Heat-killed probiotic bacteria induce apoptosis of HT-29 human colon adenocarcinoma cell line via the regulation of Bax/Bcl2 and caspases pathway

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104 · see citing works

Global cancer statistics

Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,708 · see citing works

Intestinal Inflammation and Cancer

Ullman, T. A., & Itzkowitz, S. H. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.057 · Cited by 1,127 · see citing works

The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept)

Taverniti, V., & Guglielmetti, S. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0218-x · Cited by 703 · see citing works

The probiotic paradox: live and dead cells are biological response modifiers

Adams, C. A. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000090 · Cited by 521 · see citing works

Lactobacillus casei Exerts Anti-Proliferative Effects Accompanied by Apoptotic Cell Death and Up-Regulation of TRAIL in Colon Carcinoma Cells

Tiptiri-Kourpeti, A., Spyridopoulou, K., Santarmaki, V., Aindelis, G., Tompoulidou, E., Lamprianidou, E., Saxami, G., Ypsilantis, P., Lampri, E. S., Simopoulos, C. E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147960 · Cited by 320 · see citing works

Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro

Choi, S. S., Kim, Y., Han, K. S., You, S., Oh, S., & Kim, S. H. (2006) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2006.01913.x · Cited by 292 · see citing works

Probiotics and health: An evidence-based review

Aureli, P., Capurso, L., Castellazzi, A. M., Clerici, M., Giovannini, M., Morelli, L., Poli, A., Pregliasco, F. E., Salvini, F. M., & Zuccotti, G. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.02.006 · Cited by 281 · see citing works

Cancer-preventing attributes of probiotics: an update

Kumar, M., Kumar, A., Nagpal, R., Mohania, D., Behare, P. V., Verma, V., Kumar, P., Poddar, D., Aggarwal, P., Henry, C. J., et al. (2010) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637480903455971 · Cited by 278 · see citing works

Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen–specific IgE production by stimulation of IL-12 production in mice

Murosaki, S., Yamamoto, Y., Ito, K., Inokuchi, T., Kusaka, H., Ikeda, H., & Yoshikai, Y. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70055-7 · Cited by 273 · see citing works

Roles of Probiotics and Prebiotics in Colon Cancer Prevention: Postulated Mechanisms and In-vivo Evidence

Liong, M. (2008) · International Journal of Molecular Sciences · doi:10.3390/ijms9050854 · Cited by 264 · see citing works

Therapeutical use of probiotic formulations in clinical practice

Iannitti, T., & Palmieri, B. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.05.004 · Cited by 262 · see citing works

The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer?

Azcárate-Peril, M. A., Sikes, M. L., & Bruno-Bárcena, J. M. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00110.2011 · Cited by 252 · see citing works

Gut microbiota and probiotics in colon tumorigenesis

Zhu, Y., Luo, T. M., Jobin, C., & Young, H. A. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.06.004 · Cited by 229 · see citing works

Probiotics and colon cancer

Rafter, J. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00056-8 · Cited by 208 · see citing works

Antiproliferative and Proapoptotic Effects of Viable or Heat-Killed Lactobacillus paracasei IMPC2.1 and Lactobacillus rhamnosus GG in HGC-27 Gastric and DLD-1 Colon Cell Lines

Orlando, A., Refolo, M. G., Messa, C., Amati, L., Lavermicocca, P., Guerra, V., & Russo, F. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.717676 · Cited by 170 · see citing works

Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells

Kim, Y., Oh, S., Yun, H. S., Oh, S., & Kim, S. H. (2010) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2010.02859.x · Cited by 164 · see citing works

The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition

Ma, E. L., Choi, Y. J., Choi, J., Pothoulakis, C., Rhee, S. H., & Im, E. (2009) · International Journal of Cancer · doi:10.1002/ijc.25011 · Cited by 162 · see citing works

Oral inoculation of probioticsLactobacillus acidophilusNCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue

Chen, C., Lin, W.-C., Kong, M., Shi, H. N., Walker, W. A., Lin, C., Huang, C.-T., Lin, Y., Jung, S.-M., & Lin, T. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004934 · Cited by 148 · see citing works

Prevention of colon cancer by pre- and probiotics: evidence from laboratory studies

Reddy, B. S. (1998) · British Journal Of Nutrition · doi:10.1017/s0007114500006061 · Cited by 147 · see citing works

Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives

Kahouli, I., Tomaro-Duchesneau, C., & Prakash, S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.048975-0 · Cited by 142 · see citing works

In vitro effects of lactic acid bacteria on cancer cell viability and antioxidant activity

Liu, C., & Pan, T. (2020) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.2287 · Cited by 131 · see citing works

Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enteropathogenic bacteria: Mediation by the mitochondrial pathway

Altonsy, M. O., Andrews, S. C., & Tuohy, K. M. (2009) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.11.015 · Cited by 122 · see citing works

Prognostic factors in 1,138 Iranian colorectal cancer patients

Moghimi-Dehkordi, B., Safaee, A., & Zali, M. R. (2008) · International Journal of Colorectal Disease · doi:10.1007/s00384-008-0463-7 · Cited by 118 · see citing works

