Probiotics and colon cancer
Abstract
Although a myriad of health-promoting effects have been attributed to the probiotic lactic acid bacteria, perhaps the most interesting and controversial is that of anticancer activity, the vast majority of studies in this area dealing with protective effects against colon cancer. There is no direct experimental evidence for cancer suppression in humans as a result of the consumption of probiotic cultures in fermented or unfermented dairy products, but there is a wealth of indirect evidence, based largely on laboratory studies. Reports in the literature regarding the anticancer effects of lactic acid bacteria fall into the categories of in vitro studies, animal studies, epidemiological studies and human dietary intervention studies. Examples of these reports will be given in the current paper. The mechanisms by which probiotic bacteria may inhibit colon cancer are still poorly understood, but, several potential mechanisms are being discussed in the literature, and these will also be addressed in this review.
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Lower pathogenic bacteria in the gastrointestinal tract might reduce harmful enzymes such as nitroreductase, azoreductase and β-glucuronidase, which are implicated as initial causes of colon cancer formation.
“The lower pathogenic bacteria in the gastrointestinal tract might be implicated in reducing harmful enzymes, such as nitroreductase, azoreductase and β-glucuronidase, which are implicated initial causes of colon cancer formation [39,40].”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [40]
Cites
Functional food science and gastrointestinal physiology and function
Salminen, S., Bouley, C., Boutron, M.-C., Cummings, J. H., Franck, A., Gibson, G. R., Isolauri, E., Moreau, M.-C., Roberfroid, M., & Rowland, I. (1998) · British Journal of Nutrition · doi:10.1079/bjn19980108 · Cited by 1,398 · see citing works
Important Advances in Oncology: 1986
Merrill, J. M. (1986) · JAMA · doi:10.1001/jama.1986.03380040106043 · Cited by 909 · see citing works
Important Advances in Oncology
DeVita, V. T., Hellman, S., & Rosenberg, S. A. (1991) · Anti-Cancer Drugs · doi:10.1097/00001813-199108000-00014 · Cited by 760 · see citing works
MacLennan, R., & Jensen, O. M. (1977) · PubMed · Cited by 685 · see citing works
Immunomodulation of Human Blood Cells Following the Ingestion of Lactic Acid Bacteria
Schiffrin, E. J., Rochat, F., Link‐Amster, H., Aeschlimann, J., & Donnet‐Hughes, A. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76659-0 · Cited by 553 · see citing works
Rowland, I. R. (1998) · Carcinogenesis · doi:10.1093/carcin/19.2.281 · Cited by 469 · see citing works
The effect of milk and lactobacillus feeding on human intestinal bacterial enzyme activity
Goldin, B. R., & Gorbach, S. L. (1984) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/39.5.756 · Cited by 401 · see citing works
Spanhaak, S., Havenaar, R., & Schaafsma, G. (1998) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600663 · Cited by 399 · see citing works
Diet and colon cancer in Los Angeles County, California
Peters, R. K., Pike, M. C., Garabrant, D. H., & Mack, T. M. (1992) · Cancer Causes & Control · doi:10.1007/bf00051359 · Cited by 325 · see citing works
Reddy, B. S., & Rivenson, A. (1993) · PubMed · Cited by 304 · see citing works
Effect of Diet and Lactobacillus acidophilus Supplements on Human Fecal Bacterial Enzymes23
Goldin, B. R., Swenson, L., Dwyer, J., Sexton, M., & Gorbach, S. L. (1980) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/64.2.255 · Cited by 286 · see citing works
Role of the Gut Flora in Toxicity and Cancer
(1988) · Elsevier eBooks · doi:10.1016/b978-0-12-599920-5.x5001-8 · Cited by 283 · see citing works
Bifidobacteria and Bifidogenic Factors
Modler, H. W., McKellar, R. C., & Yaguchi, M. (1990) · Canadian Institute of Food Science and Technology Journal · doi:10.1016/s0315-5463(90)70197-6 · Cited by 278 · see citing works
Lactobacillus‐ and bifidobacterium‐mediated antigenotoxicity in the colon of rats
Pool-Zobel, B. L., Neudecker, C., Domizlaff, I., Ji, S., Schillinger, U., Rumney, C. J., Moretti, M., Vilarini, I., Scassellati‐Sforzolini, R., & Rowland, I. R. (1996) · Nutrition and Cancer · doi:10.1080/01635589609514492 · Cited by 256 · see citing works
Singh, J. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.833 · Cited by 256 · see citing works
Goldin, B. R., & Gorbach, S. L. (1980) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/64.2.263 · Cited by 249 · see citing works
Case‐control study of proximal and distal colon cancer and diet in Wisconsin
Young, T. B., & Wolf, D. A. (1988) · International Journal of Cancer · doi:10.1002/ijc.2910420205 · Cited by 234 · see citing works
Binding of mutagenic heterocyclic amines by intestinal and lactic acid bacteria
Orrhage, K., Sillerström, E., Gustafsson, J.-Å., Nord, C. E., & Rafter, J. J. (1994) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(94)90182-1 · Cited by 233 · see citing works
Self-citationLing, W. H., Korpela, R., Mykkänen, H. M., Salminen, S., & Hänninen, O. (1994) · Journal of Nutrition · doi:10.1093/jn/124.1.18 · Cited by 212 · see citing works
Goldin, B. R., Gualtieri, L. J., & Moore, R. P. (1996) · Nutrition and Cancer · doi:10.1080/01635589609514442 · Cited by 186 · see citing works
Kampman, E., Giovannucci, E. L., Veer, P. V., Rimm, E., Stampfer, M. J., Colditz, G. A., Kok, F. J., & Willett, W. C. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116931 · Cited by 186 · see citing works
Immunomodulation by treatment with Lactobacillus casei strain Shirota
Matsuzaki, T. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00046-4 · Cited by 180 · see citing works
Consumption of fermented milk products and breast cancer: a case-control study in The Netherlands.
