Cited by 208Probiotics and Fermented FoodsCancer Research and TreatmentsGut microbiota and health

Probiotics and colon cancer

Rafter, Joseph·2003·Best Practice & Research Clinical Gastroenterology

Abstract

Although a myriad of health-promoting effects have been attributed to the probiotic lactic acid bacteria, perhaps the most interesting and controversial is that of anticancer activity, the vast majority of studies in this area dealing with protective effects against colon cancer. There is no direct experimental evidence for cancer suppression in humans as a result of the consumption of probiotic cultures in fermented or unfermented dairy products, but there is a wealth of indirect evidence, based largely on laboratory studies. Reports in the literature regarding the anticancer effects of lactic acid bacteria fall into the categories of in vitro studies, animal studies, epidemiological studies and human dietary intervention studies. Examples of these reports will be given in the current paper. The mechanisms by which probiotic bacteria may inhibit colon cancer are still poorly understood, but, several potential mechanisms are being discussed in the literature, and these will also be addressed in this review.

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Crossref · 10.1016/s1521-6918(03)00056-8

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Authors
Rafter, J.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Rafter, Joseph
Venue
Best Practice & Research Clinical Gastroenterology
Publisher
Elsevier BV
Published
2003-10
Volume
17
Issue
5
Pages
849-859
ISSN
1521-6918 (ISSN-L)
OpenAlex
W2062681903
Cited by
208
References
71
Citations by year
2026: 4 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 7 · 2016: 18 · 2015: 14 · 2014: 18 · 2013: 16 · 2012: 12
FWCI
1.03
Type
journal article
Language
en
Open access
closed
Locations
  • Best Practice & Research Clinical Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
probiotics, lactic acid bacteria, colon cancer, anticancer activity, chemoprevention, fermented dairy products, dietary intervention
MeSH terms
Animals, Colonic Neoplasms, Humans, Intestines, Lactobacillus, Probiotics

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