gonzalez, G. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1484-9 · Cited by 532

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi, C., Marchi, S., Simões, I. C. M., Ren, Z., Morciano, G., Perrone, M., Patalas‐Krawczyk, P., Borchard, S., Jędrak, P., Pierzynowska, K., et al. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.006 · Cited by 484

Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis

Marrie, R. A., Rudick, R. A., Horwitz, R. I., Cutter, G., Tyry, T. M., Campagnolo, D. I., & Vollmer, T. L. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d6b125 · Cited by 481

Increased Relapse Rate in Pediatric-Onset Compared With Adult-Onset Multiple Sclerosis

Gorman, M., Healy, B. C., Polgar‐Turcsanyi, M., & Chitnis, T. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.505 · Cited by 459

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

Chataway, J., Schuerer, N., Alsanousi, A., Chan, D., MacManus, D. G., Hunter, K., Anderson, V. M., Bangham, C. R. M., Clegg, S., Nielsen, C. F., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62242-4 · Cited by 456

Deep gray matter volume loss drives disability worsening in multiple sclerosis

Eshaghi, A., Prados, F., Brownlee, W. J., Altmann, D. R., Tur, C., Cardoso, M. J., Angelis, F. D., van de Pavert, S. H., Cawley, N., Stefano, N. D., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25145 · Cited by 454

Metformin restores CNS remyelination capacity by rejuvenating aged stem cells

Neumann, B., Baror, R., Zhao, C., Segel, M., Dietmann, S., Rawji, K. S., Foerster, S., McClain, C. R., Chalut, K., van Wijngaarden, P., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.08.015 · Cited by 449

Remyelination capacity of the MS brain decreases with disease chronicity

Goldschmidt, T., Antel, J., König, F. B., Brück, W., & Kuhlmann, T. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a8260a · Cited by 411

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain

Haider, L., Zrzavy, T., Hametner, S., Höftberger, R., Bagnato, F., Grabner, G., Trattnig, S., Pfeifenbring, S., Brück, W., & Lassmann, H. (2016) · Brain · doi:10.1093/brain/awv398 · Cited by 400

Dynamics of oligodendrocyte generation in multiple sclerosis

Yeung, M. S. Y., Djelloul, M., Steiner, E., Bernard, S., Salehpour, M., Possnert, G., Brundin, L., & Frisén, J. (2019) · Nature · doi:10.1038/s41586-018-0842-3 · Cited by 376

Remyelination in multiple sclerosis: From basic science to clinical translation

Lubetzki, C., Zalc, B., Williams, A., Stadelmann, C., & Stankoff, B. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30140-x · Cited by 350

Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions

Absinta, M., Sati, P., Schindler, M., Leibovitch, E. C., Ohayon, J., Wu, T., Meani, A., Filippi, M., Jacobson, S., Cortese, I. C. M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86198 · Cited by 327

Mitochondrial Dysfunction and Multiple Sclerosis

de Barcelos, I. P., Troxell, R. M., & Graves, J. (2019) · Biology · doi:10.3390/biology8020037 · Cited by 293

Gut Microbiome in Progressive Multiple Sclerosis

Cox, L. M., Maghzi, A. H., Liu, S., Tankou, S. K., Dhang, F. H., Willocq, V., Song, A., Wasén, C., Tauhid, S., Chu, R., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26084 · Cited by 292

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

Fox, R. J., Coffey, C. S., CONWIT, R. A., Cudkowicz, M., Gleason, T., Goodman, A. D., Klawiter, E. C., Matsuda, K., McGovern, M. M., Naismith, R. T., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1803583 · Cited by 285

Age and disability accumulation in multiple sclerosis

Scalfari, A., Neuhaus, A., Daumer, M., Ebers, G. C., & Muraro, P. A. (2011) · Neurology · doi:10.1212/wnl.0b013e318230a17d · Cited by 279

Relapses in multiple sclerosis are age- and time-dependent

Tremlett, H. L., Zhao, Y., Joseph, J. P., & Devonshire, V. A. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.145805 · Cited by 278

Human CD 8 + EMRA T cells display a senescence‐associated secretory phenotype regulated by p38 MAPK

Callender, L. A., Carroll, E. C., Beal, R. W. J., Chambers, E. S., Nourshargh, S., Akbar, A. N., & Henson, S. M. (2017) · Aging Cell · doi:10.1111/acel.12675 · Cited by 278

Age-Associated Changes in Gut Microbiota and Dietary Components Related with the Immune System in Adulthood and Old Age: A Cross-Sectional Study

Salazar, N., Arboleya, S., Fernández-Navarro, T., Reyes‐Gavilán, C. G. D. L., González, S., & Gueimonde, M. (2019) · Nutrients · doi:10.3390/nu11081765 · Cited by 241