The application of probiotic fermented milks in cancer and intestinal inflammation

de LeBlanc, A. D. M., & Perdigón, G. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s002966511000159x · Cited by 114 · see citing works

Fermented Milks, Probiotic Cultures, and Colon Cancer

Saikali, J., Picard, C., Freitas, M., & Holt, P. R. (2004) · Nutrition and Cancer · doi:10.1207/s15327914nc4901_3 · Cited by 104 · see citing works

Lactobacillus plantarum AS1 Isolated from South Indian Fermented Food Kallappam Suppress 1,2-Dimethyl Hydrazine (DMH)-Induced Colorectal Cancer in Male Wistar Rats

Kumar, R., Kanmani, P., Yuvaraj, N., Paari, K. A., Pattukumar, V., Thirunavukkarasu, C., & Arul, V. (2011) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-011-9453-2 · Cited by 99 · see citing works

Effects of Lactobacillus plantarum A7 with probiotic potential on colon cancer and normal cells proliferation in comparison with a commercial strain.

Sadeghi‐Aliabadi, H., Mohammadi, F., Fazeli, H., & Mirlohi, M. (2014) · Europe PMC (PubMed Central) · Cited by 86 · see citing works

Antitumor effect of heat-killed Lactobacillus plantarum L-137 through restoration of impaired interleukin-12 production in tumor-bearing mice

Murosaki, S., Muroyama, K., Yamamoto, Y., & Yoshikai, Y. (2000) · Cancer Immunology Immunotherapy · doi:10.1007/s002620050615 · Cited by 84 · see citing works

Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide

Zhang, M., Wang, F., Jiang, L., Liu, R., Zhang, L., Lei, X. G., Li, J., Jiang, J., Guo, H., Fang, B., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0427 · Cited by 83 · see citing works

Mismatch repair genes in Lynch syndrome: a review

da Silva, F. C. C., Dominguez–Valentin, M., Ferreira, F. D. O., Carraro, D. M., & Rossi, B. M. (2009) · Sao Paulo Medical Journal · doi:10.1590/s1516-31802009000100010 · Cited by 81 · see citing works

Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3–dependent pathway

WAN, Y., XIN, Y., ZHANG, C., WU, D., DING, D., TANG, L., OWUSU, L., BAI, J., & LI, W. (2014) · Oncology Letters · doi:10.3892/ol.2014.1959 · Cited by 76 · see citing works

Induction of HT-29 cells apoptosis by lactobacilli isolated from fermented products

Wang, S., Zhang, L., Fan, R., Han, X., Yi, H., Zhang, L.-L., Xue, C., Li, H., Zhang, Y.-H., & Shigwedha, N. (2014) · Research in Microbiology · doi:10.1016/j.resmic.2014.02.004 · Cited by 73 · see citing works

Probiotics Prevent the Development of 1,2-Dimethylhydrazine (DMH)-Induced Colonic Tumorigenesis through Suppressed Colonic Mucosa Cellular Proliferation and Increased Stimulation of Macrophages

Foo, N., Yang, H. O., Chiu, H.-H., Chan, H., Liao, C.-C., Yu, C.-K., & Wang, Y. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203444d · Cited by 70 · see citing works

Distinct immune response induced by peptidoglycan derived fromLactobacillus sp

Sun, J. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i40.6330 · Cited by 64 · see citing works

ANTITUMOR EFFECTS OF THE INTRAVESICAL INSTILLATION OF HEAT KILLED CELLS OF THE LACTOBACILLUS CASEI STRAIN SHIROTA ON THE MURINE ORTHOTOPIC BLADDER TUMOR MBT-2

Takahashi, T., Kushiro, A., Nomoto, K., UCHIDA, K., Morotomi, M., Yokokura, T., & Akaza, H. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)65625-x · Cited by 57 · see citing works

Inhibition of 1,2-dimethylhydrazine induced colon genotoxicity in rats by the administration of probiotic curd

Kumar, A., Singh, N. K., & Sinha, P. R. (2009) · Molecular Biology Reports · doi:10.1007/s11033-009-9519-1 · Cited by 57 · see citing works

Non-immunologically-mediated cytotoxicity of Lactobacillus casei and its derivative peptidoglycan against tumor cell lines

Fichera, G. A., & Giese, G. (1994) · Cancer Letters · doi:10.1016/0304-3835(94)90244-5 · Cited by 53 · see citing works

Live and heat-killed Lactobacillus rhamnosus GG upregulate gene expression of pro-inflammatory cytokines in 5-fluorouracil-pretreated Caco-2 cells

Fang, S., Shih, H.-Y., Huang, C. H., Li, L.-T., Chen, C.-C., & Fang, H. W. (2014) · Supportive Care in Cancer · doi:10.1007/s00520-014-2137-z · Cited by 46 · see citing works

Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product

Ghoneum, M. H., & Felo, N. (2015) · Oncology Reports · doi:10.3892/or.2015.4180 · Cited by 46 · see citing works