Veer, P. V. ’., Dekker, J. M., Lamers, J. W. J., Kok, F. J., Schouten, E. G., Brants, H. A. M., STURMANS, F., & Hermus, R. J. J. (1989) · PubMed · Cited by 180 · see citing works
Challa, A. (1997) · Carcinogenesis · doi:10.1093/carcin/18.3.517 · Cited by 159 · see citing works
Fermented dairy products, calcium, and colorectal cancer in The Netherlands Cohort Study.
Kampman, E., Goldbohm, R. A., van den Brandt, P. A., & Veer, P. V. ’. (1994) · PubMed · Cited by 159 · see citing works
Recent hypotheses for the origin of colon cancer.
Wr, B. (1987) · PubMed · Cited by 158 · see citing works
Consumption of Dairy Produce and Alcohol in a Case-Control Study of Breast Cancer2
Lê, M. G., Moulton, L. H., Hill, C., & Kramar, A. (1986) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/77.3.633 · Cited by 158 · see citing works
Sekine, K., Toida, T., Saito, M., Kuboyama, M., Kawashima, T., & Hashimoto, Y. (1985) · PubMed · Cited by 153 · see citing works
Boutron, M.-C., Faivre, J., Marteau, P. R., Couillault, C., Sénesse, P., & Quipourt, V. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.330 · Cited by 152 · see citing works
Antitumor activity of Lactobacillus casei in mice.
Kato, I., Kobayashi, S., Yokokura, T., & Mutai, M. (1981) · PubMed · Cited by 148 · see citing works
Hayatsu, H., & Hayatsu, T. (1993) · Cancer Letters · doi:10.1016/0304-3835(93)90261-7 · Cited by 147 · see citing works
Role of dietary lactobacilli in gastrointestinal microecology
SHAHANI, K. M., & Ayebo, A. D. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.11.2448 · Cited by 147 · see citing works
Prevention of colon cancer by pre- and probiotics: evidence from laboratory studies
Reddy, B. S. (1998) · British Journal Of Nutrition · doi:10.1017/s0007114500006061 · Cited by 147 · see citing works
Effect of Lactobacillus acidophilus Supplements on Mutagen Excretion in Faeces and Urine in Humans
Lidbeck, A., Övervik, E., Rafter, J. J., Nord, C. E., & Gustafsson, J. (1992) · Microbial Ecology in Health and Disease · doi:10.3109/08910609209141305 · Cited by 138 · see citing works
Self-citationMacrophage Activation by Lactobacillus casei in Mice
Kato, I., Yokokura, T., & Mutai, M. (1983) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1983.tb00622.x · Cited by 134 · see citing works
Kulkarni, N. H., & Reddy, B. S. (1994) · Experimental Biology and Medicine · doi:10.3181/00379727-207-43817 · Cited by 133 · see citing works
Kato, I., Endo, K., & Yokokura, T. (1994) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(94)90116-3 · Cited by 130 · see citing works
Antiproliferative effect of fermented milk on the growth of a human breast cancer cell line
Biffi, A., Coradini, D., Larsen, R., Riva, L., & di Fronzo, G. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514558 · Cited by 125 · see citing works
In Vitro Binding of Potent Mutagenic Pyrolyzates to Intestinal Bacteria
Morotomi, M., & Mutal, M. (1986) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/77.1.195 · Cited by 123 · see citing works
Probiotics, Cecal Microflora, and Aberrant Crypts in the Rat Colon1,2
Gallaher, D. D., Stallings, W. H., Blessing, L. L., Busta, F. F., & Brady, L. J. (1996) · Journal of Nutrition · doi:10.1093/jn/126.5.1362 · Cited by 109 · see citing works
Antitumor Activity of Yogurt Components
Reddy, G. V., Friend, B. A., SHAHANI, K. M., & Farmer, R. E. (1983) · Journal of Food Protection · doi:10.4315/0362-028x-46.1.8 · Cited by 108 · see citing works
Degradation of N -Nitrosamines by Intestinal Bacteria
Rowland, I., & GRASSO, P. (1975) · Applied Microbiology · doi:10.1128/am.29.1.7-12.1975 · Cited by 104 · see citing works
Goldin, B. R., & Gorbach, S. L. (1984) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/73.3.689 · Cited by 104 · see citing works
Bartram, H., Scheppach, W., Gerlach, S., Ruckdeschel, G., Kelber, E., & Kasper, H. (1994) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.2.428 · Cited by 104 · see citing works
Antitumor effect of Bifidobacterium infantis in mice.