Long-term evolution of multiple sclerosis iron rim lesions in 7 T MRI

Dal‐Bianco, A., Grabner, G., Kronnerwetter, C., Weber, M., Kornek, B., Kasprian, G. J., Berger, T., Leutmezer, F., Rommer, P. S., Trattnig, S., et al. (2020) · Brain · doi:10.1093/brain/awaa436 · Cited by 230

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Natrajan, M. S., de la Fuente, A. G., Crawford, A. H., Linehan, E., Núñez, V., Johnson, K. R., Wu, T., Fitzgerald, D. C., Ricote, M., Bielekova, B., et al. (2015) · Brain · doi:10.1093/brain/awv289 · Cited by 225

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

Wynne, A. M., Henry, C. J., Huang, Y., Cleland, A., & Godbout, J. P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.05.011 · Cited by 224

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis

Elliott, C., Belachew, S. M., Wolinsky, J. S., Hauser, S. L., Kappos, L., Barkhof, F., Bernasconi, C., Fecker, J., Model, F., Wei, W., et al. (2019) · Brain · doi:10.1093/brain/awz212 · Cited by 221

Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study

Maggi, P., Sati, P., Nair, G., Cortese, I. C. M., Jacobson, S., Smith, B., Nath, A., Ohayon, J. M., Pesch, V. V., Perrotta, G., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25877 · Cited by 216

Testosterone Treatment in Multiple Sclerosis

Sicotte, N. L., Giesser, B. S., Tandon, V., Klutch, R., Steiner, B., Drain, A. E., Shattuck, D. W., Hull, L., Wang, H.-J., Elashoff, R. M., et al. (2007) · Archives of Neurology · doi:10.1001/archneur.64.5.683 · Cited by 215

Sex as a determinant of relapse incidence and progressive course of multiple sclerosis

Kalinčík, T., Vivek, V., Jokubaitis, V., Lechner‐Scott, J., Trojano, M., Izquierdo, G., Lugaresi, A., Grand’Maison, F., Hupperts, R., Oreja‐Guevara, C., et al. (2013) · Brain · doi:10.1093/brain/awt281 · Cited by 210

Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients

Claes, N., Fraussen, J., Vanheusden, M., Hellings, N., Stinissen, P., Wijmeersch, B. V., Hupperts, R., & Somers, V. A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502448 · Cited by 206

Alterations in Circulating Fatty Acid Are Associated With Gut Microbiota Dysbiosis and Inflammation in Multiple Sclerosis

Saresella, M., Marventano, I., Barone, M., Rosa, F. L., Piancone, F., Mendozzi, L., d’Arma, A., Rossi, V., Pugnetti, L., Roda, G., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01390 · Cited by 206

Telomere biology and age-related diseases

Herrmann, M., Pusceddu, I., März, W., & Herrmann, W. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0870 · Cited by 200

CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia

Parajuli, B., Horiuchi, H., Mizuno, T., Takeuchi, H., & Suzumura, A. (2015) · Glia · doi:10.1002/glia.22892 · Cited by 163

Analyses of immunosenescent markers in patients with autoimmune disease

Thewissen, M. M., Somers, V. A., Venken, K., Linsen, L., van Paassen, P., Geusens, P., Damoiseaux, J. G. M. C., & Stinissen, P. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.01.005 · Cited by 160

Longitudinal Assessment of Multiple Sclerosis with the Brain‐Age Paradigm

Cole, J. H., Raffel, J., Friede, T., Eshaghi, A., Brownlee, W. J., Chard, D., Stefano, N. D., Enzinger, C., Pirpamer, L., Filippi, M., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25746 · Cited by 158

Sex Hormones in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis

Voskuhl, R. R., & Palaszynski, K. (2001) · The Neuroscientist · doi:10.1177/107385840100700310 · Cited by 158

Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin

Franklin, R. J. M., Frisén, J., & Lyons, D. A. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.09.009 · Cited by 154

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Rawji, K. S., Young, A. M. H., Ghosh, T., Michaels, N. J., Mirzaei, R., Kappen, J., Kolehmainen, K. L., Alaeiilkhchi, N., Lozinski, B., Mishra, M. K., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02129-7 · Cited by 153

Correlation between brain volume loss and clinical and MRI outcomes in multiple sclerosis

Radue, E. W., Barkhof, F., Kappos, L., Sprenger, T., Häring, D. A., de Vera, A., von Rosenstiel, P., Bright, J. R., Francis, G., & Cohen, J. A. (2015) · Neurology · doi:10.1212/wnl.0000000000001281 · Cited by 144

Long-term outcome of paediatric-onset multiple sclerosis: a population-based study

Harding, K. E., Liang, K., Cossburn, M., Ingram, G., Hirst, C. L., Pickersgill, T. P., Naudé, J. T. W., Wardle, M., Ben‐Shlomo, Y., & Robertson, N. P. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303996 · Cited by 138

Premature Immunosenescence in Rheumatoid Arthritis and Multiple Sclerosis Patients