Antiproliferative Effects ofBacillus coagulansUnique IS2 in Colon Cancer Cells

Madempudi, R. S., & Kalle, A. M. (2017) · Nutrition and Cancer · doi:10.1080/01635581.2017.1359317 · Cited by 40 · see citing works

Orally administered heat-killed Lactobacillus gasseri TMC0356 can upregulate cell-mediated immunity in senescence-accelerated mice

Kawase, M., He, F., Miyazawa, K., Kubota, A., Yoda, K., & Hiramatsu, M. (2011) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2011.02440.x · Cited by 39 · see citing works

Short communication: Antiproliferative effect of wild Lactobacillus strains isolated from fermented foods on HT-29 cells

Tuo, Y., Zhang, L., Yi, H., Zhang, Y. C., Zhang, W. Q., Han, X., Du, M., Jiao, Y. H., & Wang, S. M. (2010) · Journal of Dairy Science · doi:10.3168/jds.2010-3069 · Cited by 37 · see citing works

Cytotoxicity and apoptosis induction of Bacillus vallismortis BIT-33 metabolites on colon cancer carcinoma cells

Jeong, S.-Y., Park, S.-Y., Kim, Y.-H., Kim, M., & Lee, S. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03615.x · Cited by 29 · see citing works

Live and heat-killed probiotic: effects on chronic experimental colitis induced by dextran sulfate sodium (DSS) in rats.

Sang, L.-X., Chang, B., Wang, B., Liu, W., & Jiang, M. (2015) · PubMed Central · Cited by 22 · see citing works

Investigation of Antitumor Effects ofLactobacillus Crispatusin Experimental Model of Breast Cancer in BALB/c Mice

Motevaseli, E., Khorramizadeh, M. R., Hadjati, J., Bonab, S. F., Eslami, S., & Ghafouri‐Fard, S. (2017) · Immunotherapy · doi:10.2217/imt-2017-0088 · Cited by 18 · see citing works

A cytotoxic substance produced by a wild culture of Lactobacillus casei D-34 against tumour cells.

Manjunath, N., & Ranganathan, B. (1989) · PubMed · Cited by 17 · see citing works

The proteins (12 and 15 kDa) isolated from heat‐killed Lactobacillus plantarum L67 induces apoptosis in HT‐29 cells

Song, S., Oh, S., & Lim, K. T. (2015) · Cell Biochemistry and Function · doi:10.1002/cbf.3094 · Cited by 16 · see citing works

Combined Extract of Heated 4T1 and a Heat-Killed Preparation of Lactobacillus Casei in a Mouse Model of Breast Cancer.

Jafari, S., Froushani, S. M. A., & Tokmachi, A. (2017) · Europe PMC (PubMed Central) · Cited by 10 · see citing works

Lipopeptides Extract from Bacillus Amyloliquefaciens Induce Human Oral Squamous Cancer Cell Death

Kuo, C.-H., Lin, Y., & Chen, R.-S. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.1.91 · Cited by 8 · see citing works

[Genetic and environmental factors in colorectal cancer. Mutations in the familial adenomatous polyposis gene].

Steffensen, I., Paulsen, J. E., & Alexander, J. (1997) · PubMed · Cited by 5 · see citing works

Gut microbiota in colorectal cancer development and therapy

Wong, C. C., & Yu, J. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00766-x · Cited by 751 · see citing works

Postbiotics and paraprobiotics: From concepts to applications

Cuevas-González, P. F., Liceaga, A. M., & Aguilar-Toalá, J. E. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109502 · Cited by 431 · see citing works

An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

Durazzo, A., Nazhand, A., Lucarini, M., Atanasov, A. G., Souto, E. B., Novellino, E., Capasso, R., & Santini, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072285 · Cited by 98 · see citing works

Cell cycle arrest and anti-cancer potential of probiotic Lactobacillus rhamnosus against HT-29 cancer cells

Dehghani, N., Tafvizi, F., & Jafari, P. (2020) · Bioimpacts · doi:10.34172/bi.2021.32 · Cited by 90 · see citing works

An Update on the Effectiveness of Probiotics in the Prevention and Treatment of Cancer

Sankarapandian, V., Maran, B. A. V., Rajendran, R. L., Jogalekar, M. P., Sridharan, G., Krishnamoorthy, R., Gangadaran, P., & Ahn, B. (2022) · Life · doi:10.3390/life12010059 · Cited by 81 · see citing works

Biotechnological Applications of Probiotics: A Multifarious Weapon to Disease and Metabolic Abnormality

Singh, R. P., Shadan, A., & Ma, Y. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09992-8 · Cited by 81 · see citing works

Synthesis and characterization of alginate nanocarrier encapsulating Artemisia ciniformis extract and evaluation of the cytotoxicity and apoptosis induction in AGS cell line

Rahimivand, M., Tafvizi, F., & Noorbazargan, H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.05.006 · Cited by 45 · see citing works