Kohwi, Y., Imai, K., Tamura, Z., & Hashimoto, Y. (1978) · PubMed · Cited by 102 · see citing works
Inhibitory Effect of Yogurt on Ehrlich Ascites Tumor-Cell Proliferation2
Reddy, G. V., SHAHANI, K. M., & Banerjee, M. R. (1973) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/50.3.815 · Cited by 99 · see citing works
Baricault, L., Denariaz, G., Houri, J., Bouley, C., Sapin, C., & Trugnan, G. (1995) · Carcinogenesis · doi:10.1093/carcin/16.2.245 · Cited by 96 · see citing works
Onoue, M., KADO, S., Sakaitani, Y., Uchida, K., & Morotomi, M. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)04698-3 · Cited by 93 · see citing works
Effect of dairy products on initiation of precursor lesions of colon cancer in rats
Abdelali, H., Cassand, P., Soussotte, V., Daubèze, M., Bouley, C., & Narbonne, J. F. (1995) · Nutrition and Cancer · doi:10.1080/01635589509514400 · Cited by 91 · see citing works
Lidbeck, A., Allinger, U. G., Orrhage, K., Ottová, L., Brismar, B., Gustafsson, J.-Α., Rafter, J. J., & Nord, C. E. (1991) · Microbial Ecology in Health and Disease · doi:10.3109/08910609109140267 · Cited by 88 · see citing works
Self-citationEffect of feeding fermented milk on the incidence of chemically induced colon tumors in rats
Shackelford, L. A., Rao, D. R., Chawan, C. B., & PULUSANI, S. R. (1983) · Nutrition and Cancer · doi:10.1080/01635588309513793 · Cited by 79 · see citing works
Malhotra, S. L. (1977) · Medical Hypotheses · doi:10.1016/0306-9877(77)90024-x · Cited by 74 · see citing works
Effect of ingesting Lactobacillus acidophilus milk upon fecal flora and enzyme activity in humans.
Ayebo, A. D., Angelo, I. A., & SHAHANI, K. M. (1980) · Milk science international/Milchwissenschaft · Cited by 70 · see citing works
Activation of carcinogens and mutagens by rat colon mucosa.
Fang, W.-F., & Strobel, H. W. (1978) · PubMed · Cited by 69 · see citing works
Arimochi, H., Kinouchi, T., Kataoka, K., Kuwahara, T., & Ohnishi, Y. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7384 · Cited by 68 · see citing works
Degradation of N-Nitrosamines by Intestinal Bacteria
Rowland, I., & GRASSO, P. (1975) · Applied Microbiology · doi:10.1128/aem.29.1.7-12.1975 · Cited by 63 · see citing works
Etiology of colorectal cancer with emphasis on mechanism of action and prevention.
Jh, W., & Wynder, E. L. (1987) · PubMed · Cited by 59 · see citing works
Zhang, X. B., & Ohta, Y. (1993) · Canadian Journal of Microbiology · doi:10.1139/m93-125 · Cited by 56 · see citing works
Hirayama, K. (2000) · Carcinogenesis · doi:10.1093/carcin/21.11.2105 · Cited by 51 · see citing works
Effects of Lactic Acid Bacteria on the Uptake and Distribution of the Food Mutagen Trp-P-2 in Mice
Orrhage, K., Annas, A., Nord, C. E., Brittebo, E. B., & Rafter, J. J. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655202753416902 · Cited by 48 · see citing works
Self-citationHirayama, K., Itoh, K., Takahashi, E., & MITSUOKA, T. (1994) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v8i5.8286 · Cited by 48 · see citing works
Biasco, G., Paganelli, G. M., Brandi, G., Brillanti, S., Lami, F., Callegari, C. C., & Gizzi, G. (1991) · PubMed · Cited by 48 · see citing works
Horie, H., Zeisig, M., Hirayama, K., Midtvedt, T., Möller, L., & Rafter, J. J. (2003) · European Journal of Cancer Prevention · doi:10.1097/00008469-200304000-00003 · Cited by 42 · see citing works
Self-citationHirayama, K., Itoh, K., Takahashi, E., & MITSUOKA, T. (1995) · Microbial Ecology in Health and Disease · doi:10.3109/08910609509140098 · Cited by 38 · see citing works
Sekine, K., KAWASHIMA, T., & Hashimoto, Y. (1994) · Bifidobacteria and Microflora · doi:10.12938/bifidus1982.13.2_79 · Cited by 37 · see citing works
Mutagens in Human Faeces and Cancer of the Large Bowel
Venitt, S. (1988) · Elsevier eBooks · doi:10.1016/b978-0-12-599920-5.50021-2 · Cited by 25 · see citing works
A new factor from Bacillus mesentericus which promotes the growth of Bifidobacterium.