Thewissen, M. M., Linsen, L., Somers, V. A., Geusens, P., Raus, J., & Stinissen, P. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.066 · Cited by 133

An emerging role for eotaxins in neurodegenerative disease

Huber, A. K., Giles, D. A., Segal, B. M., & Irani, D. N. (2018) · Clinical Immunology · doi:10.1016/j.clim.2016.09.010 · Cited by 133

Comorbidity increases the risk of relapse in multiple sclerosis

Kowalec, K., McKay, K. A., Patten, S. B., Fisk, J. D., Evans, C. D., Tremlett, H. L., Marrie, R. A., For the CIHR Team in Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS), CIHR Team in Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS), Blanchard, J., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004716 · Cited by 130

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

Chataway, J., Angelis, F. D., Connick, P., Parker, R. A., Plantone, D., Doshi, A., John, N. A., Stutters, J., MacManus, D. G., Prados, F., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30485-5 · Cited by 126

Evaluating the Risk of Macrovascular Events and Mortality Among People With Multiple Sclerosis in England

Palladino, R., Marrie, R. A., Majeed, A., & Chataway, J. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.0664 · Cited by 124

Remyelination and ageing: Reversing the ravages of time

Neumann, B., Segel, M., Chalut, K. J., & Franklin, R. J. M. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458519884006 · Cited by 114

Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial

Cree, B., Cutter, G., Wolinsky, J. S., Freedman, M. S., Comı, G., Giovannoni, G., Hartung, H.-P., Arnold, D. L., Kühle, J., Block, V. J., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30347-1 · Cited by 113

Chronic White Matter Inflammation and Serum Neurofilament Levels in Multiple Sclerosis

Maggi, P., Kühle, J., Schädelin, S., van der Meer, F., Weigel, M., Galbusera, R., Mathias, A., Lu, P., Rahmanzadeh, R., Benkert, P., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000012326 · Cited by 112

Infection-related health care utilization among people with and without multiple sclerosis

Wijnands, J. M. A., Kingwell, E., Zhu, F., Zhao, Y., Fisk, J. D., Evans, C. D., Marrie, R. A., & Tremlett, H. L. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516681198 · Cited by 106

Sex effects across the lifespan in women with multiple sclerosis

Krysko, K. M., Graves, J. S., Dobson, R., Altıntaş, A., Amato, M. P., Bernard, J. T., Bonavita, S., Bove, R. M., Cavalla, P., Clerico, M., et al. (2020) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286420936166 · Cited by 105

Intracellular and Extracellular Roles of Granzyme K

Bouwman, A. C., van Daalen, K. R., Crnko, S., ten Broeke, T., & Bovenschen, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.677707 · Cited by 105

Cx3cr1- deficient microglia exhibit a premature aging transcriptome

Gyoneva, S., Hosur, R., Gosselin, D., Zhang, B., Ouyang, Z., Cotleur, A. C., Peterson, M., Allaire, N., Challa, R., Cullen, P., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201900453 · Cited by 103

Molecular signature of slowly expanding lesions in progressive multiple sclerosis

Jäckle, K., Zeis, T., Schaeren‐Wiemers, N., Junker, A., van der Meer, F., Kramann, N., Stadelmann, C., & Brück, W. (2020) · Brain · doi:10.1093/brain/awaa158 · Cited by 102

Potential role of indolelactate and butyrate in multiple sclerosis revealed by integrated microbiome-metabolome analysis

Levi, I., Gurevich, M., Perlman, G., Magalashvili, D., Menascu, S., Bar, N., Godneva, A., Zahavi, L., Chermon, D., Kosower, N., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100246 · Cited by 99

The telomere/telomerase system in autoimmune and systemic immune-mediated diseases

Georgin-Lavialle, S., Aouba, A., Mouthon, L., Londono-Vallejo, J. A., Lepelletier, Y., Gabet, A.-S., & Hermine, O. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.04.004 · Cited by 97

Exploration of changes in disability after menopause in a longitudinal multiple sclerosis cohort

Bove, R. M., Healy, B. C., Musallam, A., Glanz, B. I., Jager, P. L. D., & Chitnis, T. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515606211 · Cited by 90

Discontinuation of disease-modifying therapy in patients with multiple sclerosis over age 60

Hua, L. H., Fan, T. H., Conway, D. S., Thompson, N. R., & Kinzy, T. G. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458518765656 · Cited by 89

Body mass index, but not vitamin D status, is associated with brain volume change in MS

Mowry, E. M., Azevedo, C. J., McCulloch, C. E., Okuda, D. T., Lincoln, R., Waubant, E. L., Hauser, S. L., & Pelletier, D. (2018) · Neurology · doi:10.1212/wnl.0000000000006644 · Cited by 89

Functional microbiome deficits associated with ageing: Chronological age threshold

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Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration

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