Effects of Probiotics at the Interface of Metabolism and Immunity to Prevent Colorectal Cancer-Associated Gut Inflammation: A Systematic Network and Meta-Analysis With Molecular Docking Studies

Patra, S., Sahu, N., Saxena, S., Pradhan, B., Nayak, S. K., & Roychowdhury, A. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.878297 · Cited by 37 · see citing works

A Comprehensive Insight into Apoptosis: Molecular Mechanisms, Signaling Pathways, and Modulating Therapeutics

Mosadegh, M., Goodarzi, N. N., & Erfani, Y. (2025) · Cancer Investigation · doi:10.1080/07357907.2024.2445528 · Cited by 36 · see citing works

Inhibitory effects of probiotic Bacillus coagulans against MCF7 breast cancer cells

Dolati, M., Tafvizi, F., Salehipour, M., Movahed, T. K., & Jafari, P. (2021) · Iranian Journal of Microbiology · doi:10.18502/ijm.v13i6.8089 · Cited by 33 · see citing works

Anti-Tumor Effects of Heat-Killed L. reuteri MG5346 and L. casei MG4584 against Human Colorectal Carcinoma through Caspase-9-Dependent Apoptosis in Xenograft Model

Kim, S.-J., Kang, C.-H., Kim, G., & Cho, H. (2022) · Microorganisms · doi:10.3390/microorganisms10030533 · Cited by 31 · see citing works

Appraisal of postbiotics in cancer therapy

Sudaarsan, A. S. K., & Ghosh, A. R. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1436021 · Cited by 28 · see citing works

The Crucial Roles of Diet, Microbiota, and Postbiotics in Colorectal Cancer

Kuru-Yaşar, R., & Üstün‐Aytekin, Ö. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00525-z · Cited by 29 · see citing works

Anti-Tumor Effect of Heat-Killed Bifidobacterium bifidum on Human Gastric Cancer through Akt-p53-Dependent Mitochondrial Apoptosis in Xenograft Models

Kim, S.-J., Lee, H. H., Choi, W., Kang, C.-H., Kim, G., & Cho, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179788 · Cited by 27 · see citing works

An Update on the Pivotal Roles of Probiotics, Their Components, and Metabolites in Preventing Colon Cancer

Deng, X., Yang, J., Zhang, Y., Chen, X., Wang, C., Suo, H., & Song, J. (2023) · Foods · doi:10.3390/foods12193706 · Cited by 26 · see citing works

Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation

Srikham, K., & Thirabunyanon, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112871 · Cited by 24 · see citing works

Postbiotic metabolites derived from lactobacillus fermentum as potent antiproliferative bioresources on HeLa cells with promising biocompatibility

Asoudeh-Fard, A., Yeylagh-Beygi, M., Parsaei, A., Mohkam, M., Asoudeh-Fard, M., & Gholami, A. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-024-04730-9 · Cited by 22 · see citing works

A Combination of Two Probiotics, Lactobacillus sporogenes and Clostridium butyricum, Inhibits Colon Cancer Development: An In Vitro Study

Budu, O., Banciu, C. D., Pînzaru, I., Sarău, C. A., Lighezan, D., Şoica, C., Dehelean, C. A., Drăghici, G. A., Dolghi, A., Prodea, A., et al. (2022) · Microorganisms · doi:10.3390/microorganisms10091692 · Cited by 21 · see citing works

The inhibition effects of Lentilactobacillus buchneri-derived membrane vesicles on AGS and HT-29 cancer cells by inducing cell apoptosis

Abedi, A., Tafvizi, F., Jafari, P., & Akbari, N. (2024) · Scientific Reports · doi:10.1038/s41598-024-53773-y · Cited by 21 · see citing works

The anticancer effect of potential probiotic L. fermentum and L. plantarum in combination with 5-fluorouracil on colorectal cancer cells

Salek, S., Moazamian, E., Mohammadi‐Bardbori, A., & Shamsdin, S. A. (2024) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-024-03929-9 · Cited by 20 · see citing works

Using Postbiotics from Functional Foods for Managing Colorectal Cancer: Mechanisms, Sources, Therapeutic Potential, and Clinical Perspectives

D’Amore, T., Zolfanelli, C., Lauciello, V., Ciancia, A. D., Vagliasindi, A., Smaoui, S., & Varzakas, T. H. (2025) · Microorganisms · doi:10.3390/microorganisms13061335 · Cited by 20 · see citing works

Molecular Mechanisms of Probiotic Action Against Gastrointestinal Cancers

Thoda, C., & Touraki, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167857 · Cited by 20 · see citing works

Putative probiotics decrease cell viability and enhance chemotherapy effectiveness in human cancer cells: role of butyrate and secreted proteins

Doublier, S., Cirrincione, S., Scardaci, R., Botta, C., Lamberti, C., Giuseppe, F. D., Angelucci, S., Rantsiou, K., Cocolin, L., & Pessione, E. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127012 · Cited by 19 · see citing works

Unlocking the power of probiotics, postbiotics: targeting apoptosis for the treatment and prevention of digestive diseases

Xie, Q. M., Liu, J., Yu, P., Qiu, T., Jiang, S., & Yu, R. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1570268 · Cited by 19 · see citing works

Probiotics as Potential Biological Immunomodulators in the Management of Oral Lichen Planus: What’s New?