Seo, G., Akimoto, Y., Hamashima, H., Masuda, K., Shiojima, K., Sakuma, C., Sasatsu, M., & Arai, T. (2000) · PubMed · Cited by 21 · see citing works
EFFECT OF LACTOBACILLUS ACIDOPHILUS AND BIFIDOBACTERIUM BIFIDUM ON RECTAL CELL-KINETICS AND FECAL PH
BIASCO, G., PAGANELLI, G., BRANDI, G., et al. (1991) · Use Siena air (University of Siena) · Cited by 21 · see citing works
Seo, G., Shimizu, K., Sasatsu, M., & Kono, M. (1989) · Microbios letters · Cited by 11 · see citing works
Lino, H., Fukaya, K., Hirasawa, Y., Shimizu, K., & Seo, G. M. (1993) · Biomedical letters · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 71 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients
Rafter, J. J., Bennett, M., Caderni, G., Clune, Y., Hughes, R., Karlsson, P. C., Klinder, A., O'Riordan, M., O’Sullivan, G. C., Pool-Zobel, B. L., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.488 · Cited by 591 · see citing works
Self-citationFermented Fruits and Vegetables of Asia: A Potential Source of Probiotics
Swain, M. R., Anandharaj, M., Ray, R. C., & Rani, R. P. (2014) · Biotechnology Research International · doi:10.1155/2014/250424 · Cited by 495 · see citing works
de Almada, C. N., de Almada, C. N., Martinez, R. C. R., & Sant’Ana, A. S. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.09.011 · Cited by 425 · see citing works
Probiotics: do they have a role in oral medicine and dentistry?
Meurman, J. H. (2005) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2005.00191.x · Cited by 348 · see citing works
Lee, S.-H., Cho, S.-Y., Yoon, Y., Park, C., Sohn, J., Jeong, J.-J., Jeon, B.-N., Jang, M., An, C., Lee, S., et al. (2021) · Nature Microbiology · doi:10.1038/s41564-020-00831-6 · Cited by 325 · see citing works
Production of probiotic cabbage juice by lactic acid bacteria
Yoon, K. Y., Woodams, E. E., & Hang, Y. D. (2005) · Bioresource Technology · doi:10.1016/j.biortech.2005.06.018 · Cited by 325 · see citing works
Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis
Scanlan, P. D., Shanahan, F., Clune, Y., Collins, J. K., O'Sullivan, G. C., O'Riordan, M., Holmes, E., Wang, Y., & Marchesi, J. R. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01503.x · Cited by 245 · see citing works
Iyer, C., Kosters, A., Sethi, G., Kunnumakkara, A. B., Aggarwal, B. B., & Versalovic, J. A. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01137.x · Cited by 227 · see citing works
Use of live and dead probiotic cells in tilapia Oreochromis niloticus
Taoka, Y., Maeda, H., Jo, J., Kim, S.-M., Park, S.-I., YOSHIKAWA, T., & Sakata, T. (2006) · Fisheries Science · doi:10.1111/j.1444-2906.2006.01215.x · Cited by 221 · see citing works
Thirabunyanon, M., Boonprasom, P., & Niamsup, P. (2008) · Biotechnology Letters · doi:10.1007/s10529-008-9902-3 · Cited by 205 · see citing works
Probióticos e prebióticos: o estado da arte
Saad, S. M. I. (2006) · Revista Brasileira De Ciencias Farmaceuticas · doi:10.1590/s1516-93322006000100002 · Cited by 201 · see citing works
Beneficial Effects of Yoghurts and Probiotic Fermented Milks and Their Functional Food Potential
Hadjimbei, E., Botsaris, G., & Chrysostomou, S. (2022) · Foods · doi:10.3390/foods11172691 · Cited by 231 · see citing works
Encapsulation Technology to Protect Probiotic Bacteria
Chavarri, M., Maranon, I., & Carmen, M. (2012) · Probiotics · doi:10.5772/50046 · Cited by 180 · see citing works
Orlando, A., Refolo, M. G., Messa, C., Amati, L., Lavermicocca, P., Guerra, V., & Russo, F. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.717676 · Cited by 170 · see citing works
Ζουμποπούλου, Γ., Foligné, B., Christodoulou, K., Grangette, C., Pot, B., & Tsakalidou, E. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2007.10.013 · Cited by 155 · see citing works
Polymeric carriers for enhanced delivery of probiotics
Asgari, S., Pourjavadi, A., Licht, T. R., Boisen, A., & Ajalloueian, F. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.014 · Cited by 155 · see citing works
Probiotics and prebiotics in gastrointestinal disorders
Fedorak, R. N., & Madsen, K. L. (2004) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200403000-00017 · Cited by 148 · see citing works
Nazzaro, F., Fratianni, F., Coppola, R., Sada, A., & Orlando, P. (2009) · Journal of Functional Foods · doi:10.1016/j.jff.2009.02.001 · Cited by 151 · see citing works
Anti-Inflammatory Activity ofLactobacilluson Carrageenan-Induced Paw Edema in Male Wistar Rats
Amdekar, S., Roy, P., Singh, V. K., Kumar, A., Singh, R., & Sharma, P. (2012) · International Journal of Inflammation · doi:10.1155/2012/752015 · Cited by 150 · see citing works
Chong, E. S. L. (2013) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-013-1499-6 · Cited by 149 · see citing works
Probiotics and nutraceuticals: non-medicinal treatments of gastrointestinal diseases
PENNER, R., Fedorak, R. N., & Madsen, K. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.06.009 · Cited by 147 · see citing works
Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives
Kahouli, I., Tomaro-Duchesneau, C., & Prakash, S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.048975-0 · Cited by 142 · see citing works
Thirabunyanon, M., & Hongwittayakorn, P. (2013) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-012-9995-y · Cited by 135 · see citing works
Shori, A. B. (2015) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2015.09.010 · Cited by 132 · see citing works
Effects of on genes expression pattern in small bowel mucosa
Caro, S. D., TAO, H., Grillo, A., Elia, C., Gasbarrini, A., Sepulveda, A. R., & Gasbarrini, A. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2004.12.008 · Cited by 130 · see citing works
Roller, M., Clune, Y., Collins, K., Rechkemmer, G., & Watzl, B. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507450292 · Cited by 125 · see citing works
Hu, J., Wang, C., Ye, L., Yang, W., Huang, H., Meng, F., Shi, S., & Ding, Z. (2015) · Journal of Biosciences · doi:10.1007/s12038-015-9518-4 · Cited by 124 · see citing works
Licht, T. R., Hansen, M., Bergström, A., Poulsen, M., Krath, B. N., Markowski, J., Dragsted, L. O., & Wilcks, A. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-13 · Cited by 115 · see citing works
Sporadic colorectal cancer – role of the commensal microbiota
Hope, M. E., Hold, G. L., Kain, R., & El-Omar, E. M. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.01.029 · Cited by 109 · see citing works
Ohkawara, S., Furuya, H., Nagashima, K., Asanuma, N., & Hino, T. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2878 · Cited by 108 · see citing works
Nazzaro, F., Fratianni, F., Sada, A., & Orlando, P. (2008) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3343 · Cited by 107 · see citing works
Lactic Acid Bacteria as Source of Functional Ingredients
Florou-Paneri, P. C., Christaki, E. V., & Bonos, E. (2013) · InTech eBooks · doi:10.5772/47766 · Cited by 103 · see citing works
Influence of phenol, p-cresol and indole on growth and survival of intestinal lactic acid bacteria
Nowak, A., & Libudzisz, Z. (2006) · Anaerobe · doi:10.1016/j.anaerobe.2005.10.003 · Cited by 99 · see citing works
Saccharomyces boulardii Inhibits EGF Receptor Signaling and Intestinal Tumor Growth in Apc Mice
Chen, X., Fruehauf, J. H., Goldsmith, J. D., Xu, H. J., Katchar, K., Koon, H., Zhao, D., Kokkotou, E. G., Pothoulakis, C., & Kelly, C. P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.05.050 · Cited by 98 · see citing works
Dehghani, N., Tafvizi, F., & Jafari, P. (2020) · Bioimpacts · doi:10.34172/bi.2021.32 · Cited by 90 · see citing works
Impact of lactic acid bacteria on oxidative DNA damage in human derived colon cells
Koller, V. J., Marian, B., Stidl, R., Nersesyan, A. K., Winter, H., Simic, T. P., Sontag, G., & Knasmüller, S. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.005 · Cited by 89 · see citing works
Nazzaro, F., Fratianni, F., Nicolaus, B., Poli, A., & Orlando, P. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2012.03.002 · Cited by 87 · see citing works
Probiotics: An Emerging Therapy
O’Sullivan, G. C., Kelly, P., O'Halloran, S., Collins, C., Collins, J. K., Dunne, C. P., & Shanahan, F. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382368 · Cited by 87 · see citing works