Zanetta, P., Ormelli, M., Amoruso, A., Pane, M., Azzimonti, B., & Squarzanti, D. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073489 · Cited by 18 · see citing works

Effects of Viable and Heat-Inactivated Bifidobacterium longum D42 on Proliferation and Apoptosis of HT-29 Human Colon Cancer Cells

Zhang, Y., Cao, T., Wang, Y., Yang, R., Han, Y., Li, S., Liu, D., Yue, Y., Cao, Y., Li, B., et al. (2024) · Foods · doi:10.3390/foods13060958 · Cited by 18 · see citing works

Investigating the therapeutic potential of Bifidobacterium breve and Lactobacillus rhamnosus postbiotics through apoptosis induction in colorectal HT-29 cancer cells

Erfanian, N., Safarpour, H., Tavakoli, T., Mahdiabadi, M. A., Nasseri, S., & Namaei, M. H. (2024) · Iranian Journal of Microbiology · doi:10.18502/ijm.v16i1.14873 · Cited by 16 · see citing works

Microbiome and bladder cancer: the role of probiotics in treatment

Dadgar-Zankbar, L., Mokhtaryan, M., Bafandeh, E., Javanmard, Z., Asadollahi, P., Darbandi, T., Afifirad, R., Dashtbin, S., Darbandi, A., & Ghanavati, R. (2024) · Future Microbiology · doi:10.1080/17460913.2024.2414671 · Cited by 15 · see citing works

Anticancer Potential of Postbiotic Derived from Lactobacillus brevis and Lactobacillus casei: In vitro Analysis of Breast Cancer Cell Line

Dameshghian, M., Tafvizi, F., Ebrahimi, M. T., & Doust, R. H. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10288-2 · Cited by 13 · see citing works

The Proliferation Inhibitory Effect of Postbiotics Prepared from Probiotics with Antioxidant Activity against HT-29 Cells

Kim, Y., Kim, H. J., & Ji, K. (2022) · Applied Sciences · doi:10.3390/app122412519 · Cited by 13 · see citing works

Evaluation of the Anticancer and Probiotic Potential of Autochthonous (Wild) Lacticaseibacillus paracasei Strains from New Ecological Niches as a Possible Additive for Functional Dairy Foods

Vachkova, Е., Petrova, V., Григорова, Н., Ivanova, Z., & Beev, G. (2023) · Foods · doi:10.3390/foods12010185 · Cited by 12 · see citing works

Lactobacillus acidophilus LA‐5 Postbiotic Induces Apoptosis by Activating the Mitochondrial Apoptotic Pathway in Prostate Cancer

Yavaş, A., Akan, E., Aksel, M., & Erbay, Z. (2024) · Journal of Food Biochemistry · doi:10.1155/jfbc/7855679 · Cited by 10 · see citing works

Lactiplantibacillus plantarum Induces Apoptosis in Melanoma and Breast Cancer Cells

Budu, O., Mioc, A., Şoica, C., Căruntu, F. R., Milan, A., Oprean, C., Lighezan, D., Rotunjanu, S., Ivan, V. M., & Banciu, C. D. (2024) · Microorganisms · doi:10.3390/microorganisms12010182 · Cited by 11 · see citing works

Analysis of the roles of the Notch1 signalling pathway in modulating deoxynivalenol cytotoxicity

Xiao, Y., Wang, J., Wang, J., Wang, H., Wu, S., & Bao, W. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114183 · Cited by 9 · see citing works

Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities?

Nobre, L. M. S., Fernandes, C., Florêncio, K. G. D., de Alencar, N. M. N., Wong, D. V. T., & Lima‐Júnior, R. C. P. (2022) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2022e12522 · Cited by 10 · see citing works

Antiproliferative Potential of Bacillus coagulans Supernatant on SKBR3 Breast Cancer Cell Line

Dolati, M., Tafvizi, F., Salehipour, M., Movahed, T. K., & Jafari, P. (2022) · Iranian Journal of Medical Microbiology · doi:10.30699/ijmm.16.5.383 · Cited by 8 · see citing works

Bifidobacterium apoptosis induction by measuring bax and caspases on SW948 human colon cancer cell line

Soraya, M., Moazamian, E., Shamsdin, S. A., & Dehghani, M. (2025) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2025.106813 · Cited by 7 · see citing works

Cytotoxic and apoptosis-inducing properties of Staphylococcus aureus cytoplasmic extract on lung cancer cells: Insights from MTT assay and bax/bcl-2 gene expression analysis

Ahmadi, M., Hajikhani, B., Shamosi, A., Yaslianifard, S., Sameni, F., Qorbani, M., Mohammadzadeh, M., & Dadashi, M. (2024) · Gene Reports · doi:10.1016/j.genrep.2024.101955 · Cited by 7 · see citing works

PARAPROBİYOTİKLER, POSTBİYOTİKLER VE SAĞLIK ÜZERİNE ETKİLERİ

Geçer, E. U., Öner, Z., Bektaş, A., & Ulusoy, M. (2021) · GIDA / THE JOURNAL OF FOOD · doi:10.15237/gida.gd20141 · Cited by 6 · see citing works

Probiotics and prebiotics in the prevention and management of human cancers (colon cancer, stomach cancer, breast cancer, and cervix cancer )

Jampílek, J., Kráľová, K., & Bella, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00009-x · Cited by 7 · see citing works

Lactobacillus in cancer therapy: A critical mechanistic review

Baker, D. H. A. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.102256 · Cited by 5 · see citing works

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

Yang, X., Zhang, K., Xia, L., & Li, J. (2026) · iMetaMed · doi:10.1002/imm3.70030 · Cited by 5 · see citing works

Cell-Free Supernatant of L. buchneri Probiotic Bacteria Enhancing Apoptosis Activity in AGS Gastric Cancer Cells

Abedi, A., Tafvizi, F., Akbari, N., & Jafari, P. (2023) · Iranian Journal of Science · doi:10.1007/s40995-023-01495-7 · Cited by 5 · see citing works

Bacillus subtilis supernatant improves the efficacy of radiation therapy in rat intestinal epithelial cells by upregulation of bax and caspase-3 genes

Nazari, N., Zandsalimi, F., Abdolhosseini, M., Ghahremani, M. H., & Motevaseli, E. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08694-w · Cited by 4 · see citing works

Marine Prostanoids with Cytotoxic Activity from Octocoral Clavularia spp.

Cheng, M.-Y., Hsu, I.-C., Huang, S., Chuang, Y.-T., Ke, T., Chang, H., Chu, T., Chen, C., & Cheng, Y. (2024) · Marine Drugs · doi:10.3390/md22050219 · Cited by 4 · see citing works

Advances in research on the intestinal microbiota in the mechanism and prevention of colorectal cancer (Review)

Sun, W., Ma, S., Meng, D., Wang, C., & Zhang, J. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13498 · Cited by 4 · see citing works

Sphingosine‐1‐phosphate alleviates irradiation‐induced parotid injury in a miniature pig model

Pan, W., Hu, L., Chen, Y., Zhu, Z., Wang, Y., Song, J., & Shan, Z. (2020) · Oral Diseases · doi:10.1111/odi.13302 · Cited by 4 · see citing works

Probiotics and Cancer

Soleymani, S., Ebrahimi, F., Rezaeizadeh, H., & Rahimi, R. (2021) · Food bioactive ingredients · doi:10.1007/978-3-030-74035-1_18 · Cited by 3 · see citing works

Evaluation of Anti-bacterial, Anti-adenoviral, and Apoptosis-inducing Activity of Bacillus clausii Supernatant

Fateminasab, Z. S., Shayestehpour, M., & Zolfaghari, M. R. (2023) · Jundishapur Journal of Microbiology · doi:10.5812/jjm-132952 · Cited by 3 · see citing works

Live and heat-killed Leuconostoc mesenteroides counteract the gastrointestinal dysfunction in chronic kidney disease mice through intestinal environment modulation

Hayeeawaema, F., Sermwittayawong, N., Tipbunjong, C., Huipao, N., Muangnil, P., & Khuituan, P. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318827 · Cited by 3 · see citing works

The potential of probiotic derivatives of Bacillus coagulans Hammer on induction of apoptosis in colorectal adenocarcinoma cell line in vitro

Vayghan, M. M., Saffarian, P., Ebrahimi, M. T., Aghdaei, H. A., & Yadegar, A. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-05075-7 · Cited by 3 · see citing works

Gut microbiota: key facilitator in metastasis of colorectal cancer

Yu, S., Wang, S., Xiong, B., & Peng, C. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1270991 · Cited by 4 · see citing works

Protective Capacity of Helichrysum italicum Infusion Against Intestinal Barrier Disruption and Translocation of Salmonella Infantis

Kramberger, K., Kranjc, K., Pražnikar, Z. J., Barlič‐Maganja, D., & Kenig, S. (2024) · Pharmaceuticals · doi:10.3390/ph17101398 · Cited by 2 · see citing works

Anticancer effect of a combinatorial treatment of 5-fluorouracil and cell extract of some probiotic lactobacilli strains isolated from camel milk on colorectal cancer cells

Salek, S., Moazamian, E., Mohammadi‐Bardbori, A., & Shamsdin, S. A. (2024) · Folia Microbiologica · doi:10.1007/s12223-024-01228-2 · Cited by 2 · see citing works

Unveiling the Interplay Between the Human Microbiome and Gastric Cancer: A Review of the Complex Relationships and Therapeutic Avenues

Al-Matouq, J. A., Hawra, A., Alibrahim, N., Alsaffar, N., Radwan, Z. H., & Ali, M. D. (2025) · Cancers · doi:10.3390/cancers17020226 · Cited by 2 · see citing works