Cellular and molecular effects of yeast probiotics on cancer
Saber, A., Alipour, B., Faghfoori, Z., & Khosroushahi, A. Y. (2016) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1179622 · Cited by 83 · see citing works
Karimi Ardestani, S., Tafvizi, F., & Tajabadi Ebrahimi, M. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119851255 · Cited by 82 · see citing works
Paraprobiotics: definition, manufacturing methods, and functionality
Lee, N., Park, Y., Kang, D., & Paik, H. (2023) · Food Science and Biotechnology · doi:10.1007/s10068-023-01378-y · Cited by 79 · see citing works
Lan, A., Bruneau, A., Bensaada, M., Philippe, C., Bellaud, P., Rabot, S., & Jan, G. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508978284 · Cited by 79 · see citing works
Kahouli, I., Malhotra, M., Westfall, S., Alaoui‐Jamali, M. A., & Prakash, S. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7885-x · Cited by 79 · see citing works
Kanmani, P., Kumar, R., Yuvaraj, N., Paari, K. A., Pattukumar, V., & Arul, V. (2011) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-011-0068-9 · Cited by 78 · see citing works
da Silva, D. F., Tenório, N., Gomes, R. G., Pozza, M. S. D. S., Britten, M., & Matumoto‐Pintro, P. T. (2017) · Journal of Food Science and Technology · doi:10.1007/s13197-017-2592-x · Cited by 78 · see citing works
An Insight into the Anticancer Effects of Fermented Foods: A Review
Tasdemir, S. S., & Sanlier, N. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104281 · Cited by 77 · see citing works
WAN, Y., XIN, Y., ZHANG, C., WU, D., DING, D., TANG, L., OWUSU, L., BAI, J., & LI, W. (2014) · Oncology Letters · doi:10.3892/ol.2014.1959 · Cited by 76 · see citing works
Nouri, Z. H. M., Karami, F., Neyazi, N., Modarressi, M. H., Karimi, R., Khorramizadeh, M. R., Taheri, B., & Motevaseli, E. (2016) · Europe PMC (PubMed Central) · doi:10.22074/cellj.2016.4307 · Cited by 75 · see citing works
Induction of HT-29 cells apoptosis by lactobacilli isolated from fermented products
Wang, S., Zhang, L., Fan, R., Han, X., Yi, H., Zhang, L.-L., Xue, C., Li, H., Zhang, Y.-H., & Shigwedha, N. (2014) · Research in Microbiology · doi:10.1016/j.resmic.2014.02.004 · Cited by 73 · see citing works
Microbiota and Cancer: The Emerging Beneficial Role of Bifidobacteria in Cancer Immunotherapy
Longhi, G., van Sinderen, D., Ventura, M., & Turroni, F. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.575072 · Cited by 71 · see citing works
Dietary Components and Immune Function
WATSON, R. R., Preedy, V. R., & Zibadi, S. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-061-8 · Cited by 72 · see citing works
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response
Zhang, H., Fu, L., Leiliang, X., Qu, C., Wu, W., Wen, R., Huang, N., He, Q., Cheng, Q., Liu, G., et al. (2024) · 癌症:英文版 · doi:10.1002/cac2.12597 · Cited by 71 · see citing works
Production of Probiotic Mango Juice by Fermentation of Lactic Acid Bacteria
Reddy, L. V., Min, J.-H., & Wee, Y. (2015) · Microbiology and Biotechnology Letters · doi:10.4014/mbl.1504.04007 · Cited by 70 · see citing works
Haghshenas, B., Nami, Y., Abdullah, N., Biak, D. R. A., Rosli, R., & Khosroushahi, A. Y. (2014) · LWT · doi:10.1016/j.lwt.2014.09.058 · Cited by 68 · see citing works
Haghshenas, B., Abdullah, N., Nami, Y., Biak, D. R. A., Rosli, R., & Khosroushahi, A. Y. (2014) · Anaerobe · doi:10.1016/j.anaerobe.2014.08.009 · Cited by 66 · see citing works
The anti-cancer effects of poi(Colocasia esculenta) on colonic adenocarcinoma cellsIn vitro
Brown, A. C., Reitzenstein, J. E., Liu, J., & Jadus, M. R. (2005) · Phytotherapy Research · doi:10.1002/ptr.1712 · Cited by 66 · see citing works
Solanki, H. K., Shah, D. A., Maheriya, P. M., & Patel, C. A. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.09.059 · Cited by 64 · see citing works
The therapeutic use of symbiotics
FLESCH, A. T., Poziomyck, A. K., & Damin, D. C. (2014) · ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) · doi:10.1590/s0102-67202014000300012 · Cited by 63 · see citing works