Heat-killed Lacticaseibacillus paracasei GMNL-346 exerts anti-oral cancer effect by suppressing cancer stem cell activity and rebalancing gut microbiota dysbiosis

Chen, Y.-F., Fan, C.-S., Hung, Y.-C., Chien, P., Tsai, W.-H., Yeh, Y., Jhong, J.-H., Hsieh, Y.-N., Huang, Y.-H., Jan, M., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149033 · Cited by 2 · see citing works

Potential of yeast probiotics as immunomodulators: a new frontier in cancer management

Mahooti, M., Safaei, F., Mousavian, Z., Samimiazad, A., Bakhtiyarizadeh, M., Emadi, A., Babae, L., Hassani, F. S., Eskandari, A., Azman, E. M., et al. (2026) · Future Microbiology · doi:10.1080/17460913.2026.2624283 · Cited by 2 · see citing works

Lactobacillus acidophilus’ post biotic extracts combined with methotrexate regulated the levels of the apoptotic genes’ expressions in the acute lymphoblastic leukemia cell line

Hadad, S. E., Baik, H., Alhebshi, A. M., Aburas, M., Alrahimi, J., & Hassoubah, S. A. (2022) · Medical Science · doi:10.54905/disssi/v26i122/ms111e2020 · Cited by 2 · see citing works

SUPPRESSION OF PROLIFERATION AND INCREASED OF PRO-APOPTOTIC PROTEINS EXPRESSION IN HUMAN BREAST CANCER CELLS AFTER THEIR CO-CULTIVATION WITH BIFIDOBACTERIUM ANIMALIS IN VITRO

Kozak, T., & Lykhova, O. (2024) · Oncology · doi:10.15407/oncology.2024.01.029 · Cited by 2 · see citing works

Research Progress on the Correlation between Gut Microbes and Its Metabolites and Colorectal Cancer

李, 贤. (2025) · Medical Diagnosis · doi:10.12677/md.2025.151007 · Cited by 2 · see citing works

Effect of new bioactive substances obtained from possible probiotic bacteria on miRNA expression by in vitro cocultivation in colorectal cancer cells

Avcı, E., & Avcı, G. A. (2025) · International Journal of Environmental Health Research · doi:10.1080/09603123.2025.2495195 · Cited by 2 · see citing works

In vitro anticancer and antifungal effects of Lactobacillus paracasei supernatants: a step toward sustainable food systems

Erdal, B., Yılmaz, B., Bozgeyi̇k, E., Yıkmış, S., Ahmed, I. A. M., Aljobair, M. O., & Trif, M. (2025) · Frontiers in Sustainable Food Systems · doi:10.3389/fsufs.2025.1645521 · Cited by 2 · see citing works

The cancer microbiome

Li, H., Leaman, A. A., & Zheng, Q. (2025) · Advances in clinical chemistry · doi:10.1016/bs.acc.2025.04.001 · Cited by 1 · see citing works

Major challenges with probiotic stability and efficacy

Chakraborty, M., Budhwar, S., & Kumar, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27594-4.00005-x · Cited by 1 · see citing works

Determination of Cytotoxicity by Calcein-Propidium Iodide Staining for Live and Dead Cell Detection

Sheth, U. V. (2025) · Methods and protocols in food science · doi:10.1007/978-1-0716-4758-5_5 · Cited by 1 · see citing works

Lactic Acid Bacteria: From Bioprocessing to Nanomedicine

Rezvani, M., Manconi, M., & Düzgüneş, N. (2026) · BioChem · doi:10.3390/biochem6010003 · Cited by 1 · see citing works

Investigation of Anti-Cancerous Effects of L.Casei –Atcc-393 and L.Ramnosus-Gg on Apoptosis and Cell Cycle of B- Cpap Thyroid Cancer Cell Line in Comparison to Fibroblast Cell LinePreprint

Honardoost, M., Soleimanifar, F., Eslami, S., Cheragi, S., Khamseh, M. E., Darvish, M., & Kashani, H. H. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4766762

Yeast probiotic Saccharomycopsis fibuligera alleviates the colorectal cancer by inhibiting the choline metabolismPreprint

Li, X., Wang, C., Wang, X., & Wang, T. (2024) · Research Square · doi:10.21203/rs.3.rs-4817265/v1

Probiotic Interventions in Cancer

Singh, B., Mal, G., Kalra, R. S., & Marotta, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-65459-6_11

Function and Application Status of Lactic Acid Bacteria in Intestinal Health

岳, 元. (2024) · Hans Journal of Food and Nutrition Science · doi:10.12677/hjfns.2024.134053

Antioxidant and Anti-Inflammatory Effects of Live and Heat-Killed Limosilactobacillus fermentum isolated from Baekkimchi

Lee, G.-Y., Lee, M., Choi, J.-W., Youn, H.-J., Cho, H., & Park, H. (2024) · Current Topic in Lactic Acid Bacteria and Probiotics · doi:10.35732/ctlabp.2024.10.2.75

Limosilactobacillus fermentum UCO-979C exerts oncobiotic activity on human cancer cell linesPreprint