Cytotoxic effects of various lactic acid bacteria on Caco-2 cells
Er, S., Koparal, A. T., & Kıvanç, M. (2015) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1402-62 · Cited by 63 · see citing works
Wang, X., Li, Z., Xu, Z., Wang, Z., & Feng, J. (2014) · International Journal of Colorectal Disease · doi:10.1007/s00384-014-2054-0 · Cited by 62 · see citing works
Nazzaro, F., Fratianni, F., Orlando, P., & Coppola, R. (2012) · Pharmaceuticals · doi:10.3390/ph5050481 · Cited by 60 · see citing works
Probiotics and Chronic Disease
Broekaert, I. J., & Walker, W. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00021 · Cited by 58 · see citing works
Fermented products of India and its implication: A review
Sathe, G. B., & Mandal, S. (2016) · Asian Journal of Dairy and Food Research · doi:10.18805/ajdfr.v35i1.9244 · Cited by 54 · see citing works
Shu, G., Zhang, B., Zhang, Q., Wan, H., & Li, H. (2016) · Acta Universitatis Cibiniensis. Series E: Food Technology · doi:10.1515/aucft-2016-0013 · Cited by 45 · see citing works
Fratianni, F., Cardinale, F., Russo, I., Iuliano, C., Tremonte, P., Coppola, R., & Nazzaro, F. (2014) · Journal of Microencapsulation · doi:10.3109/02652048.2013.871361 · Cited by 46 · see citing works
Hoseinifar, S. H., Sun, Y., & Zhou, Z. (2017) · Wiley eBooks · doi:10.1002/9781119152125.ch7 · Cited by 44 · see citing works
Ghany, K. A. E., Hamouda, R. A., Elhafez, E. A., Mahrous, H. A., Salem-Bekhit, M. M., & Hamza, H. A. (2015) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2015.1050455 · Cited by 43 · see citing works
Intestinal Microbiome and Lymphoma Development
Yamamoto, M. L., & Schiestl, R. H. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000047 · Cited by 42 · see citing works
Jin, S., Kim, Y., & Je, Y. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0127 · Cited by 41 · see citing works
Krasaekoopt, W., & Kitsawad, J. A. K. (2010) · Cited by 40 · see citing works
Gut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer?
Tarashi, S., Siadat, S. D., Badi, S. A., Zali, M. R., Biassoni, R., Ponzoni, M., & Moshiri, A. (2019) · Microorganisms · doi:10.3390/microorganisms7110561 · Cited by 39 · see citing works
Desrouillères, K., Millette, M., Vu, K. D., Touja, R., & Lacroix, M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.035 · Cited by 40 · see citing works
Awaisheh, S. S., Obeidat, M., Al-Tamimi, H., Assaf, A. M., EL-Qudah, J. M., Al-Khaza’leh, J. M., & Rahahleh, R. J. (2016) · Cited by 39 · see citing works
Haghshenas, B., Nami, Y., Abdullah, N., Biak, D. R. A., Rosli, R., & Khosroushahi, A. Y. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.10.002 · Cited by 38 · see citing works
Tuo, Y., Zhang, L., Yi, H., Zhang, Y. C., Zhang, W. Q., Han, X., Du, M., Jiao, Y. H., & Wang, S. M. (2010) · Journal of Dairy Science · doi:10.3168/jds.2010-3069 · Cited by 37 · see citing works
Gohil, P. V., Patel, V., Deshpande, S. S., Chorawala, M. R., & Shah, G. B. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0370-z · Cited by 37 · see citing works
Gut Microbiota and Probiotics: Current Status and Their Role in Cancer Therapeutics
Khan, A. A., Khurshid, M., Khan, S., & Alshamsan, A. (2013) · Drug Development Research · doi:10.1002/ddr.21087 · Cited by 36 · see citing works
Ahmadi, M. A., Ebrahimi, M. T., Mehrabian, S., Tafvizi, F., Bahrami, H., & Dameshghian, M. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2014.956254 · Cited by 33 · see citing works
Khan, I., & Kang, S. C. (2017) · Journal of Food Science · doi:10.1111/1750-3841.13732 · Cited by 31 · see citing works
Macharia, J. M., Káposztás, Z., Varjas, T., Budán, F., Zand, A., Bodnár, I., & Raposa, B. L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114371 · Cited by 30 · see citing works
Lactobacillus gasseri SF1183 Affects Intestinal Epithelial Cell Survival and Growth
Luccia, B. D., Manzo, N., Baccigalupi, L., Calabrò, V., Crescenzi, E., Ricca, E., & Pollice, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069102 · Cited by 29 · see citing works