Alarcón, P., Parra-Sepúlveda, C., Alarcón-Zapata, B., Nova‐Lamperti, E., García, A., Ormazábal, V., & Zuñiga, F. A. (2025) · Research Square · doi:10.21203/rs.3.rs-6779348/v1

In-vitro evaluation of cell free supernatant from Aerococcus viridans isolated from Oreochromis niloticus: Probiotic, antimicrobial, antioxidant, and anticancer activities

KUNJIKULANGARA, S., & Venkatachalam, R. (2025) · Notulae Scientia Biologicae · doi:10.55779/nsb17212288

Postbiotic Compounds Produced by Lactobacillus fermentum as Effective Antiproliferative Agents against HeLa Cells with Favorable Biocompatibility

Fontaine, R. C., & Pelletier, O. M. (2023) · Journal of Medical Sciences and Interdisciplinary Research · doi:10.51847/ygaayo2qj8

Postbiotics as functional alternatives to probiotics in food and animal feed: health effects and industrial potential

Cho, S.-C. (2026) · Food Engineering Progress · doi:10.13050/foodengprog.260004

Investigating the Effects of Heat-Killed Cell-Free Supernatant of Lactobacillus rhamnosus on Murine Melanoma Cells and Animal Models

Deldar, N., Aghasizadeh, M., Hosseinzadeh, M., Matin, M. M., & Rassouli, F. B. (2026) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-026-10639-2

Therapeutic and Adjuvant Effects of Probiotics in the Management of Oral Cancer: A Scoping Review of Preclinical and Clinical Evidence

Kamsu, G. T., & Ndebia, E. J. (2026) · Drugs and Drug Candidates · doi:10.3390/ddc5020030

Integrated Genomic, Structural, and Metabolomic Profiling of Freeze-Dried Postbiotic Supernatants Reveals Multi-Target Anticancer Activity Against Caco-2 Cells

abdelwahab, T., Moneim, A. E. A., El‐Khadragy, M. F., Faraag, A. H. I., Elshopakey, G. E., & Abdalla, M. S. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11079-7

Vitexin-loaded phytosomes protect against high-fat diet-induced MASLD modulating PI3K/AKT/mTOR/SREBP-1c, Nrf2/HO-1, NF-κB/COX-2, and apoptotic pathways

Hegazy, A. M. S., Al-Ghafari, A. B., Doghaither, H. A. A., Elmorsy, E. M., Ghaith, M. M., Alshammari, A. N., Alfayoumi, M. G., & Hassan, A. M. E. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05576-3

Deciphering the Anticancer Potential of Bifidobacterium longum MB BBLM15 Derived Postbiotic Metabolites in Cervical Cancer: In Vitro, In Silico, and Synergy Studies

Mukherjee, A., Chakraborty, D., Khamle, A. R., Sharma, D. D., Patel, H., Shah, U., Banerjee, A., Gupta, P. S. S., Rai, A., Kaushik, G., et al. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11120-9

Molecular mechanisms involved in the anticancer activities of probiotics and postbiotics

Rocchetti, M. T., Mangieri, D., Spano, G., & Fiocco, D. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04411-2

Cytotoxic Effects of Cytoplasmic Extracts from Traditional Yogurt-derived Lactobacillus Strains on HT-29 Human Colorectal Cancer Cells

Haghighi, A., Ghiasian, M., & Ghandehari, F. (2026) · Journal of Shahrekord University of Medical Sciences · doi:10.34172/jsums.1125

Molecular detection of heat-killed probiotic bacteria and study of apoptosis induction on colon cancer HT-29 cell line

Ardestani, S. K., Tafvizi, F., & Ebrahimi, M. T. (2016) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 2 · see citing works

Investigation of the Effect of Lactobacillus Brevis Bacteria on the Expression of Rel A, IKB, and Casp3 Genes in HT29 Colon Cancer Cells

Adeli, H., Ahmadizadeh, C., & Zali, M. H. S. (2022) · Quarterly of Horizon of Medical Sciences · doi:10.32598/hms.28.3.3277.3 · Cited by 1 · see citing works

Cytotoxicity and analysis of apoptosis gene expression in colon cancer cell line treated with cell extract of Lactobacillus casei as indigenous probiotic bacterium

Mirzaie, A., Asgari, E. A., Noorbazargan, H., & Bagheri, A. A. (2017) · DOAJ (DOAJ: Directory of Open Access Journals)

Cell-bound exopolysaccharide extract from indigenous probiotic bacteria induce apoptosis in HT–29 cell-line

Mojibi, P. (2018) · Iranian journal of pathology · doi:10.30699/ijp.14.1.41 · Cited by 40 · see citing works

Lactic Acid Bacteria Mediated Apoptosis Induction: Natural Way of Colon Cancer Cells’ Inhibition

Kurhan, Ş., & Çakır, İ. (2017) · International Conference on Natural Products for Cancer Prevention and Therapy · doi:10.3390/proceedings1101041 · Cited by 5 · see citing works