RetractedRago, D., Mette, K., Gürdeniz, G., Marini, F., Poulsen, M., & Dragsted, L. O. (2013) · Metabolomics · doi:10.1007/s11306-013-0534-9 · Cited by 29 · see citing works
Vacuum Impregnation of Probiotics in Fruit Pieces and Their Survival During Refrigerated Storage
Krasaekoopt, W., & Suthanwong, B. (2008) · Agriculture and Natural Resources · Cited by 29 · see citing works
Salek, F., Mirzaei, H., Khandaghi, J., Javadi, A., & Nami, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-34894-2 · Cited by 29 · see citing works
Lymphoma Caused by Intestinal Microbiota
Yamamoto, M. L., & Schiestl, R. H. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110909038 · Cited by 29 · see citing works
Islam, N. N., Islam, K. N., Akbar, T., & Akther, F. (2016) · Asian Journal of Biological Sciences · doi:10.3923/ajbs.2016.1.9 · Cited by 25 · see citing works
Priyashantha, H., Madushan, R. N. D., Pelpolage, S., Wijesekara, A. V., & Jayarathna, S. (2025) · Frontiers in Food Science and Technology · doi:10.3389/frfst.2025.1581877 · Cited by 24 · see citing works
Bakken, T., Braaten, T., Olsen, A., Hjartåker, A., Lund, E., & Skeie, G. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518000752 · Cited by 24 · see citing works
Kim, J., & Baik, S. (2015) · Food Science and Biotechnology · doi:10.1007/s10068-015-0076-1 · Cited by 24 · see citing works
Ушакова, Г. А., Fedkiv, O., Prykhodko, O., Pierzynowski, S. G., & Kruszewska, D. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.06.010 · Cited by 24 · see citing works
Probióticos e prebióticos na atenção primária ao câncer de cólon
Denipote, F. G., Trindade, E. B. S. D. M., & Burini, R. C. (2010) · Arquivos de Gastroenterologia · doi:10.1590/s0004-28032010000100016 · Cited by 24 · see citing works
Functional foods classification system: exemplifying through analysis of bioactive compounds
Martirosyan, D. M., & Ekblad, M. (2022) · Functional Food Science · doi:10.31989/ffs.v2i4.919 · Cited by 23 · see citing works
In vitro binding of mutagenic heterocyclic aromatic amines by Bifidobacterium pseudocatenulatum G4
Faridnia, F., Hussin, A. S. M., Saari, N., Mustafa, S., Yee, L., & Manap, M. (2010) · Beneficial Microbes · doi:10.3920/bm2009.0035 · Cited by 23 · see citing works
Srikham, K., & Thirabunyanon, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112871 · Cited by 24 · see citing works
Lactic Acid Bacteria—From Nature Through Food to Health
Teneva‐Angelova, T., Hristova, I., Pavlov, A. I., & Бешкова, Д. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811443-8.00004-9 · Cited by 24 · see citing works
Manea, I., & Buruleanu, C. L. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 21 · see citing works
Shu, G., Zhang, Q., Chen, H., Wan, H., & Li, H. (2015) · Acta Universitatis Cibiniensis. Series E: Food Technology · doi:10.1515/aucft-2015-0015 · Cited by 21 · see citing works
Health Claims Associated with Probiotics
O’May, G. A., & Macfarlane, G. T. (2006) · doi:10.1002/9780470995785.ch7 · Cited by 21 · see citing works
Shori, A. B., & Baba, A. S. (2014) · Journal of the Association of Arab Universities for Basic and Applied Sciences · doi:10.1016/j.jaubas.2014.02.006 · Cited by 20 · see citing works
Characterization of selected strains from Lactobacillus acidophilus and Bifidobacterium bifidum
Goderska, K., & CZARNECKI, Z. (2007) · African Journal of Microbiology Research · doi:10.5897/ajmr.9000157 · Cited by 20 · see citing works
- Authors
- Rafter, J.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Rafter, Joseph
- Venue
- Best Practice & Research Clinical Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 17
- Issue
- 5
- Pages
- 849-859
- ISSN
- 1521-6918 (ISSN-L)
- OpenAlex
- W2062681903
- Cited by
- 208
- References
- 71
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 7 · 2016: 18 · 2015: 14 · 2014: 18 · 2013: 16 · 2012: 12
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, lactic acid bacteria, colon cancer, anticancer activity, chemoprevention, fermented dairy products, dietary intervention
- MeSH terms
- Animals, Colonic Neoplasms, Humans, Intestines, Lactobacillus, Probiotics
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